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(Click for frequent words.) 73 contractile function 70 contractility 68 osteoblast 68 myocytes 67 osteoblastic 67 vasodilation 67 autoregulation 67 proteoglycan 67 baroreflex 67 hypothalamic 67 hypothalamic pituitary 66 sarcomere 66 F actin 66 calcium homeostasis 66 myocyte 66 catabolism 66 fibrin deposition 66 catecholamine 66 neovascularization 66 BMP signaling 66 electrical conduction 65 junctional 65 beta adrenergic receptors 65 proximal tubule 65 rostral 65 PIP2 65 isoenzyme 65 cardiac myocytes 65 myofibroblasts 65 adipocyte 65 fatty acid oxidation 65 dorsolateral 65 ERK1 2 65 nephron 65 telomeric 65 hypothalamus pituitary 65 neuronal plasticity 65 glomerular 64 arteriolar 64 chondrocyte 64 mitochondrial respiration 64 autophagic 64 Skeletal muscle 64 cyclic AMP 64 atrial tissue 64 ouabain 64 excitatory 64 spermatogenesis 64 elastic fibers 64 mitogenic 64 striated muscle 64 osteoclast 64 myocardial 64 actin binding 64 catenin 64 inferior frontal 64 Fig. 4B 64 myocardial tissue 64 efferent 64 innervation 64 GH secretion 63 homeostatic 63 KATP channels 63 neuronal synapses 63 epididymal 63 myocardium 63 skeletal muscle 63 S#A# [002] 63 sinus node 63 mesoderm 63 depolarization 63 β catenin 63 intraventricular 63 locomotor activity 63 ACh 63 hyperactivation 63 lordosis 63 muscarinic receptors 63 GRK2 63 TGF ß1 63 GSNO 63 capillary density 63 parathyroid gland 63 epithelia 63 umbilical vein 63 Ca2 + 63 CaM 63 afferents 63 acinar 63 myofibroblast 63 retinal neurons 62 vasodilatation 62 vWF 62 epicardium 62 SUMOylation 62 vascularization 62 desmin 62 corticospinal 62 cortical neurons 62 microglial 62 mRNA encoding 62 hindlimb 62 systole 62 caveolin 1 62 morphogen 62 PIP3 62 Rab5 62 suprachiasmatic nucleus 62 afferent 62 podocytes 62 eNOS 62 dephosphorylation 62 BMAL1 62 STAT1 62 HUVEC 62 HPA axis 62 TGFb 62 endothelial nitric oxide synthase 62 nitric oxide synthase 62 GluR1 62 vagal 62 periosteum 62 adrenocortical 62 postsynaptic 62 adipogenic 62 transmembrane 62 mitochondrial biogenesis 62 motoneurons 62 inhomogeneity 62 polyamine 62 hormone secretion 62 distension 62 hippocampal neurons 62 MMP2 62 tubule 62 renal tubular 62 echogenicity 62 TNFalpha 62 immunoreactivity 62 myogenic 62 dermal papilla 62 FGF# 62 monocyte 62 Cdc# 62 collagen degradation 62 IL 1ß 62 focal adhesions 62 actin myosin 62 conformational changes 62 HIF 1a 62 dorsomedial 62 sinoatrial node 62 upregulates 62 adrenal cortex 62 neuromuscular junction 61 infarcted myocardium 61 mRNA expression 61 Runx2 61 CaM kinase II 61 hypoperfusion 61 Aβ 61 skeletal muscles 61 intestinal epithelium 61 Purkinje cell 61 skeletal muscle cells 61 left ventricular LV 61 MAP kinase 61 inflammatory cytokine 61 Fig. 2b 61 Thyroid hormone 61 tyrosine phosphorylation 61 calcineurin 61 lateral ventricle 61 ciliary body 61 innervated 61 neuroepithelial cells 61 antioxidant enzyme 61 detrusor 61 fibrotic 61 urothelial 61 cellular metabolism 61 sarcoplasmic reticulum 61 cytosolic 61 PTH secretion 61 thrombus formation 61 angiotensinogen 61 dopamine signaling 61 cyclic AMP cAMP 61 Rac1 61 ligand induced 61 vascularisation 61 guanosine 61 articular surface 61 intracellular calcium 61 macrophage infiltration 61 atherogenesis 61 gliosis 61 NADPH 61 noradrenergic 61 myogenesis 61 intervertebral discs 61 IRE1 61 perivascular 61 vesicle fusion 61 Myosin II 61 iNOS 61 systolic function 61 Aâ 61 Purkinje cells 61 physiologic 61 hematopoiesis 61 fractional shortening 61 depolarizing 61 glomerulus 61 transgenic mice expressing 61 innervate 61 axonal 61 vascular endothelial cells 61 AV node 61 amyloid β 61 Sgk1 61 neurite outgrowth 61 β cell 61 pyrimidine 61 atherosclerotic plaques 61 presynaptic 61 cerebral ischemia 61 lacrimal gland 61 sulci 61 clot formation 61 platelet activation 61 erythropoiesis 61 mTORC1 61 activin 61 ipsilateral 61 neuronal migration 61 GLUT4 61 inducible nitric oxide synthase 61 proinflammatory 61 circadian pacemaker 61 Left ventricular 61 osteoblast differentiation 61 GABAA receptors 61 rCBF 61 titin 61 miR# 61 ATPase activity 60 myometrium 60 beta globin 60 nucleus pulposus 60 E cadherin expression 60 eicosanoids 60 vasodilatory 60 mitral annulus 60 vasoconstriction 60 afterload 60 diastole 60 cardiomyocyte 60 apical 60 ERK activation 60 antiapoptotic 60 striatal 60 MT1 MMP 60 TGF β 60 extracellular calcium 60 hemoglobin molecule 60 natriuretic peptides 60 baroreceptors 60 medulla 60 beta subunit 60 neuronal signaling 60 renal fibrosis 60 excitation contraction 60 aldosterone 60 lactate dehydrogenase 60 ectopic expression 60 regulated kinase ERK 60 microvessels 60 osteocytes 60 mesenchyme 60 ciliary 60 intestinal mucosa 60 left ventricular diastolic 60 collagen synthesis 60 parenchyma 60 endothelial 60 IL #p# 60 lymphoid cells 60 radial glia 60 leptin signaling 60 electrically stimulated 60 TGFbeta 60 somites 60 ERK signaling 60 serine protease 60 somatosensory cortex 60 hedgehog signaling 60 deacetylation 60 podocyte 60 baroreceptor 60 dopaminergic neurons 60 cytoskeletal protein 60 protein actin 60 VE cadherin 60 alveolar epithelium 60 ligamentous 60 glucose homeostasis 60 coronary vasodilation 60 IL 1beta 60 erythrocytes 60 neurohormonal 60 heme oxygenase 60 TGF b 60 tenascin C 60 natriuresis 60 hepatic glucose production 60 SOCS3 60 substrate specificity 60 endothelial cell 60 stromal 60 synaptic transmission 60 neuronal function 60 trabecular bone 60 granule cells 60 semicircular canals 60 autonomic nerves 60 papillary muscle 60 pericytes 60 explants 60 myelination 60 peripheral tissues 60 gut mucosa 60 pRb 60 p#NTR 60 mitogen 60 aggrecan 60 nitrotyrosine 60 microcirculation 60 baroreceptor reflex 60 glycolytic 60 CD1d 60 hippocampal 60 GAGs 60 allergic inflammation 60 plasma lipids 60 glucocorticoid hormones 60 ATP hydrolysis 60 transmural 60 insulin secretion 60 cortical bone 60 adventitia 60 neuronal pathways 60 overactivation 60 parenchymal 60 adherens junctions 60 UCP1 60 P cadherin 60 JNK activation 60 striatal dopamine 60 atherosclerotic lesions 60 trabeculae 60 TGF ß 60 hemoglobin Hb 60 Tbx5 60 kidney tubules 60 Fig. 1D 60 osteoclastic 60 downregulation 60 caveolae 60 interconversion 60 osteogenic 60 actin cytoskeleton 60 proteolytic 60 ß1 60 cAMP signaling 60 nociceptive 60 Wnt signaling 59 endothelium dependent 59 neurite 59 glutamate signaling 59 connexin# 59 matrix metalloproteinases 59 humeral head 59 TRPV4 59 proteolysis 59 aortic wall 59 posterior parietal 59 infarcted 59 cone photoreceptors 59 collagen fibers 59 MMP9 59 toxic beta amyloid 59 hypertrophy 59 muscle contractility 59 cholesterol homeostasis 59 epithelial cells lining 59 ligand binding 59 intima 59 proximal femur 59 diastolic dysfunction 59 corneal endothelium 59 RhoA 59 IL 1β 59 upregulating 59 axonal transport 59 insulin secreting cells 59 cardiac fibroblasts 59 NF kappaB activation 59 ablated 59 fig. S1 59 transcriptional activation 59 CEACAM1 59 paracellular 59 mPFC 59 laminae 59 nociceptors 59 Gata4 59 glutamatergic 59 endothelial activation 59 ischaemia 59 glutamate transporters 59 limbal 59 rhythmicity 59 cytoskeletal 59 mdx mice 59 pro angiogenic 59 atrioventricular 59 VSMCs 59 astrocytic 59 microglial activation 59 WNK1 59 KLF2 59 detrusor muscle 59 T2 weighted images 59 plasminogen 59 mitochondrial enzyme 59 aerobic metabolism 59 trophoblast cells 59 melanocyte 59 huntingtin 59 fibrillar 59 chondrocytes 59 transcriptional activity 59 cellular prion protein 59 NKT cell 59 protein myosin 59 prefrontal cortical 59 Aldosterone 59 uncoupling protein 59 FGFs 59 intimal hyperplasia 59 left ventricular systolic 59 P selectin 59 arterioles 59 pituitary hormone 59 ABCA1 59 palmitate 59 photoreceptor cell 59 enterocytes 59 interstitial fluid 59 gluconeogenesis 59 vascularity 59 compressive stress 59 sensory nerve fibers 59 metalloproteases 59 hindbrain 59 notochord 59 alkalosis 59 transcriptional repressor 59 caspase activation 59 tissue oxygenation 59 PGC 1α 59 tumor suppressor p# 59 sensory axons 59 ciliated 59 phosphorylated 59 S nitrosylation 59 apoptosis pathway 59 Smad4 59 parasympathetic 59 secretory pathway 59 matrix metalloproteinase 59 ERK pathway 59 cardiolipin 59 intrahepatic 59 plasma fibrinogen 59 distensibility 59 superior temporal gyrus 59 adenosine diphosphate ADP 59 bone morphogenetic proteins 59 secrete hormones 59 splenic 59 potentiation 59 antiangiogenic 59 coexpression 59 brown adipose tissue 59 degranulation 59 acetylcholine receptor 59 IFN γ 59 epidermal cells 59 gyrus 59 steroidogenic 59 anabolism 59 dentate gyrus 59 ectoderm 59 cytokine signaling 59 infarct size 59 hypoxia inducible transcription 59 β 59 lipogenesis 59 pulmonary arterial 59 constitutively active 59 Aß 59 membrane permeability 59 motor neurones 59 downregulate 59 Treg cells 59 synovial 59 neurone 59 tissue homeostasis 59 corticospinal tract 59 proinflammatory cytokines 59 hyperactivated 59 arrhythmogenic 59 glucocorticoid 59 tyrosine hydroxylase 59 elastase 59 beta globin gene 59 thymosin 59 axon guidance 59 hyperalgesia 59 electrically stimulating 59 ventricular dilatation 59 ependymal cells 59 myocardial function 59 mitotic spindle 59 Fig. 1C 59 repolarization 59 receptor subtypes 59 cadherin 59 micronuclei 59 fatty infiltration 59 lymphatic vasculature 59 seminal vesicles 59 stomatal 59 procaspase 3 58 axonal degeneration 58 #BP# 58 palytoxin 58 Smad3 58 modulatory 58 fluid shear 58 Hair follicles 58 surgical decompression 58 proton pump 58 pyramidal cells 58 resorption 58 neointimal hyperplasia 58 receptor activation 58 reductase 58 lymphangiogenesis 58 reticular 58 IL6 58 intermittent hypoxia 58 atheroma 58 EGFR signaling 58 choroid 58 synaptic function 58 globus pallidus 58 nitric oxide synthase NOS 58 amyloid deposition 58 ventricular remodeling 58 posterior cingulate 58 ephrin 58 intravascular volume 58 thermoregulatory 58 collagenous 58 vasoconstrictor 58 proapoptotic 58 glial 58 epithelial tissues 58 microstructural 58 TGFβ 58 synovial cells 58 phosphocreatine 58 intracellular pH 58 lamina 58 triacylglycerol 58 septal 58 ventromedial 58 bioelectrical 58 agonist induced 58 Notch signaling 58 physis 58 striatal neurons 58 cardiac fibrosis 58 cell adhesion 58 tropomyosin 58 downregulated 58 cofilin 58 endoplasmic reticulum ER 58 UCP2 58 Sonic hedgehog 58 TORC2 58 tumoral 58 proinflammatory mediators 58 adipose cells 58 connexin 58 amyloid peptides 58 hyaline cartilage 58 metaplasia 58 rumen fermentation 58 PrPC 58 secrete insulin 58 oxidized LDL 58 hypoxic tumor 58 pineal 58 hypothalamus gland 58 polyglutamine 58 hormone secreting 58 glucose uptake 58 MMP# 58 hormone aldosterone 58 LDL receptor 58 normoxic 58 anti apoptotic 58 cysteines 58 flexor digitorum 58 serotonin transporters 58 hyperintensity 58 mineralocorticoid 58 4E BP1 58 immunoreactive 58 subcortical 58 myosin filaments 58 K + ATPase 58 trophoblasts 58 excitatory neurons 58 cellularity 58 serotonergic 58 transmembrane protein 58 somatosensory 58 catalase 58 mitogen activated protein kinase 58 coiled coil 58 diastolic function 58 senescent cells 58 γ secretase 58 XBP1 58 anterior temporal lobe 58 secretory cells 58 bursae 58 prostaglandin synthesis 58 Fig. 1a 58 secretory 58 Supplementary Fig 58 Notch1 58 Fig. 1A 58 Fig. 3a 58 Hsp# [001] 58 leptin receptor 58 mitochondrial membrane 58 aortic arch 58 insulin secreting 58 keratinocyte 58 intervertebral disk 58 multinucleated 58 c MYC 58 PTHrP 58 myocardial contractility 58 brain hypothalamus 58 collagen deposition 58 pylorus 58 orbitofrontal 58 hypothalamic pituitary adrenal HPA 58 glycosaminoglycan 58 synovitis 58 uracil 58 medial prefrontal 58 oxidative metabolism 58 osteolytic 58 carbohydrate metabolism 58 monoamine 58 outflow tract 58 Proteostasis Network 58 inhibitory neurons 58 corpus luteum 58 osteoid 58 GABAergic interneurons 58 OGG1 58 punctate 58 myosins 58 nigrostriatal 58 PKC beta 58 atherogenic 58 transmit nerve impulses 58 abnormal angiogenesis 58 cytochrome c 58 Androgen receptor 58 myometrial 58 Dpp 58 epicardial 58 condensin 58 trabecular 58 redox sensitive 58 posttranslational modification 58 sensory nerve 58 malonyl CoA 58 serotonin signaling 58 cyclic adenosine monophosphate cAMP 58 ectodermal 58 PER2 58 matrix metalloproteinases MMPs 58 nonvascular 58 synovial fluid 58 haematopoietic 58 clotting cascade 58 alveolar epithelial cells 58 ß amyloid 58 dyssynchrony 58 autocrine 58 hypothalamic pituitary adrenal axis 58 POMC neurons 58 leukemic cell 58 intercellular communication 58 ultrastructural 58 exocytosis 58 Leydig cells 58 cortical 58 calpain 58 PON1 58 Smad7 58 histone acetylation 58 osteoclast formation 58 branching morphogenesis 58 SIRT2 58 neuropeptide Y 58 β amyloid 58 penile tissue 58 gyri 58 sarcomeres 58 glycosaminoglycans 58 macroscopically 58 palmitoylation 58 microvascular endothelial cells 58 serotonin reuptake 58 KaiC 58 platelet aggregation 58 sciatic nerves 58 Leydig cell 58 ERa 58 GABAergic neurons 58 phagocytosis 58 dorsal horn 58 oligomerization 58 interstitium 58 FGFR4 58 ventricular dilation 58 mitochondrial oxidative 58 circadian genes 58 cystic fibrosis transmembrane conductance 57 S6K 57 ventricular septum 57 neural tissues 57 tortuosity 57 CXCL# 57 TGF beta1 57 lysosomal 57 pudendal nerve 57 premotor 57 catalytic subunit 57 RAS RAF MEK 57 p#Kip# 57 Fig. 2a 57 coronary perfusion 57 NR2B subunit 57 adrenals 57 interstitial fibrosis 57 capillary endothelial cells 57 parietal lobes 57 Cx# [001] 57 pulmonary vasculature 57 heme oxygenase 1 57 mitochondrial membrane potential 57 basal ganglia 57 vastus medialis 57 hyperinsulinemia 57 da mage 57 tau phosphorylation 57 microcirculatory 57 actin myosin interaction 57 microtubule dynamics 57 cardiac autonomic 57 interferon γ 57 thioredoxin 57 MyoD 57 dopamine neuron 57 synovium 57 PDE1 57 mesenchymal cells 57 metabolizing enzymes 57 interneuron 57 cadherins 57 hypovolemic 57 hyperexcitability 57 ischemic preconditioning 57 Vpr 57 osmotic pressure 57 collagen fibrils 57 receptor subtype 57 urinary excretion 57 Alu RNA 57 greater trochanter 57 hydroxylation 57 joints tendons 57 Osteoclasts 57 estrogen receptor alpha 57 Bcl xL 57 neuromuscular junctions 57 erythrocyte 57 osteogenesis 57 Oxidative stress 57 cardiac contractility 57 basolateral 57 pericyte 57 NPD1 57 secretase 57 5 HT1A 57 goblet cells 57 dendritic spines 57 embryonic tissues 57 transcriptionally 57 stromal cells 57 leukaemic stem cells 57 glycogen metabolism 57 osteoconductive 57 lymphocyte activation 57 pituitary hormones 57 proximal tubules 57 tibialis anterior muscle 57 neurofilament 57 lytic 57 TGF alpha 57 oxidant stress 57 intrathoracic 57 dorsal root ganglia 57 catabolic 57 dopaminergic nerve 57 Vascular endothelial growth 57 dopamine transporter 57 hind limb 57 transmembrane domain 57 Kupffer cells 57 clonogenic 57 echogenic 57 vasculature 57 Amino acid 57 Hcrt 57 brain parenchyma 57 cytoprotective 57 CCR7 57 transferase 57 malperfusion 57 hyperoxia 57 diffusivity 57 HuR 57 overactivated 57 CD#b 57 neuronal activity 57 spermatic cord 57 anterior cingulate gyrus 57 cystine 57 epithelial cell 57 gastric motility 57 caveolin 57 gamma H2AX 57 telomerase activity 57 glycosyltransferase 57 ileal 57 TERT 57 intronic 57 sural nerve 57 allopregnanolone 57 luminal surface 57 epithelial barrier 57 Cyclin D1 57 Stress hormones 57 serum PTH 57 dopaminergic 57 inferior parietal lobule 57 mucosal immunity 57 PDGF BB 57 glomeruli 57 dystroglycan 57 morphologic 57 occipital lobes 57 ATPase 57 Rab# 57 gastric distension 57 COOH terminal 57 lipid peroxidation 57 urothelial cells 57 NFATc1 57 neuritic plaques 57 glial cell 57 basal layer 57 fibrin matrix 57 microvessel 57 exocrine 57 fig. S# 57 retinal nerve 57 AMPA receptor 57 cardiac troponin 57 Dystrophin 57 toxic amyloid beta 57 cardioplegic arrest 57 intracytoplasmic 57 cAMP 57 heterozygotes 57 GTP hydrolysis 57 gastrocnemius muscle 57 Fc receptor 57 Rap1 57 omentum 57 temporoparietal 57 neoplastic cells 57 hepatocyte 57 nodulation 57 gastric mucosa 57 cortico 57 fluorescence intensity 57 erythroid 57 cortical activation 57 oncogenic transformation 57 midbrain 57 LDL receptors 57 pDCs 57 neuronal differentiation 57 PDGFR 57 oncomodulin 57 c Myb 57 disulfide bond 57 ADAMTS# 57 casein kinase 57 plasminogen activator inhibitor 57 endoplasmic reticulum stress 57 growth hormone secretion 57 VEGF expression 57 p# activation 57 oculomotor 57 osteocalcin 57 fibrillin 1 57 noradrenaline 57 pulmonary arteries 57 beta adrenergic receptor 57 entorhinal cortex 57 activated macrophages 57 demyelinated 57 serine 57 tubulin 57 dopamine depletion 57 Skeletal muscles 57 acinar cells 57 polypeptide chain 57 circadian cycle 57 receptor kinase 57 malignant transformation 57 osteogenic differentiation 57 tetramer 57 endogenous 57 oxidative phosphorylation 57 fatty acid metabolism 57 intestinal microflora 57 #ß 57 GABA neurotransmitter 57 condyles 57 neurohormones 57 hexamer 57 histone H4 57 electroencephalographic 57 insertional 57 endogenous opioid 57 ankyrin 57 centrosome 57 FOXO3a 57 neuro transmitters 57 erectile tissue 57 phosphorylates 57 ERK2 57 deformability 57 Peripheral nerves 57 PrP 57 Fig. 2B 57 prostaglandin E2 57 bile acid 57 creatine kinase 57 telomeric DNA 57 venous drainage 57 DLPFC