Related by context. All words. (Click for frequent words.) 71 causal 62 causal pathway 61 causation 60 pathophysiologic 60 biologically plausible 59 etiologic 58 aetiological 57 pathophysiological 57 pathogenesis 56 causal relationship 56 aetiology 56 causative factor 56 causal relation 55 airway remodeling 55 etiologic agent 54 causally 54 causal link 54 protein conformation 54 pathogenetic 54 underlying molecular mechanisms 54 genetic loci 54 endophenotypes 54 etiology 54 statistical correlations 53 arrhythmogenic 53 gene polymorphisms 53 autistic enterocolitis 53 epiphenomenon 53 oncogenesis 53 genetic polymorphisms 53 amyloid cascade 53 Genetic predisposition 53 inherited predisposition 52 C. pneumoniae 52 atherogenesis 52 polygenic 52 underlying pathophysiology 52 serotonin deficiency 52 neuroinflammation 52 HBx 52 etiological 52 GPIHBP1 52 confounder 52 surrogate marker 52 biologic plausibility 52 causally linked 52 prognostic marker 52 mechanistically 52 HLA DRB1 52 genetic polymorphism 52 hyperinsulinemia 52 virulence genes 51 pleiotropic 51 PECAM 1 51 incompletely understood 51 pathogenic mechanisms 51 Lyn kinase 51 airway hyperresponsiveness 51 biochemical abnormalities 51 pathophysiology 51 motor neuron degeneration 51 elevated homocysteine 51 congenital muscular dystrophies 51 systemic inflammation 51 intracellular signal transduction 51 prothrombotic 51 endocannabinoid signaling 51 causative agent 51 carcinogenesis 51 oxidases 51 SLC#A# [002] 51 dysregulation 51 familial clustering 51 cardioprotective effects 51 causally related 51 Genetic variants 51 modulatory 51 Chlamydia pneumoniae 51 osteogenic differentiation 50 predisposing factor 50 podocyte 50 oncogene addiction 50 telomere dysfunction 50 metabolic alterations 50 etiologic factors 50 oligomerization 50 nongenetic 50 pathognomonic 50 unmeasured confounders 50 paracrine 50 prostate carcinogenesis 50 autocrine 50 mitochondrial dysfunction 50 epistasis 50 PON1 gene 50 causal connection 50 chromosome #p#.# 50 MECP2 gene 50 immunomodulatory effects 50 Multiple linear regression 50 renal fibrosis 50 MYH9 50 unmeasured confounding 50 epigenetic modification 50 overactivation 50 myocardial dysfunction 50 LIS1 50 hypermethylation 50 epigenetic alterations 50 periodontal infection 50 susceptibility gene 50 Helicobacter pylori infection 49 TLR4 49 familial aggregation 49 endogenous ligand 49 predisposing 49 neuronal dysfunction 49 endogenous opioid 49 mitochondrial defects 49 causality 49 potentially modifiable 49 extramedullary 49 glycolytic 49 aberrant activation 49 causative factors 49 hypothalamic pituitary 49 axonal degeneration 49 alexithymia 49 intestinal microbiota 49 Genetic variations 49 mechanistic explanation 49 causal variants 49 Genetic variation 49 WNK1 49 gene loci 49 glomerular 49 polyglutamine 49 DNA methylation patterns 49 PI3K pathway 49 cathepsins 49 ATG#L# 49 LRP5 49 CEACAM1 49 cofactors 49 phosphatases 49 cofactor 49 physiologic mechanisms 49 PrPC 49 susceptibility locus 49 lipoprotein metabolism 49 Vpr 49 GABAB receptors 49 multifactorial 49 periodontal infections 49 MAPK pathway 49 postsynaptic neuron 49 intracellular bacteria 49 Dysregulation 49 NKX#.# 49 pro oxidant 49 cholesterol homeostasis 49 environmental toxicants 49 overactivated 49 causative genes 49 dysbindin 49 hyperalgesia 49 genetic locus 49 correlational 49 Raf MEK ERK 49 biogenesis 49 nucleolar 49 pancreatic carcinogenesis 49 β1 49 Nod1 49 p# MAPK 49 SARS CoV 48 unmeasured factors 48 histone H4 48 chronicity 48 matriptase 48 Chronic inflammation 48 transcriptional regulation 48 nanobacteria 48 Oxidative stress 48 multi factorial disease 48 IDH mutations 48 pleiotropic effects 48 c myc gene 48 microdeletion 48 biological plausibility 48 metabolic abnormalities 48 immunological mechanisms 48 genetic susceptibility 48 surrogate markers 48 leaky gut 48 IL#R 48 objectively verifiable 48 artifactual 48 SMAD4 48 missense mutations 48 chlamydial 48 monogenic 48 hypothalamic pituitary adrenal axis 48 atherothrombotic 48 etiological agent 48 oncogenic 48 PTPN# 48 pressure natriuresis 48 amyloidogenic 48 cerebellar 48 retinoid X 48 susceptibility genes 48 Kenneth S. Kendler 48 NKG2D 48 amyloid accumulation 48 epigenetic regulation 48 transcriptional activation 48 APOE genotype 48 epigenetic inheritance 48 murine model 48 heritable variation 48 histone methylation 48 S nitrosylation 48 FGFs 48 elevated CRP 48 STAT4 48 Smad3 48 predisposing factors 48 NFTs 48 OPRM1 48 SNP rs# [001] 48 airway responsiveness 48 xenobiotics 48 melatonin receptor 48 inflammasome 48 chromosome #q# [001] 48 DISC1 48 immunopathology 48 susceptibility loci 48 genetic susceptibilities 48 pDCs 48 residual confounding 48 symbioses 48 centrosome 48 neuroregenerative 48 epidemiologic studies 48 Oxidative damage 48 coronary artery atherosclerosis 48 demethylation 48 flavin 48 neuroligins 48 pathophysiologic mechanism 48 foreseeability 48 NS3 protease 48 mutant huntingtin protein 48 phenotypic differences 48 metabolizing enzymes 48 TCF#L# gene 48 subclinical 48 MEF2A 48 chromosomal rearrangement 48 physiological mechanisms 48 misregulation 48 diathesis 48 proinflammatory 48 proline rich 48 COX2 47 utero exposure 47 MSH2 47 oligomeric 47 interleukin 1beta 47 causal link between 47 mGluR 47 evolutionarily conserved 47 cAMP signaling 47 immune dysregulation 47 null hypothesis 47 ABCB1 47 transactivation 47 rs# [002] 47 noradrenergic 47 disregulation 47 estrogen metabolism 47 synapse formation 47 oxysterols 47 posttranslational modifications 47 transcriptional repressor 47 gliosis 47 SSc 47 cardioprotective effect 47 clinicopathological 47 DNMT1 47 genomic alterations 47 hypothesised 47 FOXO3a 47 prognostic indicator 47 eotaxin 47 carbohydrate metabolism 47 PPARγ 47 SNP rs# [002] 47 epigenetic changes 47 cellular prion protein 47 occludin 47 Alzheimer disease pathogenesis 47 neuroanatomical 47 granulomatous 47 Brain derived neurotrophic 47 circadian clock genes 47 EBV infection 47 lipid rafts 47 ligases 47 intestinal permeability 47 synovial cells 47 mechanistic 47 PB1 F2 47 pleiotropy 47 causal pathways 47 genomic imprinting 47 potent inducer 47 APOE e4 47 comorbid disorders 47 prodynorphin 47 angular gyrus 47 DLX5 47 colocalization 47 myopathies 47 endothelial activation 47 molecular mimicry 47 inflammatory cytokine 47 COX enzymes 47 DNA demethylation 47 polymicrobial 47 MAP kinases 47 commensal bacteria 47 murine models 47 shorter telomere length 47 cardiac fibrosis 47 E#F# 47 cerebral venous 47 pathophysiologic mechanisms 47 TRPV1 receptors 47 epigenetic silencing 47 multivariate Cox 47 KRAS mutation status 47 mGluR5 inhibition 47 biologic pathways 47 developmental neurotoxicity 47 TCF#L# 47 physico chemical properties 47 mitogenic 47 neuroendocrine 47 CD1d 47 isotope fractionation 47 osteoblast 47 NOD2 47 HLA DRB1 * 47 receptor subtypes 47 KIAA# 47 myosin VI 47 neurotrophic 47 endotoxin exposure 47 KLF4 47 cytopathic 47 NPM1 gene 47 prenatal exposures 47 HLA G 47 p# activation 47 bronchial epithelial cells 47 G6PD deficiency 47 heterologous expression 47 drug metabolizing enzymes 47 OCA2 47 regulating gene expression 47 coexpression 47 HPA axis 47 mRNA decay 47 TMPRSS2 ERG fusion 47 constitutively active 47 disulfide bond 47 mirror neuron system 46 viral etiology 46 phenotypic expression 46 radiographic findings 46 neuropathological 46 teratogens 46 Epidemiologic studies 46 nitrotyrosine 46 anterograde 46 imply causality 46 lowering homocysteine 46 histone modifications 46 genes predisposing 46 nicotinic acetylcholine receptors 46 resistin 46 transcriptional coactivator 46 excitotoxicity 46 proteinases 46 neuropsychiatric diseases 46 ORMDL3 46 neuronal signaling 46 biologically implausible 46 Vitamin D insufficiency 46 functional polymorphism 46 cytoplasmic tail 46 causal inference 46 pathophysiological mechanisms 46 primary cilia 46 TXNIP 46 chromosome #p# [002] 46 Rab# 46 serotonergic 46 mechanotransduction 46 adipokines 46 amyloid beta plaques 46 sporadic ALS 46 colorectal carcinogenesis 46 germline mutations 46 modifier genes 46 CHRNA5 46 calcium homeostasis 46 ACE2 46 upregulates 46 secretory pathway 46 protein misfolding 46 CYP #A# 46 allergen induced 46 fig. S1 46 vaso occlusive crisis 46 orthologs 46 ataxias 46 vitamin D receptor 46 Hox proteins 46 multifactorial disease 46 protein beta catenin 46 IL 1ß 46 heparan sulfate 46 folate deficiency 46 MMP# 46 serine protease 46 neuro developmental disorders 46 pRb 46 protein tyrosine phosphatase 46 rs# [004] 46 caveolae 46 Elevated CRP 46 SE alleles 46 Proximate cause 46 RUNX3 46 autopsied brains 46 TNF blocker therapy 46 hypothesis 46 chromosomal translocations 46 familial predisposition 46 gut microbiota 46 biochemical pathways 46 vimentin 46 Observational studies 46 Angiotensin converting enzyme 46 Epidemiological studies 46 structural lineaments 46 multi factorial 46 sGC 46 metabolic dysfunction 46 signaling cascades 46 mitogen activated protein kinase 46 Contagious yawning 46 Hh pathway 46 xenobiotic 46 prognostic significance 46 evolutionarily ancient 46 Vps# 46 bone metabolism 46 neuritic 46 subtyping 46 myocardial fibrosis 46 neuronal apoptosis 46 ovarian hormones 46 redox active 46 immunostimulatory effects 46 antiphospholipid antibodies 46 soluble fms 46 apo E 46 androgen signaling 46 highly pathogenic viruses 46 genotype phenotype 46 beta1 integrin 46 leptin receptor 46 highly heritable 46 genetic aberrations 46 γ secretase 46 neurobiological basis 46 partial agonists 46 potent inhibitors 46 normal prion protein 46 amyloid deposition 46 JNK1 46 astrocytic 46 estrogen receptor alpha 46 chromosomal instability 46 estrogenic effects 46 microglial 46 ERK signaling 46 MLH1 46 #q# deletion 46 outer membrane proteins 46 renal osteodystrophy 46 metabolic enzymes 46 chromatin modifications 46 CHD7 46 psychogenic 46 Stat5 46 multisensory integration 46 Mycobacterium smegmatis 46 TGFß 46 nucleoli 46 sickle cell hemoglobin 46 MALAT1 46 impair fertility 46 MT1 MMP 46 hypercoagulable 46 gastric carcinogenesis 46 glucocorticoid receptors 46 PTEN mutations 46 efferent 46 CNTNAP2 46 AhR 46 genomewide 46 GSK 3ß 46 Singh Manoux 46 gene locus 46 p# mutations 46 sonographic diagnosis 46 PTHrP 46 IntroductionThe 46 EGFR signaling 46 underdiagnosis 46 constitutively expressed 46 #q# [001] 46 causative mutations 46 myofibroblasts 46 ADAMTS# 46 epithelial barrier 46 antidepressant efficacy 46 D2 dopamine receptor 46 pharmacologic intervention 46 alpha synuclein gene 46 sporadic Creutzfeldt Jakob 46 thyroid dysfunction 46 covariate 46 glutamatergic 46 genetically tractable 46 Alternative splicing 46 nicotine receptor 46 tryptase 46 Kaplan Meier curve 46 Cognitive impairment 46 thiomersal 46 alkalosis 46 upregulation 46 phenotypic variability 46 Magnesium deficiency 46 nicotinic receptor 46 downstream effector 46 inverse association 46 polymorphisms 46 glycosylated 46 chorioamnionitis 46 Rab5 45 IL 1β 45 Notch signaling 45 PON1 45 Marc Weisskopf 45 XMRV infection 45 aberrant methylation 45 anthropogenic warming 45 colon carcinogenesis 45 UCP2 45 plausible hypothesis 45 Phylogenetic analysis 45 M. catarrhalis 45 ubiquitylation 45 IGFBP2 45 uPAR 45 caveolin 45 mediated inhibition 45 dopaminergic 45 neurodevelopmental disorders 45 androgen receptor AR 45 tyrosine phosphatase 45 c Src 45 FGF signaling 45 histopathological 45 chromosomal aberrations 45 abnormal glucose metabolism 45 CYP#D# 45 clusterin 45 spongiform encephalopathies 45 oncogenic mutations 45 potentiating 45 AT1R 45 autonomic dysfunction 45 proteoglycan 45 PTEN gene 45 amyloid hypothesis 45 phenotype 45 arterial calcification 45 Alzheimer pathology 45 biopsychosocial 45 phenotypic variation 45 Chlamydia psittaci 45 subcellular localization 45 hypermethylated 45 meiotic recombination 45 lung epithelium 45 inverse agonist 45 APOL1 45 multigenic 45 Siglec 8 45 coevolution 45 Protein folding 45 eNOS 45 susceptibility alleles 45 endoxifen 45 paraneoplastic 45 hypothalamic 45 alpha synuclein protein 45 5 HT1A 45 E. faecalis 45 alpha7 NNR 45 probiotic supplementation 45 homologues 45 IFRD1 45 statistically significant correlation 45 Src kinase 45 observable traits 45 GSK3B 45 GH IGF 45 synaptogenesis 45 urinary excretion 45 platelet activation 45 hypothalamic pituitary adrenal HPA 45 alternans 45 Wnt signaling pathway 45 underlying vasculopathy 45 filaggrin gene 45 contributory 45 neurobiological mechanisms 45 allergic sensitization 45 MGUS 45 APOE4 45 serum biomarker 45 autophagic 45 apoE 45 biogeochemical cycles 45 neuropsychiatric disorders 45 di GMP 45 #p#.# [001] 45 excitotoxic 45 hyperresponsiveness 45 microglial cells 45 rs# [003] 45 VE cadherin 45 diabetic kidney 45 plasma lipid 45 CYP#D# gene 45 PI3K AKT 45 intact parathyroid hormone 45 cell adhesion molecules 45 neuro endocrine 45 bacteria Helicobacter pylori 45 H#Y 45 genetic determinants 45 hypoxemia 45 AMACR 45 muscarinic receptors 45 primary cilium 45 homodimers 45 trans palmitoleate 45 genotoxic 45 KATP channel 45 prognostic factor 45 alpha defensin 45 ontogeny 45 neuromuscular junction 45 helicase 45 neuropathologic 45 LDL receptor 45 bacterial virulence 45 tau phosphorylation 45 adenosine receptors 45 rACC 45 ADAM# 45 phenotypes 45 #q#.# [002] 45 proteasome inhibition 45 dysregulated 45 fibrogenesis 45 immunotoxicity 45 polynucleotide 45 kinase domain 45 cardiac myocytes 45 chromosomal alterations 45 ER alpha 45 mitochondrial disorders 45 SGK1 45 ERK2 45 D aspartic acid 45 uncharacterized genes 45 adrenocortical 45 Previous epidemiological studies 45 ASIC1a 45 pathogenic 45 SCN9A 45 carboxy terminal 45 mito 45 osteopontin 45 Leydig cell 45 Apc 45 lipid metabolism 45 nNOS 45 TrkB 45 genetic predisposition 45 guanine nucleotide exchange 45 epithelia 45 endosymbiosis 45 karyotypes 45 RIP1 45 physico chemical 45 N Myc 45 monocyte chemoattractant protein 45 alpha syn 45 carotid bruit 45 DRB1 * 45 CD# expression [002] 45 CPEB 45 ALI ARDS 45 TGF β 45 MTHFR 45 lymphoid 45 genomic instability 45 NF kappaB pathway 45 leukocyte recruitment 45 subcellular compartments 45 pathogenetic mechanisms 45 osteocalcin protein 45 ectopic expression 45 multiplicative 45 electrophilic 45 G allele 45 anthropic 45 tumorigenicity 45 evolvability 45 Genetic mutations 45 Mechanistic studies 45 TLRs 45 dietary folate 45 genetic heterogeneity 45 oncogenic transformation 45 gene polymorphism 45 chromosome #q 45 impaired glucose metabolism 45 deacetylation 45 intestinal microflora 45 C. neoformans 45 sphingolipid 45 Amino acid 45 TSC1 45 LPA1 45 clinicopathological features 45 #BP# 45 DRD2 45 metalloprotease 45 activated macrophages 45 IKK2 45 mirror neuron 45 transmembrane protein 45 druggable target 45 normal prion proteins 45 galanin 45 calcineurin 45 heritable diseases 45 sequence homology 45 diabetes dyslipidemia 45 CNTNAP2 gene 45 neural substrates 45 protein kinase C 44 TMEM#B 44 fatty acid synthase 44 delayed gastric emptying 44 Th2 immune 44 AL amyloidosis 44 membrane proximal 44 neurocognitive deficits 44 glial 44 chemosensitivity 44 induced apoptosis 44 Endothelial dysfunction 44 GABAA receptors 44 fig. S4 44 testicular tumors 44 etiological factors 44 μ opioid receptor 44 TNFAIP3 44 coinfection 44 SIRT3 44 perivascular 44 acetylcholine receptor 44 Epstein Barr Virus EBV 44 COL#A# 44 urocortin 44 polyadenylation 44 BARD1 44 neuroactive 44 irreducibly complex 44 hypovitaminosis D 44 Integrins 44 parkinsonian 44 neuronal synapses 44 eicosanoid 44 CDK5 44 Bcl xL 44 allergic inflammation 44 membrane fusion 44 regressive autism 44 Helicobacter 44 sterile neutrino 44 Dietary restriction 44 p#INK#a 44 PM#.# exposure 44 endocrine dysfunction 44 p# alpha [002] 44 homolog 44 anatomic abnormalities 44 periodontal pathogens 44 steroidogenic 44 breast carcinogenesis 44 c MET 44 nAChR 44 thyrotropin 44 unconventional superconductivity 44 pseudogene 44 coagulation cascade 44 subclinical atherosclerosis 44 monoamine 44 hydroxylation 44 lysosomal 44 Entamoeba 44 atherothrombotic disease 44 ACh 44 tyrosine phosphorylation 44 biochemical imbalance 44 obesity insulin resistance 44 SH#B# 44 microsaccades 44 cyclic adenosine monophosphate cAMP 44 chloroplast DNA 44 Th2 44 HSF1 44 cholesterol metabolism 44 KRAS variant 44 V2 receptor 44 DARPP 44 incurability 44 endothelial dysfunction 44 allelic variation 44 mtDNA mutations 44 oxidized phospholipids 44 CCR2 44 Fig. 2b 44 neurosteroid 44 Mechanistically 44 fetal microchimerism 44 gastric carcinoma 44 genotoxicity 44 correlations 44 thyrotropin levels 44 induced sputum 44 Prox1 44 HDAC3 44 eIF4E 44 causal nexus 44 hemoglobins 44 tubule 44 renin angiotensin system 44 DQB1 * 44 FGFR2 44 neuronal degeneration 44 S. sanguinis 44 IRAK1 44 epigenetic markers 44 Hedgehog signaling 44 SERT gene 44 biofilm formation 44 metal zonation 44 Cdc7 44 chemokine receptor 44 prion infection 44 Mycoplasma pneumoniae 44 parietal regions 44 postulated 44 metabolic syndromes 44 hypothalamus pituitary 44 tumorigenesis 44 SH2 domain 44 cellular organelles 44 hypoxia inducible 44 ascertainment bias 44 hereditary predisposition 44 Sox# 44 radiogenic 44 visceral adiposity 44 brain neurotransmitter 44 Radiographic findings 44 CagA 44 microchimerism 44 ligand binding domain 44 promoter methylation 44 catabolism 44 vagal 44 signaling cascade 44 Six3 44 COMT genotype 44 neurochemical 44 ontogenetic 44 Causal 44 epidemiological studies 44 lithological controls 44 multivariable Cox 44 superior mesenteric artery 44 Hh signaling 44 COMMD1 44 TRPV4 44 Israeli Acute Paralysis 44 Sporadic CJD 44 gp# protein [002] 44 medial prefrontal cortex mPFC 44 vasodilatory 44 coactivators 44 LPS induced 44 nucleotide sequence 44 coronary atherosclerosis 44 pathophysiological effects 44 bone marrow mesenchymal stem 44 LRP6 44 transcriptionally 44 synaptic vesicle 44 florbetaben 44 RBP4 44 metabolic abnormality 44 ionizing irradiation 44 cis regulatory 44 clinically meaningful differences 44 LSD1 44 p# mutation 44 lymphovascular invasion 44 AKT1 44 subclinical infection 44 paralogs 44 PPARg 44 metabolic disturbances 44 Aβ 44 Gata4 44 S. maltophilia 44 meniscal damage 44 ALK gene 44 MMP7 44 sarcosine 44 tropomyosin 44 lymphocyte activation 44 sonographic appearance 44 demethylase 44 causal linkage 44 mesolimbic 44 proto oncogene 44 amyloid peptide 44 logistic regression models 44 corona virus 44 neuroimaging studies 44 histocompatibility 44 synaptic function 44 idiopathic pulmonary 44 proinflammatory mediators 44 remnant lipoproteins 44 nonvascular 44 retinol binding protein 44 nonvaccine 44 hypercapnia 44 C5aR 44 antemortem 44 γ 44 lymphocytic 44 CYP#C# gene 44 BCL#A 44 LVNC 44 MMR autism 44 veridical 44 leukocyte adhesion 44 cell adhesion molecule 44 homologs