Related by context. All words. (Click for frequent words.) 84 clots 77 blood clot 74 clot 69 Blood clots 69 deep vein thrombosis 64 thrombosis 63 pulmonary embolism 63 pulmonary embolisms 63 DVT blood clots 61 clotting 61 aneurysm 61 blood thinners 60 blood thinning 60 Clots 60 thrombotic events 60 artery blockages 59 DVT 59 rhythm disturbances 59 DVTs 59 atrial fibrillation 59 irregular heartbeats 59 aneurysms 58 deep vein thromboses 58 venous thromboembolism 58 thromboses 57 Deep Vein Thrombosis DVT 57 arterial blockages 57 blood clotting 57 venous thromboembolism blood clot 56 arterial blockage 56 hardened arteries 56 pulmonary emboli 56 pulmonary hypertension 56 venous blood clots 56 scar tissue 56 vein clots 56 blot clots 55 VTE 55 arrhythmia 55 coated stents 55 artery clogging plaque 55 aortic aneurysms 55 gastrointestinal bleeding 55 hemorrhagic strokes 55 artery blockage 55 DVT blood clot 55 Blood clot 54 embolisms 54 anticoagulants blood thinners 54 heart disease 54 gallstones 54 heart arrhythmias 54 blot clot 54 brain aneurysms 54 Compression stockings 54 aortic rupture 54 pre eclampsia 54 thrombi 54 clogged arteries 54 bone fracture 54 spine fractures 54 bone fractures 54 noncancerous tumor 54 venous thromboembolisms 53 lungs pulmonary embolism 53 blocked arteries 53 prolonged immobility 53 anti clotting 53 thromboembolism 53 colon polyps 53 atherosclerosis narrowing 53 hyperkalemia 53 venous thrombosis 53 thromboembolic events 53 forming clots 53 arrhythmias 53 aneurisms 53 uncontrolled bleeding 53 Pulmonary embolism 53 adhesions 53 fatty plaque 53 Abdominal aortic aneurysms 53 kidney stones 52 Clogged arteries 52 renarrowing 52 post thrombotic syndrome 52 clot formation 52 hemorrhagic stroke 52 anticlotting drugs 52 irregular heartbeat 52 intracerebral hemorrhage 52 abnormal heartbeats 52 uric acid stones 52 calcium buildup 52 coronary artery disease 52 bleeding ulcers 52 heart arrhythmia 52 arterial plaque 52 lung 52 Blood thinners 52 unstable angina 52 ischemic strokes 52 ischemic stroke 52 coronary blockages 52 deep venous thrombosis 52 fluid buildup 52 silent ischemia 52 pulmonary embolism blood clot 52 venous thromboembolism VTE 52 microvascular angina 52 gastro intestinal bleeding 52 reclogging 52 blocked coronary arteries 51 fatty deposits 51 blood vessels 51 precancerous polyps 51 sudden cardiac death 51 ticlopidine 51 Pulmonary embolisms 51 wearing compression stockings 51 arteries 51 precancerous colon polyps 51 Aneurysms 51 pre cancerous growths 51 vascular disease 51 stomach ulcer 51 emboli 51 plaque ruptures 51 drug coated stents 51 postoperative pulmonary 51 thrombosis blood clot 51 stent 51 thoracic aortic aneurysms 51 postpartum bleeding 51 pancreatitis 51 clogged coronary arteries 51 cancerous nodules 51 preeclampsia 51 anticoagulant medications 51 atherosclerotic disease 51 cancerdefine 51 invasive breast cancer 51 complications 51 upper gastrointestinal bleeding 51 carotid artery blockage 50 rhythm abnormalities 50 malignant melanoma 50 fatty plaques 50 intestinal polyps 50 ruptured aneurysms 50 wear compression stockings 50 abnormal rhythms 50 pre cancerous polyps 50 pulmonary embolism blood clots 50 medicated stents 50 anticlotting 50 dissolve clots 50 Ischemic strokes 50 benign growths 50 Hemorrhagic strokes 50 untreated celiac disease 50 colon polyp 50 Ortho Evra patch 50 Pulmonary hypertension 50 carotid artery disease 50 abdominal aortic aneurysms 50 cardiovascular disease 50 Ortho Evra 50 ulcer 50 angina chest 50 diverticulosis 50 neurological complications 50 ovarian hyperstimulation syndrome 50 Varicose veins 50 amino acid homocysteine 50 bowel obstruction 50 embolus 50 intravenous bisphosphonates 50 brain tumors 50 stent inserted 50 left ventricular dysfunction 50 post surgical adhesions 50 primary pulmonary hypertension 50 gouty arthritis 50 femur fractures 50 uncoated stents 50 inflamed gallbladder 50 atypical fractures 50 cancerous growths 50 Reye Syndrome 50 fractures 50 angioplasty 50 bowel cancers 49 blockages 49 anti coagulants 49 reclog 49 aortic dissections 49 persistent pulmonary hypertension 49 pre cancerous cells 49 gastric ulcers 49 ximelagatran 49 implanted stent 49 bowel obstructions 49 hormone progestin 49 endometrial cancer 49 abdominal aortic aneurysm 49 basal cell cancers 49 embolism 49 aspirin 49 stents 49 triglycerides 49 aneurysm sac 49 reopen clogged arteries 49 clot dissolving 49 Hemorrhagic stroke 49 thoracic aortic aneurysm 49 ACE inhibitors 49 angina pectoris 49 infarction STEMI 49 blocked carotid arteries 49 ischemic colitis 49 varicose veins 49 non steroidals 49 acid reflux disease 49 liver toxicity 49 pulmonary embolism PE 49 painkiller ibuprofen 49 drug depresses breathing 49 mitral valve prolapse 49 GI bleeding 49 stent grafts 49 menstrual migraines 49 heartbeat abnormality 49 polyps growths 49 coronary arteries 49 coronary artery stents 49 peripheral artery disease 49 blood clot thrombus 49 Eisenmenger syndrome 49 aorta 49 ectopic pregnancy 49 esophageal cancers 49 thromboembolic 49 coronary disease 49 valvular heart disease 49 edema swelling 49 keloids 49 Pre eclampsia 49 Deep vein thrombosis 49 lung embolism 49 drospirenone 49 clotting disorder 49 ruptured aneurysm 49 anticoagulants 49 clot buster 49 thrombus blood clot 49 blood thinner Coumadin 49 implanting defibrillator 49 COX 2s 49 noncardiac surgery 48 nonfatal heart 48 inflamed pancreas 48 reblockage 48 Estrogen therapy 48 cerebral hemorrhages 48 osteosarcoma bone 48 sleep apnea 48 colon tumors 48 Oral contraceptives 48 microvascular disease 48 idiopathic cardiomyopathy 48 prescribed blood thinners 48 pacemakers implanted 48 advanced adenomas 48 cerebral aneurysms 48 clot busting medication 48 Lowering cholesterol 48 myocardial ischemia 48 internal bleeding 48 cerebral aneurysm 48 nonvertebral fracture 48 unclog arteries 48 systemic scleroderma 48 squamous cell cancers 48 clot busters 48 postoperative delirium 48 cardiovascular 48 skin cancers 48 lungs 48 inflamation 48 gastrointestinal bleed 48 keloid 48 colon cancer 48 retinal detachment 48 narrowings 48 colon perforation 48 noncancerous growths 48 placenta accreta 48 LW Fleischmann 48 atherosclerotic plaque 48 Brain aneurysms 48 Plaque buildup 48 hip fractures 48 endometrial hyperplasia 48 tumors 48 Pulmonary Embolism PE 48 cancerous tumors 48 Blood Clots 48 Digoxin toxicity 48 Compartment Syndrome 48 stents coated 48 inflammation 48 Coated stents 48 phlebitis 48 bypass surgery 48 clot dissolving drug 48 COX inhibitors 48 intractable epilepsy 48 uterine bleeding 48 narrowed arteries 48 cystic acne 48 VTEs 48 angiotensin receptor blockers ARBs 48 pulmonary fibrosis scarring 48 Scar tissue 48 aortic valve stenosis 48 abdominal aorta 48 abdomen pelvis 48 DVT PE 48 melanoma 48 atherosclerosis 48 blood thinner 48 Hip fractures 48 venous thromboembolic events 48 precancerous growths 48 tissue plasminogen activator tPA 48 ONJ 48 inoperable tumors 48 recurrent atrial fibrillation 48 warfarin Coumadin 48 beta agonists 48 Torsades de Pointes 48 diverticula 48 testicular cancers 48 underwent coronary angiography 47 Heavy snorers 47 malignant tumors 47 fibrin clots 47 disease focal segmental 47 infantile hemangiomas 47 intracranial bleeding 47 thromboembolisms 47 haemorrhagic stroke 47 pulmonary thromboembolism 47 prosthetic valve 47 angina 47 atypical femur fractures 47 alcoholic cirrhosis 47 postoperative infections 47 arterial plaques 47 subdural hematoma blood clot 47 Pulmonary embolism PE 47 arteries atherosclerosis 47 statins 47 staphylococcus infection 47 thoracic outlet syndrome 47 Migraine headaches 47 oral contraceptives 47 acute coronary 47 artery calcification 47 airway constriction 47 organ rejection 47 cyst 47 cerebral vascular disease 47 untreated sleep apnea 47 thromboembolic disease 47 fatal arrhythmias 47 peritoneal mesothelioma 47 aortic stenosis 47 microbleeds 47 arrythmia 47 calcium oxalate stones 47 Statin drugs 47 restrictive cardiomyopathy 47 migraines 47 intracranial aneurysm 47 Erythropoietic therapies may 47 ventricular arrhythmia 47 indomethacin 47 precancerous tumors 47 atherosclerotic lesions 47 unruptured aneurysms 47 coronary blockage 47 lung cancer 47 ductal cancer 47 stomach ulcers 47 Adhesions 47 recurrent stroke 47 pituitary tumors 47 embolic strokes 47 infarctions 47 lung disease 47 undiagnosed sleep apnea 47 blood thinner warfarin 47 blood clotting disorder 47 fewer uterine cancers 47 Congestive heart failure 47 ovarian cancer 47 Preeclampsia 47 premenopausal breast cancer 47 blood clotting disorders 47 calcified plaques 47 dermatologic reactions 47 rhythm abnormality 47 prolonged QT interval 47 acid reflux 47 angiosarcoma 47 restenosis reblockage 47 superficial vein thrombosis 47 vertebral fractures 47 cholesterol lowering medication 47 liver bile ducts 47 postmenopausal breast cancer 47 uterine cancer 47 bacterial infection 47 recurrent myocardial infarction 47 nasal polyps 47 progestin 47 iron overload 47 amniotic fluid embolism 47 ulcers 47 sudden cardiac arrest 47 Kidney stones 47 atherosclerotic plaques 47 Candida infections 47 glitazones 47 uterine rupture 47 urinary infections 47 peritoneal cancer 47 ovarian hyperstimulation syndrome OHSS 47 brain hemorrhages 47 aortic aneurysm 47 erratic heartbeats 47 breast cancer recurrence 47 undergoing angioplasty 47 ectopic pregnancies 47 precancerous cervical lesions 47 carotid arteries 47 Atacand 47 prescribed statins 47 painkiller Celebrex 47 tibolone 47 benign tumors 47 artery 47 bacterial endocarditis 47 Ortho Evra contraceptive 47 Hypertensive Cardiovascular Disease 47 ductal breast cancer 47 leaky valve 47 reclogged 47 hypertrophic cardiomyopathy thickening 47 platelet stickiness 47 gastrointestinal perforations 47 Hypertrophic Cardiomyopathy 47 Medtronic stent 47 noncancerous tumors 47 pulmonary edema fluid 47 nonmelanoma skin cancers 47 diseased coronary arteries 47 Squamous cell carcinomas 47 lung scarring 47 Drug coated stents 46 embolic stroke 46 Statin therapy 46 cervical vaginal 46 estrogen progestin combination 46 mitral valve regurgitation 46 abnormal heartbeat 46 prevent reclogging 46 directly degrades fibrin 46 lymphatic fluid 46 colorectal cancer 46 uric acid kidney stones 46 transvaginal mesh 46 basal cell carcinomas 46 arteriovenous malformation 46 adenomas 46 Fibroid tumors 46 breast cancers 46 cardiomyopathy 46 calcified plaque 46 angiotensin receptor blockers 46 spinal fractures 46 breast cancer 46 occipital nerve 46 insert stent 46 kidney dysfunction 46 macular edema 46 cardiovascular disease CVD 46 allograft rejection 46 dermopathy 46 bisphosphonates 46 arterial thrombosis 46 spinal compression fractures 46 tubal pregnancy 46 laryngospasm 46 precancerous condition 46 unblock arteries 46 Venous thromboembolism 46 brain aneurysm 46 cardiac insufficiency 46 pulmonary stenosis 46 aortic dissection 46 fracture 46 reinterventions 46 recurrent DVT 46 estrogen therapy 46 pleural mesothelioma 46 carcinoid cancer 46 selective NSAIDs 46 uterus womb 46 Cardiac arrhythmia 46 lung diseases 46 acute urinary retention 46 ministroke 46 prasugrel 46 arrythmias 46 deep venous thromboses 46 hemorrhagic bleeding 46 Aortic aneurysms 46 acute coronary syndrome 46 compartment syndrome 46 vaginal yeast infections 46 coronary 46 malignant melanomas 46 endometrial cancers 46 urate 46 ventricular arrhythmias 46 intestinal obstructions 46 prostate tumors 46 peripheral arteries 46 dose aspirin 46 endometrial lining 46 Reye syndrome rare 46 acute pancreatitis 46 oral contraceptive pills 46 dilated cardiomyopathy 46 beta blockers 46 angioedema 46 squamous cell cancer 46 abdominal aneurysms 46 postoperative bleeding 46 gastro oesophageal reflux disease 46 Transient Ischemic Attack 46 coronary artery 46 amiodarone 46 plasminogen activators 46 NAION 46 arachnoiditis 46 Fibroids 46 drug eluting stents 46 bone thinning 46 cerebrovascular events 46 gastrointestinal GI bleeding 46 lobular breast cancer 46 plaque buildups 46 S. aureus sepsis 46 variceal 46 tachyarrhythmias 46 Raloxifene 46 fibroids 46 Celebrex celecoxib 46 severe asthma exacerbations 46 dexrazoxane 46 Atrial fibrillation 46 Deep Vein Thrombosis 46 incontinence impotence 46 GI bleeds 46 clot dissolving drugs 46 embolic debris 46 Intussusception 46 cardioembolic stroke 46 esophagus 46 intestinal blockages 46 vein grafts 46 ovarian cysts 46 congestive heart failure 46 parathyroid gland 46 gastrointestinal perforation 46 acetaminophen ibuprofen 46 Implantable cardioverter defibrillators 46 breast endometrial 46 plaque buildup 46 Sleep apnea 46 pericardial mesothelioma 46 NSAIDs 46 ruptured brain aneurysm 46 nonischemic 46 impair fertility 46 bad cholesterol LDL 46 biphosphonates 46 thrombotic complications 46 cysts 46 bowel cancer 46 preventive mastectomies 46 HDL cholesterol 46 aortic stenosis narrowing 46 afib 46 precancerous lesions 46 atrial arrhythmias 46 cardiac tamponade 46 loop diuretics 46 cholesterol 46 torsade de pointes 46 restenosis 46 viral pneumonia 46 suppurative 46 uterine tumors 46 clogged coronary artery 46 unblock clogged arteries 46 gastrointestinal ulcers 46 gall stones 46 lung cancer mesothelioma 46 GnRH agonists 46 dose ionizing radiation 46 uterine cancers 46 untreated OSA 46 Regranex 46 thrombo embolic 46 abnormal uterine bleeding 46 intracranial pressure 46 gastrointestinal reflux 46 vasospasm 46 inferior vena cava 46 Clot busting 46 colorectal adenoma 46 fibrotic tissue 46 preterm labor 45 cancer 45 noncardiovascular 45 patent foramen ovale 45 intracranial haemorrhage 45 GlaxoSmithKline Avandia 45 carotid stents 45 Stomach cancer 45 cardiac 45 atrial fibrillation AF 45 gangrene infection 45 cardiovascular hospitalizations 45 placenta praevia 45 bowel perforations 45 Celebrex painkiller 45 hemorrhagic complications 45 thrombophlebitis 45 ARVD 45 Hypertrophic cardiomyopathy 45 aortic valve 45 kidney insufficiency 45 ADPKD 45 myocardial infarction MI 45 thrombus 45 acid suppressing 45 emphysema 45 acute aortic dissection 45 antiplatelet medications 45 infective endocarditis 45 circulatory 45 acute myocarditis 45 Avandia rosiglitazone 45 vasovagal syncope 45 anticoagulant heparin 45 losartan Cozaar 45 hemolytic anemia 45 microemboli 45 vein thrombosis 45 implant ruptures 45 Stress fractures 45 hypertension 45 thrombus formation 45 Vitamin B# deficiency 45 Ovary removal 45 pneumonia 45 digestive tract cancers 45 intracranial aneurysms 45 LDL cholesterol 45 cardiopulmonary bypass surgery 45 clog arteries 45 cardiac arrhythmia 45 neurologic complications 45 cancerous colon 45 popliteal aneurysms 45 Clot busting drugs 45 precancerous tissue 45 wide necked aneurysms 45 leiomyosarcoma 45 postoperative atrial fibrillation 45 cardio vascular disease 45 prostate cancer 45 Bone marrow stem cells 45 femoral shaft fractures 45 pulmonary embolus 45 breast tenderness 45 proliferative diabetic retinopathy 45 Tranexamic acid 45 biliary stent 45 Spiriva 45 Acute pancreatitis 45 fluid retention 45 blocked artery 45 Cholesterol lowering statin 45 myocarditis 45 intestines 45 adenoma 45 pneumothorax 45 Aortic stenosis 45 gastrointestinal toxicity 45 bladder dysfunction 45 antiplatelet drugs 45 adenoid cystic carcinoma 45 implanted pacemaker 45 statins cholesterol lowering 45 Ovarian cysts 45 debilitating headaches 45 decompression sickness 45 Obstructive sleep apnea 45 cerebral thrombosis 45 benign breast 45 Carotid artery 45 Atrial fibrillation AF 45 duodenal ulcer 45 intestinal ulcers 45 Prilosec Nexium 45 arterial plaque buildup 45 recurrent miscarriages 45 diverticuli 45 abnormal growths 45 torsades de pointes 45 coumadin 45 dissected aorta 45 reflux disease 45 pleural cavity 45 AAT deficiency 45 oral anticoagulants 45 uncontrolled hypertension 45 bladder cancers 45 ischemic complications 45 coronary artery blockages 45 statin medications 45 blood platelets 45 Bloodstream infections 45 prostate cancers 45 bisphosphonate therapy 45 infection 45 Anticoagulants 45 thoracic aneurysms 45 Nexium Prevacid 45 arteriovenous malformation AVM 45 unsightly blotches 45 pancreatitis inflammation 45 NSAIDS 45 subarachnoid haemorrhage 45 refractory ischemia 45 intestinal perforations 45 clogged carotid arteries 45 anti coagulant therapy 45 breast abscesses 45 Darapladib 45 distal embolization 45 serum HDL cholesterol 45 diabetes pill Avandia 45 venous hypertension 45 tendonitis 45 constipation hemorrhoids 45 arrhythmogenic right 45 carotid stenosis 45 subarachnoid hemorrhages 45 Adhibit 45 debilitating migraine headaches 45 bloodstream infection 45 Enteryx 45 postoperative complications 45 plaque rupture 45 gastric reflux 45 Trasylol 45 jaw necrosis 45 Cardiac hypertrophy 45 Migraines 45 Hormone pills 45 oesophageal cancers 45 amyloid proteins 45 postpartum hemorrhage 45 Pericarditis 45 NOLVADEX 45 lung tumors 45 contractures 45 gallbladder 45 hypertrophic cardiomyopathy HCM 45 hormone therapy 45 STEMIs 45 pancreas 45 Coreg 45 pre cancerous 45 embolic 45 urinary tract infections UTIs 45 Uterine fibroids 45 Uterine cancer 45 encephalitis meningitis 45 Clotting 45 medicated stent 45 NSAID 45 density lipoprotein HDL cholesterol 45 bleedings 45 uncontrolled epilepsy 45 NSAID therapy 45 bowel polyps 45 Procardia 45 obstructive jaundice 45 premature menopause 45 liver 45 malignant growths 45 statin 45 hematoma 45 lichen planus 45 bursae 45 vertebrae fused 45 spontaneous preterm delivery 45 bloodstream infections CRBSI 45 fibroid tumor 45 uterine fibroid tumors 45 Hemolytic Uremic Syndrome HUS 45 lymph glands 45 dissolving blood clots 45 Vitamin D supplements 45 arthritis painkiller 45 ADPKD patients 45 vein clot 45 skin abscesses 45 bronchial inflammation 45 cancerous colon polyps 44 stress incontinence 44 premature birth 44 uterine fibroid 44 transfusion syndrome 44 Chiari malformation 44 Gall bladder 44 colorectal adenomas 44 thrombotic 44 variceal bleeding 44 antiplatelet medication 44 Aspirin 44 lipid lowering drugs 44 nifedipine 44 aortas 44 pleural effusions 44 intraoperative complications 44 tendon ruptures 44 venous disorders 44 Stents 44 Calcium supplements 44 Mitral valve 44 blood clotting protein 44 pre cancerous lesion 44 viral cardiomyopathy 44 axillary vein 44 blood clots tecarfarin ATI 44 atrial fibrillation fluttering 44 Deep venous thrombosis 44 thyroid tumors 44 preventer inhalers 44 diseased arteries 44 bladder cancer 44 migraine headaches 44 abnormal mammograms 44 brachial plexus injuries 44 urinary stones 44 liver dysfunction 44 tonsil tissue 44 postoperative infection 44 Emboli 44 Blocked arteries 44 neural tube birth defects 44 thiazide diuretics 44 dilated aorta 44 Merck painkiller Vioxx 44 bronchoscopic procedures 44 tension pneumothorax 44 ovarian cancers 44 Avandia Actos 44 Idiopathic Thrombocytopenic Purpura 44 raloxifene Evista 44 cartilage degeneration 44 cryptogenic stroke 44 pericardial sac 44 clot busting 44 DETROL LA 44 Rivaroxaban 44 Cholesterol lowering statins 44 nonmelanoma skin cancer 44 thoracic aortic disease 44 carotid plaque 44 salicylate 44 Celebrex 44 CMV infection 44 amenorrhoea 44 osteoporotic fractures 44 sudden cardiac 44 cancerous lesions 44 Irregular heartbeat 44 pericardial effusions 44 abdominal aortic 44 transplanted kidneys 44 underactive thyroid gland 44 dronedarone 44 vascular disorders 44 tardive dyskinesia 44 oophorectomy 44 migraine 44 bowel blockage 44 Colorectal cancers 44 pancreas liver 44 brain aneurism 44 ventricular dysplasia 44 underdeveloped lungs 44 NIASPAN 44 lightheadedness fainting 44 drug coated stent 44 desogestrel 44 cardiovascular ischemic 44 pancreas pancreatitis 44 Sprint Fidelis Lead 44 Dronedarone 44 oligohydramnios 44 atherothrombotic events 44 pelvic inflammatory disease 44 Contraceptive pill 44 Caesarean deliveries 44 Avandia 44 stenting procedure 44 recombinant tissue plasminogen 44 Malignant tumors 44 occlusive disease 44 cardiac stents 44 β blockers 44 dissolve blood clots 44 costochondritis 44 bypass grafting 44 clot busting drugs 44 inserting stent 44 non aspirin NSAIDs 44 bleed uncontrollably 44 peripheral arterial disease 44 seroma formation 44 irregular quivering 44 aspirin clopidogrel 44 revascularization procedure 44 Aortic dissection 44 diseased artery 44 treat brain aneurysms 44 bladder prostate 44 surgical biopsies 44 aneurysmal subarachnoid hemorrhage 44 reinfarction 44 transient ischemic attacks 44 aneurysm rupture 44 tumor 44 enlarged aorta 44 ketoacidosis 44 inflamed tissues 44 cerebral infarction 44 homocysteine levels 44 arterial calcification 44 airway irritation 44 Fibrous Dysplasia 44 papilledema 44 unruptured aneurysm 44 ReoPro 44 anaphylactic reactions 44 Peripheral arterial disease 44 acute subdural hematoma 44 lung adenocarcinoma 44 fatal pulmonary embolism 44 pulmonary vasculature 44 polyhydramnios 44 segment elevation myocardial 44 Cholesterol lowering drugs 44 testicular cancer 44 warfarin 44 severely clogged arteries 44 Bisphosphonates 44 implanted defibrillator 44 seizures comas 44 urgent coronary revascularization 44 leaky valves 44 hormones estrogen 44 postpartum haemorrhage 44 S. aureus infection 44 AVANDIA 44 oral anticoagulation therapy 44 Von Willebrand disease