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(Click for frequent words.) 68 eNOS 67 transcriptional activation 67 constitutively 66 ERK1 2 66 inhibitory 66 mRNA expression 66 Rab5 65 Ca2 + 65 autophagic 65 tyrosine phosphorylation 65 TGF ß 65 paracrine 65 transcriptional regulator 65 TNFalpha 65 catenin 65 proteolysis 65 overexpression 65 intracellular 65 upregulation 64 IL 1beta 64 MT1 MMP 64 ß catenin 64 actin cytoskeleton 64 IL 1β 64 p# activation 64 cytosolic 64 inducible 64 downregulated 64 IL 1ß 64 cofactor 64 constitutively expressed 64 histone acetylation 64 proapoptotic 63 transcriptional regulation 63 transcriptional repressor 63 p# MAPK 63 CD1d 63 Smad3 63 caveolin 1 63 FasL 63 neurite outgrowth 63 Fc receptor 63 mitogen activated protein kinase 63 cytokine 63 osteoblast 63 induced apoptosis 63 guanosine 63 proinflammatory 63 somatostatin 63 GAPDH 63 downregulation 63 Wnt signaling 63 MAP kinase 63 cardiac myocytes 63 MAPK 63 thymic 63 c myc 63 HIF 1a 63 endothelial 63 kinase domain 63 inflammatory cytokine 63 TGFbeta 63 homodimers 63 adipocyte 63 HIF 1alpha 63 endogenously 62 interferon γ 62 mediated inhibition 62 microglial 62 cAMP 62 circadian clock genes 62 signaling pathways 62 efflux 62 glutamatergic 62 ubiquitination 62 pDCs 62 osteoclast formation 62 anti inflammatory cytokine 62 pro angiogenic 62 enzymatic activity 62 NKT cell 62 transgene expression 62 TGFβ 62 PKC isoforms 62 β1 62 lysosomal 62 transactivation 62 62 FOXO3a 62 kinase pathway 62 palytoxin 62 miR# 62 beta catenin 62 proinflammatory cytokines 62 isoforms 62 proteoglycan 62 superoxide dismutase 62 TGFß 62 glucocorticoid receptor 62 Cdc# 62 serine protease 62 murine 62 STAT1 62 NKG2D 62 extracellular signal 62 MyoD 62 synaptogenesis 62 RhoA 62 uPAR 62 β catenin 62 AMPA receptor 62 hepatocyte 62 Th2 62 inducible nitric oxide synthase 62 transmembrane 61 BMP signaling 61 MEK1 61 Aβ 61 E#F# 61 inhibition 61 endothelin 61 TGF b 61 antiapoptotic 61 endocytic 61 F actin 61 IRE1 61 tumorigenesis 61 PGE2 61 melanocyte 61 p#Kip# 61 FGFs 61 deacetylation 61 TGF β1 61 proteolytic cleavage 61 IFN gamma 61 coexpression 61 LPS induced 61 DNA demethylation 61 caspase activation 61 CD#b 61 exocytosis 61 BMP4 61 epithelia 61 Rac1 61 JNK1 61 estrogen receptor alpha 61 overexpressing 61 activin 61 Clusterin 61 metabolic enzymes 61 catabolism 61 cyclic AMP 61 dopaminergic 61 transgenic mouse model 61 inhibitory effects 61 mTOR signaling 61 ATPase 61 muscarinic receptors 61 mitogenic 61 ERK activation 61 Vps# 61 β 61 TGF beta1 61 neuronal differentiation 61 operon 61 basolateral 61 downregulate 61 heterodimers 61 KLF4 61 transgenic mice expressing 61 CTGF 61 phosphorylated 61 coactivators 61 matrix metalloproteinase 61 receptor mediated 61 striatal dopamine 61 hyperactivation 61 Rap1 61 overactivation 61 E cadherin 60 polyamines 60 NAD + 60 CEACAM1 60 cyclin B1 60 ENaC 60 selective inhibition 60 mitochondrial biogenesis 60 extracellular calcium 60 ERK signaling 60 H#K# [002] 60 angiogenic 60 nodulation 60 Notch1 60 exogenous 60 TGF ß1 60 TRPV4 60 calpain 60 upregulate 60 receptor gamma 60 TNF α 60 peptide hormone 60 MAPKs 60 RANKL 60 prostaglandin E2 60 erythropoiesis 60 ubiquitin ligase 60 keratinocyte 60 TGF β 60 RANTES 60 microglial activation 60 IL #p# 60 synthetase 60 Foxp3 60 hypoxia inducible factor 60 tropomyosin 60 matrix metalloproteinases 60 HepG2 cells 60 neutrophil 60 JNK activation 60 mRNAs 60 adrenergic receptors 60 apoptotic 60 secretory 60 nitric oxide synthase 60 HPA axis 60 oligomerization 60 lymphangiogenesis 60 prostaglandin E2 PGE2 60 phosphoinositide 60 chloroplast 60 hypothalamic 60 amino terminal 60 calcineurin 60 signaling pathway 60 Hh pathway 60 platelet activation 60 protein kinase C 60 PTHrP 60 cell motility 60 thyrotropin 60 Hedgehog signaling 60 HBx 60 DNMT1 60 transmembrane protein 60 glucocorticoid 60 receptor 60 prolyl 60 glycosyltransferase 60 cell adhesion molecule 60 Htt 60 PDGFR 60 secretory pathway 60 epithelial mesenchymal transition 60 cytoplasmic domain 60 BMAL1 60 STAT3 activation 60 mucosal immune 60 cathepsins 60 ERalpha 60 isoform 60 Id1 60 Klf4 60 TNFa 60 neurotrophic 60 evolutionarily conserved 60 NF kappaB 60 Dpp 60 Sgk1 60 nNOS 60 serine threonine 60 proteolytic 60 autocrine 60 phosphatidylinositol 3 60 osteocalcin 60 ncRNAs 60 IL #R 60 cells transfected 60 glycosylated 60 p# Shc 60 subcellular compartments 60 Exogenous 60 HDAC2 60 proinflammatory cytokine 60 thymocyte 60 cytochrome c 60 triacylglycerol 60 Wnts 60 reactive oxygen species 60 FOXO 60 cytochrome 60 intracellular signaling 60 ERK pathway 60 NPD1 59 uracil 59 polyamine 59 apoptosis pathways 59 cyclic AMP cAMP 59 cyclins 59 lipoxygenase 59 H#K#me# 59 leptin signaling 59 phenotype 59 dephosphorylation 59 extracellular 59 beta subunit 59 intracellular pH 59 tyrosine 59 SUMOylation 59 acetylcholine receptor 59 membrane protein 59 myocyte 59 neuronal 59 eotaxin 59 MAPK pathway 59 neuromuscular junction 59 eIF4E 59 NADPH oxidase 59 Dysregulation 59 Endogenous 59 p#NTR 59 pro inflammatory cytokines 59 stromal cells 59 glutamate 59 PPAR gamma 59 ectopic expression 59 circadian genes 59 adipogenesis 59 caveolin 59 cytoplasmic 59 N Myc 59 VE cadherin 59 TSLP 59 ABCA1 59 erythrocyte 59 Androgen receptor 59 demethylation 59 presynaptic 59 genetic polymorphism 59 constitutively active 59 Th1 59 BCL2 59 CXCL# 59 hypothalamic pituitary 59 gastric mucosa 59 M1 muscarinic 59 myofibroblast 59 biogenesis 59 phosphorylates 59 NADPH 59 protein kinase 59 glomerular 59 phosphorylation 59 proto oncogene 59 mRNA 59 FGF# 59 c Myb 59 HSF1 59 pro inflammatory cytokine 59 glucose transporter 59 Pim kinases 59 VEGF receptor 59 ERK phosphorylation 59 GLI1 59 TLR2 59 upregulated 59 MeCP2 59 proteases 59 hematopoiesis 59 lipid synthesis 59 alveolar epithelial cells 59 transiently 59 phagocytosis 59 leukemia inhibitory 59 Smoothened 59 Treg cells 59 Nampt 59 estrogen receptor 59 telomere dysfunction 59 thrombin receptor 59 plasminogen 59 receptor subtypes 59 upregulating 59 antigenic epitopes 59 pRb 59 astrocytic 59 eicosanoid 59 eIF2 59 Akt signaling 59 ACE2 59 peroxisome proliferator activated 59 anti apoptotic 59 gluconeogenesis 59 FGF2 59 chromatin remodeling 59 redox 59 TGFb 59 c fos 59 peroxisome 59 bone morphogenetic proteins 59 morphogen 59 ACh 59 iNOS 59 IFN γ 59 splenocytes 59 MMP9 59 phosphatases 59 ERK2 59 K + ATPase 59 striatal 59 plasmacytoid dendritic cells 59 renal fibrosis 59 dimerization 59 SIRT2 59 proton pump 59 Macrophage 59 posttranslational modification 59 transcriptional 59 substrate specificity 59 STAT3 59 plasma membrane 59 GABAergic 59 RAR beta 59 upregulates 59 c MYC 59 transferase 59 GH secretion 59 muscarinic 59 Oncogenic 59 guanine nucleotide exchange 59 4E BP1 59 receptor subtype 59 DMT1 59 tumorigenicity 59 glucose homeostasis 59 Skp2 59 PU.1 59 inhibitory effect 59 renal tubular 59 signaling molecule 59 axonal 59 GRP# 59 MyD# 58 PPARγ 58 oligomeric 58 regulated kinase ERK 58 cardiac fibroblasts 58 induces apoptosis 58 ligases 58 morphogens 58 transcription factors 58 catecholamine 58 innate immune responses 58 LRP6 58 XBP1 58 intracellular calcium 58 cyclin D1 58 hydroxylation 58 signaling cascades 58 transcription factor 58 keratinocytes 58 ERK1 58 casein kinase 58 Aß 58 Jhdm2a 58 endothelial cell 58 GPR# [002] 58 GTPase 58 lymphoid cells 58 glutamate receptor 58 PGC 1α 58 focal adhesions 58 cytoskeletal 58 endothelial nitric oxide synthase 58 P cadherin 58 PHD2 58 clonal expansion 58 cadherin 58 chemokine 58 Sox9 58 histone H3 lysine 58 endonuclease 58 histone modifications 58 neuropeptides 58 monocyte 58 hippocampal neurons 58 induce apoptosis 58 JAK STAT 58 ligand induced 58 mu opioid 58 endogenous opioid 58 cytokine secretion 58 T lymphocyte 58 oxidase 58 mitochondrial 58 Smad4 58 SMAD4 58 proteins 58 leukocyte 58 heme oxygenase 1 58 actin binding 58 fibroblast 58 lipid rafts 58 aberrantly activated 58 Src kinase 58 nucleolar 58 Runx2 58 adipocyte differentiation 58 prodynorphin 58 SOX9 58 adrenergic receptor 58 metalloproteinase 58 suppressor cells 58 cell adhesion molecules 58 protein phosphatase 58 phosphatase 58 reductase 58 effector memory 58 Saccharomyces cerevisiae 58 NKT cells 58 CCL# 58 protein conformation 58 nitrotyrosine 58 acetyl CoA 58 fibrogenesis 58 isoenzyme 58 chromosome condensation 58 Vpr 58 estrone 58 adenylate cyclase 58 RRM1 58 androgen 58 vascular endothelial 58 intestinal mucosa 58 peroxynitrite 58 p# [001] 58 astrocyte 58 Phosphorylation 58 adhesion molecule 58 epithelial cell 58 endosomal 58 MDR1 58 steroidogenic 58 transcriptional activity 58 transduction 58 MEF2 58 oxidative 58 degrading enzyme 58 serotonergic 58 secretion 58 NF KappaB 58 Rho GTPases 58 NF kappaB activation 58 c Fos 58 cytochrome P# 58 phosphatidylinositol 58 drug metabolizing enzymes 58 glutamate receptors 58 Kupffer cells 58 telomeric 58 agonist induced 58 cytokines 58 Akt 58 metallothionein 58 chemokine receptor 58 endoplasmic reticulum 58 MMP7 58 lymphocyte 58 CCR2 58 cytoskeletal proteins 58 FGF receptor 58 Pten 58 UCP2 58 palmitoylation 58 NMDA receptor 58 acinar 58 glioma cells 58 effector function 58 NMDA receptors 58 isomerase 58 hypermethylation 58 gene encoding 58 FKBP# 58 repressor 58 Overexpression 58 xenobiotic 58 phosphorylate 58 intestinal epithelium 58 ligand receptor 58 vimentin 58 neuroendocrine 58 transcriptionally 58 apoE 58 cAMP signaling 58 adipogenic 58 SOCS3 58 apoptosis pathway 58 NFκB 58 haematopoietic 58 lipopolysaccharide 58 sRNA 58 potent stimulator 58 functional polymorphism 58 TNF 58 adipokines 58 cytokine signaling 58 eicosanoids 58 redox sensitive 58 ras gene 58 aldosterone 58 NFkappaB 58 thromboxane 58 Akt activation 58 intestinal epithelial cells 58 FAK 57 oncogenic transformation 57 EGFR signaling 57 insulin signaling pathway 57 virulence genes 57 beta adrenergic receptors 57 isoenzymes 57 pathophysiological 57 Wnt 57 vascular endothelial cells 57 humoral 57 myofibroblasts 57 cathepsin B 57 IGFBP 57 bacterial virulence 57 signaling molecules 57 vasodilatory 57 TAp# 57 cyclooxygenase 57 synapse formation 57 amyloid β 57 paxillin 57 E selectin 57 interleukins 57 colony stimulating factor 57 cellular prion protein 57 cytokine IL 57 habenula 57 glycolipids 57 genes encoding 57 steroidogenesis 57 ß1 57 phosphoprotein 57 estrogen receptor beta 57 inflammatory cytokines 57 S#A# [002] 57 Th# 57 hydroxylase 57 glyceraldehyde 3 57 SGK1 57 endocytosis 57 purine 57 inosine 57 excitotoxic 57 dimeric 57 nociceptive 57 anaphase promoting complex 57 insulin secretion 57 cytotoxicity 57 cholesterol efflux 57 GSK 3ß 57 TRAF6 57 synthase 57 erythroid 57 genomic instability 57 TGF beta signaling 57 hematopoietic 57 Th2 cytokines 57 calcium homeostasis 57 protein synthesis 57 fatty acid oxidation 57 factor HGF 57 aquaporin 57 trophoblast cells 57 immunomodulatory effects 57 exogenously 57 PC# cells 57 coenzyme 57 endogenous cannabinoids 57 adrenergic 57 TIMP 57 glutathione S transferase 57 myocardial tissue 57 COX2 57 PTPN# 57 antioxidant enzyme 57 dopaminergic neurons 57 neuronal plasticity 57 suppressor gene 57 excitatory 57 tumor suppressor protein 57 coactivator 57 SCD1 57 antimicrobial peptides 57 5 lipoxygenase 57 GLUT4 57 glial 57 sequence homology 57 Vascular endothelial growth 57 NF κB 57 mammary epithelial cells 57 beta actin 57 adult neurogenesis 57 osteogenic differentiation 57 mice lacking 57 Sirt1 57 androgen receptor AR 57 NMDAR 57 TXNIP 57 NHEJ 57 mesenchymal cells 57 ncRNA 57 ligand 57 thioredoxin 57 γ 57 homologue 57 FGF signaling 57 MDSCs 57 protease activated 57 receptor tyrosine kinase 57 Nedd4 57 vivo 57 histone deacetylases 57 pyrimidine 57 lysophosphatidic acid 57 synaptic vesicle 57 progranulin 57 cytochrome P 57 estrogen receptors 57 glucagon receptor 57 Mcl 1 57 cellular metabolism 57 caveolae 57 TRPV3 57 proximal tubule 57 utrophin 57 subcellular localization 57 macrophage 57 antiproliferative activity 57 signal transduction 57 synaptic transmission 57 #β HSD1 57 noncoding RNA 57 cofactors 57 Cx# [001] 57 brain derived neurotrophic 57 serotonin receptor 57 PDE1 57 diffusible 57 hnRNP 57 HDAC6 57 cholesterol homeostasis 57 monocytes 57 cotransporter 57 GATA3 57 NO synthase 57 transmembrane receptor 57 neuregulin 57 Skeletal muscle 57 cyclic adenosine monophosphate 57 uPA 57 cardiolipin 57 overexpressing cells 57 autoantibody 57 nAChR 57 synaptic plasticity 57 Fig. 1C 57 immunological 57 contractility 57 Immunohistochemical analysis 57 oncoprotein 57 antibody mediated 57 cyclin dependent kinase 57 Notch signaling 57 immunodominant 57 homeostatic 57 arachidonic acid 57 ErbB2 57 arachidonic acid AA 57 neurosteroid 57 apoptotic cells 57 adrenal hormone 57 alternatively spliced 57 beta globin gene 57 LKB1 57 innate immune 57 RNAi pathway 57 immunostimulatory 57 UCP1 57 survivin 57 TLR4 57 potentiating 57 IGF1 57 mitochondrial proteins 57 adipose cells 57 cytoprotective 57 arginase 57 vacuolar 57 Tie2 57 receptor kinase 57 secretase 57 PlGF 57 TGF alpha 57 bcl 2 57 airway remodeling 57 c MET 57 LNCaP cells 57 mammalian 57 posttranslational modifications 57 oxidative phosphorylation 57 spermatogenesis 57 E cadherin expression 57 heme oxygenase 57 glycolytic 57 contractile 57 GABAergic interneurons 57 GABAergic neurons 57 secreted protein 57 oxidases 57 spermidine 57 GTP hydrolysis 57 NF kB pathway 57 mTOR 57 Hsp# [001] 57 mitochondrial respiration 57 heterochromatic 57 chondrocyte 57 GluR1 57 aT cell 57 homeostasis 57 cytosol 57 isozymes 57 receptors 57 RAS RAF MEK 57 c Src 57 MMP2 57 prostaglandin synthesis 57 ubiquitylation 57 postsynaptic 57 Nod1 57 mitochondrial enzyme 57 IGF IR 57 physiologic 57 cyclic nucleotide 57 phospho 57 neural crest 57 motoneurons 57 efferent 57 regulates gene expression 57 interneurons 57 immunoreactivity 57 cholinergic neurons 57 PI3K pathway 57 vasoactive 57 IL6 57 EGFP 57 monocytes macrophages 57 apoptosis 57 S1P 57 pleiotropic 57 thrombospondin 57 MAPK signaling pathway 57 S nitrosylation 57 ribonucleoprotein 57 dehydrogenase 57 receptor activation 57 sphingolipid 57 diphosphate 57 interferon IFN 57 CB1 receptor 57 cytokinesis 57 chemotactic 57 CD4 + CD# 57 receptor signaling 57 anterior pituitary 57 selenoproteins 57 CYP# [002] 57 defensin 57 microglia 57 CaM 57 siRNA mediated 57 monoamine 57 tumor suppressor p# 57 endogenous ligands 57 hypothalamus pituitary 57 VEGF expression 56 Th2 cells 56 lysine residues 56 Caspase 56 hematopoietic progenitors 56 polyadenylation 56 fatty acid synthesis 56 phospholipase 56 tyrosine hydroxylase 56 allosteric 56 dopamine transporter 56 factor PlGF 56 p# protein 56 bronchial epithelial cells 56 aminobutyric acid 56 gene encodes 56 PIP2 56 costimulatory 56 NFAT 56 mucins 56 E3 ubiquitin ligase 56 outer membrane proteins 56 cyclooxygenase 2 56 intestinal microflora 56 adrenoceptor 56 hepatic stellate cells 56 methyltransferase 56 leptin receptors 56 NR2B 56 cholinergic 56 bile acid 56 autophagy 56 Lyn kinase 56 redox active 56 MAP kinases 56 transfected 56 overactivated 56 C5aR 56 CaMKII 56 aromatase 56 β cell 56 carbohydrate metabolism 56 act synergistically 56 Monocyte 56 N methyl 56 soluble CD# 56 mRNA decay 56 TrkB 56 IGFBP 3 56 calcium ion 56 Pol IV 56 cytidine 56 carcinoembryonic antigen 56 β cells 56 LIS1 56 baroreflex 56 naturally occurring molecule 56 eukaryotic 56 annexin V 56 oncogenesis 56 oncogenic 56 miR #a [001] 56 auxin 56 amino acid 56 neuronal signaling 56 Ago2 56 RANK ligand 56 glutamine 56 MnSOD 56 inhibitory receptor 56 ouabain 56 ERa 56 signaling cascade 56 renin angiotensin aldosterone 56 AMPA receptors 56 alpha secretase 56 histone 56 MMPs 56 dysregulation 56 FSH receptor 56 allergic inflammation 56 metalloproteinases 56 endocannabinoid system 56 E1A 56 Aldosterone 56 PAX5 56 gene transcription 56 glucan 56 hypoxia inducible transcription 56 DRG neurons 56 BH3 56 Wnt beta catenin 56 leukemic cell 56 neuronal cell 56 CD# ligand 56 effector molecules 56 COL#A# 56 protein 56 GABAA receptors 56 neoplastic 56 hyperactivated 56 mutant SOD1 56 polycystin 56 PcG proteins 56 PTH secretion 56 VEGF 56 glutamine synthetase 56 PON1 56 Src 56 systemic inflammation 56 hepatocytes