Related by context. All words. (Click for frequent words.) 71 birthweight 68 low birthweight babies 67 macrosomia 67 low birthweight infants 66 low birthweights 66 preterm 65 preterm deliveries 64 Low birthweight 63 Apgar scores 63 born preterm 62 singleton pregnancy 62 preterm babies 62 IUGR 61 ELBW infants 61 normal birthweight 61 neonatal morbidity 61 antenatal depression 60 perinatal mortality 60 perinatal outcomes 60 persistent pulmonary hypertension 60 VLBW 60 birthweights 60 preterm infants 59 preterm delivery 59 spontaneous vaginal 59 congenital abnormalities 59 neural tube defect 59 undescended testicles 59 perinatal complications 58 fetal malformations 58 gestational age 58 VLBW infants 58 stillbirth 58 neonatal mortality 58 maternal morbidity 58 premature birth 58 ELBW 58 bronchopulmonary dysplasia 57 Preterm infants 57 preterm birth 57 Preterm births 57 Maternal obesity 57 de ath 57 preeclamptic 57 gestational hypertension 57 weeks gestation 57 intra uterine 57 intraventricular hemorrhage 57 singleton babies 57 placental abnormalities 57 parous women 56 unexplained stillbirth 56 gestational diabetes mellitus 56 preterm births 56 Preterm birth 56 postnatally 56 pre eclamptic 56 pre eclampsia 56 thyroid hormone levels 56 prematurity 56 cryptorchidism 56 placental malaria 56 nulliparous 56 obstetric interventions 56 neurodevelopmental outcomes 55 hypertensive disorders 55 premature births 55 placenta previa 55 breech births 55 birthweight babies 55 neurodevelopmental 55 obstetric complications 55 BLLs 55 anovulatory infertility 55 Birth Weight 55 elective caesarean section 55 spontaneous preterm birth 55 multiple gestations 55 prepregnancy BMI 55 cotinine levels 55 congenital malformations 55 vaginal deliveries 55 dietary calcium intake 55 stillbirth miscarriage 55 nonpregnant women 55 exposed prenatally 55 Premature birth 54 Secondhand smoke exposure 54 born prematurely 54 placental abruption 54 placenta accreta 54 IVF pregnancies 54 adverse perinatal 54 preterm infant 54 plasma homocysteine levels 54 socioeconomic status SES 54 folate deficiency 54 mcg dl 54 breastfed infants 54 breastfed exclusively 54 gestational diabetes 54 intrauterine 54 Preterm 54 CVD mortality 54 spontaneous preterm delivery 54 orofacial clefts 54 neonatal encephalopathy 54 hyperbilirubinemia 54 metabolic abnormalities 54 obstetrical complications 54 PGD PGS 53 socioeconomic status 53 placental insufficiency 53 glucose intolerance 53 neural tube birth defects 53 polycystic ovary syndrome 53 singleton births 53 neurodevelopment 53 utero exposure 53 onset diabetes mellitus 53 delivered vaginally 53 CHD mortality 53 perinatal asphyxia 53 delaying childbirth 53 iodine deficient 53 death syndrome SIDS 53 preeclampsia 53 developmental delays 53 singleton pregnancies 53 habitual snoring 53 chromosomal disorders 53 breastfed babies 53 prenatally diagnosed 53 neurodevelopmental outcome 53 menarche 53 chorioamnionitis 53 placenta praevia 53 subclinical hypothyroidism 53 gastroschisis 53 recurrent wheezing 53 postpartum hemorrhage 53 Premature babies 53 bronchopulmonary dysplasia BPD 53 neuro developmental 53 congenital anomalies 53 depressive symptoms 53 shorter telomere length 53 waist circumferences 52 developmental abnormalities 52 Cesarean delivery 52 neurodevelopmental impairment 52 Multiple births 52 thyrotropin levels 52 recurrent miscarriages 52 Gestational 52 pelvic inflammatory disease 52 Breastfed babies 52 fetal distress 52 infant mortalities 52 shorter telomeres 52 Prematurity 52 Pre eclampsia 52 phthalate exposure 52 Caesarean deliveries 52 intrapartum 52 FeNO 52 recurrent miscarriage 52 Postnatal depression 52 adiponectin concentrations 52 Postpartum depression affects 52 congenital toxoplasmosis 52 Socioeconomic status 52 uterine rupture 52 hydrops 52 oral clefts 52 Gestational diabetes 52 Birthweight 52 prenatal exposure 52 choline intake 51 oligohydramnios 51 iodine intake 51 infertility miscarriage 51 enamel defects 51 uncomplicated pregnancies 51 miscarriages premature births 51 folate intake 51 intrauterine fetal 51 subfertile 51 gestational diabetes mellitus GDM 51 extreme prematurity 51 vaginal births 51 premature babies 51 miscarriages stillbirths 51 Rh incompatibility 51 Pre eclampsia affects 51 phthalate metabolites 51 untreated hypothyroidism 51 folic acid intake 51 prepregnancy weight 51 folate supplementation 51 coronary calcification 51 perinatal 51 triplet pregnancies 51 chromosomal abnormalities 51 severe hyperbilirubinemia 51 body fatness 51 Secondhand smoke causes 51 allergic sensitization 51 nonmarital births 51 growth restriction IUGR 51 fetal chromosomal abnormalities 51 Physical inactivity 51 dizygotic 51 cephalic presentation 51 irregular menstrual periods 51 BMI percentiles 51 monozygotic 51 endometriosis ovarian cysts 51 intelligence quotient IQ 51 Cesarean Section 51 neonates 51 abdominally obese 51 Premature infants 51 breastfed 51 anencephaly 51 umol L 51 CHD CVD 51 chromosomal disorder 51 serum lipid levels 51 postpartum haemorrhage 50 cesarean delivery 50 highest quintile 50 Millennium Cohort Study 50 preemies 50 Folic acid deficiency 50 deliver vaginally 50 neurodevelopmental disorders 50 breech babies 50 Postpartum depression 50 IVF ICSI 50 eclampsia 50 psychiatric comorbidities 50 Beckwith Wiedemann syndrome 50 born vaginally 50 congenital CMV 50 TT genotype 50 caesarean delivery 50 #q#.# deletion syndrome 50 autistic traits 50 colorectal neoplasia 50 dietary intakes 50 MMSE scores 50 circulatory diseases 50 Moderate drinkers 50 phthalate syndrome 50 Birth defects 50 AOR = 50 hydroxyvitamin D levels 50 infant mortality 50 Sudden infant 50 socioeconomic deprivation 50 fetal chromosomal 50 Folate deficiency 50 Preterm delivery 50 index BMI 50 MetS 50 pyloric stenosis 50 non pledgers 50 ambiguous genitalia 50 prenatal exposures 50 Unintentional injuries 50 asymptomatic hypothyroidism 50 nulliparous women 50 PPHN 50 neural tube defects NTDs 50 AUDs 50 serum folate 50 serum bilirubin 50 fasting triglyceride levels 50 transferrin saturation 50 Iron deficiency 50 elevated CRP 50 SRBD 50 postoperative pulmonary 50 psychiatric morbidity 50 behavioral disinhibition 50 fibroids endometriosis 50 elevated LDL cholesterol 50 quadruplet births 50 puerperal psychosis 50 androgen depletion 50 pregnancies 50 Gestational age 50 spontaneous abortions 49 peripartum cardiomyopathy 49 BMI ≥ 49 Premature Ovarian Failure 49 elevated triglycerides 49 neo natal mortality 49 tertile 49 insecurely attached 49 nmol L. 49 intrauterine infection 49 unhealthy dietary habits 49 Passive smoking 49 prevalences 49 prematurity birth defects 49 placental 49 recurrent UTI 49 asymptomatic PAD 49 cardiovascular mortality 49 Preterm babies 49 sociodemographic characteristics 49 nondepressed 49 #q# deletion syndrome 49 adiponectin levels 49 Exclusive breastfeeding 49 androgen excess 49 cesarean deliveries 49 abdominal adiposity 49 internalizing disorders 49 cow's milk formula 49 serum estradiol 49 Wisborg 49 Morbid obesity 49 membrane rupture 49 chronic undernourishment 49 Premature births 49 vitamin D inadequacy 49 postnatal 49 Recurrent miscarriage 49 fatal IHD 49 Masche sextuplets 49 onset sepsis 49 comorbid conditions 49 Caesarean delivery 49 genital defects 49 exclusively breastfed 49 folic acid deficiency 49 brachial plexus palsy 49 triplet births 49 magnesium intake 49 leptin resistant 49 urinary BPA 49 infants 49 cardiorespiratory fitness 49 Foetal Alcohol Spectrum Disorder 49 contraceptive prevalence 49 cohabiting relationships 49 NICU admissions 49 genital abnormalities 49 polyhydramnios 49 fasting insulin 49 obesity insulin resistance 49 chromosomal defect 49 serum vitamin D 49 ovarian dysfunction 49 hyperemesis gravidarum 49 cardio respiratory fitness 49 prolactin levels 49 obesity sedentary lifestyle 49 anovulation 49 hypoxic ischemic encephalopathy 49 Depressive symptoms 49 polycystic ovary syndrome PCOS 49 births 49 sociodemographic factors 49 mIU L 49 recessive disorders 49 #kg/m# 49 miscarriage ectopic pregnancy 49 gallstone disease 49 carotid IMT 49 Munk Olsen 49 irregular menstrual cycles 49 postmenopausal breast cancer 49 facial clefts 49 serum IGF 49 subfertility 49 elective caesarean 49 impaired glucose metabolism 49 Amy Branum 49 nonobese 49 gestations 49 CHDs 49 attention-deficit/hyperactivity disorder ADHD 49 primary ovarian insufficiency 49 highly heritable 49 elevated serum ALT 48 subclinical hyperthyroidism 48 elevated cortisol 48 Infant mortality rates 48 Gestational diabetes affects 48 premenopausal breast cancer 48 stillbirths 48 paternal discrepancy 48 Anorexia nervosa 48 handgrip strength 48 vitamin D deficient 48 Fasting blood glucose 48 Cesarean deliveries 48 hormonal abnormalities 48 ductal breast cancer 48 severe periodontitis 48 hydrocephaly 48 albumin excretion 48 modifiable risk 48 definite stent thrombosis 48 Complication rates 48 Prehypertension 48 recessive genetic disorders 48 reproductive abnormalities 48 transfusion syndrome 48 IPAH 48 neurologic complications 48 elevated TSH 48 thyroid function 48 apnea hypopnea index 48 DHA supplementation 48 poorer prognosis 48 perinatal morbidity 48 pneumococcal carriage 48 babies 48 parous 48 birth asphyxia 48 hirsutism 48 anogenital distance 48 BRCA1 mutations 48 Subclinical hypothyroidism 48 colorectal adenomas 48 attending antenatal clinics 48 Neural tube defects 48 myelomeningocele 48 dizygotic twins 48 Irva Hertz Picciotto 48 rs# [001] 48 carbohydrate intolerance 48 Skin sterol 48 telomere length 48 coinfection 48 cervical dilation 48 mild gestational diabetes 48 periventricular leukomalacia 48 undescended testes 48 Unintended pregnancies 48 Reye syndrome rare 48 postoperative delirium 48 iron deficient 48 YPDP 48 pregnancy 48 weaning weights 48 elective Caesarean 48 cesareans 48 SE alleles 48 caesarean section 48 nmol l 48 Klinefelter syndrome 48 salivary cotinine 48 preterm neonates 48 peri natal 48 LQTS 48 disease CHD 48 multivariable analysis 48 chromosomal anomaly 48 undernutrition 48 Stillbirths 48 Sociodemographic 48 asthma rhinitis 48 Triglyceride levels 48 neural tube defects 48 #mg/dL [001] 48 endometrial thickness 48 episiotomy 48 bilirubin levels 48 potential confounders 48 NNRTI resistance 48 BMI #-#.# 48 Preterm Birth 48 Multivariate analyzes 48 HELLP 48 maternal mortalities 48 Teenage pregnancies 48 dyslipidaemia 48 IDDM 48 ultra rapid metabolizers 48 subclinical atherosclerosis 48 sodium valproate 48 newborns 48 PLMs 48 hypoxic ischemic brain 48 postoperative mortality 48 dysglycemia 48 azoospermia 48 Apert syndrome 48 caesareans 47 Insulin sensitivity 47 Unintended pregnancy 47 nonfasting triglyceride levels 47 menstrual irregularity 47 uterine scar 47 unintentional poisoning 47 coronary heart 47 chromosome abnormalities 47 APOE e4 47 SIDS infants 47 confidence interval #.#-#.# 47 MCADD 47 familial hypercholesterolemia 47 Myocardial infarction 47 nonfatal MI 47 elevated bilirubin 47 acrylamide intake 47 premature infants 47 familial AF 47 macrovascular 47 % CI #.#-#.# [008] 47 prenatal 47 tertiles 47 thyroid dysfunction 47 #OHD levels 47 educational attainment 47 insulin resistance syndrome 47 confounder 47 neurologic impairment 47 dystocia 47 Mental disorders 47 elevated triglyceride levels 47 hemolytic disease 47 untreated celiac disease 47 Bombs Away Dream 47 BRCA2 mutations 47 EPICure study 47 caesarian sections 47 ante partum 47 adenotonsillectomy 47 inhaled budesonide 47 hindbrain herniation 47 Syndrome SIDS 47 elevated depressive symptoms 47 externalizing behaviors 47 oral cleft 47 precancerous cervical 47 nonexposed 47 nondiabetic 47 fetal abnormalities 47 NAFLD 47 slow metabolizers 47 transient tachypnea 47 antisocial behaviors 47 abnormal lipid levels 47 cardiac malformations 47 depressive symptomatology 47 juvenile idiopathic arthritis JIA 47 PON1 47 neurodevelopmental disorder 47 Pregnancies 47 cesarean births 47 cardiovascular disease hypertension 47 hypopneas 47 atherogenic dyslipidemia 47 RhD 47 monozygotic twins 47 multivariate logistic regression 47 artificially sweetened soft drinks 47 placental function 47 blood glucose concentrations 47 BRCA1 mutation carriers 47 Northridge Moschella 47 perimenopausal women 47 malformations 47 polycystic ovaries 47 caesarean births 47 unwed births 47 myocardial infarctions MIs 47 proband 47 μg dL 47 meconium aspiration 47 congenital adrenal hyperplasia 47 fructose intake 47 lignan intake 47 estimated glomerular filtration 47 abnormal lipid 47 calcium intakes 47 spastic diplegia 47 haemorrhagic stroke 47 prenatal phthalate exposure 47 impaired fasting glucose 47 callous unemotional traits 47 Preeclampsia 47 maternal fetal 47 Reefhuis 47 impaired endothelial 47 serum sodium 47 Shabaniyah festival marks 47 pyelonephritis 47 Breastfed 47 Neural Tube Defects 47 Amillia Taylor 47 % CI #.#-#.# [006] 47 RSV infections 47 febrile seizure 47 hypoxemia 47 congenital birth defects 47 premenopausal 47 ketoacidosis coma 47 neonatal 47 Moderately obese 47 colorectal adenoma 47 polyp recurrence 47 MCAD deficiency 47 prepubertal 47 neonate 47 folate folic acid 47 PBDE chemicals 47 persistent wheezing 47 prepregnancy 47 Breastfed infants 47 posing suffocation 47 APOE ε4 47 elective Caesarean section 47 dangerously underweight 47 polycystic ovarian syndrome 47 aneuploidy 47 colorectal cancer incidence 47 lipid levels 47 congenital hypothyroidism 47 underactive thyroids 47 Genetic predisposition 47 Unwed mothers 47 HbA1C levels 47 chlamydia infections 47 IgA deficiency 47 Vaginal Birth After 47 mild analgesics 47 highest tertile 47 strongest predictors 47 chromosomal defects 47 shoulder dystocia 47 alcoholic fatty liver 47 hypoxic respiratory failure 47 Gestational Diabetes 47 carotid atherosclerosis 47 μg dl 47 Iron deficiency anemia 47 NIHSS score 47 triglyceride concentrations 47 trivial Klatsky 46 hypoxia ischemia 46 asthma exacerbations 46 perfluorooctanoate PFOA 46 atopic disease 46 Ovali 46 potentially modifiable 46 neurodevelopmental disability 46 NLSY 46 kg m² 46 genital birth defects 46 obese 46 Eclampsia 46 #q# deletion 46 Bayley Scales 46 elective inductions 46 sperm motility 46 BRCA gene mutations 46 elective cesarean delivery 46 Abdominal obesity 46 maternal neonatal 46 ASD prevalence 46 experienced miscarriage stillbirth 46 systolic blood pressure 46 intracytoplasmic sperm injection ICSI 46 internalizing behaviors 46 Peanut allergies 46 irregular ovulation 46 habitual snorers 46 asthma hay fever 46 severe dehydrating diarrhea 46 SIDS Sudden Infant Death 46 undergoing bariatric surgery 46 Vitamin D supplementation 46 atopy 46 AI AN 46 homocysteine concentrations 46 central adiposity 46 inherited mutations 46 confounders 46 #OHD 46 urine albumin 46 T1DM 46 microvascular disease 46 clinically insignificant 46 Cesarean sections 46 Low Birthweight 46 waist circumference 46 uncomplicated vaginal 46 mcg dL 46 maintaining cardiorespiratory fitness 46 EDSS scores 46 postnatal depression 46 pulmonary hypoplasia 46 neurobehavioural 46 thromboembolism 46 limiting generalizability 46 suicide attempters 46 Charlson comorbidity index 46 neurodevelopment disorder 46 fasting glucose levels 46 trisomy 46 respiratory distress syndrome 46 Infant mortality 46 metabolic syndrome cluster 46 Unplanned pregnancy 46 CI #.#-#.# [001] 46 Chlamydia infection 46 Waist circumference 46 male hormone androgen 46 intermittent exotropia 46 premies 46 gestational 46 vaginal delivery 46 antenatal corticosteroids 46 marsupial mammals 46 airway responsiveness 46 ectopic pregnancies 46 multivariate adjustment 46 depressive disorders 46 Homocysteine levels 46 dietary fiber intake 46 Magnesium sulfate 46 Study Spacing 46 G6PD deficiency 46 use disorders AUDs 46 biliopancreatic diversion 46 neonatal sepsis 46 thrombophilia 46 advanced adenoma 46 diagnosed prenatally 46 baseline HbA1c 46 sociodemographic 46 elevated fasting glucose 46 elective caesareans 46 unmarried childbearing 46 abdominal obesity 46 postnatal depression PND 46 nmol L 46 7lb 7oz 46 plasma triglycerides 46 lowest tertile 46 Alagille syndrome 46 PM#.# exposure 46 amenorrhea 46 Giraffe gives 46 atopic 46 bisexual LGB 46 hypospadias 46 hemolytic diseases 46 retiree Virgilio Colajanni 46 Premature Infants 46 nicotine metabolite 46 hypovitaminosis D 46 deafness neurological 46 thyroid hormone deficiency 46 heterozygous familial 46 Alvergne 46 Comorbid 46 Polycystic ovary syndrome PCOS 46 glycated hemoglobin levels 46 Cotinine 46 prenatal care 46 drank pomegranate juice 46 delaying childbearing 46 Hb A1C 46 autonomic dysfunction 46 confounding variables 46 post partum hemorrhage 46 cesarean sections 46 prenatally 46 vaginal tearing 46 perioperative mortality 46 Stent thrombosis 46 SIDS 46 BRCA mutation carriers 46 cesarean section 46 serum folate concentrations 46 dyslipidemia hypertension 46 BRCA2 mutation 46 meconium aspiration syndrome 46 teratogens 46 precocious puberty 46 elevated ALT 46 foveal thickness 46 Muraskas 46 AMOR IPAT 46 chronic lung 46 confounding factors 46 toxemia 46 AAT deficiency 46 Child Behavior Checklist 46 serum homocysteine 46 neuromotor 46 caesarean section births 46 congenital adrenal hyperplasia CAH 46 rhinoconjunctivitis 46 sonographic diagnosis 46 Teenage pregnancy 46 chromosomal abnormality 46 hyperemesis 46 prime childbearing 46 eczema hay fever 46 serum leptin 46 bronchiolitis 46 neurologic outcomes 46 dose ionizing radiation 46 morbidities 46 ovulatory infertility 46 Kailas Gheewala 46 preterm labor 46 NHANES III 46 Listeria infections 46 nonfasting triglycerides 46 Maisie Roxanne 46 Post partum depression 46 intracerebral hemorrhages 46 APOE gene 46 caesarian section 46 infants Sundlof 46 advanced adenomas 46 salmeterol HFA MDI 46 undiagnosed celiac disease 46 β = 46 triacylglycerol concentrations 46 PBDE concentrations 46 Avon Longitudinal Study 46 CLBP 46 Congenital heart 46 mammary tumors 46 Folic acid supplements 46 extrapyramidal symptoms 46 abruption 46 dietary choline 46 spontaneously aborted 46 neurological sequelae 46 unfavorable prognostic 46 noncardiovascular mortality 46 NICHD sponsors research 46 ASDs 46 Premature Birth 46 elevated homocysteine 46 chromosome abnormality 46 leukocyte telomere length 46 valproate 46 triplet pregnancy 46 Caesarean section 46 Elevated cholesterol 46 rebreeding 46 folate intakes 46 albumin excretion rate 45 atopic disorders 45 antidiabetic medication 45 serum parathyroid hormone 45 sugar sweetened soft drinks 45 onset puberty 45 iNO 45 immunocompromised individuals 45 abdominal circumference 45 benign noncancerous 45 perinatal depression 45 alpha amylase 45 leucopenia 45 maternal 45 Personality traits 45 Kozyrskyj 45 caesarean sections 45 del 5q MDS 45 cerebral palsy blindness 45 untreated sleep apnea 45 OF MULTIPLES Mothers 45 adiposity 45 hypoxic ischemic encephalopathy HIE 45 activity MAOA 45 elevated serum creatinine 45 Inhibin B 45 disease NAFLD 45 periodontal gum disease 45 amniotic fluid embolism 45 ruptured uterus 45 Sleep disordered breathing 45 serum creatinine levels 45 twins triplets 45 infant mortality rate 45 Adequate vitamin D 45 postpartum 45 Children ALSPAC 45 Malnourishment 45 RhD negative 45 Kinship caregivers 45 physical inactivity 45 Polycystic ovary syndrome 45 penetrance 45 LDL HDL ratio 45 journal Acta Paediatrica 45 mammary gland tumors 45 Contraceptive Use 45 systemic embolism 45 congenital abnormality 45 post partum haemorrhage 45 Premature menopause 45 IQs 45 e4 allele 45 genetic susceptibility 45 multivariate analyzes 45 A1c levels 45 Spina bifida 45 epidural analgesia 45 preventing premature births 45 exclusively breastfeed 45 atrophic gastritis 45 allergic eczema 45 serum uric acid 45 HbA 1c levels 45 Gestational Diabetes Mellitus 45 Professor Najman 45 Hospitalizations 45 Child Wellbeing 45 primary ciliary dyskinesia 45 cardio vascular disease 45 Kay Tee Khaw 45 arterial thickening 45 comorbidity 45 earlier Dorlean Nadege 45 Unplanned pregnancies 45 5 HTTLPR 45 Follicle Stimulating Hormone 45 micronutrient supplementation 45 ruptured ectopic 45 hepatic steatosis 45 organophosphate pesticides 45 Cardiorespiratory fitness 45 systolic blood pressures 45 density lipoprotein cholesterol 45 neonatal respiratory distress 45 % CI #.#-#.# [007] 45 plasma lipid 45 hypoglycemic events 45 Genetic variants 45 severely obese 45 psychiatric comorbidity 45 Hyperactivity 45 CC genotype 45 Fasting glucose levels 45 saturated fat intake 45 Marital status 45 suicide ideation 45 Fetal distress 45 Caesarean births 45 HF hospitalization 45 serum concentrations 45 Serum calcium 45 thicker carotid arteries 45 glomerular filtration rate 45 chronic bilirubin encephalopathy 45 hsCRP levels 45 cesarean 45 molar pregnancy 45 RSV bronchiolitis 45 teen birthrates 45 Cognitive impairment 45 coronary artery calcification 45 nonalcoholic steatohepatitis 45 comorbid 45 Nonalcoholic Fatty Liver Disease 45 prospective longitudinal 45 stillborn fetuses 45 perioperative morbidity 45 microalbuminuria 45 pregnancy childbirth 45 telomere lengths 45 inflammatory markers 45 mammographic density 45 per deciliter 45 maternal deaths 45 Eloysa Vasquez 45 bivariate analyzes 45 affective psychoses 45 neutrophil counts 45 caffeine intake 45 impaired cognition 45 hypocaloric diet 45 reinfarction 45 organochlorine compounds 45 amino acid homocysteine 45 Vitamin D deficiency 45 obese postmenopausal 45 congenital cytomegalovirus 45 micronutrient supplements 45 BCG vaccinated 45 obese adolescents 45 comorbidities 45 insulin resistance