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(Click for frequent words.) 79 induces apoptosis 72 selective inhibition 72 potently inhibited 72 IL 1β 72 phosphorylate 72 mitogenic 72 selectively inhibit 71 FLT3 71 antiproliferative activity 71 potent inhibitor 71 inhibit tumor 71 VEGF receptor 71 cathepsins 71 ERK1 2 71 mitogen activated protein kinase 71 proapoptotic 70 E#F# 70 somatostatin 70 upregulate 70 c MET 70 cyclin dependent kinase inhibitor 70 pro apoptotic 70 IGF 1R 70 potently inhibit 70 c MYC 70 HIF 1alpha 70 IL #p# 70 SIRT2 70 Clusterin 70 Aurora kinase 70 pRb 70 apoptotic pathway 70 catenin 70 Overexpression 70 partial agonist 70 prostaglandin E2 PGE2 70 IL 1ß 70 androgen receptor AR 70 JAK2 enzyme 69 neurite outgrowth 69 tyrosine phosphorylation 69 phosphorylates 69 MAPK pathway 69 HCV protease 69 TNF α 69 poly ADP ribose polymerase 69 NF kappaB activation 69 PDGFR 69 ERK signaling 69 pro angiogenic 69 potent inhibitors 69 induced apoptosis 69 p# activation 69 BCL2 69 apoptosis 69 upregulation 69 triggers apoptosis 69 CDK inhibitor 69 histone deacetylases 69 CTLA 4 69 potent inhibition 69 FasL 69 selective inhibitor 69 IL 1beta 69 mediated apoptosis 69 IFN γ 69 glucocorticoid receptor 69 aberrantly activated 69 TRAIL induced apoptosis 69 interferon IFN 69 serine protease 68 Factor Receptor 68 apoptotic 68 JAK#/JAK# 68 NKG2D 68 PI3 kinase 68 MEK1 68 microglial activation 68 EGFr 68 proto oncogene 68 oncoprotein 68 BCR ABL 68 β catenin 68 V#F mutation 68 antiapoptotic 68 inhibitory effects 68 iNOS 68 XL# inhibits 68 inhibiting tumor 68 cyclin dependent kinase 68 tubulin polymerization 68 Src kinase 68 inducible nitric oxide synthase 68 apoptotic cell 68 tryptase 68 PDGF receptor 68 sphingosine 1 68 acetylcholinesterase 68 tumorigenicity 68 serine threonine 68 HIF 1a 68 TNFa 68 HDAC 68 splice variants 68 adipogenic 68 upregulates 68 Hedgehog pathway 68 γ secretase 68 HepG2 cells 68 ligand TRAIL 68 mediated inhibition 68 FGFR 68 selective inhibitors 68 anti apoptotic 68 cytolytic 68 inhibits tumor 68 cytoprotective 68 Eg5 68 NS#/#A protease 68 PTP 1B 68 MAP kinase 68 cytotoxicity 68 VEGFR2 67 tyrosine kinase receptor 67 muscarinic 67 Hedgehog signaling 67 colon carcinoma 67 potent inducer 67 phosphate S1P 67 hypoxia inducible factor 67 downregulated 67 TGF b 67 immune stimulatory 67 orally administered inhibitor 67 selectively inhibits 67 Factor VEGF 67 transgene expression 67 OXi# 67 ERK pathway 67 4E BP1 67 Upregulation 67 apoptosis programmed cell 67 LRP6 67 MDM2 67 ENMD # 67 CD#b 67 PKC isoforms 67 Fas ligand 67 p# mitogen activated 67 dephosphorylation 67 FKBP# 67 deacetylation 67 antitumor 67 protein kinase C 67 autophagic 67 p# MAPK 67 phosphatidylinositol 3 67 TNFalpha 67 xenograft models 67 NFkB 67 isoenzyme 67 EGF receptor 67 LPA1 receptor 67 glycosylated 67 JAK2 67 Flt3 67 inhibit viral replication 67 lysosomal 67 selectively inhibited 67 EP1 receptor 67 Hsp# inhibitors 67 #HT#A 67 GGTase 67 CCR2 67 potently inhibits 67 cytokine signaling 67 IFN gamma 67 oncoproteins 67 oncogenic 67 cisplatin resistant 67 TNFα 67 PKM2 67 MMP2 67 vWF 67 cyclin E 67 constitutively activated 67 upregulated 67 effector function 67 inverse agonist 67 CDK4 67 COX2 67 dysregulated 67 IAP inhibitor 67 PI3K/mTOR 67 lytic 67 ectopic expression 67 Akt signaling 67 activate p# 67 receptor tyrosine kinase 67 kinase inhibition 67 activin 67 Smad3 67 hypermethylation 67 antiangiogenic 67 pro inflammatory cytokine 67 tumor vasculature 67 triphosphate 66 small molecule inhibitors 66 thioredoxin 66 Notch1 66 ERK phosphorylation 66 aurora kinase 66 histone deacetylase 66 EGFR HER2 66 MUC1 66 selective modulator 66 thymidylate synthase TS 66 APOPTONE 66 glycogen synthase kinase 66 tyrosine kinases 66 anticancer activity 66 overactivation 66 inducing apoptosis 66 chemokine receptor 66 eNOS 66 HDACi 66 NKX#.# 66 glioma cells 66 immunostimulatory 66 immunoregulatory 66 anti mitotic 66 neuronal dysfunction 66 heparanase 66 anti CD3 66 act synergistically 66 CEACAM1 66 signaling cascades 66 constitutively active 66 GSK3B 66 mTOR signaling 66 pDCs 66 undergo apoptosis 66 antiangiogenesis 66 PI3K Akt 66 cyclins 66 HBx 66 mRNA expression 66 ErbB2 66 IL #E 66 downregulates 66 TRAIL R2 66 novel anticancer 66 mouse xenograft models 66 HDAC6 66 cyclooxygenase 66 MetAP2 66 Syk 66 selective antagonist 66 miR #a [002] 66 PPARg 66 orally bioavailable 66 TTR gene 66 activating mutations 66 Protein Kinase C 66 neurotrophic 66 TAp# 66 Hedgehog signaling pathway 66 thrombin receptor 66 B Raf 66 anti inflammatory cytokine 66 tumorigenic 66 ENaC 66 FGFR1 66 microtubule dynamics 66 PPARγ 66 nitric oxide synthase 66 immunomodulating 66 radiosensitivity 66 axonal degeneration 66 SCD1 66 FUS1 66 Phosphorylation 66 adhesion molecule 66 ERK activation 66 Cathepsin B 66 acyl CoA 66 MDR1 66 thyroid hormone receptor 66 Wnt signaling pathway 66 cyclooxygenase COX 66 FGFR4 66 monocytes macrophages 66 cyclin dependent kinases CDKs 66 ErbB 66 leukemic cell 66 uPA 66 glycolipids 66 anti proliferative 66 Preclinical studies suggest 66 myeloma cells 66 tyrosine kinase 66 small molecule inhibitor 66 caveolin 66 antiproliferative effects 66 IFNg 66 glutamate receptors 66 effector cells 66 inhibitory effect 66 hedgehog pathway 65 cytotoxic 65 protein tyrosine phosphatase 1B 65 ERBB2 65 PTHrP 65 SGLT2 65 AT1R 65 CCR9 65 matrix metalloproteinases 65 overexpressing 65 basophils 65 K ras mutations 65 reversible inhibitor 65 downregulation 65 apoptosis inducing 65 EGFR protein 65 serotonin reuptake 65 MAPK 65 VEGF inhibitors 65 JAK1 65 oncogenic transformation 65 excitotoxic 65 CYT# potent vascular disrupting 65 5 hydroxytryptamine 65 Foxp3 65 apoptosis induced 65 immunomodulatory 65 caspase activation 65 65 selective kinase inhibitor 65 DHFR 65 irreversible inhibitor 65 antisense inhibition 65 5 HT2A serotonin 65 adenoviral 65 immunomodulatory effects 65 Immunohistochemical analysis 65 peroxisome proliferator activated 65 Epidermal Growth Factor Receptor 65 N methyl 65 chemokine receptors 65 CTGF 65 Akt activation 65 IGF1R 65 pathophysiological effects 65 casein kinase 65 uPAR 65 Symadex 65 N Myc 65 downstream effectors 65 receptor tyrosine kinase inhibitor 65 FGFR2 65 PKC inhibitor 65 Raf MEK ERK 65 clusterin 65 PKC delta 65 MEK ERK 65 WT1 65 PPARgamma 65 prolyl 65 tumorigenesis 65 receptor subtype 65 eIF4E 65 adrenoceptor 65 T#I mutant 65 miR #a [001] 65 autocrine 65 GABAergic 65 RAS RAF MEK 65 anti fibrotic 65 Akt 65 M1 muscarinic 65 inhibits protein synthesis 65 cyclic AMP cAMP 65 vimentin 65 transduced 65 dihydrofolate reductase 65 Src 65 bleomycin 65 NF κB 65 protein tyrosine kinase 65 ERK5 65 potent antiproliferative 65 antiangiogenic activity 65 myeloid 65 Nampt 65 LPS induced 65 eicosanoid 65 transcriptional activation 65 sphingolipid 65 PKCi 65 lipoxygenase 65 phosphatases 65 transcriptional repressor 65 HIF 1α 65 hydrolase 65 inflammatory cytokine 65 prostanoid 65 Skp2 65 interleukins 65 highly selective inhibitor 65 B lymphocyte stimulator 65 KRAS oncogene 65 novel VDA molecule 65 PI3K/Akt pathway 65 HLA DR 65 effector functions 65 inhibit angiogenesis 65 VIPR2 65 humanized monoclonal antibodies 65 metalloprotease 65 targeting CD# 65 receptor inhibitor 65 downregulate 65 CYP #A# 65 PI3K 65 Cyclin E 65 lymphotoxin 65 receptor CXCR4 65 immunomodulation 65 transmembrane receptor 65 HDACs 65 adenylate cyclase 65 tyrosine kinase inhibitor 65 Rap1 65 AhR 65 virulence genes 65 soluble tumor necrosis 65 phosphorylated 65 deacetylase inhibitors 65 Hypoxia Inducible Factor 65 caspases 65 miR #b [001] 65 TGF beta1 65 tumor suppressor protein 65 cytochrome P 65 transactivation 65 antitumor efficacy 65 NFκB 65 pDC 65 protein encoded 65 glucagon receptor 65 inhibits apoptosis 65 TXNIP 65 CD# receptor 65 Dysregulation 65 overexpression 65 triggers apoptosis programmed 65 cytochrome P# 65 polyamine 65 hepatoma 65 erlotinib Tarceva ® 65 alpha subunit 65 mGluR2 NAM 65 receptor antagonists 65 CYP#A# CYP#D# 65 HER1 65 investigational humanized monoclonal antibody 65 cathepsin B 65 PIK3CA 65 haematopoietic 65 FOXO3a 65 VEGFR 65 PGE2 65 Hsp# chaperone system 65 GRP# 65 Bcl XL 65 NK1R 65 acetylcholine receptor 65 cytokine 64 telomerase reverse transcriptase 64 serine threonine kinase 64 KIT mutations 64 small molecule tyrosine 64 homodimers 64 regulated kinase 64 c myc 64 sPLA2 64 HER3 64 related apoptosis inducing 64 syngeneic 64 mTOR 64 receptor PPAR 64 heme oxygenase 64 TGF ß 64 anti apoptotic proteins 64 Vidofludimus 64 LTB4 64 receptor subtypes 64 T#I [002] 64 antibody mediated 64 HDAC inhibition 64 S#A# [002] 64 sortilin 64 estrogen receptor beta 64 mGluR 64 lymphoid cells 64 Enzastaurin 64 oxidase 64 PTPN# 64 serotonin receptor 64 transgenic mouse model 64 fibrotic disease 64 Tumor Necrosis Factor 64 PLK1 64 cytochrome c 64 intracellular accumulation 64 antiproliferative 64 ErbB3 64 alpha#beta# integrin 64 isoenzymes 64 TrkA 64 ERb 64 leukocyte adhesion 64 effector memory 64 inhibited tumor 64 IGF IR 64 myeloproliferative disorders 64 potent anti angiogenic 64 receptor activation 64 HepG2 64 mineralocorticoid receptor 64 TLR4 64 Androgen receptor 64 superoxide dismutase 64 Aß 64 SERMs 64 DFMO 64 Gleevec resistant 64 retinoic acid receptor 64 EphA2 64 CLL cells 64 Mcl 1 64 #ME# 64 cyclooxygenase 2 64 IL #R 64 CYP# [002] 64 pyruvate kinase 64 phosphatidylinositol 64 Fc fusion protein 64 VE cadherin 64 p# alpha [001] 64 prostaglandin synthesis 64 fatty acid synthase 64 upregulating 64 elastase 64 LNCaP cells 64 hypereosinophilic syndrome 64 muscarinic receptors 64 GRK2 64 E3 ligase 64 promoter methylation 64 UsiRNAs 64 selectively binds 64 suppressor cells 64 apoptosis proteins 64 cytotoxin 64 mutant p# 64 interleukin 1ß 64 Janus kinase 64 pan HDAC inhibitor 64 nucleoside analog 64 secretase 64 IgG1 antibody 64 VEGF pathway 64 PDE#A 64 humanized monoclonal antibody 64 inhibitory receptor 64 Cyclin D1 64 enzyme inhibitor 64 Oncogenic 64 synthetase 64 5alpha reductase 64 mTOR inhibitors 64 neuropilin 64 NADPH oxidase 64 interleukin IL -# 64 selectively inhibiting 64 regulates gene expression 64 histone deacetylase inhibitor 64 MDSCs 64 ubiquitinated 64 frataxin 64 Cytotoxic T 64 Vascular Endothelial Growth 64 HDAC2 64 RNA antagonist 64 mesenchymal cell 64 Preclinical studies 64 VEGF receptors 64 neuroinflammatory 64 vascular disrupting agents 64 Tie2 64 EGFRvIII 64 caveolin 1 64 RAF kinase 64 cell adhesion molecules 64 DNMT1 64 specific lectin receptors 64 inhibit replication 64 renal fibrosis 64 extracellular signal 64 Pim kinases 64 transferase 64 induce apoptosis programmed 64 cytokines IL 64 estrogen receptor alpha 64 costimulatory 64 nicotinic receptor 64 DNA methyltransferases 64 CD#L 64 TMEM#B 64 TNFR 64 EGFR signaling 64 PP2A 64 derived neurotrophic factor 64 Hh pathway 64 5 HT2A receptor 64 phagocytosis 64 CD#c 64 1α 64 Abl 64 NF kappaB 64 #beta HSD1 64 paxillin 64 p# deficient 64 CDK5 64 downregulating 64 lysophosphatidic acid 64 anti amnesic 64 endoplasmic reticulum stress 64 cytosolic 64 intracellular signaling 64 uricase 64 paracrine 64 CagA 64 Cdc7 64 Tumor necrosis factor 64 5 HT2B receptor 64 delta isoform 64 isotypes 64 metabotropic glutamate receptors 64 ERa 64 synaptogenesis 64 PPAR alpha 64 eotaxin 64 alkylating agent 64 c Myc 64 inducible 64 imatinib Gleevec 64 kinase pathway 64 demonstrated antitumor activity 64 histone acetylation 64 PTP1B 64 LKB1 64 factor HGF 64 NFkappaB 64 monocyte chemotactic protein 64 FAAH 64 NF kB pathway 64 AMACR 64 TGF β 64 inhibitory activity 64 vascular endothelial cells 64 HDAC enzymes 64 gastrin 64 p#Kip# 64 ganglioside 64 Lyn kinase 64 leukemia AML 64 Vpr 64 EZH2 64 endothelial nitric oxide synthase 64 topoisomerase 64 proteolysis 64 erythropoietic 64 neuronal cell 64 transcriptional regulation 64 HDAC inhibitor 64 selective agonist 64 activated lymphocytes 64 geldanamycin 64 aberrant activation 63 mesothelin 63 granzyme B 63 integrin receptors 63 thrombopoietin 63 PLA2 63 novel peptide 63 Tissue Factor 63 sodium glucose cotransporter 63 TrkB 63 myelofibrosis polycythemia vera 63 calcineurin 63 siRNA mediated 63 5 lipoxygenase 63 plasmacytoid dendritic cells 63 ubiquitination 63 gene inactivation 63 RKIP 63 peroxidase 63 PI3K pathway 63 cyclin dependent kinases 63 histone deacetylases HDACs 63 dimerization 63 constitutively 63 Androgen Receptor 63 Survivin 63 lung fibrosis 63 angiogenesis inhibitor 63 Sp1 63 antitumor effects 63 taxane resistant 63 HIF PH 63 Th2 cytokines 63 FGFs 63 pharmacokinetic interactions 63 GSTP1 63 immunotoxin 63 Hsp# chaperone 63 pancreatic endocrine 63 TGF alpha 63 TNF receptor 63 potent cytotoxic 63 ABCA1 63 neuronal apoptosis 63 FGFR3 63 Fibroblast Growth Factor Receptor 63 erythropoiesis 63 cytokine receptor 63 STAT3 signaling 63 TGF ß1 63 antisense inhibitors 63 MAP kinases 63 potent antitumor activity 63 heterodimers 63 NO synthase 63 HMG CoA reductase 63 endogenous ligands 63 STAT1 63 xenograft tumors 63 neuronal nitric oxide synthase 63 HSP# inhibitor 63 E selectin 63 5 HT6 receptor 63 kinase 63 coagulation cascade 63 ACh 63 dependent cellular cytotoxicity 63 small molecule activator 63 Activating mutations 63 cytopathic 63 hypermethylated 63 imatinib Gleevec ® 63 tumor suppressive 63 SIRT3 63 β cells 63 Induces Apoptosis 63 GPR# [002] 63 lysyl oxidase 63 alpha folate receptor 63 CB1 receptor 63 cytokine secretion 63 murine 63 immune modulator 63 procaspase 3 63 Akt pathway 63 neuroblastoma cells 63 metastatic malignant 63 survivin 63 5 HT1A 63 GLI1 63 mTOR mammalian target 63 histone deacetylation 63 epithelial tumors 63 anti angiogenic 63 plasmin 63 T#M 63 NS4A 63 regulated kinase ERK 63 fibrogenesis 63 intestinal epithelium 63 ErbB4 63 reductase 63 transient receptor 63 mTOR pathway 63 p#INK#a 63 Ras MAPK pathway 63 lymphangiogenesis 63 kinase inhibitor 63 pharmacodynamic biomarkers 63 CD# monoclonal antibody 63 HbF 63 SOD1 63 beta amyloid peptide 63 Treg cell 63 microtubule destabilizing agent 63 Plk1 63 peripheral blood mononuclear 63 HDAC inhibitors 63 c KIT 63 tau phosphorylation 63 ABCB1 63 HER2/neu 63 CYP#B# 63 antisense inhibitor 63 HER2 receptor 63 nucleolin 63 Bcl 2 63 glucose transporter 63 GRNCM1 63 kallikrein 63 cell adhesion molecule 63 aldehyde dehydrogenase 63 cardiac valvulopathy 63 immune modulators 63 cAMP 63 CRAC channel 63 monocyte chemoattractant protein 63 constitutively expressed 63 guanylate cyclase 63 phosphoprotein 63 proteinase 63 ERalpha 63 transfected cells 63 immuno modulatory 63 CYP3A 63 IGFBP2 63 antitumor activity 63 accumulate preferentially 63 RRM1 63 bcl 2 63 Nedd4 63 metalloproteinase 63 STAT3 63 inflammatory cytokines 63 HCV replication 63 eIF 4E 63 Abeta# 63 mineralocorticoid 63 mitotic progression 63 nicotinic acetylcholine receptor 63 beta catenin 63 serine proteases 63 Angiolix 63 cystic fibrosis transmembrane conductance 63 Kv#.# 63 myeloproliferative 63 CDKs 63 ras gene 63 IL8 63 secreted protein 63 osteogenic 63 factor PlGF 63 Î ² 63 β amyloid 63 colorectal carcinoma 63 PDE1 63 PDE4 63 insulin sensitizing 63 HER2 neu 63 RANK Ligand 63 P#X# receptor 63 receptor mediated endocytosis 63 HSF1 63 LRP5 63 Selective Inhibitor 63 Th1 type 63 beta adrenergic 63 thyrotropin 63 p# subunit 63 dopaminergic 63 protein CETP 63 EGFR pathway 63 phosphoinositide 3 63 activated microglia 63 matrix metalloproteinases MMPs 63 tyrosine kinase inhibitors 63 HER2 receptors 63 CCR3 63 #ß 63 intracellular protein 63 enkephalin 63 receptor antagonist 63 S6K 63 FOXP3 63 FK# 63 MEK inhibitor 63 UCP2 63 chemokine 63 receptor agonists 63 CCR1 63 Sertoli cell 63 Gleevec inhibits 63 HMG CoA reductase inhibitors 63 phospho 63 binding affinity 63 proinflammatory cytokines 63 targets Galectin receptors 63 inhibiting COX 63 EGFR mutant 63 PC3 cells 63 Vidaza ® 63 histone deacetylase HDAC 63 Aβ 63 gastric carcinoma 63 intratumoral injection 63 integrin receptor 63 CYC# 63 melanocyte 63 cytoplasmic domain 63 tumor suppressor proteins 63 Fibroblast 63 AEG# 63 potent stimulator 63 MEK inhibitors 63 inflammatory mediators 63 5 HT4 receptor 63 anti leukemic 63 HuLuc# 63 immunomodulator 63 annexin 63 vitro studies 63 cytostatic 63 pleiotropic 63 GNAQ 63 myeloproliferative diseases 63 Kinase Inhibitor 62 TFPI 62 vascular disrupting agent 62 NFAT 62 CD# expressing 62 oligomerization 62 Notch signaling 62 humanized monoclonal 62 MCF7 62 molecularly targeted 62 transmembrane protein 62 oral prodrug 62 TGF beta pathway 62 cMET 62 tumor xenograft models 62 Transgenic Mice 62 B7 H1 62 ß catenin 62 kinase enzymes 62 Bcl xL 62 hepatic lipase 62 cells transfected 62 protein secreted 62 Epratuzumab 62 isoforms 62 myeloid cells 62 Her-2/neu 62 nanomolar range 62 mimetics 62 Smoothened 62 H#K# [002] 62 neurokinin 62 signaling pathway 62 kinases 62 Smad7 62 receptors PPARs 62 replicon 62 mitogen activated protein kinases 62 Pegylated 62 cytokine interleukin 62 fatty acid oxidation 62 induces apoptosis programmed 62 MTHFR 62 clioquinol 62 humanized antibody 62 Hsp# [001] 62 tumor antigen 62 MGd 62 NMDAR 62 dose dependently 62 agent VDA 62 Kupffer cells 62 gamma secretase inhibitor 62 mitotic kinesins 62 interleukin 1β 62 A3 adenosine receptor 62 TRAIL receptors 62 adenosine receptor 62 dystroglycan 62 Treg cells 62 IgG1 62 cis retinoic acid 62 HER pathway 62 hTERT