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(Click for frequent words.) 72 proteolytic cleavage 72 serine protease 71 F actin 71 phosphoprotein 71 vesicle fusion 70 conformational changes 70 DNA methyltransferases 70 intramolecular 70 coiled coil 69 serine threonine kinase 69 VE cadherin 69 PDZ domain 69 adipogenic 69 antibody antigen 69 Annexin V 69 transferrin receptor 69 intracellular signaling 69 heterochromatic 69 transmembrane protein 69 tyrosine phosphorylation 68 VEGF receptor 68 6S RNA 68 cathepsin B 68 vacuolar 68 centromeric 68 chromatin structure 68 CCL# 68 #S subunit 68 cytoskeletal structure 68 transmembrane domains 68 intercellular signaling 68 annexin 68 membrane receptors 68 CaM 68 miRNA expression 68 osteoblastic 68 transmembrane domain 68 ERK1 2 68 dimeric 68 coexpression 68 pharmacophore 68 antigen binding 68 biogenesis 68 chromatin modification 68 occludin 68 tropomyosin 68 Vps# 68 Fig. 1d 67 perivascular 67 glycan 67 subcellular localization 67 antiapoptotic 67 pro angiogenic 67 C3 convertase 67 centromeres 67 ligand induced 67 rRNA 67 MAPK pathway 67 nucleases 67 nuclease 67 dimerization 67 aggrecan 67 transcriptional activation 67 pRb 67 fibrillar 67 vimentin 67 pyrimidine 67 telomeric 67 immunoregulatory 67 Anticalins ® 67 nucleotide binding 67 5 hmC 67 proline rich 67 endonuclease 67 protein phosphorylation 67 non coding RNA 67 SIRT2 67 transmembrane 67 trimeric 67 cell nuclei 67 titin 67 cytoplasmic domain 67 ribonucleoprotein 67 FGFR3 67 alpha subunit 67 histone acetylation 67 γ secretase 67 glycosyltransferase 67 potent inhibitors 67 oligomer 67 catalytically active 67 proteomic analysis 66 basolateral 66 ultrastructure 66 transcriptional regulation 66 proteoglycan 66 MMP9 66 kinesin motor 66 DNA demethylation 66 phosphorylates 66 presynaptic 66 Nedd4 66 oligomerization 66 proteolytic 66 tetramer 66 p#/CBP 66 colocalization 66 PKC delta 66 HCV replication 66 M1 muscarinic 66 substrate specificity 66 biotransformation 66 Western blotting 66 GLUT4 66 Fc receptor 66 BMAL1 66 EGF receptor 66 Upregulation 66 IL #p# 66 homodimers 66 CD1d 66 RNA polymerases 66 untranslated regions 66 ligase 66 lymphoid cells 66 cytosolic 66 H#K#me# 66 posttranslational modification 66 EF Tu 66 cyclic AMP cAMP 66 vascular endothelial cells 66 methyltransferase 66 guanosine 66 amino acid substitutions 66 neuroepithelial cells 66 ncRNA 66 Fas ligand 66 beta subunit 66 ERK pathway 66 allosteric 66 nucleolar 66 SH2 domain 66 ENaC 66 bisulfite sequencing 66 osteogenic 66 posttranslational modifications 66 cis regulatory 66 peroxidation 66 Fig. 1D 66 clathrin 66 CD# ligand 66 adherens junctions 66 tumorigenicity 66 COOH terminal 66 bispecific 66 Rb#/p# 66 keratinocyte 66 osteoclast 66 carboxyl terminal 66 receptor ligand 66 exocytosis 66 tRNA synthetase 66 Cathepsin B 66 heterodimers 66 efflux pump 66 mitogen activated protein kinase 66 virulence genes 66 CTCF 65 heterodimer 65 splice variant 65 HEK# cells 65 secretory pathway 65 phosphorylated proteins 65 splice variants 65 transferase 65 FGFs 65 USP# 65 EGFR receptor 65 JAK STAT 65 ribonucleic acid RNA 65 DNA ligase 65 neurite outgrowth 65 chromatin remodeling complex 65 gamma H2AX 65 receptor tyrosine kinase 65 sequence homology 65 polyamine 65 TGF beta1 65 noncoding 65 vascular endothelial 65 endoglin 65 KLF4 65 intergenic regions 65 mediated inhibition 65 ERK1 65 isotype 65 subcellular 65 CCR9 65 monomeric 65 c Src 65 ribosomal DNA 65 glycan structures 65 TNFR 65 GAGs 65 plasminogen 65 peptidic 65 FGF signaling 65 P selectin 65 retinoic acid receptor 65 ribonuclease 65 actin polymerization 65 PIP3 65 β 65 hERG 65 binding affinity 65 chromatin immunoprecipitation ChIP 65 integrin receptors 65 fig. S1 65 ryanodine receptor 65 evolutionarily conserved 65 immunostaining 65 directed mutagenesis 65 mRNA translation 65 membrane protein 65 eIF4E 65 eIF2 65 E1A 65 epithelial cell 65 morphogen 65 hematopoietic progenitor cells 65 ribosomal 65 bilayers 65 GABAA receptor 65 actin binding 65 disulfide bond 65 palytoxin 65 ER alpha 65 kinase substrate 65 PIP2 65 polynucleotide 65 site directed mutagenesis 65 Rap1 65 granzyme B 65 transporter proteins 65 mitochondrial respiration 65 RecA 65 endocytic 65 dopamine transporter 65 membrane fusion 65 microglial 65 voltage gated 65 conformational 65 β catenin 65 cytoplasmic 65 tenascin C 65 stromal 65 proteinase 65 cell lysis 65 glomerular 65 HER2 HER3 65 extracellular matrix proteins 65 intercellular communication 65 mononuclear 65 synthases 65 peptidoglycan 65 P cadherin 65 microRNA molecule 65 TLE3 65 RNA sequences 65 postsynaptic 65 siRNA duplexes 65 CpG 65 c myb 65 c MYC 65 adhesion molecule 65 transduction 65 glycosylated 65 NR2B subunit 65 amino acid residues 65 Amino acid 65 axon guidance 65 kinase domain 64 RRM1 64 Notch signaling pathway 64 protein tyrosine phosphatase 64 hexamer 64 deacetylation 64 fast skeletal troponin 64 muscarinic 64 ectodomain 64 receptor molecule 64 Immunohistochemical analysis 64 fibronectin 64 TGF ß 64 Protein Kinase C 64 polyadenylation 64 integrins 64 lysate 64 fluorogenic 64 microsomal 64 5 hydroxymethylcytosine 64 apical membrane 64 bacterial enzyme 64 MALAT1 64 myocyte 64 uncharacterized genes 64 matrix metalloproteinases 64 osteoconductive 64 cytotoxicity assays 64 RT qPCR 64 RAS RAF MEK 64 myofibroblasts 64 TGF β 64 TFIIH 64 ribonucleotide 64 ERK signaling 64 DNA gyrase 64 glycolytic 64 meiotic recombination 64 cytochrome P# 64 ChIP Seq 64 caveolae 64 experimentally validated 64 somatostatin receptors 64 tyrosine 64 ribosomal protein 64 covalently bound 64 Wnts 64 acyltransferase 64 extracellular matrix ECM 64 cytokine receptor 64 transmembrane proteins 64 carboxy terminal 64 thymidine 64 #ß 64 pyrophosphate 64 HDACi 64 trans splicing 64 Fig. 2B 64 nAChRs 64 peptoid 64 NF kappaB activation 64 pre mRNA splicing 64 coactivators 64 therapeutically relevant 64 gene expression microarrays 64 BMP signaling 64 isoenzyme 64 tenascin 64 apoE 64 previously uncharacterized 64 ankyrin repeat 64 dephosphorylation 64 lytic 64 integrin expression 64 FGFR1 64 assay detects 64 p# subunit 64 Arp2 3 64 PHD2 64 Runx2 64 protein conformation 64 transgene expression 64 cathepsins 64 immunodominant 64 HER1 64 HOTAIR 64 macromolecular 64 CPEB 64 biotinylated 64 PKC isoforms 64 focal adhesions 64 excision repair 64 streptavidin 64 immunoblotting 64 mRNA expression 64 ligand receptor 64 P2X 64 DNA intercalator 64 transgenic mice expressing 64 soluble proteins 64 p# MAPK 64 astrocytic 64 effector function 64 Aâ 64 anterior pituitary 64 amino terminal 64 β1 64 T#M 64 endosomal 64 spectrin 64 adduct 64 heterologous expression 64 AMACR 64 phagocytosis 64 galectin 64 catenin 64 oligomeric 64 PAK1 64 triphosphate 64 steroidogenic 64 enzymatic reactions 64 primary cilia 64 magnetosomes 64 receptor binding 64 inflammatory cytokine 64 PI3K AKT 64 FSH receptor 64 gene rearrangements 64 VSV G 64 Htt 64 metabolomic profiles 64 cadherin 64 effector protein 64 acetylcholine receptor 64 ENMD # 64 peroxisomes 64 Fig. 3A 64 depolarizing 64 S nitrosylation 64 antiparallel 64 ß1 64 noncoding RNA 64 cytoprotective 64 drug metabolizing enzymes 64 molecular biomarkers 64 histone modifications 64 protein tyrosine kinase 64 autophagic 64 signal transduction 64 cytoskeletal proteins 64 bone morphogenetic proteins 64 constitutively active 64 HER3 64 cationic lipid 64 uracil 64 paxillin 64 homology modeling 64 LRP6 63 LSD1 63 protein biosynthesis 63 serine threonine 63 mitotic spindles 63 DNMT1 63 TAp# 63 antiproliferative effects 63 NF κB 63 thymidylate synthase TS 63 IKKß 63 ligand binding domain 63 fission yeast 63 zebrafish larvae 63 homodimer 63 metalloprotease 63 acinar 63 Fc receptors 63 Smad4 63 mRNA sequences 63 PDZ domains 63 ubiquitin ligase 63 gp# [002] 63 E3 ubiquitin ligase 63 cAMP dependent 63 BMP4 63 immunoglobulin genes 63 neuromuscular junction 63 Ca2 + 63 S#A# [002] 63 ssDNA 63 antiproliferative activity 63 uPAR 63 isoenzymes 63 Supplementary Fig 63 post translational modifications 63 E#F# 63 peroxidase 63 nucleolin 63 anti CD3 63 glycolipids 63 STAT1 63 epithelia 63 osteoblast 63 4E BP1 63 supramolecular 63 hapten 63 KIAA# 63 DNase 63 Microarray analysis 63 intracellular proteins 63 caveolin 1 63 flow cytometric 63 structural rearrangements 63 aT cell 63 junctional 63 glucocorticoid receptor 63 mitochondrial gene 63 HER2 receptor 63 methylated DNA 63 bispecific antibody 63 Oncogenic 63 hexamers 63 oligo 63 RNA binding 63 glycoproteins 63 vitro assay 63 homologues 63 opioid receptor 63 ChIP chip 63 proline 63 thyroid hormone receptor 63 prostanoid 63 #S rRNA 63 Immunohistochemical staining 63 peptidomimetic 63 siRNA mediated 63 cAMP signaling 63 IL 1ß 63 quinone 63 N Myc 63 putative biomarkers 63 transcriptionally 63 Sgk1 63 vesicle formation 63 Cdc# 63 Cytochrome 63 donor acceptor 63 CEACAM1 63 molecularly targeted 63 post transcriptional 63 NS3 63 Kv#.# 63 picomolar 63 caspase activation 63 porphyrin 63 Hedgehog signaling 63 peptide fragments 63 PAX5 63 avidin 63 x ray crystallographic 63 G Protein Coupled 63 p# activation 63 orthologous 63 1beta 63 glucokinase 63 proteomes 63 PDGF BB 63 biomolecular interactions 63 EGF receptors 63 subcellular compartments 63 epidermal cells 63 RNA transcripts 63 serine proteases 63 Rab5 63 annexin V 63 sphingolipid 63 c myc 63 TNF receptors 63 Ferritin 63 analyte 63 GPI anchored 63 TGF alpha 63 γ 63 proapoptotic 63 chondrocyte 63 proton pump 63 synaptotagmin 63 immunohistochemical 63 rDNA 63 antitumoral 63 fig. S4 63 tubulin binding 63 chemosensitivity 63 Nicotinic 63 Wnt beta catenin 63 immunoreactive 63 N glycan 63 TIMP 1 63 siRNA knockdown 63 pericytes 63 UTRs 63 paracellular 63 enzymatic pathways 63 endonucleases 63 kinase inhibition 63 MAP kinase 63 splice junctions 63 antiangiogenic 63 histidine 63 histone H4 63 cyclic adenosine monophosphate cAMP 63 cell adhesion molecules 63 cGPS ® 63 microRNA molecules 63 plasmin 63 Histone 63 cytosine 63 lesional 63 microRNA profiling 63 apoptosis inducing 63 ciliated 63 synaptogenesis 63 protein filaments 63 Fibroblast Growth Factor Receptor 63 HER2 HER2 63 Eg5 63 noncoding RNAs 63 MyoD 63 macrocyclic 63 Pentraxin 2 63 adrenoceptor 63 microRNA expression 63 Tissue Factor 63 lysates 63 stem cell pluripotency 63 Figure 1C 63 Fig. 2a 63 cellular organelles 63 transcriptional repressor 63 secretase 63 receptor CD# 63 extracellular domains 63 functionalization 63 RhoA 63 uPA 63 microRNAs miRNAs 63 modulatory 63 EphB4 63 polypeptides 63 proto oncogene 63 lymphangiogenesis 63 subcellular structures 63 peptide receptor 63 β galactosidase 63 peptide antigens 63 P gp 63 GAPDH 63 ouabain 63 monocyte 63 IRE1 63 multinucleated 63 transfected cells 63 LDL receptor 63 mesenchymal cells 63 cytidine 63 γδ T cells 62 cells transfected 62 cell adhesion molecule 62 membrane proximal 62 liquid crystalline 62 CXCR2 62 bacterial ribosome 62 radiolabeled 62 beta adrenergic receptors 62 cofactors 62 ß catenin 62 phospholipase 62 cysteine residues 62 Phosphorylation 62 dsDNA 62 TNFalpha 62 topoisomerase II 62 eotaxin 62 Fig. 1A 62 GRP# 62 scavenger receptor 62 SOCS3 62 lamellar 62 transcriptional coactivator 62 62 immunoprecipitation 62 indel 62 cadherins 62 GMX# 62 PPARg 62 beta globin gene 62 prostaglandin synthesis 62 interconversion 62 demethylase 62 mesenchyme 62 plastid 62 A3 adenosine receptor 62 glutamine synthetase 62 acetylcholinesterase AChE 62 differentially expressed genes 62 coding genes 62 stilbene 62 membrane lipids 62 Galectin 62 proteomic analyzes 62 transactivation 62 miR# 62 MT1 MMP 62 chemokine receptor 62 oxidative phosphorylation 62 antigen receptors 62 HIF 1a 62 lysosomal 62 cardiomyocyte 62 multiplex assay 62 phospholipid 62 MDSCs 62 cardiac fibroblasts 62 inactivating mutations 62 nanomolar range 62 polypeptide chain 62 glycosylation 62 condensin 62 lipoxygenase 62 constitutively 62 amino acid residue 62 peroxisomal 62 phosphate S1P 62 BCL2 62 exonuclease 62 carcinoembryonic antigen 62 3'UTR 62 molecule binds 62 polynucleotides 62 PARP inhibition 62 hexose 62 ephrin 62 physiologically relevant 62 replicase 62 Ago2 62 PI3K Akt 62 dipeptide 62 secreted protein 62 RGD peptide 62 oncogenic transformation 62 selective inhibition 62 ADAM# 62 translationally 62 #T# L1 62 HDAC6 62 biochemical assays 62 metazoan 62 ligases 62 chromosome condensation 62 lysine residues 62 mitochondrial membranes 62 hammerhead ribozyme 62 antisense molecules 62 MAPKs 62 polypeptide 62 somatostatin receptor 62 Sertoli cell 62 axonal degeneration 62 antisense RNA 62 multiprotein complex 62 beta amyloid peptide 62 p# mitogen activated 62 mesothelin 62 biological macromolecules 62 FOXO3a 62 MMP# 62 Fig. 1C 62 intermediate filaments 62 flavin 62 costimulatory 62 quantitative PCR 62 PTPN# 62 radiolabeling 62 adipocyte 62 intracellular pH 62 thymocyte 62 isotypes 62 somatic mutations 62 cytolytic 62 nonlinear optical 62 TRPV3 62 activin 62 receptor subtypes 62 fluorescently labeled 62 fascin 62 Drp1 62 autocrine 62 mitotic progression 62 serpin 62 K + ATPase 62 PML RARA 62 Lp PLA 2 62 amplicon 62 transduce 62 polycystin 62 ncRNAs 62 CD# molecule 62 sphingomyelin 62 NFAT 62 GABAB receptors 62 Huntingtin 62 tumor suppressor protein 62 erythropoiesis 62 EBNA1 62 HER2 neu 62 proteolytic enzymes 62 HepG2 cells 62 glycopeptides 62 5' triphosphate 62 Drosha 62 secretory 62 trophoblast cells 62 receptor mediated 62 lipid membranes 62 histone H3 62 thrombin receptor 62 protein fragment 62 Cdc7 62 lipid bilayers 62 neoplastic transformation 62 miR #a [002] 62 protein ligand 62 gene inactivation 62 synaptic vesicles 62 naturally occurring molecule 62 FGFR4 62 myogenic 62 phosphorylate 62 intracellular 62 PDGF B 62 #S rDNA 62 Rad# 62 IGF 1R 62 Fig. 4a 62 intracellular protein 62 NSCLC tumors 62 FasL 62 soluble receptor 62 immunofluorescence 62 RNA splicing 62 Actin filaments 62 Rab# 62 TRIM5 62 binding affinities 62 steric 62 heparan sulfate 62 cytokine receptors 62 budding yeast 62 bacterial virulence 62 redox active 62 Raman spectra 62 intron 62 Golgi apparatus 62 PC# cells 62 morphogens 62 mutational analysis 62 lipid vesicles 62 apoptotic pathway 62 transcriptional regulator 62 regulating gene expression 62 SDS PAGE 62 phagocyte 62 mesenchymal cell 62 macromolecular complexes 62 supernatants 62 receptor mediated endocytosis 62 beta globin 62 Fig. 2C 62 cytokine signaling 62 Histone deacetylase 62 ChIP seq 62 cathepsin 62 chaperone protein 62 cohesin 62 upregulates 62 cyclophilin D 62 phytochrome 62 miR #b [002] 62 nucleic acid sequence 62 KLF2 62 oligosaccharide 62 bicyclic 62 vinculin 62 ERBB2 62 amyloid fibrils 62 chloride channels 62 AT1R 62 metaphase 62 metaplasia 62 radiotracer 62 basal lamina 62 mesoderm 62 effector molecules 62 beta actin 62 cytoskeletal 62 branching morphogenesis 62 epigenomic 62 intronic 62 nucleic acid molecules 62 photoactivation 62 PPARgamma 62 glycoprotein 62 replicon 62 ligand 62 chemotactic 62 intracellular bacteria 62 gp# protein [002] 62 H#K# [002] 62 Cre recombinase 62 micelle 62 disulfide 62 FKBP# 62 lipid rafts 62 PDGFR 62 pDCs 62 Nod1 62 ultrastructural 62 metalloproteinases 62 hepatic stellate cell 62 cytolytic activity 62 ADAMTS# 62 calpain 62 BChE 62 PTHrP 62 CDK9 62 GABAA receptors 62 ubiquitinated 62 deuterated 62 PCR primers 62 recombinase 62 paramagnetic 62 amino acid alanine 62 fig. S# 62 nucleotide sequences 62 umbilical vein 62 Schematic representation 62 HIP1 62 nitric oxide synthase 62 short hairpin RNAs 62 activatable 62 HERV 62 viral genomes 62 E3 ligase 62 inhibit viral replication 62 dioxygenase 62 cleavable 62 Figure 1A 62 RNase L 62 cyclic nucleotide 62 integral membrane proteins 62 pertussis toxin 62 Secretase 62 Androgen receptor 62 binds selectively 62 tumorigenic 62 recombinant antibody 62 cytostatic 62 GTPase 62 lymphotoxin 62 coactivator 62 metalloenzymes 62 xenobiotic 62 ribosomal proteins 62 cofactor 62 amino terminus 62 xenograft 62 Microtubule 62 adenosine diphosphate ADP 62 osteoblast differentiation 62 hTERT 62 EphA2 62 osteoinductive 62 muscarinic receptors 62 nucleotide sequence 62 druggable targets 62 EGFR HER 62 ERK2 62 synthetase 62 PDGF receptor 62 human mammary epithelial 61 TNF α 61 syntaxin 61 cysteines 61 chemoattractant 61 histone deacetylase HDAC 61 osteogenic differentiation 61 outer membrane proteins 61 hnRNP 61 Leydig cells 61 tumoral 61 CK2 61 #HT#A 61 At#g# 61 enzymatic activity 61 androgen receptor AR 61 tumor microenvironment 61 antigen receptor 61 protein secretion 61 V3 loop 61 HMG CoA reductase 61 mRNA encoding 61 MSn 61 Wnt signaling pathway 61 apoptosis pathways 61 endothelial activation 61 eIF3 61 chimeric monoclonal antibody 61 C3b 61 primary cilium 61 Tyrosine