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(Click for frequent words.) 66 homeostatic 64 glucose homeostasis 61 neuronal function 60 tissue homeostasis 60 proteostasis 60 dysregulation 60 metabolic 60 physiologic 59 intestinal flora 59 metabolism 59 adipocyte 58 neuroendocrine 58 insulin secretion 58 calcium homeostasis 58 lipid metabolism 58 carbohydrate metabolism 58 metabolic homeostasis 58 intracellular pH 58 leptin signaling 58 autophagic 58 GABA neurotransmitter 58 Thyroid hormone 57 hypothalamic 57 metabolic processes 57 cellular metabolism 57 synaptic function 57 catabolism 57 gut microflora 57 β catenin 57 superoxide dismutase 57 mitochondrial oxidative 57 intestinal epithelium 57 endogenous 57 Sox9 57 podocytes 57 intestinal microflora 57 Proteostasis Network 56 proteolysis 56 Oxidative stress 56 GAPDH 56 mitochondrial biogenesis 56 endocrine 56 neuronal signaling 56 catecholamine 56 Sgk1 56 activin 56 cholesterol homeostasis 56 physiological 56 HPA axis 56 gluconeogenesis 56 hypothalamic pituitary adrenal axis 56 actin cytoskeleton 56 Cdc# 56 Wnt signaling 56 cytoskeletal 56 signaling pathways 56 SIRT6 56 oxidative phosphorylation 56 hematopoiesis 56 E cadherin expression 55 contractile 55 antioxidant enzyme 55 Rab5 55 tumor suppressor protein 55 eicosanoids 55 selenoproteins 55 TNFalpha 55 Ago2 55 synaptic plasticity 55 EGFR signaling 55 Thyroid hormones 55 GluR1 55 baroreflex 55 p# activation 55 hypothalamic pituitary 55 matrix metalloproteinases 55 thyroid hormones 55 hypoxia inducible transcription 55 metabolic enzymes 55 oxidases 55 antioxidant enzymes 55 plasma lipids 55 mRNA expression 55 FOXO3a 55 autoregulation 55 estrogen receptor alpha 55 glomerular 55 TGF b 55 podocyte 55 acid alkaline 55 biogenesis 55 biochemical 55 S#A# [002] 55 lysosomal 55 SH2 B 55 FoxO1 55 anti inflammatory cytokine 55 telomere maintenance 55 hormone secretion 55 lung epithelium 54 oxidative 54 oxidized LDL 54 endocrine glands 54 fatty acid metabolism 54 exocytosis 54 regulates gene expression 54 fibrogenesis 54 proximal tubule 54 HSF1 54 bone metabolism 54 FGF# 54 proton pump 54 pathogenesis 54 HepG2 cells 54 SIRT1 54 NF kappaB 54 neuropeptides 54 epithelia 54 osteocytes 54 mutant huntingtin protein 54 Phosphorylation 54 Sirt3 54 BMP signaling 54 mitochondrial respiration 54 mitochondrial function 54 protein synthesis 54 microbiota 54 hepcidin 54 tumorigenesis 54 carcinogenesis 54 pathophysiological 54 mucosal immune 54 insulin secreting cells 54 anabolism 54 muscarinic receptors 54 ubiquitylation 54 apoE 54 endothelial 54 axon guidance 54 innate immune 54 epithelial tissues 54 Skeletal muscle 54 synapse maturation 54 proteoglycan 54 encodes protein 54 osteocalcin 54 HIF 1a 54 morphogenesis 54 neuronal plasticity 54 adipose cells 54 palmitoylation 54 neurohormonal 54 adiposity 54 myocyte 54 gut flora 54 tyrosine phosphorylation 54 inflammasome 54 endocannabinoid system 54 hippocampal synapses 54 phosphorylation 54 osteoblast 53 lipid synthesis 53 beta adrenergic receptors 53 glucocorticoid hormones 53 paracrine 53 secretory pathway 53 neurofibromin 53 osteoclast formation 53 lymphocyte activation 53 mitochondrial 53 neovascularization 53 CD#b 53 neuronal synapses 53 UCP2 53 PIP2 53 mitochondrial proteins 53 dopaminergic 53 humoral 53 catenin 53 circadian clock genes 53 beta catenin 53 nephron 53 autonomic nervous system 53 transcriptional 53 CD1d 53 microflora 53 SGK1 53 electrical conduction 53 neuromuscular junction 53 cholesterol efflux 53 E cadherin 53 embryogenesis 53 β cell 53 hyperinsulinemia 53 neurotransmitter GABA 53 IRE1 53 digesting enzymes 53 Hh signaling 53 Dysregulation 53 PIP3 53 posttranslational modification 53 telomere length 53 glucose uptake 53 transcriptional activation 53 Smad3 53 polyamine 53 fatty acid oxidation 53 spermatogenesis 53 metalloproteinase 53 autocrine 53 intestinal mucosa 53 caveolin 1 53 c Myb 53 acetylcholine neurotransmitter 53 synaptic transmission 53 receptor subtype 53 osmotic stress 53 neuronal pathways 53 mitogen activated protein kinase 53 UCP1 53 lipids 53 FGFs 53 transcriptional regulation 53 mammalian 53 synapse formation 53 Ca2 + 53 catabolic 53 mucosal barrier 53 amyloid β 53 Circadian rhythm 53 induced neuronal 53 secrete insulin 53 GSNO 52 nNOS 52 PTEN protein 52 NAD + 52 tumor metastasis 52 neuronal differentiation 52 paxillin 52 intracellular 52 cAMP signaling 52 p# pathway 52 atherogenesis 52 mitogenic 52 prolactin 52 TXNIP 52 gene expression 52 branching morphogenesis 52 eNOS 52 antioxidant glutathione 52 thyrotropin 52 transcriptional repressor 52 phenotype 52 cyclins 52 endocytosis 52 signaling pathway 52 Sonic hedgehog 52 ectopic expression 52 mRNA decay 52 circadian 52 telomerase activity 52 cAMP 52 homeostatic mechanisms 52 protein kinase C 52 peripheral insulin sensitivity 52 cholesterol metabolism 52 dysregulated 52 TGFβ 52 stem cell differentiation 52 reductase 52 erythropoiesis 52 growth hormone secretion 52 oligomerization 52 microglial 52 peroxisome 52 regulating gene expression 52 HIF 1alpha 52 calcineurin 52 TORC2 52 SCD1 52 DNA methylation patterns 52 neuronal degeneration 52 dephosphorylation 52 #ß 52 ERK signaling 52 oxidative DNA 52 heme oxygenase 52 Hypothalamic 52 iron homeostasis 52 ferritin 52 bile salts 52 antibody mediated 52 S6K 52 cardiolipin 52 HuR 52 adiponectin 52 phenotypic expression 52 TGF β 52 mitochondrial fusion 52 neuro endocrine 52 intracellular proteins 52 GATA3 52 histone acetylation 52 adrenocortical 52 adipokine 52 transmit nerve impulses 52 proteins 52 cell adhesion 52 signaling cascades 52 serotonergic neurons 52 enteric nervous 52 LIS1 52 NKT cell 52 contractile function 52 ENaC 52 melanocyte 52 epithelial barrier 52 glycogen metabolism 52 receptor gamma 52 breast cancer metastasis 52 tumor angiogenesis 52 elastic fibers 52 secretion 52 Wnt pathway 52 redox reactions 52 cytokine 52 ERK1 2 52 BMAL1 52 signaling molecule 52 ubiquitination 52 steroid hormones 52 isoenzyme 52 mTORC1 52 axon outgrowth 52 immunological tolerance 52 naturally occurring enzyme 52 Rab# 52 muscle contractility 52 remyelination 52 neurite outgrowth 52 VE cadherin 52 renal fibrosis 52 phagocytosis 52 Vpr 52 myogenesis 51 hypothalamus pituitary 51 JNK1 51 Notch pathway 51 chloroplast 51 LDL receptor 51 leucine 51 cellular senescence 51 enzymatic activity 51 caveolin 51 primary cilia 51 oxidative stress 51 amylin 51 hedgehog signaling 51 striatal dopamine 51 microbial flora 51 transgene expression 51 calpain 51 eotaxin 51 serine protease 51 systemic inflammation 51 synaptotagmin 51 glucocorticoid 51 neurotrophic 51 intact parathyroid hormone 51 receptor activation 51 metabolizing enzyme 51 methylation patterns 51 TGFbeta 51 MMP2 51 adrenal function 51 Hh pathway 51 membrane fusion 51 LXRs 51 Wnt proteins 51 Rap1 51 p# MAPK 51 ATP hydrolysis 51 insulin sensitivity 51 prostaglandin E2 PGE2 51 nitrogenase 51 RUNX3 51 extracellular calcium 51 biochemical pathways 51 cardiac autonomic 51 LRP5 51 overexpression 51 hormones leptin 51 malignant transformation 51 adipogenesis 51 endocannabinoid signaling 51 proinflammatory 51 leukocyte recruitment 51 GPR# receptor [002] 51 thyroid hormone 51 kinase pathway 51 estrogen metabolism 51 glucocorticoid receptor 51 membrane protein 51 cytokine signaling 51 leptin receptor 51 CTGF 51 endogenous cannabinoids 51 lipolysis 51 efferent 51 caspase activation 51 intestinal microbiota 51 tumor microenvironment 51 evolutionarily conserved 51 alveolar epithelium 51 adrenals 51 telomere dysfunction 51 epithelial 51 isoform 51 bioelectrical 51 acetyl CoA 51 catecholamines 51 glycolytic 51 serotonin signaling 51 Sirt1 51 CagA 51 pleiotropic effects 51 coactivators 51 Aldosterone 51 DNA demethylation 51 Th2 immune 51 peroxynitrite 51 motility 51 vasopressin 51 homodimers 51 urocortin 51 redox active 51 demethylation 51 KATP channels 51 excitatory 51 Nedd4 51 opioid receptor 51 Th1 51 SUMOylation 51 insulin resistance 51 epigenetic mechanisms 51 cell motility 51 hippocampal neurons 51 Hedgehog signaling 51 lipoic acid 51 Rb#/p# 51 arginase 51 axonal transport 51 pRb 51 neurotransmission 51 tau phosphorylation 51 pathogenetic 51 chromatin structure 51 neuronal dysfunction 51 GLUT4 51 beta globin gene 51 molecular pathways 51 proapoptotic 51 Bcl xL 51 hypocretin 51 brain neurochemistry 51 Reactive oxygen species 51 Prolactin 51 PP2A 51 interleukins 51 defensin 51 coenzyme 51 neuroligins 51 cellular signaling pathways 51 MT1 MMP 51 dystroglycan 51 interconversion 51 glutamatergic 51 corticospinal 51 casein kinase 51 hyperactivated 51 baroreceptor reflex 51 adaptive immunity 51 glutamate neurotransmission 51 innate immunity 51 POMC neurons 51 secrete hormones 51 ovarian function 51 circadian genes 51 peptide hormone 51 hepatic stellate cells 51 Ghrelin 51 cardiac myocytes 51 locomotor activity 51 RANK ligand 51 NFAT 51 DARPP 51 neurohormone 51 TGFb 51 endogenous opioid 51 CFTR protein 51 TLR4 51 RANKL 51 IL 1β 51 hepatic glucose production 51 S#K# 51 proto oncogene 50 adult neurogenesis 50 vivo 50 T lymphocyte 50 RBP4 50 AMPA receptor 50 allergic inflammation 50 Jhdm2a 50 hematopoietic 50 apoptotic pathway 50 4E BP1 50 apoptotic 50 Nod1 50 lymphatic vasculature 50 keratinocyte 50 brain hypothalamus 50 airway hyperresponsiveness 50 bacterial flora 50 astrocytic 50 cellular respiration 50 IL 1ß 50 triacylglycerol 50 thermoregulation 50 XBP 1s 50 uPAR 50 Akt 50 cyclic AMP cAMP 50 epigenetic 50 Ashwell receptor 50 inhibitory 50 H#K# [002] 50 NF kappaB pathway 50 cyclic adenosine monophosphate cAMP 50 SMN1 50 beta1 integrin 50 stomatal 50 oncogenic 50 glucocorticoid receptor GR 50 tissue oxygenation 50 Notch signaling 50 neural cells 50 senescent cells 50 inflammatory cytokine 50 physiological mechanisms 50 NKG2D 50 palmitate 50 β1 50 proNGF 50 immunological 50 isotope fractionation 50 circadian rhythmicity 50 Oxidative damage 50 molecular mechanisms underlying 50 cellular pathways 50 HGPS 50 epithelial cell 50 cell adhesion molecule 50 circadian rhythm 50 biochemical processes 50 follicle stimulating hormone FSH 50 arachidonic acid AA 50 NADPH oxidase 50 leptin receptors 50 HDAC2 50 neuropeptide 50 GRK2 50 serotonergic 50 prognostic significance 50 MAP kinase pathway 50 genotoxic stress 50 collagen synthesis 50 Wnts 50 dopamine neuron 50 pituitary hormones 50 thyroid function 50 FGFR3 50 PGC1 50 Essential fatty acids 50 skeletal muscle 50 neuronal 50 cystic fibrosis transmembrane conductance 50 insulin secreting beta 50 neurotransmitter 50 GABA gamma aminobutyric acid 50 subcellular compartments 50 extracellular signal 50 glucagon secretion 50 Endocannabinoids 50 FOXP3 50 secretes insulin 50 sodium potassium calcium 50 IL 1beta 50 nutrient absorption 50 AMPA receptors 50 inducible 50 lipoprotein metabolism 50 cardiac fibrosis 50 ERK pathway 50 urinary excretion 50 steroidogenesis 50 epithelial mesenchymal transition 50 endothelial nitric oxide synthase 50 NRF2 50 constitutively 50 ER alpha 50 transduction 50 metalloproteinases 50 transmembrane protein 50 tumor suppressor p# 50 angiotensinogen 50 Autophagy 50 motor neuron degeneration 50 pancreatic cells 50 Wnt beta catenin 50 BMP4 50 FGF2 50 cyclic AMP 50 GH secretion 50 neuropeptide Y NPY 50 intestinal absorption 50 effector T 50 MAPK 50 morphogen 50 protein tyrosine kinase 50 adipogenic 50 ß catenin 50 glycosaminoglycans 50 metabolic dysfunction 50 subcellular 50 TRPV3 50 Fc receptor 50 modulatory 50 metabolic parameters 50 nitric oxide synthase 50 Notch1 50 metabolic disturbances 50 mitochondria 50 mitochondrial enzyme 50 adipocyte differentiation 50 Mcl 1 50 pathophysiologic 50 oncogenic transformation 50 downregulated 50 oncogenesis 50 insulin resistance HOMA IR 50 circadian rhythms 50 Angiotensin converting enzyme 50 innate immune responses 50 phenotypes 50 Endothelin 50 genomic instability 50 FOXO1 50 monocyte 50 TGF beta1 50 pituitary hormone 50 upregulate 50 intercellular communication 50 bile acids 50 deacetylation 50 osmolality 50 airway remodeling 50 CD# expression [002] 50 cell signaling pathways 50 serum glucose 50 XBP1 50 upregulating 50 penile erection 50 histone modifications 50 platelet activation 50 FOXP3 + 50 ACh 50 glucose metabolism 50 osmotic pressure 50 insulin receptors 50 Cdc7 50 brain neurotransmitter 50 lymphangiogenesis 50 TGF ß 50 antiapoptotic 50 triiodothyronine 50 LKB1 50 insulin signaling pathways 50 matrix metalloproteinase 50 intestinal motility 50 procaspase 3 50 miR #a [001] 50 calcium phosphorus 50 beta arrestin 50 oxidase 50 parasympathetic 50 helicase 50 Endothelial 50 neuro transmitter 50 epigenetic regulation 50 DISC1 50 miRNA expression 50 neoplastic 50 ABCA1 50 caveolae 50 molecular pathway 50 Norepinephrine 50 tumor suppressor gene 50 metabolic pathways 50 cellular organelles 50 cofactors 50 prostaglandin E 50 humoral immunity 50 ACE2 50 regulated kinase ERK 49 anti apoptotic 49 gene encodes 49 chromosome condensation 49 sphingomyelin 49 plasticity 49 phosphatases 49 bile acid metabolism 49 hypoxia inducible factor 49 signaling cascade 49 serotonin neurotransmitter 49 prostate epithelial cells 49 myelination 49 Treg cells 49 hypothalamic pituitary axis 49 glutamate receptors 49 lipoxygenase 49 epigenetic alterations 49 HOTAIR 49 interferon γ 49 gene p# 49 Clusterin 49 Neurogenesis 49 catalytically active 49 proteinases 49 upregulates 49 mammary epithelial cells 49 autoimmunity 49 proinflammatory cytokines 49 adipokines 49 neuronal connections 49 CEACAM1 49 hormonal 49 myocardial tissue 49 vessel dilation 49 vasodilation 49 neurotrophins 49 circadian cycle 49 biosynthesis 49 constitutively expressed 49 cellular prion protein 49 vimentin 49 cofilin 49 morphogens 49 metabolizing enzymes 49 TGFß 49 orexin neurons 49 sphingolipid 49 TGF ß1 49 physiologic functions 49 synaptogenesis 49 induced apoptosis 49 p# protein 49 contractility 49 PDGFR 49 overactivation 49 resorption 49 bronchial airway 49 cofactor 49 Htt 49 bile acid 49 oligomeric 49 parasympathetic nervous system 49 intestinal epithelial cells 49 protein 49 cathepsins 49 signaling molecules 49 cholinergic neurons 49 vWF 49 protein Hsp# 49 epigenetically 49 PPAR gamma 49 serum lipid 49 folate metabolism 49 aldosterone 49 thyroid hormone levels 49 SIRT1 gene 49 fibrotic 49 Runx2 49 cytochrome oxidase 49 receptor subtypes 49 antigenic epitopes 49 Stress hormones 49 osteogenesis 49 basophils 49 gastric mucosa 49 posttranslational modifications 49 neuroinflammatory 49 desmin 49 dopamine signaling 49 telomeric 49 S nitrosylation 49 ubiquitin ligase 49 Nitric oxide NO 49 neurotrophic factors 49 microvascular endothelial cells 49 SMAD4 49 Leptin 49 killer NK 49 microtubule dynamics 49 gene transcription 49 potentiation 49 sumoylation 49 immunomodulatory effects 49 receptor gene 49 ciliary 49 neuronal migration 49 hydroxyl radical 49 MAP kinase 49 cytokine secretion 49 hepatic 49 arginine vasopressin 49 metazoans 49 circadian cycles 49 Circadian rhythms 49 Monocyte 49 KLF4 49 vasodilatation 49 Six3 49 microcirculation 49 secreting insulin 49 PTEN gene 49 acetylation 49 macrophage activation 49 GLI1 49 lactate dehydrogenase 49 parasympathetic tone 49 mesenchymal transition 49 CaM kinase II 49 E3 ubiquitin ligase 49 MMP# 49 STAT3 49 hormone serotonin 49 Th1 cells 49 Thiamine 49 CIB1 49 glycosylation 49 neutrophilic 49 miR# 49 lysosome 49 nodulation 49 cell signaling pathway 49 bone resorption 49 Kv#.# 49 N acetyl 49 gut microbiota 49 molecular signaling pathway 49 excitatory neurotransmitter 49 calmodulin kinase II 49 excitotoxic 49 insulin signaling pathway 49 vasomotor 49 corticotropin releasing hormone 49 blood glucose concentrations 49 KLF# 49 epididymal 49 cypin 49 costimulatory 49 SH#B# 49 secretory 49 inducible nitric oxide synthase 49 regulate gene expression 49 downregulation 49 tumor suppressive 49 fibroblast growth 49 habenula 49 steroidogenic 49 serotonin receptor 49 sGC 49 nicotinic receptor 49 cobalamin 49 hyperalgesia 49 CXCL# 49 upregulation 49 Smoothened 49 striatal 49 Hsp# [001] 49 exocrine 49 intracellular signaling 49 C. elegans 49 neurite 49 GTPases 49 androgen hormones 49 TPMT 49 isotypes 49 NK cells 49 kinase domain 49 vaginal flora 49 monocyte chemoattractant protein 49 organismal 49 spermidine 49 serine proteases 49 PGE2 49 Fas ligand 49 acetylcholine receptor 49 STAT1 49 angiogenesis 49 TFIIH 49 axonal 49 ligand receptor 49 glucose transporter 49 hypothalamus gland 49 glycaemia 49 H#K# methylation 49 organogenesis 49 incretin hormones 49 leukemic stem cells 49 heparan sulfate 49 PGC 1α 49 β cells 49 eukaryotic cell 49 Vasopressin 49 microglial cells 49 NF kappaB activation 48 calcium absorption 48 cytokines 48 GABAA receptors 48 Pim kinases 48 virulence genes 48 Carbohydrate intake 48 Ferritin 48 transcription factor 48 fibrin deposition 48 Leptin hormone 48 adipocytes 48 hyperactivation 48 Wnt signaling pathway 48 MMP9 48 NMDA receptors 48 glucose tolerance 48 pro angiogenic 48 MEF2 48 thermoregulatory 48 Id1 48 Src kinases 48 biochemical pathway 48 C EBP alpha 48 renal tubular 48 DNMT1 48 Hypoxia Inducible Factor 48 plasminogen 48 GRP# 48 adhesion proteins 48 Klotho 48 somatic motility 48 ncRNAs 48 TGF beta 48 mechanotransduction 48 suprachiasmatic nucleus 48 overactivated 48 cholinergic 48 tropomyosin 48 oxysterols 48 peroxisomes 48 Sertoli cells 48 plasma kallikrein 48 cyclic nucleotide 48 nitric oxide synthase NOS 48 TSLP 48 hindbrain 48 ischemia reperfusion injury 48 MMPs 48 activate AMPK 48 Androgen receptor 48 Nrf2 48 RIP1 48 thermogenesis 48 mutant proteins 48 Skp2 48 Glutamate 48 glycosylated hemoglobin HbA1c 48 mitochondrial mutations 48 JAK STAT 48 postsynaptic neuron 48 MCH neurons 48 leptin concentrations 48 intracellular pathways 48 transcriptional regulator 48 IFN gamma 48 sortilin 48 galanin 48 improves insulin sensitivity 48 diffusible 48 Robo4 48 interleukin IL -# 48 intercellular signaling