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(Click for frequent words.) 78 chemotherapeutic agents 76 chemotherapy regimens 73 chemotherapy 71 chemotherapeutic regimens 71 chemotherapeutics 71 chemotherapeutic drugs 69 chemotherapy regimen 69 5 FU 68 standard chemotherapy regimens 67 therapies 67 chemotherapeutic 67 hormonal therapies 67 gemcitabine 66 therapeutic regimens 66 cytotoxic chemotherapy 66 docetaxel chemotherapy 66 doxorubicin 66 cisplatin 66 treatment regimens 66 imatinib Gleevec 66 chemotherapeutic drug 65 chemotherapeutic agent 65 temozolomide 65 5FU 65 etoposide 65 topotecan 65 bortezomib 65 tyrosine kinase inhibitors 65 cytotoxic agents 64 docetaxel Taxotere 64 cyclophosphamide 64 anticancer agents 64 rituximab 64 taxanes 64 anticancer drugs 64 irinotecan 64 5 fluorouracil 64 idarubicin 64 pegfilgrastim 64 Cisplatin 63 TNF inhibitor 63 leucovorin 63 taxane chemotherapy 63 cisplatin chemotherapy 63 Cytoxan 63 TACE 63 trastuzumab 63 imatinib 63 immunotherapy 63 fluorouracil 63 immunosuppressive agents 63 cetuximab 63 treatments 63 DMARDs 63 docetaxel 63 mycophenolate mofetil 63 irinotecan chemotherapy 63 gemcitabine chemotherapy 63 interferon 63 anthracyclines 62 bevacizumab Avastin 62 tyrosine kinase inhibitors TKIs 62 overlapping toxicities 62 anti angiogenic agents 62 dacarbazine 62 fulvestrant 62 relapsed ovarian cancer 62 chemoradiation 62 mitoxantrone 62 Doxil ® 62 Fludara 62 immunosuppressive drugs 62 paclitaxel Taxol 62 anticancer treatments 62 decitabine 62 chemo 62 sorafenib Nexavar 61 standard chemotherapy regimen 61 gemcitabine Gemzar 61 erlotinib Tarceva ® 61 cytarabine 61 interferon therapy 61 vincristine 61 proteasome inhibitors 61 anticancer therapies 61 anticancer therapy 61 carboplatin 61 methotrexate 61 sunitinib 61 Doxil 61 azacitidine 61 chemotherapy docetaxel 60 TKIs 60 bevacizumab Avastin ® 60 sorafenib 60 metastatic RCC 60 chemotherapy gemcitabine 60 trabectedin 60 conventional chemotherapies 60 pegylated interferon alfa 60 dasatinib 60 NNRTIs 60 EGFR inhibitors 60 taxane therapy 60 interferon alfa 60 lapatinib Tykerb 60 adjuvant therapy 60 Gemcitabine 60 biologic therapy 60 cytotoxic 60 carboplatin paclitaxel 60 PARP inhibitors 60 dasatinib Sprycel 60 MMP inhibitors 60 Chemotherapy 60 mTOR inhibitors 60 Sunitinib 60 immunosuppressive regimens 60 protease inhibitors 60 vorinostat 60 immunotherapies 60 temsirolimus 60 alkylating agents 60 nucleoside analogs 60 erlotinib 60 pegylated liposomal doxorubicin 60 interferon alfa 2a 60 epirubicin 59 Taxotere 59 bleomycin 59 oxaliplatin 59 dosing schedules 59 Gefitinib 59 lapatinib 59 cediranib 59 Interferon 59 molecularly targeted 59 trastuzumab Herceptin ® 59 immunosuppressive therapies 59 Fludarabine 59 metastatic kidney 59 eflornithine 59 radiation chemoradiation 59 alkylating agent 59 docetaxel Taxotere ® 59 immunosuppressant 59 monoclonal antibody therapies 59 Cremophor 59 taxane 59 antiretroviral regimens 59 dexamethasone Decadron 59 GnRH agonists 59 metastatic colon cancer 59 vinca alkaloids 59 NRTIs 59 pegylated interferon 59 olaparib 59 chlorambucil 59 alpha interferon 58 VEGF inhibitors 58 interferons 58 pemetrexed 58 allopurinol 58 chemoradiotherapy 58 intravenous bisphosphonates 58 Doxorubicin 58 EGFR tyrosine kinase inhibitors 58 sorafenib Nexavar ® 58 vinorelbine 58 TNF inhibitors 58 arsenic trioxide 58 antihypertensive agents 58 bevacizumab 58 uric acid lowering 58 CHOP chemotherapy 58 paclitaxel Taxol ® 58 Irinotecan 58 immune suppressing 58 Cetuximab 58 pertuzumab 58 gefitinib 58 cytoreduction 58 bendamustine 58 disease modifying antirheumatic 58 interferon ribavirin 58 BAY #-# 58 daunorubicin 58 taxol 58 immunosuppressant drugs 58 calcineurin inhibitors 58 gemcitabine carboplatin 58 interferon alpha 58 patients undergoing chemotherapy 58 xenograft models 58 erlotinib Tarceva 58 microwave hyperthermia 58 neoadjuvant chemotherapy 58 trastuzumab Herceptin 58 hormonal therapy 58 radiation therapy SBRT 58 tyrosine kinase inhibitor 58 solid tumors 58 gefitinib Iressa 58 VIDAZA 58 heavily pretreated patients 58 dosing regimens 58 regimens 58 oral clodronate 58 aminoglycosides 58 Gleevec imatinib 58 adriamycin 58 Interferon alpha 58 fludarabine 58 lipid lowering therapies 58 surgical debulking 58 lupus nephritis 58 Methotrexate 58 paclitaxel 58 cetuximab Erbitux ® 58 abiraterone 58 azathioprine 58 vandetanib 57 hepatic metastases 57 immunosuppressants 57 TKI therapy 57 pegylated interferons 57 Novartis AG Gleevec 57 Gleevec 57 kinase inhibitors 57 DMARDS 57 anti TNF 57 cilengitide 57 paclitaxel Taxol R 57 ixabepilone 57 mapatumumab 57 FOLFIRI 57 immunomodulators 57 gastrointestinal stromal tumors GIST 57 docetaxel Taxotere R 57 immunosuppressive 57 Allovectin 7 ® 57 enzastaurin 57 MEK inhibitors 57 radiation therapy 57 palliative radiotherapy 57 Oxaliplatin 57 biologic therapies 57 Pemetrexed 57 Bevacizumab 57 neoadjuvant therapy 57 Xeloda capecitabine 57 Velcade bortezomib 57 Mitoxantrone 57 preoperative chemotherapy 57 DOXIL 57 Sorafenib 57 Taxol 57 triptans 57 Tarceva erlotinib 57 antihypertensive drugs 57 cetuximab Erbitux R 57 intravenous cyclophosphamide 57 brain metastases 57 topical retinoids 57 JAK inhibitors 57 Taxotere docetaxel 57 tamoxifen 57 DMARD 57 Imatinib 56 myeloablative 56 Gleevec imatinib mesylate 56 toxicities 56 rituximab Rituxan ® 56 antiviral therapies 56 cabazitaxel 56 Corticosteroids 56 milatuzumab 56 Peg IFN 56 gemcitabine cisplatin 56 immunomodulatory therapies 56 infliximab Remicade 56 Taxol paclitaxel 56 ribavirin 56 liposomal doxorubicin 56 antitumor activity 56 metastatic renal cell carcinoma 56 Erlotinib 56 thalidomide Thalomid 56 radiochemotherapy 56 cytotoxicity 56 Paraplatin ® 56 tamoxifen Nolvadex ® 56 tamoxifen therapy 56 paclitaxel cisplatin 56 imatinib therapy 56 cytotoxic therapy 56 methotrexate therapy 56 HGS# 56 FOLFOX chemotherapy 56 sulfasalazine 56 immunosuppressives 56 DFMO 56 mRCC 56 paclitaxel chemotherapy 56 N acetylcysteine 56 mealtime insulin 56 antimetabolite 56 Pegylated Interferon 56 cidofovir 56 chemotherapeutic treatments 56 Trastuzumab 56 DMARD therapy 56 trans retinoic acid ATRA 56 Mylotarg 56 antiviral therapy 56 rituximab Rituxan 56 cardiotoxicity 56 endocrine therapies 56 chemopreventive agents 56 TTF Therapy 56 CA4P 56 FOLFOX4 56 photodynamic therapy 56 immunomodulatory therapy 56 zoledronic acid 56 nilotinib Tasigna ® 56 Hycamtin 56 thrombolytic agents 56 HAART regimen 56 Docetaxel 56 cyclophosphamide Cytoxan 56 YONDELIS 56 5-FU/LV 56 AMN# [001] 56 Sutent 56 antifungal therapy 56 anakinra 56 dose regimens 56 fallopian tube carcinoma 56 durable remissions 56 advanced NSCLC 56 Gleevec resistant 56 antiplatelet therapy 56 Bortezomib 56 Lapatinib 56 antihypertensive therapy 56 pancreatic NET 56 cisplatin carboplatin 56 visilizumab 56 Novartis Gleevec 56 potentially hepatotoxic 56 anti angiogenic drugs 56 Revlimid lenalidomide 56 cytoreductive surgery 55 fluvastatin 55 differentiated thyroid 55 postoperative chemotherapy 55 L dopa 55 iron chelation 55 multitargeted 55 ceftriaxone 55 aromatase inhibitor 55 Fludara ® 55 Riluzole 55 superficial bladder cancer 55 tigecycline 55 ABVD 55 peginterferon 55 HER2 positive metastatic breast 55 nifurtimox 55 bicalutamide 55 colorectal liver metastases 55 adalimumab 55 imatinib Gleevec ® 55 indolent NHL 55 antiangiogenic therapy 55 Xcytrin 55 lenalidomide dexamethasone 55 coxibs 55 low dose cytarabine 55 amphotericin B 55 dexrazoxane 55 anti leukemic 55 Taxol ® 55 capecitabine 55 androgen deprivation 55 corticosteroid therapy 55 letrozole Femara 55 dose cytarabine 55 Taxotere ® 55 heavily pretreated 55 acid suppressing 55 chronic lymphocytic leukemia CLL 55 neurologic progression 55 multiple myeloma 55 intra arterial chemotherapy 55 Pertuzumab 55 chemo radiotherapy 55 Radiofrequency ablation 55 interferon alfa 2b 55 infliximab 55 interferon IFN 55 Ribavirin 55 cisplatin gemcitabine 55 trans retinoic acid 55 nilotinib 55 adecatumumab 55 Taxotere R 55 intraperitoneal therapy 55 beta interferon 55 GVHD 55 FOLFOX 55 nucleoside analogues 55 bronchodilators 55 immunomodulatory 55 radiofrequency ablation RFA 55 immune suppression 55 fluoropyrimidine 55 LHRH analogues 55 Taxotere chemotherapy 55 immunotoxins 55 antiemetics 55 myelosuppression 55 chemotherapeutic regimen 55 BRAF inhibitor 55 MyVax R 55 anticoagulants 55 pancreatic adenocarcinoma 55 Platinol ® cisplatin 55 drug DMARD 55 eribulin 55 microtubule inhibitor 55 imipenem 55 recurrent GBM 55 FUSILEV enhances 55 Campath alemtuzumab 55 Herceptin trastuzumab 55 angiogenesis inhibitor 55 proteasome inhibitor bortezomib 55 aromatase inhibitor therapy 55 concurrent chemoradiation 55 cyclosporin 55 GRN#L 55 LHRH agonists 55 azoles 55 azacytidine 55 intravesical instillation 55 Gemzar ® 55 intravenous chemotherapy 55 imetelstat 55 antiplatelet therapies 55 disease modifying 55 interferon beta 55 clopidogrel Plavix 55 anidulafungin 55 doxorubicin HCl 55 Rituximab 55 dosage regimens 55 celecoxib 55 bortezomib Velcade 55 panitumumab 55 itraconazole 55 steroid prednisone 55 anticancer 55 therapy 55 direct thrombin inhibitors 55 lenalidomide Revlimid R 55 antiangiogenic agents 55 CLL cells 55 iniparib 55 HDAC inhibitors 55 echinocandin 55 hyperthermia therapy 55 adalimumab Humira 55 raltegravir 55 Adjuvant chemotherapy 54 intraperitoneal chemotherapy 54 PXD# 54 idraparinux 54 chemotherapy cisplatin 54 hydroxyurea 54 peg IFN 54 5 FU leucovorin 54 Gemzar gemcitabine 54 sirolimus 54 Rituxan rituximab 54 Copegus ribavirin 54 pyridostigmine 54 cetuximab Erbitux 54 thymic carcinoma 54 hematologic malignancies 54 proteasome inhibitor 54 FOLFIRINOX 54 dasatinib Sprycel ® 54 metastatic melanoma 54 ribavirin therapy 54 Cyclophosphamide 54 intravesical 54 Combination therapy 54 fibrinolytic 54 octreotide 54 statins 54 Kantarjian 54 EGFR antibodies 54 anthracycline taxane 54 PegIFN RBV 54 Erbitux cetuximab 54 LMWH 54 colorectal cancer liver metastases 54 inhaled steroids 54 androgen ablation 54 axitinib 54 5 Fluorouracil 54 follicular lymphoma 54 Platinol ® 54 Velcade 54 Camptosar ® 54 alpha interferons 54 protease inhibitor PI 54 HIV protease inhibitors 54 pentamidine 54 HCV protease inhibitors 54 OncoVEX GM CSF 54 beta agonists 54 Tamoxifen 54 Seliciclib 54 Torisel 54 care regimens CCR 54 pomalidomide 54 basiliximab 54 pazopanib 54 leukemia CLL 54 phosphate binders 54 recurrent NSCLC 54 intravenously administered 54 leukotriene receptor antagonist 54 intravenous antibiotic 54 curative therapies 54 PLX# 54 leflunomide 54 Zolinza 54 external beam radiotherapy 54 relapsed SCLC 54 Dasatinib 54 levosimendan 54 panobinostat 54 ipilimumab 54 IAP inhibitors 54 mAbs 54 Gemzar 54 HAART regimens 54 platelet transfusions 54 Platinol 54 tocilizumab 54 anthracycline 54 cyclophosphamide chemotherapy 54 drugs DMARDs 54 BRAF inhibitors 54 bevacizumab Avastin R 54 Vidaza 54 liver metastases 54 antibiotic regimens 54 Anthracycline 54 Ontak 54 zalutumumab 54 sunitinib malate 54 adjuvant therapies 54 CMV disease 54 Sutent sunitinib 54 Panzem R NCD 54 calcitriol 54 epithelial tumors 54 bone marrow transplants 54 myelosuppressive 54 LY# [003] 54 Xeloda 54 HER2 positive breast cancer 54 tissue plasminogen activator tPA 54 TNFa 54 gastrointestinal stromal tumors 54 malignant pleural mesothelioma 54 aspirin clopidogrel 54 Adriamycin 54 pegylated interferon alfa 2a 54 APTIVUS r 54 fondaparinux 54 antiarrhythmic drugs 54 androgen deprivation therapy 54 chemoresistance 54 Pegasys ® 54 xanthine oxidase inhibitor 54 G CSF 54 transarterial chemoembolization 54 WBRT 54 somatostatin analogues 54 spironolactone 54 topical corticosteroids 54 chemotherapy radiotherapy 54 convenient dosing regimens 54 deacetylase inhibitors 53 busulfan 53 Etoposide 53 glioblastoma 53 CoFactor 53 TRV# [001] 53 oral anticoagulants 53 rt PA 53 irinotecan doxorubicin oxaliplatin paclitaxel 53 5 fluorouracil leucovorin 53 myeloproliferative disorders 53 Temodar 53 steroid dexamethasone 53 immune suppressants 53 Capecitabine 53 humanised monoclonal antibody 53 endocrine therapy 53 metastatic colorectal cancer 53 ACE inhibitor ramipril 53 recurrent metastatic 53 cardiac toxicity 53 curative therapy 53 EGF receptor 53 clot busters 53 Rituxan 53 mitomycin 53 administered intravenously 53 IMGN# 53 ganciclovir 53 protamine 53 bexarotene 53 levodopa 53 dose regimen 53 amrubicin 53 PegIntron 53 Bexxar 53 infusional 5-FU/LV 53 Pegasys peginterferon alfa 2a 53 exemestane 53 metastatic disease 53 recurrent prostate cancer 53 pimozide 53 Carboplatin 53 Vidaza ® 53 anti rheumatic 53 pamidronate 53 corticosteroids 53 metastatic lung cancer 53 Oral corticosteroids 53 EGFr 53 efalizumab 53 cytotoxic therapies 53 exemestane Aromasin 53 beta lactam antibiotics 53 Imprime PGG 53 immunosuppression 53 relapsed CLL 53 pyrazinamide 53 Navelbine ® 53 rifampicin 53 anastrozole 53 antiretroviral therapies 53 chemoembolization 53 TNF antagonist 53 recombinant erythropoietin 53 denileukin diftitox 53 glioblastomas 53 gamma secretase inhibitors 53 resistant ovarian cancer 53 ganetespib 53 antifolates 53 molecularly targeted therapies 53 OMP #M# 53 Abatacept 53 GIST tumors 53 panitumumab Vectibix 53 PREZISTA r 53 antifolate 53 platelet inhibitor 53 prostate cancer HRPC 53 protease inhibitor 53 BEACOPP 53 vancomycin 53 isoniazid 53 inhaled corticosteroids 53 corticosteroid dexamethasone 53 ZOLINZA 53 beta interferons 53 TNF antagonists 53 bisphosphonate therapy 53 OHR/AVR# 53 mitoxantrone chemotherapy 53 vinca alkaloid 53 SCIg 53 stavudine 53 Radiation therapy 53 induce remission 53 conventional DMARDs 53 CBLC# 53 flavopiridol 53 goserelin 53 herceptin 53 lamivudine 53 meropenem 53 CellCept mycophenolate mofetil 53 antibiotic therapy 53 immunomodulator 53 Protease inhibitors 53 Vidofludimus 53 Caelyx 53 p# inhibitors 53 temozolomide TMZ 53 antiepileptic medications 53 EBRT 53 vasodilators 53 IMC A# 53 SERMs 53 EGFR TKIs 53 fluconazole 53 estramustine 53 dexamethasone 53 antitumor effect 53 cancer immunotherapies 53 basal insulin 53 forodesine 53 paricalcitol 53 leukemia AML 53 etanercept 53 pharmacokinetic interactions 53 anti TNFs 53 posaconazole 53 infusional 53 HGS ETR1 53 TELINTRA 53 unresectable 53 L asparaginase 53 rifamycins 53 therapies ACTs 53 antiandrogen 53 Ixempra 53 VELCADE 53 tumor recurrence 53 paclitaxel carboplatin 53 sodium stibogluconate 53 PROCHYMAL 53 adjuvant radiation 53 XELOX 53 receptor tyrosine kinase inhibitor 53 radiotherapy 53 Neulasta ® 53 Pfizer Sutent 53 pegylated interferon ribavirin 53 cytotoxics 53 HuLuc# 53 radiolabeled antibodies 53 proliferative disorders 53 complete remissions 53 KRAS status 53 vincristine doxorubicin 53 immunosuppressant drug 53 chemotherapy treatments 53 opioid analgesia 53 quinolone 53 endostatin 53 raloxifene Evista 53 hypomethylating agents 53 oblimersen 53 clot dissolving drug 53 TNF alpha antagonist 53 antiemetic 53 nucleoside analog 53 ribavirin RBV 53 antidepressant therapy 53 metastatic gastric 53 alfa 2a 53 relapsing MS 53 melphalan 53 Paraplatin ® carboplatin 53 Alimta 53 refractory NSCLC 52 anti androgen 52 Dabigatran 52 radionuclide therapy 52 NSAIDs 52 surrogate endpoint 52 IGIV 52 Vincristine 52 renal toxicity 52 Bcr Abl inhibitors 52 PEG interferon 52 Avastin 52 preclinically 52 Cellcept 52 MGd 52 Navelbine 52 grade gliomas 52 serologically active systemic lupus 52 relapsed refractory 52 anticancer agent 52 malignancies 52 seliciclib 52 Gliadel Wafer 52 Sprycel 52 sorafenib tablets 52 Pazopanib 52 carvedilol 52 clopidogrel 52 ritonavir boosted 52 breast irradiation 52 immunosuppressant therapy 52 temozolomide Temodar 52 Clofarabine 52 imatinib mesylate 52 Genentech Herceptin 52 antiangiogenic 52 radioimmunotherapy 52 conventional IMRT 52 virotherapy 52 Anastrozole 52 pemetrexed Alimta 52 Avastin bevacizumab 52 peginterferon alfa 2a 52 viral kinetics 52 anticlotting drugs 52 teriparatide 52 immune modulators 52 radiotherapy SBRT 52 thrombolytics 52 myelofibrosis 52 Xanafide 52 anthracyclines taxanes 52 IVIg 52 GvHD 52 antithrombotic therapy 52 Immunosuppressive drugs 52 metastatic malignant 52 ranibizumab Lucentis 52 Hsp# inhibition 52 granisetron 52 bone metastases 52 hematological cancers 52 glargine 52 anti angiogenic therapies 52 PARP inhibitor 52 disease progression 52 antitumor efficacy 52 ISF# 52 hydroxychloroquine 52 allogeneic HSCT 52 clot dissolving drugs 52 Telintra 52 FluCAM 52 bone marrow suppression 52 trastuzumab Herceptin R 52 neoadjuvant treatment 52 tumor regression 52 Symadex 52 Cytarabine 52 nonmelanoma skin cancers 52 pharmacokinetic properties 52 antihormonal 52 immune reconstitution 52 bone marrow transplantation 52 adjuvant chemotherapy 52 CD# antibody [001] 52 TORISEL 52 tumors 52 biphosphonates 52 efavirenz Sustiva 52 T DM1 52 immunosuppressive regimen 52 cyclophosphamide methotrexate 52 dosing frequency 52 DCVax ® Brain 52 androgen suppression therapy 52 Desferal 52 IFN alpha 52 Chemophase 52 dacarbazine chemotherapy 52 Targretin 52 eniluracil 52 antitumor 52 clozapine 52 gastrointestinal stromal tumor GIST 52 nevirapine Viramune 52 Tykerb 52 recurrent ovarian cancer 52 adefovir 52 proton pump inhibitors PPIs 52 hormonal treatments 52 Jevtana 52 monotherapy 52 levodopa carbidopa 52 Th2 cytokines 52 TNF alpha inhibitors 52 Yervoy 52 stage IIIB IV 52 allogeneic SCT 52 metformin 52 antianginal 52 ifosfamide 52 talabostat 52 Hydroxyurea 52 β blockers 52 tipranavir 52 ONCASPAR 52 DAPT 52 inhibitor RG# 52 antifungal agents 52 Alocrest 52 Rilutek 52 PRT# 52 iron chelation therapy 52 aflibercept VEGF Trap 52 pegylated interferon alpha 52 apoptotic pathway 52 Alessandro Riva 52 nanoviricides 52 targeted biologic therapies 52 VAPRISOL 52 TREANDA 52 Revimmune 52 OPAXIO 52 SBRT 52 locoregional 52 oral NSAIDs 52 antiplatelet drugs 52 IFN beta 52 unfractionated heparin 52 doxorubicin Adriamycin 52 recurrent glioblastoma multiforme 52 dose dexamethasone 52 glucocorticoids 52 relapsed MM 52 EGFRIs 52 adeno associated viruses 52 androgen suppression 52 Vidaza azacitidine 52 UsiRNAs 52 pegylated interferon alfa 2b 52 gastrointestinal stromal tumor 52 Carfilzomib 52 alpha 2a 52 personalized immunotherapy 52 immunosuppressive medications 52 KRAS mutant tumors 52 subcutaneous immunotherapy 52 CANCIDAS 52 boosted protease inhibitor 52 Ph + ALL 52 neoadjuvant 52 pharmacologic 52 hydralazine 52 HIPEC 52 antibiotics 52 IV bisphosphonates 52 refractory ovarian cancer 52 ethambutol 52 stavudine d4T 52 Azathioprine 52 Factor Xa inhibitors 52 cardiotoxic 52 multikinase inhibitor 52 velafermin 52 microtubule targeting 52 cranial irradiation 52 Camptosar 52 cytarabine daunorubicin 52 rHuEPO 52 peptide antigens 52 NEUGENE 52 untreated CLL 52 neuroendocrine tumors 52 Tekamlo 52 cisplatin resistant 52 tinidazole 52 GW# [003] 52 TNFerade 52 nonsurgical treatments 52 H. pylori eradication 52 proton pump inhibitor 52 zidovudine AZT 52 capecitabine Xeloda R 52 GEMZAR 52 non squamous NSCLC 52 indinavir 52 chronic GVHD 52 macrolide antibiotics 52 SUTENT 52 Vorinostat 52 oral deforolimus 52 Temozolomide 52 nab paclitaxel 52 anti emetics 52 samalizumab 52 EGFR TKI 52 voriconazole 52 dosing regimen 52 metastatic cancers 52 ALIMTA