Related by context. All words. (Click for frequent words.) 71 bradycardia 69 renal insufficiency 68 infusion reactions 68 hyperkalemia 67 hypomagnesemia 67 hypokalemia 66 thrombocytopenia 66 lactic acidosis 65 hypoxemia 65 hyperglycemia 65 orthostatic hypotension 65 peripheral edema 65 syncope 64 hypercalcemia 64 leukopenia 64 hypersensitivity reaction 64 left ventricular dysfunction 64 electrolyte abnormalities 64 metabolic acidosis 64 hypocalcemia 64 renal dysfunction 64 Hypotension 64 nasopharyngitis 64 cerebrovascular events 64 thromboembolic events 63 hypoglycemia 63 hypotensive 63 ventricular fibrillation VF 63 hypersensitivity reactions 63 neuroleptic malignant syndrome 63 extrapyramidal symptoms 63 QTc prolongation 63 MULTAQ 63 VIIBRYD 63 febrile neutropenia 63 Adverse events 63 hepatotoxicity 63 cytopenias 62 bronchospasm 62 cardiogenic shock 62 nephrotoxicity 62 hypophosphatemia 62 Thrombocytopenia 62 pericardial effusions 62 torsade de pointes 62 dyspnea 62 myelosuppression 62 myopathy rhabdomyolysis 62 adrenal insufficiency 62 arterial thromboembolic events 62 milrinone 62 systemic hypotension 62 postural hypotension 62 hematologic toxicity 61 angioedema 61 angina pectoris 61 β blockers 61 thrombophlebitis 61 severe neutropenia 61 verapamil 61 gastrointestinal perforation 61 hypoperfusion 61 pericardial effusion 61 fluid retention 61 tirofiban 61 proteinuria 61 heparin induced thrombocytopenia 61 primidone 61 thrombotic events 61 symptomatic hypotension 61 leucopenia 61 paresthesias 61 diarrhea nausea vomiting 61 hepatic dysfunction 61 severe hypoglycemia 61 constipation nausea 61 IIIa inhibitor 61 myocardial ischemia 61 fluid overload 61 Infusion Reactions Severe 61 tachycardia 61 hemodynamic instability 61 sinus bradycardia 61 Lactic acidosis 61 tumor lysis syndrome 60 vasodilators 60 VAPRISOL 60 myalgias 60 thromboembolism 60 ventricular tachycardia 60 EXJADE 60 dizziness headache 60 thrombocytopenia neutropenia 60 alanine aminotransferase 60 headache nausea 60 severe exacerbations 60 myalgia 60 angiotensin converting enzyme inhibitor 60 nicardipine 60 ATACAND 60 neutropenia thrombocytopenia 60 tolvaptan 60 reinfarction 60 events AEs 60 urinary retention 60 renal impairment 60 sinus tachycardia 60 rhythm disturbances 60 amiodarone 60 endophthalmitis 60 QT prolongation 60 severe hypersensitivity reactions 60 cardiac tamponade 60 intracranial bleeding 60 ileus 60 nausea constipation 60 peripheral sensory neuropathy 60 progressive dyspnea 60 pruritis 60 vasovagal syncope 59 hypoglycemic events 59 atrioventricular block 59 generalized seizures 59 anaphylactoid reactions 59 periprocedural 59 aspartate aminotransferase AST 59 blood dyscrasias 59 induce orthostatic hypotension 59 neurologic symptoms 59 neutropenia dehydration dyspnea 59 TEAEs 59 headache nausea fatigue 59 neutropenia 59 antihypertensive medications 59 serum potassium 59 pancytopenia 59 nausea diarrhea 59 asystole 59 Atacand 59 transaminases 59 hemoptysis 59 metabolic alkalosis 59 pleural effusion 59 TNF antagonist 59 TMP SMX 59 renal toxicity 59 β blocker 59 ropivacaine 59 drowsiness nausea 59 hepatic failure 59 angioneurotic edema 59 epistaxis 59 aminotransferases 59 phenytoin 59 corticosteroid therapy 59 recurrent DVT 59 acute decompensation 59 akathisia 59 abciximab 59 intracranial hemorrhage ICH 59 receiving VELCADE 59 bacteremia 58 stable angina 58 NYHA Class II 58 hallucinations dyskinesia 58 thiazide diuretic 58 stomatitis 58 myocardial infarction stroke 58 SGPT 58 cerebral vasospasm 58 ventricular tachycardia VT 58 arrhythmias 58 tardive dyskinesia TD 58 aspartate aminotransferase 58 pruritus rash 58 mucosal inflammation 58 failure ADHF 58 posaconazole 58 vecuronium 58 systolic dysfunction 58 rhinorrhea 58 adrenal suppression 58 PREZISTA r 58 hyperglycaemia 58 Known hypersensitivity 58 QT interval prolongation 58 Neutropenia 58 mcg QD 58 NATRECOR ® 58 hypovolemia 58 ALT flares 58 systemic corticosteroid 58 allopurinol 58 bone marrow suppression 58 recurrent VTE 58 serum sodium 58 transaminase elevations 58 gout flares 58 hypoglycaemia 58 nausea vomiting dizziness 58 elevated intraocular pressure 58 paroxysmal supraventricular tachycardia 58 inotropes 58 Vaprisol 58 nausea diarrhea constipation 58 hyperammonemia 58 discontinuations due 58 inotropic 58 occlusive disease 58 laboratory abnormalities 58 intracerebral hemorrhage 58 myalgia arthralgia 58 coagulopathy 58 ventricular fibrillation 58 recurrent ischemia 58 headache abdominal pain 58 thromboembolic complications 58 pruritus 58 nonfatal MI 58 delayed CINV 58 diarrhea vomiting rash 58 mcg kg REBETOL 58 thyrotoxicosis 58 sustained ventricular tachycardia 58 Peripheral edema 58 hyperprolactinemia 58 hematological toxicity 58 angina chest 58 aldosterone antagonists 58 pheochromocytoma 58 unstable angina pectoris 58 mcg BID 58 nephrotoxic drugs 58 microvascular complications 58 Toxicities 58 #mm Hg 58 concomitant medications 58 tachyarrhythmias 58 edema 57 salmeterol HFA MDI 57 haloperidol Haldol 57 vomiting abdominal pain 57 Hypokalemia 57 hyperphenylalaninemia HPA due 57 systemic corticosteroids 57 NSTEMI 57 lamotrigine 57 PROCRIT 57 pyrexia mucositis sepsis febrile 57 dysuria 57 ALT elevations 57 Eltrombopag 57 extrapyramidal disorder 57 elevated serum creatinine 57 syncope fainting 57 strong CYP#A# inducers 57 ecchymosis 57 generalized tonic clonic seizures 57 torsades de pointes 57 anticholinergics 57 valsartan amlodipine 57 macrovascular events 57 amphotericin B 57 sotalol 57 unfractionated heparin 57 myoclonus 57 BYSTOLIC 57 postoperative nausea 57 overt nephropathy 57 COPD exacerbations 57 paroxysmal 57 vasospasm 57 pulmonary exacerbations 57 coadministration 57 Stent thrombosis 57 INVEGA ® 57 Angioedema 57 elevated ALT 57 hepatorenal syndrome 57 elevated creatinine 57 benazepril 57 headache dizziness 57 interstitial lung disease 57 nausea vomiting headache 57 MAO inhibitors 57 headache diarrhea nausea 57 hyperreflexia 57 decompensated heart failure 57 Neuroleptic Malignant Syndrome NMS 57 papilledema 57 PAOD 57 thioridazine 57 LVEF 57 post thrombotic syndrome 57 PRADAXA 57 diarrhea abdominal pain 57 trimethoprim sulfamethoxazole 57 UA NSTEMI 57 enalapril 57 necrotizing pancreatitis 57 pyrexia 57 kidney dysfunction 57 angiotensin converting enzyme inhibitors 57 cerebral ischemia 57 NATRECOR R 57 cerebral perfusion 57 EDARBI 57 Beta blockers 57 fatigue shortness 57 ictal 57 treatment emergent adverse 57 lopinavir r arm 57 thiazide 57 rFVIIa 57 somnolence fatigue 57 hypervolemic hyponatremia 57 pulmonary infiltrates 57 antiarrhythmic drug 57 BENICAR HCT 57 lymphopenia 57 dobutamine 57 akinesia 57 receiving XGEVA 57 isoproterenol 57 PaO 2 57 fatal myocardial infarction 57 left ventricular hypertrophy 57 asthenia 57 aspirin heparin 57 symptomatic intracranial 57 MACCE 57 Erythropoietic therapies may 57 antiarrhythmic drugs 57 hypoventilation 57 fractional shortening 57 hepatic impairment 57 tamponade 57 levetiracetam 57 INTEGRILIN R 57 ximelagatran 57 ADHF 57 VT VF 57 dopaminergic therapy 57 COPD exacerbation 57 terazosin 57 severe renal impairment 57 OAB symptoms 57 voriconazole 57 olmesartan 57 zolmitriptan 57 irbesartan 56 diabetic gastroparesis 56 pulmonary capillary wedge 56 isolated systolic hypertension 56 thromboembolic 56 airway obstruction bronchospasm stridor 56 abdominal pain nausea 56 liver dysfunction 56 prolonged QT interval 56 NovoLog ® Mix 56 AST ALT 56 clazosentan 56 acutely decompensated congestive heart 56 ACTOplus met XR 56 hypoglycemic episodes 56 ACTOplus met 56 OADs 56 perioperatively 56 eptifibatide 56 LEXIVA 56 dysfunction LVSD 56 euvolemic 56 nonfatal myocardial infarction MI 56 rash urticaria 56 urge urinary incontinence 56 somnolence sedation 56 ventricular arrhythmia 56 revascularization procedures 56 electrolyte disturbances 56 vomiting PONV 56 plus GP IIb 56 aldosterone antagonist 56 serum phosphate levels 56 pulmonary embolus 56 capillary leak 56 insulin detemir 56 lung edema 56 jugular venous 56 AEs 56 elevated liver enzymes 56 eosinophilia 56 hypovolemic shock 56 QTc interval 56 thrombosis 56 detrusor overactivity 56 rapid heartbeats 56 hyperalgesia 56 generalized edema 56 bosentan 56 mg dose 56 serum phosphate 56 postoperative AF 56 antithrombotics 56 dermatologic reactions 56 Hypersensitivity reactions 56 hemorrhagic complications 56 Torsades de Pointes 56 anaphylactic reactions bronchospasm 56 ulceration 56 PDE5 inhibitors 56 impaired renal 56 cardiac toxicity 56 abdominal pain diarrhea 56 gastrointestinal hemorrhage 56 thrombotic complications 56 paroxysmal AF 56 left ventricular systolic 56 hepatic encephalopathy 56 splenic rupture 56 neutropaenia 56 candidemia 56 platelet inhibition 56 valvular disease 56 Hypoglycemia 56 Lopressor 56 certolizumab 56 abdominal distension 56 valsartan 56 risperidone Risperdal 56 anterior uveitis 56 alpha blockers 56 aripiprazole 56 bolus dose 56 fibrinolysis 56 paresthesia 56 diarrhea dyspepsia 56 lispro 56 tachypnea 56 EFFEXOR XR 56 abdominal distention 56 otamixaban 56 eplerenone 56 nasopharyngitis headache 56 PGTC seizures 56 hyperbilirubinemia 56 BENICAR 56 chlorthalidone 56 cyanosis 56 dyskinesia 56 APTIVUS r 56 ramipril 56 intracranial hypertension 56 antihypertensive agents 56 uncontrolled bleeding 56 Adverse reactions 56 enoxaparin 56 macular edema 56 sulfonylurea 56 aspirin clopidogrel 56 divalproex sodium 56 nonhematologic adverse reactions 56 esophagitis 56 cerebrovascular accident 56 hemolysis 56 RLAI 56 hypoglycaemic 56 alpha interferons 56 bronchodilation 56 somnolence dizziness 56 Ventricular Tachycardia 56 zonisamide SR 56 AVELOX 56 PRADAXA #mg 56 cardiac dysfunction 56 QTc 56 methemoglobinemia 56 uncontrolled hypertension 56 apneic episodes 56 proliferative diabetic retinopathy 56 #mmHg [001] 56 decompensation 56 angina 56 purpura 55 danazol 55 rt PA 55 CYP #A# 55 oral corticosteroids 55 myocardial infarction ventricular fibrillation 55 cough wheezing 55 renal function 55 aortic regurgitation 55 alanine aminotransferase ALT 55 mmHg diastolic 55 tachyarrhythmia 55 Myelosuppression 55 Oral corticosteroids 55 ARIXTRA 55 hepatic function 55 diplopia 55 Serious adverse reactions 55 PREZISTA r arm 55 elevated lipase 55 parecoxib 55 ocular adverse 55 ST elevation myocardial 55 chronic metabolic acidosis 55 glomerular filtration 55 headache nasopharyngitis 55 virologic failure 55 ventricular dysfunction 55 etomidate 55 salmeterol fluticasone 55 headache nausea diarrhea 55 intravitreal injections 55 nocturnal hypoglycaemia 55 dysrhythmias 55 delayed gastric emptying 55 HCTZ 55 moderate renal impairment 55 FRAGMIN R 55 silent ischemia 55 exacerbations 55 headache flushing 55 urticaria hives 55 neurologic dysfunction 55 myoclonic seizures 55 mucositis 55 nitrofurantoin 55 tenecteplase 55 acute renal failure 55 nausea vomiting 55 abdominal pain headache 55 clopidogrel Plavix 55 virologic breakthrough 55 Apidra ® 55 myopathy 55 mm Hg systolic 55 flecainide 55 hepatic insufficiency 55 spinal cord compression 55 quinidine 55 angiotensin converting enzyme ACE 55 metformin accumulation 55 vasodilatation 55 malperfusion 55 events TEAEs 55 arterial occlusion 55 potassium sparing diuretics 55 elevated IOP 55 failure NYHA 55 x ULN 55 muscarinic receptors 55 Primary Hypercholesterolemia 55 chlorpheniramine 55 teriflunomide 55 vein thrombosis 55 detrusor 55 amlodipine 55 quetiapine 55 Nausea vomiting 55 endotracheal intubation 55 typical antipsychotics 55 hepatic 55 severe hypoglycemic 55 beta blocker therapy 55 coronary insufficiency 55 sensory neuropathy 55 acarbose 55 HMG CoA reductase inhibitors 55 RPLS 55 labetalol 55 diabetic kidney 55 bolus injection 55 ICD shocks 55 dizziness constipation 55 cardiovascular hospitalization 55 dyspnoea 55 INVEGA R 55 unfavorable cytogenetics 55 alpha blocker 55 nausea vomiting constipation 55 serotonin syndrome 55 ascites 55 liver transaminases 55 Keppra R 55 pyelonephritis 55 IIIa inhibitors 55 pharyngolaryngeal pain 55 unfractionated heparin UFH 55 Pulmonary hypertension 55 kidney insufficiency 55 muscle rigidity 55 cyclosporine 55 serum phosphorous 55 clomipramine 55 nesiritide 55 dizziness nausea confusion 55 anticholinergic 55 corticosteroids 55 hemodynamics 55 mitral stenosis 55 resynchronization therapy 55 angiotensin receptor blockers 55 oral antidiabetic medication 55 primary generalized tonic 55 arthralgias 55 elevated plasma concentrations 55 ULORIC 55 p = NS 55 agitation hallucinations 55 opioid induced 55 symptomatic VTE 55 Hyponatremia 55 narcotic analgesics 55 deep venous thromboses 55 Mitral regurgitation 55 solifenacin 55 CrCl 55 tranylcypromine 55 Digoxin 55 Cushing syndrome 55 fatigue asthenia 55 plasma creatinine 55 angiotensin receptor blocker ARB 55 upper gastrointestinal bleeding 55 photophobia 55 ventricular tachyarrhythmias 55 Venous thromboembolism 55 captopril 55 retinal vein occlusion 55 intravascular 55 AVAPRO 55 hydrops 55 tamsulosin 55 artery stenosis 55 nephropathy 55 renal artery stenosis 55 pressor response 55 non valvular atrial 55 urticaria 55 paraesthesia 55 streptokinase 55 creatinine clearance 55 headache myalgia 55 omeprazole Prilosec 55 moderate hepatic impairment 55 sweating nausea 55 anemia neutropenia 54 contrast induced nephropathy 54 edema swelling 54 dronedarone 54 infective endocarditis 54 fondaparinux 54 lymphadenopathy 54 DLTs 54 triamcinolone 54 gastrointestinal toxicity 54 xanthine oxidase inhibitor 54 diarrhea headache nausea 54 stenoses 54 optic neuropathy 54 interstitial pneumonia 54 neurologic complications 54 emesis 54 hemorrhagic 54 hypercalciuria 54 serum creatinine levels 54 albuminuria 54 cytopenia 54 diarrhea nausea fatigue 54 ischemia driven 54 conventional antipsychotics 54 pentoxifylline 54 FluCAM arm 54 nasal obstruction 54 secondary hyperparathyroidism 54 vWD 54 cinacalcet 54 euvolemic hyponatremia 54 receiving INTRON 54 reintubation 54 variant angina 54 #mg doses [002] 54 aortic valve stenosis 54 cardiac conduction 54 nadolol 54 Pioglitazone 54 vasoactive 54 AZILECT 54 inotropic agents 54 beta adrenergic 54 ARCOXIA 54 Elitek 54 infarctions 54 infarction STEMI 54 splenomegaly 54 narrow angle glaucoma 54 coronary stenosis 54 NYHA class 54 mild renal insufficiency 54 Paliperidone 54 ventricular tachyarrhythmia 54 opioid analgesia 54 lorazepam Ativan 54 ventricular arrhythmias 54 lightheadedness fainting 54 Lantus ® 54 hematuria 54 Anaphylactic reactions 54 transient ischemic attack 54 Captopril 54 Postoperative complications 54 hematologic toxicities 54 4mg/kg 54 reoperations 54 ULTRAM ER 54 tricuspid regurgitation 54 antiplatelet drugs 54 frequent awakenings 54 gastrointestinal ulcers 54 pulmonary emboli 54 calcineurin inhibitors 54 oral corticosteroid 54 arterial thrombosis 54 discontinuations 54 included exfoliative dermatitis 54 mEq L 54 drowsiness dizziness 54 concomitant AEDs 54 LOVENOX 54 gastrointestinal disturbances 54 allograft rejection 54 Abdominal pain 54 6R BH4 54 Postoperative 54 mucocutaneous reactions 54 reteplase 54 anticholinergic agents 54 mL kg 54 anastomotic leak 54 venous insufficiency 54 extrapyramidal 54 unresectable HCC 54 Thrombotic events 54 fulminant hepatitis 54 hyponatremia 54 ischemic complications 54 binary restenosis 54 AGGRASTAT R 54 somnolence sleepiness 54 tapentadol ER 54 T2DM 54 intraocular pressure IOP 54 refractory ischemia 54 hypercapnia 54 invasive candidiasis 54 intermittent claudication 54 vomiting drowsiness 54 apneas 54 chills fatigue 54 pilocarpine 54 transaminase elevation 54 bronchoconstriction 54 esomeprazole Nexium 54 acute aortic dissection 54 bypass grafting 54 rizatriptan 54 hemorrhagic cerebrovascular events 54 preserved ejection fraction 54 hypertonic saline 54 sinus node dysfunction 54 diarrhea nausea 54 intra arterial 54 thromboembolic disorders 54 invasive aspergillosis 54 antiepileptic drug 54 thoracentesis 54 trandolapril 54 transaminase 54 antiemetics 54 acute coronary syndromes 54 NUCYNTA R 54 levosimendan 54 phenobarbital phenytoin 54 mg BID 54 lightheadedness dizziness 54 dose limiting toxicities 54 alteplase 54 headache muscle aches 54 antihypertensive therapy 54 epoprostenol 54 fibrinolytic 54 pressor 54 Intrathecal 54 ß blockers 54 candesartan cilexetil 54 ischemic 54 heart arrhythmias 54 hypertensive patients 54 adverse reactions ≥ 54 venous thromboembolic events 54 HF hospitalization 54 DAPT 54 glycated hemoglobin levels 54 hyperhydrosis 54 dizziness fatigue 54 symptomatic hyponatremia 54 QTc intervals 54 arrythmias 54 postoperative morbidity 54 macroalbuminuria 54 alfuzosin 54 gastrointestinal bleeds 54 receiving FUSILEV 54 SAEs 54 cardiac insufficiency 54 Peg IFN 54 pulmonary hypertension 54 tacrolimus 54 Monopril 54 idraparinux 54 facial flushing 54 monoamine oxidase inhibitors 54 HAPE 54 infectious sequelae 54 topical steroid 54 intravascular hemolysis 54 intravenous diuretics 54 Diovan HCT 54 erythropoietic 54 Asymptomatic 54 methylprednisolone 54 myocardial infarction 54 severe hepatomegaly 54 neointimal hyperplasia 54 gastric ulcers 54 elevated uric acid 54 primary aldosteronism 54 antithrombotic therapy 54 dizziness headache nausea 54 Fibrates 54 NPH insulin 54 acute coronary syndromes ACS 54 pioglitazone HCl 54 vomiting nausea 54 cardiac ischemia 54 immunosuppressive agents 54 Reversible Posterior Leukoencephalopathy Syndrome 54 dose colchicine 54 ventricular repolarization 54 bacteriuria 54 Oral mucositis 54 ranitidine Zantac 54 gastrointestinal motility 54 acute hepatic 54 AVANDIA 54 haematological toxicity 54 Ranolazine 54 prednisone prednisolone 53 intraocular pressure 53 mCi kg 53 coronary revascularization 53 intravesical therapy 53 extrapyramidal symptoms EPS 53 purpura ITP 53 macrovascular 53 Exacerbation 53 NSAID therapy 53 serotonergic drugs 53 antiarrhythmic 53 H2 receptor antagonists 53 ischemia 53 mm Hg 53 colorectal liver metastases 53 CK MB 53 intravenous bolus 53 candesartan 53 thrombolytic therapy 53 DOXIL 53 serum calcium levels 53 methimazole 53 reperfusion injury 53 pulmonary arterial 53 intravenous vancomycin 53 orthostatic 53 hepatic enzymes 53 mycophenolate mofetil 53 vitreous hemorrhage 53 toxicities 53 inhaled glucocorticoids 53 bowel perforation 53 Candesartan 53 subcutaneous insulin 53 BUPHENYL 53 conjunctival hyperemia 53 polyuria 53 H2 blockers 53 HPA axis suppression 53 tyramine 53 bisoprolol 53 tricyclic antidepressants 53 creatine kinase CK 53 adrenocorticotropic hormone 53 fatigue nausea 53 clinically meaningful reductions 53 nimodipine 53 acidosis 53 ranolazine 53 asthma exacerbations 53 serum urate 53 budesonide formoterol 53 superficial femoral 53 pooled comparator 53 arthralgia 53 diarrhea vomiting nausea 53 phenelzine 53 hematologic adverse 53 GnRH agonist 53 REYATAZ ritonavir 53 irregular quivering 53 antiplatelet agent 53 atelectasis 53 headache nausea dizziness 53 selective A1 adenosine 53 urge incontinence 53 CK # administered 53 receptor blockers ARBs 53 fluvastatin 53 levodopa therapy 53 ischemic cardiomyopathy 53 DETROL LA 53 CsA 53 aliskiren 53 oral antidiabetes 53 losartan Cozaar 53 hives itching 53 systolic 53 premedication 53 biliary tract disease 53 antihypertensives 53 Severe hypoglycemia 53 abacavir lamivudine 53 gastrointestinal symptoms 53 NSAID induced 53 thrombocytosis 53 pleural effusions 53 esomeprazole 53 MAO inhibitor 53 unstable angina 53 angiotensin II receptor blockers 53 immune thrombocytopenic purpura 53 HbA 1c levels 53 diastolic heart 53 amenorrhoea 53 P = .# 53 analgesic medications 53 suppurative 53 sulphonylurea 53 pharmacokinetic interactions 53 metformin HCl 53 paroxysmal atrial fibrillation 53 desmopressin 53 Intussusception 53 macrolide antibiotic 53 infarction 53 diastolic dysfunction 53 chlorambucil 53 azacitidine 53 glycoprotein IIb IIIa inhibitors 53 severe hypotension 53 anemia hemoglobin 53 cholecystitis 53 #.#/#.# mmHg [001] 53 gastrointestinal GI 53 Dasatinib 53 ribavirin therapy 53 rosuvastatin #mg 53 tiotropium 53 Fluid retention 53 idiopathic 53 neurologic deficits 53 hemorrhagic cystitis 53 daytime drowsiness 53 intravenous heparin 53 thrombolytic agents 53 recurrent venous thromboembolism 53 Concomitant 53 composite endpoint 53 acute coronary syndrome 53 erosive gastritis 53 status epilepticus 53 ACE inhibitor 53 acute myocardial infarction 53 rebleeding 53 idiopathic thrombocytopenic purpura ITP 53 vasopressor 53 renal scarring 53 ischaemia 53 mu opioid receptor antagonist