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(Click for frequent words.) 77 Histone 77 Phosphorylation 75 Intracellular 75 Polymorphisms 74 Apoptotic 74 Neuronal 74 Inhibits 74 Epithelial 74 Cell Adhesion 73 Modulates 73 Oncogenic 73 Macrophage 72 Dopaminergic 72 Transcription Factor 72 Tumor Suppressor 72 Signaling Pathway 72 Homeostasis 72 Mammalian 72 Germline 72 Inactivation 72 Endothelial 72 Signaling Pathways 72 Cytoplasmic 72 Cell Proliferation 71 Proteasome 71 Inhibitory 71 Induces 71 Estrogen Receptor 71 Transcriptome 71 Clusterin 71 Dehydrogenase 71 Polymorphism 71 extracellular signal 71 Cell Differentiation 71 deacetylation 71 Dysregulation 70 Extracellular 70 Progenitor Cells 70 Upregulation 70 Immune Responses 70 Epigenetic 70 Epidermal Growth Factor Receptor 70 Neuroprotection 70 Metabolites 70 mediated inhibition 70 Smooth Muscle 70 Protein Kinase 70 Glucocorticoid 69 Dendritic Cells 69 DNA Methylation 69 Genetic Variation 69 Protein Interactions 69 Factor Receptor 69 Cytochrome P# 69 OCT4 69 Mutational 69 Rap1 69 Protein Expression 69 Fibroblast 69 Cytokine 69 MicroRNA 69 RNA Interference 69 intracellular signaling 69 Inducible 69 serine threonine kinase 69 Differentially 69 Skeletal Muscle 69 Mouse Model 69 Protein Kinase C 69 Phenotypic 69 monocytes macrophages 69 downstream effector 69 Anti Tumor 68 downregulates 68 Secretion 68 Hematopoietic 68 Conjugated 68 Tumor Growth 68 adipogenic 68 proapoptotic 68 Regulates 68 Lymphocyte 68 ERK1 2 68 tumor suppressor PTEN 68 Apoptosis 68 Immune Cell 68 PKC isoforms 68 ERK signaling 68 Mimetics 68 Superoxide 68 Integrin 68 Eukaryotic 68 RNA polymerases 68 Potent Inhibitor 68 Microtubule 68 Tumor Necrosis Factor 68 Cannabinoid 68 Suppresses 68 Extracellular Matrix 68 p#Kip# 68 Tyrosine Kinase Inhibitor 68 Endothelial Cells 68 Neurogenesis 68 Cancer Cells 68 Muscarinic 68 Calcineurin 68 Stromal 68 mTOR signaling 68 Methylation 68 TSC1 68 Tumor Suppressor Gene 68 JAK STAT 68 Hepatic 68 Inhibition 68 Attenuates 68 Immunomodulatory 68 prostaglandin synthesis 68 phosphatidylinositol 3 68 Oxidative 67 Inhibit 67 FasL 67 HIF 1alpha 67 Nicotinic 67 tyrosine phosphorylation 67 Oxidase 67 Mutagenesis 67 MAP kinase 67 transcriptional activation 67 Endoplasmic Reticulum 67 Monocytes 67 serine threonine 67 FKBP# 67 Cytotoxic T 67 Endogenous 67 Hematopoietic Stem Cells 67 Angiogenic 67 Motility 67 Transgenic Mice 67 Novel Mechanism 67 Gene Mutation 67 Kinase Inhibitors 67 RNase L 67 Innate Immunity 67 Conformational 67 Tyrosine Kinase 67 phosphorylates 67 Genotypes 67 proteolysis 67 Circadian Clock 67 Oxidative Stress 67 Synthase 67 Therapeutic Potential 67 Tumor Cell 67 Transmembrane 67 Targeted Therapy 67 phosphoinositide 67 X Chromosome 67 BMAL1 67 P2X 67 Autoantibodies 66 Aberrant 66 Kinase Inhibitor 66 JAK2 enzyme 66 Breast Cancer Metastasis 66 Protein Synthesis 66 Phenotypes 66 actin dynamics 66 mediated apoptosis 66 Conserved 66 GLI1 66 Epitope 66 miRNA expression 66 ß catenin 66 Mitotic 66 Monoclonal Antibody 66 Subunit 66 HIF 1a 66 beta actin 66 E#F# 66 Antigen Specific 66 Neural Stem Cells 66 Glycoprotein 66 HepG2 cells 66 Overexpression 66 glucokinase 66 telomerase reverse transcriptase 66 Glycosylation 66 Transfection 66 inducible nitric oxide synthase 66 Hedgehog signaling 66 subcellular localization 66 Chromosomal 66 mitogen activated protein kinase 66 gene polymorphisms 66 Antitumor 66 Kinase 66 Secretory 66 Kinases 66 protein CETP 66 induced apoptosis 66 Clinical Outcome 66 Mitochondrial 66 antiapoptotic 66 hypoxia inducible factor 66 Shows Promise Against 66 Breast Cancer Cells 66 HIF 1α 66 Tumor Cells 66 Gene Variants 66 Cytotoxic 66 AT1R 66 Hypoxia Inducible Factor 66 FGFR3 66 Fibroblast Growth Factor 66 Structure Function 66 Nuclear Receptors 66 Modulating 66 Receptor Signaling 66 Cathepsin B 66 MMP2 66 constitutively expressed 66 proto oncogene 66 miR #a [001] 66 Osteopontin 66 Small Molecule 66 Neurotrophic Factor 66 Rho GTPases 66 Receptor Antagonists 66 Alleles 66 β catenin 66 microglial activation 66 Antiangiogenic 66 Nuclear Receptor 66 Dendritic Cell 66 Immunologic 66 cells transfected 66 HepG2 66 Gene Expression 66 constitutively active 66 Sp1 66 Androgen 66 Inflammatory Pain 66 Hypothalamic 66 cystic fibrosis transmembrane conductance 65 Rab5 65 microglial 65 Insulin Resistance 65 Molecular Basis 65 androgen receptor AR 65 Ischemic 65 cystic fibrosis transmembrane 65 tropomyosin 65 Tumor Angiogenesis 65 transgenic mouse models 65 ERK pathway 65 kinase pathway 65 NFkB 65 BCL#A 65 Prognostic Factors 65 downregulation 65 Ion Channels 65 Interferon gamma 65 autophagic 65 methyltransferase 65 Systemic Delivery 65 c myb 65 adipogenesis 65 Angiotensin II 65 circadian genes 65 pDC 65 LNCaP cells 65 SIRT2 65 Lentiviral 65 Cyclooxygenase 2 65 Inhibiting 65 Leukocyte 65 Mechanistic 65 c Src 65 transcriptional regulation 65 Cortical 65 adenylate cyclase 65 transiently transfected 65 Hippocampal 65 T#M 65 1beta 65 Tumor Targeting 65 Cytotoxicity 65 selective inhibition 65 Polymerase 65 NF kappaB activation 65 matrix metalloproteinase 65 NFAT 65 EP4 65 TNFalpha 65 Prolongs Survival 65 TNF Alpha 65 Allogeneic 65 bacterial virulence 65 Antigens 65 Nucleic Acids 65 inducible 65 overactivation 65 COX2 65 Coronary Arteries 65 protein phosphorylation 65 Impairs 65 Protease 65 Neurotoxicity 65 TGF ß 65 Reductase 65 glycosyltransferase 65 Fibrinogen 65 PC# cells 65 E3 ubiquitin ligase 65 Androgen Receptor 65 lipid homeostasis 65 Western blotting 65 upregulates 65 immunoregulatory 65 Phospholipase A2 65 Chemokine Receptor 65 Synaptic Plasticity 65 Genes Involved 65 decarboxylase 65 Prolactin 65 cyclooxygenase 2 65 At#g# 65 ubiquitylation 65 Monoclonal 65 antiproliferative activity 65 steroidogenic 65 PI3K Akt 65 Novel Inhibitor 65 Adrenergic 65 neurite outgrowth 65 steroidogenesis 65 Epitopes 65 Lymphoid 64 GABAergic 64 Anti Angiogenic 64 thrombospondin 64 Ribosome 64 nAChRs 64 Flt3 64 Antisense Drug 64 Epstein Barr Virus EBV 64 functional polymorphism 64 NKX#.# 64 biogenesis 64 FUS1 64 Antitumor Activity 64 vimentin 64 DNA methyltransferases 64 SOCS3 64 HDAC enzymes 64 Antisense Oligonucleotides 64 V#F mutation 64 CDKs 64 β1 64 Figure S4 64 Proteases 64 Mesenchymal Stem Cells 64 Aptamer 64 LPS induced 64 receptor tyrosine kinase 64 Oocyte 64 Recombinant Human 64 glucocorticoid receptor GR 64 Oncogene 64 siRNA Delivery 64 mitogenic 64 aberrantly activated 64 oocyte maturation 64 Testis 64 activin 64 Therapeutic Antibody 64 Chimeric 64 Binding Protein 64 noncoding RNAs 64 H#K#me# 64 Leukemias 64 Mucosal 64 Immunological 64 Drug Resistant 64 γ secretase 64 hypothalamic pituitary adrenal axis 64 Dendritic cell 64 Induces Apoptosis 64 catenin 64 Histone Deacetylase 64 Glial 64 microRNAs miRNAs 64 NS5A 64 phosphatases 64 cytokine signaling 64 Epithelial Cell 64 Biosynthesis 64 Mouse Models 64 cytoplasmic domain 64 triggers apoptosis 64 JAK2 V#F 64 Huntingtin 64 Molecular Mechanism 64 Gene Silencing 64 Protein Linked 64 SOD2 64 adhesion molecule 64 virulence genes 64 Novel Therapeutic 64 protein encoded 64 carboxyl terminal 64 MAP kinase pathway 64 Homology 64 synthetases 64 Adenoma 64 differential gene expression 64 transgene expression 64 Dose Response 64 Therapeutic Effects 64 Nucleic Acid 64 Meta Analysis 64 eIF4E 64 IL #p# 64 coexpression 64 Scientists Identify 64 RT qPCR 64 Peripheral Blood 64 BCL2 64 Senescence 64 KLF4 64 Interferon Beta 64 interferon γ 64 Pathogenesis 64 Morphological 64 Aldosterone 64 micro RNA 64 iNOS 64 ESR1 64 hydrolase 64 ERK1 64 apoptosis inducing 64 hematopoiesis 64 IL 1ß 64 regulated kinase ERK 64 acyltransferase 64 Phosphatase 64 Drp1 64 Molecular Mechanisms 64 protein tyrosine kinase 64 Replacement Therapy 64 Oncolytic 64 oncogenic signaling 64 phospholipase A2 64 VE cadherin 64 Researchers Identify 64 Cystic Fibrosis Transmembrane Conductance 64 Runx2 64 missense mutation 64 cyclin dependent kinase inhibitor 64 Nucleotide 64 Chemotherapeutic Agents 64 Autoimmune Diseases 64 prolyl 64 Myeloid 64 vascular endothelial 64 matrix metalloproteases 64 cyclooxygenase COX 64 protein tyrosine phosphatase 1B 64 genes encoding 63 constitutive activation 63 Insulin Sensitivity 63 p# MAPK 63 Attenuated 63 induced phosphorylation 63 Catenin 63 TGF beta1 63 ubiquitination 63 Pegylated 63 Endothelium 63 Incretin 63 Tumor Progression 63 mRNA expression 63 cytokine receptor 63 retinoic acid receptor 63 Telomere 63 Expression Profiling 63 protein secreted 63 Leukemic 63 Cell Derived 63 lymphangiogenesis 63 acetylcholine receptor 63 uPAR 63 Tie2 63 Effective Treatments 63 chromosome condensation 63 morphogenesis 63 urate oxidase 63 Hypercholesterolemia 63 intronic 63 matrix metalloproteinases 63 matrix metalloproteinases MMPs 63 Cell Signaling 63 Selective Inhibitor 63 Platelet Derived Growth 63 Transdermal Delivery 63 TGF β 63 Premature Aging 63 Immunohistochemical 63 phospholipase C 63 TIMP 1 63 peroxidase 63 Metastasis 63 Secretase 63 proteolytic cleavage 63 cyclic nucleotide 63 Oligonucleotides 63 5 hydroxytryptamine 63 Histone H3 63 promoter methylation 63 Malignancies 63 stably expressing 63 Smad3 63 Retroviral 63 Synuclein 63 Stem Cell Differentiation 63 Immune Cells 63 eicosanoid 63 Subtypes 63 ERBB2 63 Aurora Kinase 63 replicase 63 glucose transporter 63 eNOS 63 cell adhesion molecule 63 FoxP3 63 Mammalian Cells 63 proximal tubule 63 MTHFR 63 LDL receptor 63 HDAC 63 DNA intercalator 63 Genetic Mutation 63 cAMP dependent 63 apoE 63 cotransporter 63 ACER paper 63 histone acetyltransferase 63 proinflammatory 63 Circulating Tumor Cells 63 caveolin 63 adipocyte 63 ERK phosphorylation 63 Breast Tissue 63 BRAF V#E 63 hydroxylase 63 RRM1 63 Genes Linked 63 acyl CoA 63 adrenocortical 63 prostaglandin E 63 Neurotransmitter 63 CpG island 63 Protein kinase 63 ERalpha 63 Preclinical Study 63 Antithrombin 63 Present Preclinical Data 63 airway epithelial 63 oxidase 63 Virus Infection 63 Protein Function 63 Brain Function 63 Elucidation 63 cyclic adenosine monophosphate cAMP 63 PAX5 63 transduced 63 metalloproteinase 63 stably transfected 63 Signal transduction 63 potent inhibitors 63 Ligands 63 Factor VEGF 63 Myostatin 63 Supplemental Figure 63 Epidermal 63 transcriptional repressor 63 myopathies 63 Clinical Relevance 63 Hepatocyte 63 Anti Tumor Activity 63 gene rearrangements 63 dependent protein kinase 63 Adenoviral 63 chromatin remodeling 63 siRNA knockdown 63 beta globin gene 63 lysates 63 adrenoceptor 63 Renin 63 FGF receptor 63 BiTE Antibody 63 protein phosphatase 63 Neonatal Diabetes 63 Brain Derived Neurotrophic 63 Heterogeneity 63 Arp2 3 63 Nitric Oxide Synthase 63 Somatostatin 63 hepatic lipase 63 Plasmid DNA 63 tumorigenicity 63 Treating Chronic 63 Microarray Analysis 63 mechanotransduction 63 receptor mediated endocytosis 63 Wnts 63 Protein Involved 63 ubiquitin ligase 63 methylenetetrahydrofolate reductase 63 Molecular Evolution 63 Situ Hybridization 63 proteasome inhibition 63 Progenitor Cell 63 mTOR mammalian target 63 regulator CFTR gene 63 mediated phosphorylation 63 Carnegie Institution Embryology 63 peroxisome proliferator activated 63 Pharmacologic 63 PDGFR 63 transcriptional regulator 63 Cytochrome 63 Antisense 63 IL6 63 Immunostimulatory 63 Cancer Stem Cells 63 Endothelial Cell 63 antisense inhibitor 63 polycystin 1 63 regulated kinase 63 GABAA receptors 63 Drug Candidate 63 overexpressing 63 Nedd4 63 Novel Method 63 c MYC 63 Disease Progression 63 P#Y# [001] 63 protein tyrosine phosphatases 63 hematopoietic progenitors 63 serine protease 63 Pancreatic 63 glucocorticoid receptor 62 COL#A# 62 Radiofrequency Ablation 62 Peroxisome proliferator activated 62 Radiation Induced 62 Amyloid 62 GRP# 62 Abnormalities 62 EGFR signaling 62 actin cytoskeleton 62 CYP#A# CYP#D# 62 TGF beta pathway 62 isomerase 62 Inflammatory Markers 62 factor HGF 62 caveolin 1 62 Neuroprotective 62 Oligonucleotide 62 peptide receptor 62 c Myb 62 Calcification 62 MDR1 62 NF kappaB 62 potent inhibition 62 Rho GTPase 62 TrkA 62 humoral immunity 62 Pharmacological 62 HER2 HER3 62 Zinc Finger 62 ligand induced 62 c KIT 62 Orally Active 62 MT1 MMP 62 Monocyte 62 apoptosis pathways 62 TMEM#B 62 FGFs 62 Fas ligand 62 Morpholino 62 Glutamate 62 RUNX3 62 Quantitation 62 Epithelium 62 Activating mutations 62 Therapeutic Targets 62 5 HT2A serotonin 62 BCR ABL1 62 murine model 62 Apc 62 #:#-# [037] 62 transactivation 62 PLA2 62 transgenic mice expressing 62 Brain derived neurotrophic 62 TXNIP 62 Aromatase 62 Therapeutic Agents 62 Tubulin 62 p# p# 62 microsomal 62 transmembrane protein 62 Epidermal Growth Factor 62 lipopolysaccharide 62 druggable target 62 Cerebral Cortex 62 Bile Acid 62 protein biosynthesis 62 Major Histocompatibility Complex 62 p#NTR 62 pRb 62 Autoimmune Disorders 62 Breast Cancer Stem Cells 62 evolutionarily conserved 62 Autoimmune Disease 62 TGF b 62 Neutrophil 62 Reperfusion Injury 62 dinucleotide 62 prostaglandin E2 PGE2 62 receptor subtypes 62 neuronal signaling 62 Adipose Tissue 62 annexin V 62 transcriptionally 62 forkhead 62 SNCA 62 μ opioid receptor 62 beta1 integrin 62 intercellular signaling 62 hypermethylation 62 Salivary 62 induces apoptosis 62 transcriptional repression 62 Analogs 62 Disease Causing 62 Polycomb 62 Gene Linked 62 GTPase 62 beta subunit 62 Antiviral Activity 62 protein kinase C 62 Receptor Agonist 62 S#P# 62 homodimers 62 Malaria Parasite 62 F actin 62 dopamine D2 62 Novel Oral 62 messenger ribonucleic acid 62 AnaSpec Introduces 62 annexin 62 pharmacological inhibition 62 Dystrophin 62 noncoding RNA 62 Kir#.# 62 Allosteric 62 carboxylase 62 osteoprotegerin 62 cytokine receptors 62 CYP#C# [002] 62 deacetylase 62 1alpha 62 GluR1 62 genes encode proteins 62 Toxicogenomics 62 Leukotrienes 62 Antiviral Therapy 62 WNK1 62 Receptor Antagonist 62 Beta Amyloid 62 Th1 type 62 cAMP signaling 62 cisplatin resistant 62 polyamine 62 Jhdm2a 62 Cytogenetic 62 alveolar macrophages 62 cytotoxic T lymphocyte 62 phosphoprotein 62 alternatively spliced 62 Biol 62 Bacterial Cell 62 anaphase promoting complex 62 Solid Tumors 62 c Fos 62 Ubiquitin 62 anti CD3 62 peroxisome 62 Endometrial 62 Androgen receptor 62 H#K# [002] 62 antisense molecules 62 potently inhibit 62 mRNA translation 62 catechol O methyltransferase 62 cell motility 62 Therapeutic Efficacy 62 thyrotropin 62 Galectin 3 62 Microfluidic Devices 62 PDE4 62 Wnt signaling 62 WT1 62 Nerve Cells 62 PPARg 62 apoptotic pathway 62 Highly Potent 62 MEK ERK 62 Mediated 62 Antifungal 62 Cadherin 62 RANTES 62 Pharmacodynamics 62 noradrenergic 62 MAPK 62 Hepatocytes 62 PDGF receptor 62 activating mutation 62 Polymerase Inhibitor 62 extracellular dopamine 62 Fibrosis 62 Study Sheds Light 62 Pathogenic 62 deaminase 62 osteoclast formation 62 Anticancer 62 Axonal 62 transthyretin 62 Nucleoside 62 Left Ventricular 62 mitogen activated protein 62 FLT3 62 Neural Circuits 62 #q#.# [001] 62 Protease Inhibitor 62 Apolipoprotein E 62 Rb#/p# 62 Evoked 62 E3 ligase 62 SCD1 62 Abeta peptide 62 monocyte 62 Notch receptor 62 Zinc Finger Nucleases 62 muscle contractility 62 FGFR4 62 HDAC3 62 succinate dehydrogenase 62 LRP6 62 Neuropeptide Y 62 alpha subunit 62 DNA hypermethylation 62 Macromolecular 62 hypothalamic pituitary 62 chemokine receptors 62 NFκB 62 Nf1 62 ribosomal proteins 62 Pharmacokinetic Study 62 Genetic Marker 62 retinal ischemia 62 hepatoma 62 Gamma secretase 62 Vitro Activity 62 Immunosuppression 62 pathophysiological effects 62 Tyrosine 62 Leukemia Cells 62 #:#-# [023] 62 selective modulator 61 neurofibromin 61 Mesenchymal 61 selectively inhibited 61 subcellular compartments 61 phosphatase 61 receptor kinase 61 CD8 T cell 61 Liposomal 61 Nucleation 61 histone acetylation 61 histone H3 61 MAPK pathway 61 PI3K/Akt 61 sortilin 61 Membrane Proteins 61 Breast Tumors 61 GTPases 61 Bioavailability 61 Single Molecule 61 Phenotype 61 PGC 1α 61 somatostatin 61 PTPN# 61 LRP5 61 SPINK1 61 ectopic expression 61 NR2B subunit 61 fibrogenesis 61 c fos 61 LPA1 receptor 61 isoenzymes 61 Akt signaling 61 sphingolipid 61 Virulence 61 ultrastructure 61 synthases 61 Adiposity 61 CD# CD# 61 N methyl 61 PAR1 61 NMDAR 61 presynaptic 61 BMP signaling 61 P cadherin 61 SMN1 61 Provides Clues 61 cytidine 61 CYP #D# 61 GLUT4 61 Ribosomal 61 Neoplastic 61 synaptogenesis 61 Neurodegenerative Disease 61 NF KappaB 61 poly ADP ribose polymerase 61 Kidney Function 61 mineralocorticoid 61 Prostatic 61 humanized monoclonal 61 FOXO1a 61 muscarinic receptors 61 BMP2 61 hTERT 61 Mcl 1 61 ABCB1 61 1ß 61 Amino acid 61 LDLR 61 CK2 61 Lymphocytes 61 N myc 61 ouabain 61 M1 muscarinic 61 IGF IR 61 monocyte chemotactic protein 61 bFGF 61 Reactive Oxygen Species 61 Immune Mediated 61 pertussis toxin 61 neuroinflammatory 61 pro angiogenic 61 pleiotropic 61 myeloid derived 61 colon carcinoma 61 Shown Effective 61 histone deacetylase 61 MLH1 61 Spatiotemporal 61 HLA DR4 61 HPA axis 61 calcium homeostasis 61 histone methyltransferase 61 PPARgamma 61 oligomerization 61 Cyclin Dependent 61 potent inducer 61 Gene Variant 61 bone morphogenetic proteins BMPs 61 astrocytic 61 Wnt signaling pathway 61 Liver Injury 61 HOTAIR 61 Kv#.# 61 Interfacial 61 nitric oxide synthase NOS 61 lipoprotein metabolism 61 upregulating 61 Retinoic Acid 61 experimental autoimmune encephalomyelitis 61 Blood Flow 61 EGF receptor 61 Diabetic Neuropathy 61 See CLINICAL PHARMACOLOGY 61 embryonal carcinoma 61 Cutaneous 61 Presents Preclinical Data