Related by context. All words. (Click for frequent words.) 64 upregulates 61 potentiated 60 modulates 60 agonism 60 potentiation 60 potentiates 60 muscarinic receptors 60 vasoconstrictor 59 noradrenergic 59 lipopolysaccharide induced 59 nociceptive 59 mitogenic 59 attenuate 59 NF kappaB activation 59 vagal 58 afferents 58 nicotinic 58 downregulates 58 excitotoxic 58 ERK activation 58 suppresses 58 attenuating 58 dose dependently 58 astrocytic 58 proinflammatory 58 D aspartate 58 overactivity 58 prostaglandin E2 PGE2 57 serotonin reuptake 57 endothelium dependent 57 pleiotropic 57 Fig. 3B 57 #HT#A 57 muscarinic 57 nitric oxide synthase NOS 57 mu receptors 57 lipopolysaccharide 57 modulating 56 nociceptors 56 inhibit platelet aggregation 56 insertional 56 hypothalamic pituitary adrenal HPA 56 proximal tubule 56 modulatory 56 glomerular 56 microglial activation 56 detrusor 56 degranulation 56 ouabain 56 adrenoceptor 56 potentiate 56 partial agonist 56 M1 muscarinic 56 mediated inhibition 56 efferent 56 cyclooxygenase COX 56 amyloid β 56 5 hydroxytryptamine 56 airway hyperreactivity 56 Angiotensin II 56 chloride secretion 56 glucocorticoid 56 selectively binds 56 p# MAPK 56 autophagic 56 mineralocorticoid 56 inflammatory cytokines TNF 56 MAP kinase 56 oxidative metabolism 56 thromboxane A2 56 HPA axis 56 induced apoptosis 56 somatostatin 55 Î ² 55 induces 55 vaso 55 vasodilatation 55 CYP #A# 55 baroreceptor 55 platelet adhesion 55 prostaglandin synthesis 55 AT1 receptor 55 Aldosterone 55 LPS induced 55 5 HT1A 55 N methyl 55 5 HT2A receptor 55 attenuated 55 receptor subtypes 55 hindlimb 55 IL 1ß 55 GHRH 55 acetylcholine receptor 55 raphe 55 dephosphorylation 55 PKC inhibitor 55 eicosanoid 55 glutamatergic 55 cerebral ischemia 55 mechanical allodynia 55 Sgk1 55 neuronal dysfunction 55 overactivation 55 lysosomal 55 cholesterol homeostasis 55 hypothalamic pituitary 55 NFkappaB 55 NMDAR 55 myofibroblast 55 platelet activation 55 mu receptor 55 P cadherin 55 hypoxia induced 55 catabolism 55 ERK1 2 55 autocrine 55 downregulation 54 sinus tachycardia 54 vasodilatory 54 mineralocorticoid receptor 54 depolarizing 54 peptide CGRP 54 hyperalgesia 54 endogenous opioid 54 adrenocortical 54 ERK phosphorylation 54 CD#b 54 IL 1β 54 eNOS 54 analgesic effects 54 Oxidative 54 natriuresis 54 MEK1 54 potentiating 54 alveolar epithelial cells 54 downregulating 54 nitric oxide synthase 54 interleukin 1β 54 hypothalamic 54 IL6 54 alveolar macrophage 54 overactivated 54 somatostatin receptor 54 AMPA receptor 54 collagen degradation 54 heme oxygenase 54 Hsp# chaperone 54 inflammatory cytokine 54 potent inducer 54 Extracellular 54 downregulate 54 neurohormonal 54 eotaxin 54 GABAA receptors 54 inferior frontal 54 metabolizing enzyme 54 1alpha 54 dopaminergic 54 renal excretion 54 antiapoptotic 54 tryptase 54 TGF beta1 54 gastric mucosa 54 immunomodulatory effects 54 induced cytotoxicity 54 receptor inhibitor 54 receptor antagonism 53 baroreflex sensitivity 53 ERalpha 53 glutamyl 53 innervation 53 anti inflammatory cytokine 53 muscarinic receptor 53 inducible 53 calcitonin gene related 53 hyperresponsiveness 53 LPA1 receptor 53 lysyl oxidase 53 chondrocyte 53 pathway inhibitor 53 constipating effects 53 induced phosphorylation 53 mitogen activated protein kinase 53 coexpression 53 upregulation 53 Fig. 3a 53 apoptosis induced 53 intimal hyperplasia 53 nociception 53 HIF 1a 53 proteolysis 53 acidic reflux 53 hyperexcitability 53 tyrosine hydroxylase 53 neurofilament 53 leukotriene 53 pharmacological inhibition 53 inhibitory effect 53 #HT#A receptor 53 transcriptional activity 53 paracrine 53 constitutively expressed 53 thermosensitive 53 Fig. 2B 53 microsomal 53 c Fos 53 p# alpha [001] 53 collagen synthesis 53 NKG2D 53 beta. 53 polydipsia 53 leukocyte infiltration 53 dorsolateral 53 XP# Transported Prodrug 53 aminobutyric acid 53 receptor mediated 53 induces apoptosis 53 dysregulated 53 β cell 53 5 HT2C 53 β 53 counteracts 53 ADAMTS# 53 thrombin receptor 53 prostaglandin E1 53 Fig. 1C 53 inhibitory effects 53 alpha1 53 prostatic tissue 53 hepatocellular 53 cyclooxygenase 2 53 contractility 53 anterograde 53 cotransporter 53 adenylate cyclase 53 RANK Ligand 53 dopamine reuptake 53 baroreflex 53 esterase 53 renin angiotensin system 53 preterm neonates 53 neuro transmitters 53 myocyte 53 glycosaminoglycan 53 vasoactive 53 cytokine interleukin 53 diffusible 53 inhibits 53 monoamine 53 natriuretic 53 endothelial 53 selective antagonist 53 acid GABA 53 JAK#/JAK# 53 tyrosinase 53 TRPV1 receptors 53 LTB4 53 TRPM8 53 heme oxygenase 1 53 proteoglycan 53 reuptake 53 GABAergic 53 5 HT2A serotonin 53 adrenergic 53 ß catenin 53 extracellular calcium 53 dorsal horn 53 allergen induced 53 posterior cingulate 52 5 HT1A receptor 52 γ 52 peripheral insulin sensitivity 52 cerebellar 52 iNOS 52 dopamine D2 52 Modulates 52 μ opioid receptor 52 MMP2 52 neurohormones 52 oxidase 52 occludin 52 fig. S2 52 experimentally induced 52 receptor blockers 52 selective modulator 52 membrane permeability 52 immunoreactive 52 F actin 52 induced oxidative stress 52 p#Kip# 52 inhibiting COX 52 growth hormone secretion 52 cytoprotective 52 modulate 52 converting enzyme 52 phosphatidylinositol 3 52 diphosphate 52 hapten 52 plasminogen activator inhibitor 52 gamma aminobutyric acid 52 immunostimulatory 52 oncogenic transformation 52 eccrine 52 covalently bound 52 agonist induced 52 act synergistically 52 isoproterenol 52 oligomerization 52 CaM 52 mitochondrial pore 52 proapoptotic 52 catecholamine 52 activator 52 Th2 52 ERK signaling 52 gyri 52 Inhibition 52 beta endorphin 52 SOCS3 52 neurotrophic 52 akinesia 52 adipocyte 52 Akt signaling 52 peritumoral 52 hypotensive 52 leptin receptor 52 intestinal absorption 52 myoclonus 52 NR2B subunit 52 Aâ 52 covalently linked 52 CCR2 52 depolarization 52 prolyl 52 reticular 52 endothelial activation 52 CD1d 52 neuritic 52 prostaglandin E 52 brain neurotransmitter 52 saturable 52 BMP signaling 52 phenothiazines 52 Prefrontal 52 transduction 52 isoenzymes 52 Smad4 52 TGF ß 52 inverse agonist 52 pilocarpine 52 mu opioid 52 stimulate insulin secretion 52 serine threonine 52 TRPV4 52 alpha subunit 52 intestinal mucosa 52 aberrantly activated 52 Exogenous 52 transcriptional repressor 52 physis 52 transmural 52 receptor gamma 52 S6K 52 inhibits tumor 52 leukocyte recruitment 52 #β HSD1 52 glucocorticoid receptors 52 cardiac myocytes 52 Eq. 52 monocyte 52 CEACAM1 52 TrkB 52 thrombogenic 52 potent inhibitors 52 impaired hepatic 52 cyclic nucleotide 52 endoplasmic 52 STAT1 52 hypoperfusion 52 selectively inhibited 52 #ß 52 cholesterol biosynthesis 52 striatal 52 Fig. 1a 52 inhibition 52 TNFalpha 52 PPARg 52 proline residues 52 HepG2 cells 52 parkinsonian 52 Phosphorylation 52 bronchodilatory 52 tympanic 52 receptor subtype 52 lipid soluble 52 Ca2 + 52 GLP 1R 52 Notch1 52 luminal surface 52 upregulated 52 intraventricular 52 inhibits bacterial 52 superoxide anion 52 detuning 52 tibial nerve 52 induced neuronal 52 epithelial barrier 52 neocortical 52 phonophobia 52 TRPV3 51 beta adrenergic 51 distension 51 melatonin receptors 51 inflammatory mediators 51 steroidogenic 51 GI motility 51 PON1 51 receptor activation 51 Rho kinase 51 amide 51 monophosphate 51 thyrotropin 51 hypertrophic 51 methyl D aspartate 51 hypothalamic pituitary adrenal axis 51 AT1R 51 reductase 51 costimulation 51 gamma amino butyric 51 vibrationally excited 51 adrenocorticotropic hormone 51 1beta 51 neurosteroid 51 intra tumoral 51 Fig. 2b 51 enkephalin 51 D3 receptors 51 receptor mediated endocytosis 51 epididymal 51 HuR 51 mitochondrial membrane 51 neuroinflammatory 51 opioid antagonist 51 opioid receptor antagonist 51 potassium ion 51 nitrotyrosine 51 TGFβ 51 potent inhibition 51 photic 51 upregulate 51 solubilization 51 TGFß 51 caspase activation 51 fibrogenesis 51 Nampt 51 chloride channels 51 glucocorticoid receptor 51 tau phosphorylation 51 IRE1 51 adrenocorticotropic hormone ACTH 51 elastase 51 pyrophosphate 51 chlordiazepoxide 51 sinus node 51 renin angiotensin aldosterone 51 cyclic AMP cAMP 51 morphologic characteristics 51 excitatory neurotransmitter glutamate 51 interleukin 1ß 51 fatty acid oxidation 51 mesolimbic 51 galactosidase 51 tumorigenicity 51 siRNA mediated 51 nicotinic receptor 51 rostral 51 transgene expression 51 TRPA1 receptor 51 ATP hydrolysis 51 hormone secretion 51 metaplasia 51 fibrin deposition 51 locomotor activity 51 inhibiting 51 lowers blood glucose 51 receptor modulator 51 TrkA 51 renal tubular 51 extracellular signal 51 hypertonic 51 allopregnanolone 51 mu opioid receptor 51 MMP9 51 allergic inflammation 51 serotonergic 51 FasL 51 motilin 51 peroxynitrite 51 mRNA expression 51 M2 macrophages 51 protein synthesis inhibitors 51 ß1 51 paxillin 51 KATP channels 51 Dysregulation 51 protein Hsp# 51 GH secretion 51 Th1 51 acyl CoA 51 homeostatic 51 corticotropin 51 infected erythrocytes 51 guanosine 51 intratumoral 51 endothelial nitric oxide synthase 51 EP1 receptor 51 innervated 51 Ras MAPK pathway 51 MT1 MMP 51 pharyngeal 51 endogenous ligand 51 inhibitory 51 SIRT2 51 catenin 51 Tubulin 51 hypersecretion 51 podocyte 51 TNFα 51 endocannabinoid signaling 51 Kinoid 51 Nav#.# 51 mGluR5 inhibition 51 collagen deposition 51 adsorbs 51 selective agonists 51 nicotinic acetylcholine receptor 51 beta subunit 51 soluble CD# 51 pulmonary inflammation 51 phosphatidylinositol 51 gastric acid secretion 51 perivascular 51 thromboxane 51 MMP# 51 adrenal cortex 51 unconjugated 51 cardioprotection 51 TNF α 51 phosphorylates 51 interleukin 1beta 51 proinflammatory cytokine 51 soluble TNF receptor 51 PDGF alpha receptor 51 alveolar macrophages 51 endogenous 51 pulmonary arterial 51 mitogen activated protein 51 nasal mucosa 51 Purkinje cell 51 erythrocyte 51 receptor CXCR4 51 ATPase 51 leptin signaling 51 myofibroblasts 51 type glutamate receptor 51 inactivates 51 glutamate receptors 51 IL #p# 51 γ secretase 51 hydrolytic 51 hERG channel 51 N acetyl 51 vasodilation 51 osteoclast formation 51 hypothalamus pituitary 51 PTP1B 51 neuro transmitter 51 enkephalins 51 choroidal 51 GABAB receptors 50 hydrolase 50 afferent 50 ciliary 50 H#K#me# 50 predisposing factor 50 PKC isoforms 50 hepatic lipid 50 PPAR peroxisome proliferator activated 50 atherogenesis 50 transferase 50 opioid receptor 50 secretase 50 NADPH oxidase 50 pro angiogenic 50 cholecystokinin CCK 50 thrombus formation 50 trigeminal 50 subtype selective 50 tubule 50 GABAA 50 Amino acid 50 metabotropic glutamate 50 physiologic 50 pudendal 50 NMDA N 50 activated macrophages 50 serine 50 PGC 1α 50 intestinal epithelium 50 PECAM 1 50 Foxp3 + 50 gonadotrophin releasing hormone 50 null mice 50 cAMP signaling 50 murine 50 CaMKII 50 androgenic 50 vasodilator 50 tyrosine phosphorylation 50 ischemia induced 50 nAChR 50 Selective inhibition 50 ENaC 50 GLP1 50 metalloproteases 50 antidiuretic hormone 50 denervation 50 proteolytic 50 airway epithelial 50 fractional shortening 50 sub maximal 50 eluted 50 experimental autoimmune encephalomyelitis 50 theta rhythm 50 neuronal excitability 50 pro inflammatory cytokine 50 Inhibitory 50 VE cadherin 50 postsynaptic neuron 50 neuropeptide Y 50 mutant huntingtin protein 50 hepatotoxic 50 Cx# [001] 50 myocardial 50 vascular inflammation 50 voltage gated 50 Parkinsonian 50 neuronal signaling 50 glucose transporter 50 IFN γ 50 lymphotoxin 50 posttraumatic 50 VEGF induced 50 Fig. 2C 50 Preclinical studies suggest 50 transcriptional regulator 50 BMAL1 50 V#F mutation 50 FGFR4 50 thermoregulatory 50 edematous 50 inhibits platelet aggregation 50 mitochondrial oxidative phosphorylation 50 lactational 50 Dopaminergic 50 deacetylation 50 mitochondrial respiration 50 anti apoptotic 50 CCL# 50 allantoin 50 antiproliferative activity 50 protein tyrosine phosphatase 1B 50 chemokine SDF 1 50 lipid accumulation 50 phagocytic 50 microtubule dynamics 50 transiently 50 cytokine signaling 50 alveolar 50 cardiac myocyte 50 chemotactic 50 fatty acid amide hydrolase 50 cyclic adenosine monophosphate cAMP 50 ablates 50 prostanoid 50 Macrophage 50 autoantibody levels 50 IKKß 50 pulse amplitude 50 Upregulation 50 Alanine 50 muscle spasticity 50 fronto 50 orexin receptors 50 ERK5 50 macrophage infiltration 50 selective inhibition 50 dopamine transporter DAT 50 lytic 50 diffusive 50 antiinflammatory 50 myometrial 50 mu opioid receptors 50 modulated 50 #β estradiol 50 cathepsin B 50 Figure 1A 50 diuresis 50 endogenously 50 NKT cell 50 oligomeric 50 airway hyperresponsiveness 50 Overexpression 50 aminopeptidase 50 fibril formation 50 Inhibiting 50 transcriptional activation 50 DRG neurons 50 cortico 50 P#X# receptor 50 IL 1beta 50 alpha secretase 50 eIF4E 50 autoregulation 50 HMG CoA reductase 50 TGF beta signaling 50 tumor vasculature 50 calcium homeostasis 50 downregulated 50 parenchymal 50 PGI2 50 lowering blood glucose 50 coagulopathy 50 amino acid glutamate 50 pathophysiological effects 50 renal fibrosis 50 stimulated insulin secretion 50 CD#c 50 VEGF expression 50 isozyme 50 NS3 protease 50 Neuropeptide Y 50 polyuria 50 aggrecan 50 splanchnic 50 digesting enzymes 50 peroxidase 50 P#X# receptors 50 myocardial contractility 50 ACh 50 thymic 50 mesenteric 50 lipoprotein lipase 50 electroencephalographic 50 leukocyte adhesion 50 murine model 50 mediated apoptosis 50 allosteric 50 nephrotoxicity 50 bax 50 uM 50 Vasopressin 50 β catenin 50 bladder contractions 50 TNFR 50 dissociation 50 cytoplasmic domain 50 neutrophil elastase 50 inhibiting renin 50 leukocyte counts 50 vascular endothelial 50 Runx2 50 #Hz #Hz [001] 50 BPH benign prostatic 50 selectively inhibiting 50 autonomic nerve 50 Mice deficient 50 enzymatic degradation 50 plasmin 50 mitochondrial biogenesis 50 potentiator 50 oscillatory behavior 50 ornithine decarboxylase 50 pro oxidant 50 Kupffer cells 50 PTHrP 50 pyramidal cells 50 triggers apoptosis 50 sensory gating 50 dissociates 50 tropomyosin 50 serine protease 50 pulmonary artery pressure 50 mPGES 1 50 feedforward 50 myocardial tissue 50 dispersive 50 coadministration 50 extraocular 50 cytidine 50 TRPV1 receptor 50 Hsp# chaperone system 50 intracellular calcium 50 anorectic 50 D2 receptor 50 gastric mucosal 50 erythropoiesis 50 mRNA translation 50 SMase 49 keratinocyte 49 inducible nitric oxide synthase 49 lung epithelium 49 thrombopoietin TPO natural 49 hypothalamic pituitary axis 49 amyloid peptide 49 fig. S3 49 antegrade cerebral perfusion 49 gastrointestinal motility 49 messenger ribonucleic acid 49 plasma lipid 49 regulated kinase ERK 49 topo II 49 Androgen receptor 49 neurotransmitters serotonin 49 NMDA receptors 49 antiproliferative 49 EGFR signaling 49 osteoblast differentiation 49 fibrotic disease 49 ventromedial 49 Schematic representation 49 ErbB receptors 49 blood vessel constriction 49 neuronal differentiation 49 activate p# 49 5 HT2A 49 osteolytic 49 junctional 49 systemic inflammation 49 c myc gene 49 induce apoptosis 49 serine threonine kinase 49 ligand induced 49 receptor kinase 49 muscarinic antagonist 49 dopamine norepinephrine 49 pineal 49 c Src 49 systolic ejection 49 anterior cortex 49 constitutively active 49 postprandial insulin 49 alpha adrenergic 49 serotonin receptor 49 acetylated 49 5' triphosphate 49 T2 weighted images 49 adrenergic receptor agonist 49 mTOR signaling 49 opioid receptors 49 ASIC1a 49 acyclic 49 colorectal carcinogenesis 49 plasmatic 49 monocyte chemotactic protein 49 glycosaminoglycans 49 adipokine 49 intestinal permeability 49 anterolateral 49 prothrombotic 49 ischemia reperfusion 49 TLR2 49 Optic nerve 49 Phenylalanine 49 chemosensory 49 Kv#.# 49 innervate 49 inhibit 49 posttranslational modification 49 improves insulin sensitivity 49 osteogenic 49 hyperactivation 49 satiety hormone 49 nephrotoxic 49 excitatory 49 axonal damage 49 stimulates insulin secretion 49 adventitia 49 ^ sup ^ 49 transactivation 49 hyperinsulinemia 49 LDL receptor 49 Th1 cells 49 gonadal 49 PDGFR 49 glucagon receptor 49 vasoconstriction 49 hypercapnia 49 phagocytosis 49 Rap1 49 protein CETP 49 phorbol 49 receptor blocker 49 epithelial sodium 49 hydrolases 49 Adrenergic 49 β1 49 vaso occlusive 49 lactate dehydrogenase 49 CB1 receptors 49 SCD1 49 glycolytic 49 H2 antagonists 49 transduced 49 opiate antagonist 49 vasopressor 49 PI3K/Akt pathway 49 cyclooxygenase 49 glucokinase 49 Myosin II 49 repolarization 49 hyperintensity 49 dysregulation 49 hyper responsiveness 49 pulvinar 49 T lymphocyte 49 jugular venous 49 insulin signaling pathways 49 corticotrophin releasing factor 49 histamine receptors 49 plasma fibrinogen 49 dopamine transporter 49 Hippocampal 49 intraperitoneal injection 49 2A receptor 49 Thyroid hormone 49 NMDA antagonist 49 DNMT1 49 transduce 49 cell adhesion molecules 49 periocular 49 dopamine depletion 49 removes endotoxin 49 related apoptosis inducing 49 mevalonate 49 Tasigna prolongs 49 glycosyltransferase 49 dorsal anterior cingulate cortex 49 Norepinephrine 49 FOXO 49 parasitemia 49 dehydrogenase 49 potently inhibited 49 neuromuscular junction 49 pupillary 49 inhibiting viral replication 49 GLUT4 49 phrenic 49 viral polymerase 49 WNK1 49 corticotrophin releasing hormone 49 focally 49 inhibited tumor 49 researchers hypothesised 49 sural nerve 49 upregulating 49 Inosine 49 phosphatidylserine 49 interferon γ 49 adrenergic receptors 49 CYP#E# 49 hepatic 49 glucocerebroside primarily 49 #.#dB [003] 49 umbilical artery 49 mice overexpressing 49 mal absorption 49 cleavable 49 longus tendon 49 metalloproteinase 49 PI3K/Akt 49 hypoxemia 49 serine proteases 49 CDK5 49 dermal papilla 49 Th2 cytokines 49 p# activation 49 Factor Receptor 49 lipogenesis 49 gene polymorphism 49 selective serotonin 2C receptor 49 cysteines 49 ototoxic 49 intermodulation 49 irreversible inhibitor 49 SUMOylation 49 effector memory 49 phosphoinositide 49 hsp#