Related by context. All words. (Click for frequent words.) 72 hyperinsulinemia 71 neurological abnormalities 70 metabolic disturbances 69 underlying pathophysiology 69 metabolic dysfunction 68 T1DM 68 biochemical abnormalities 68 neuronal dysfunction 68 vascular dysfunction 68 predisposing factor 67 prostate carcinogenesis 67 elevated triglyceride levels 67 plasma lipids 67 p# activation 67 insulin resistance 67 hyperglycaemia 66 lipid abnormalities 66 obesity insulin resistance 66 behavioral disinhibition 66 macrovascular complications 66 dysregulation 66 potentially modifiable 66 Genetic variants 66 subclinical atherosclerosis 66 neurocognitive deficits 66 serum PTH 66 autonomic dysfunction 66 etiologic 66 predisposing factors 66 hereditary predisposition 66 microvascular disease 66 cardiac fibrosis 66 elevated triglycerides 66 gallstone disease 66 abnormal lipid 66 Glucocorticoids 66 chromosomal rearrangement 66 metabolic parameters 66 dysregulated 66 CVD mortality 65 nerve degeneration 65 mitochondrial mutations 65 pleiotropic effects 65 thyrotropin 65 phenotypes 65 arterial calcification 65 behavioral abnormalities 65 androgen depletion 65 cognitive dysfunction 65 lipid levels 65 prothrombotic 65 left ventricular hypertrophy 65 NAFLD 65 adiponectin levels 65 atherosclerotic disease 65 metabolic acidosis 65 endothelial dysfunction 65 parkinsonism 65 neuropsychological deficits 65 motor neuron degeneration 65 cortisol secretion 65 atherogenic dyslipidemia 65 synaptic function 65 Insulin resistance 65 Oxidative stress 65 thyroid hormone levels 64 Genetic predisposition 64 HDL2 64 insulin resistance syndrome 64 amyloid deposition 64 pathophysiologic 64 mitochondrial dysfunction 64 pathophysiological mechanisms 64 prostate cancer CaP 64 thyrotropin levels 64 developmental abnormalities 64 nonalcoholic steatohepatitis 64 neuroinflammation 64 impaired cognition 64 PON1 64 HGPS 64 pressure natriuresis 64 microvascular dysfunction 64 systolic hypertension 64 HPA axis 64 glucose homeostasis 64 maintaining cardiorespiratory fitness 64 prefrontal cortical 64 glucose intolerance 64 neuropsychiatric disorders 64 inherited mutations 64 hyperinsulinism 64 neuritic plaques 64 cardiometabolic risk 64 cognitive deficits 64 leptin deficiency 64 neurocognitive impairment 64 basal cell nevus syndrome 64 shorter telomere length 64 diabetes dyslipidemia 64 genetic polymorphisms 64 extrapyramidal symptoms 64 mtDNA mutations 64 subclinical hypothyroidism 64 adiposity 64 cerebral infarction 64 proliferative diabetic retinopathy 64 Thyroid hormone 64 folate deficiency 64 RBP4 64 brain lesions 63 Wernicke Korsakoff syndrome 63 fasting glucose levels 63 metabolic derangements 63 metabolic abnormality 63 myopathies 63 polycystic ovary syndrome PCOS 63 airway hyperresponsiveness 63 urinary excretion 63 neurologic disorders 63 central adiposity 63 impaired glucose metabolism 63 abnormal glucose tolerance 63 abdominal adiposity 63 systemic inflammation 63 Hashimoto thyroiditis 63 causal pathways 63 elevated CRP 63 carotid IMT 63 hamartomas 63 hypothalamic pituitary 63 proinflammatory cytokines 63 alexithymia 63 untreated celiac disease 63 chronicity 63 T2DM 63 telomere lengths 63 hypothalamic pituitary adrenal axis 63 Sleep disordered breathing 63 thyroid dysfunction 63 epigenetic changes 63 modifiable risk 63 onset diabetes mellitus 63 carotid atherosclerosis 63 mutant huntingtin protein 63 HbF 63 neuropsychiatric disorder 63 type2 diabetes 63 etiologic factors 63 narcolepsy cataplexy 63 Alzheimer pathology 63 androgen deficiency 63 colorectal carcinogenesis 63 abnormal glucose metabolism 63 gastric carcinogenesis 63 DNA methylation patterns 63 carbohydrate metabolism 63 FTLD 63 renal fibrosis 63 EBV infection 63 hypogonadotropic hypogonadism 63 comorbid disorders 63 hepatic steatosis 63 metabolic syndrome MetS 63 serum uric acid 63 inflammatory markers 63 improves insulin sensitivity 63 hormonal abnormalities 63 genetic loci 63 postnatally 63 serum retinol 63 atherogenesis 63 de ath 63 comorbid conditions 62 elevated cortisol 62 coinfection 62 aminotransferase levels 62 beta1 integrin 62 inhibitory neurotransmitters 62 fatty acid oxidation 62 familial clustering 62 FGFs 62 disc degeneration 62 lipid concentrations 62 neuroinflammatory 62 dietary antioxidants 62 clefting 62 carotid plaques 62 diabetic microvascular complications 62 intermittent hypoxia 62 missense mutations 62 HIV HCV coinfected 62 elevated homocysteine 62 lowering blood glucose 62 postoperative AF 62 mixed hyperlipidemia 62 serum lipid levels 62 ovarian hormones 62 subclinical 62 receptor subtypes 62 hypoxemia 62 androgen excess 62 AUDs 62 oxidized cysteine 62 neuropathological 62 airway reactivity 62 platelet activation 62 neurodevelopmental outcome 62 chromosomal regions 62 abnormal lipid levels 62 #q#.# [002] 62 tic severity 62 highly heritable 62 PTH secretion 62 cerebral ischemia 62 cardiac dysfunction 62 muscular dystrophies 62 lipoprotein metabolism 62 IPAH 62 endocrine abnormalities 62 hydrops 62 antiphospholipid syndrome 62 cystic fibrosis chronic pancreatitis 62 autoregulation 62 hyperbilirubinemia 62 endocannabinoid signaling 62 neuroblastomas 62 albuminuria 62 pharmacologic intervention 62 cortical thinning 62 serum lipid 62 albumin excretion 62 hepatic cirrhosis 62 gallstone formation 62 de novo mutations 62 plasma lipid 62 liver steatosis 62 granulomatous 62 neurosensory 62 blood glucose concentrations 62 somatic symptoms 62 adiponectin 62 microvascular complications 62 IDH mutations 62 Genetic mutations 62 estrogen metabolism 62 subclinical hyperthyroidism 62 neuropathologic 62 Chronic pancreatitis 62 Cognitive impairment 62 atherothrombotic 62 hyperhomocysteinemia 62 MTHFR 62 hypercalciuria 62 shortened telomeres 62 PTEN mutations 62 Leydig cell 62 ADPKD 62 calcium homeostasis 62 sporadic ALS 62 endocrine glands 62 cataract formation 62 thyroid hormone deficiency 62 cardiac hypertrophy 61 causal pathway 61 urate levels 61 K ras mutations 61 alkalosis 61 colorectal adenoma 61 PTPN# 61 hypoperfusion 61 fructose intake 61 nongenetic 61 neuroendocrine 61 SLC#A# [002] 61 metabolizing enzymes 61 gestational diabetes mellitus 61 familial hypercholesterolemia FH 61 aetiological 61 cardiometabolic disorders 61 elevated LDL cholesterol 61 metabolic syndromes 61 Genetic variations 61 amyloid plaque formation 61 folate metabolism 61 ABCB1 61 glucose tolerance 61 visceral fat accumulation 61 euthymic patients 61 Dysregulation 61 gene polymorphisms 61 comorbid depression 61 coronary calcification 61 genes predisposing 61 CYP #A# 61 MTHFD1L gene 61 chromosomal anomalies 61 hepatic glucose production 61 arterial stiffness 61 neurologic abnormalities 61 vasodilatation 61 CHD mortality 61 arterial stiffening 61 psychiatric comorbidity 61 molecular abnormalities 61 hypercholesterolemia 61 nonalcoholic steatohepatitis NASH 61 endothelial activation 61 body fatness 61 CLA supplementation 61 macrovascular events 61 osteosarcomas 61 SE alleles 61 hippocampal atrophy 61 vascular cognitive impairment 61 cardiovascular mortality 61 cardiovascular disease hypertension 61 pathophysiological 61 cardiovascular morbidity 61 serum cholesterol 61 adrenal cortex 61 IgA deficiency 61 multifactorial 61 metabolic syndrome 61 chronic pancreatitis 61 serum leptin 61 cardiomyopathies 61 UCP1 61 metaplasia 61 neurodevelopmental outcomes 61 coronary artery atherosclerosis 61 nondemented 61 estrogen deficiency 61 bile acid metabolism 61 ERK signaling 61 utero exposure 61 myeloproliferative diseases 61 Smad3 61 autoimmune thyroiditis 61 extramedullary 61 glycosylated hemoglobin HbA1c 61 paraneoplastic 61 intestinal microflora 61 Singh Manoux 61 activated microglia 61 neurologic symptoms 61 da mage 61 hypertension diabetes mellitus 61 neurologic complications 61 PDGFR 61 serum calcium 61 brain neurochemistry 61 dysglycemia 61 airway remodeling 61 APOE e4 61 p# mutations 61 NFTs 61 systemic amyloidosis 61 stratifying patients 61 parkinsonian 61 folic acid deficiency 61 macrovascular disease 61 remnant lipoproteins 61 insulin sensitizing agents 61 circulating estrogens 61 lipid profiles 61 lipid parameters 61 NADPH oxidase 61 leptin resistance 61 monogenic 61 ciliopathies 61 acidosis 61 SRBD 61 MGUS 61 chromosomal disorders 61 ataxias 61 adrenal function 61 atherothrombosis 61 poorer prognosis 61 gastric carcinoma 61 Sjögren syndrome 61 nitric oxide synthase 61 STAT4 61 neuropsychiatric diseases 61 familial hypercholesterolemia 61 leptin deficient mice 61 STAT3 signaling 61 PPAR γ 61 neuropsychological impairments 61 rCBF 61 morbidities 61 dietary patterns 61 microdeletion 61 IUGR 61 atherogenic 61 hypercalcaemia 61 nitrotyrosine 61 biologic pathways 61 downregulation 61 carcinoids 61 hypovolemia 61 glycogen metabolism 61 nonfasting triglyceride levels 61 normal karyotype 61 circadian clock genes 61 signaling cascades 61 hyperinsulinemic 60 torsade de pointes 60 cardioprotection 60 circadian genes 60 biochemical imbalances 60 primary biliary cirrhosis 60 serum IGF 60 airflow limitation 60 airway responsiveness 60 Excessive daytime sleepiness 60 serum phosphate 60 eicosanoids 60 Stress hormones 60 locomotor activity 60 neurodevelopmental disorders 60 lipoprotein levels 60 neuroimaging studies 60 neurodevelopmental impairment 60 microbleeds 60 potent inhibition 60 hyperplastic 60 disease NAFLD 60 malignant transformation 60 aminotransferases 60 KLF4 60 repolarization 60 EoE 60 SORL1 60 anovulatory infertility 60 progressive neurodegenerative disorder 60 amyloid peptide 60 pulmonary hypoplasia 60 ovarian dysfunction 60 Orthostatic hypotension 60 LRRK2 mutations 60 dietary interventions 60 chronic periodontitis 60 sCJD 60 Vitamin B# deficiency 60 acetabular dysplasia 60 aetiology 60 CagA 60 familial pancreatic cancer 60 heritable disorders 60 preterm deliveries 60 atherosclerotic vascular disease 60 SCD1 60 infarcts 60 GBA mutations 60 MetS 60 cardiorespiratory fitness 60 hypothalamus pituitary 60 prognostic indicator 60 depressive symptomatology 60 metabolite concentrations 60 vascular inflammation 60 G6PD deficiency 60 glycemia 60 prepubertal 60 Abnormalities 60 Endothelial dysfunction 60 microangiopathy 60 nephropathy 60 microglial activation 60 cirrhosis liver failure 60 seminomas 60 Hp2 2 60 antioxidant supplementation 60 left ventricular diastolic 60 Aß 60 chronic hepatitis cirrhosis 60 amyloid beta plaques 60 normotensive 60 autistic traits 60 hormone secretion 60 glycated hemoglobin levels 60 corticosterone levels 60 cardiac conduction 60 primary hyperparathyroidism 60 pathogenetic mechanisms 60 prefrontal regions 60 neurodevelopmental disorder 60 Vitamin D insufficiency 60 hypercapnia 60 overt hypothyroidism 60 unmeasured factors 60 dopaminergic therapy 60 pharmacological interventions 60 MYH9 gene 60 CP CPPS 60 mRNA expression 60 hepatocellular 60 abdominal obesity 60 elevated fasting glucose 60 amyloid beta plaque 60 neurotrophic 60 hyperphenylalaninemia HPA due 60 premalignant 60 ACh 60 leptin resistant 60 cholesterol metabolism 60 loop diuretics 60 intestinal epithelium 60 calculi 60 psychiatric comorbidities 60 dietary intakes 60 neuroligins 60 artery stenosis 60 brown adipose tissue 60 FGFR2 60 hyperreflexia 60 essential thrombocythemia 60 GH deficiency 60 aldehyde dehydrogenase 60 microglial 60 transferrin saturation 60 nondiabetic 60 intracranial hemorrhage ICH 60 demethylation 60 Chronic inflammation 60 lipid metabolism 60 parietal cortices 60 shorter telomeres 60 anticonvulsant medications 60 CETP gene 60 fasting insulin 60 hippocampal function 60 COX enzymes 60 β blockers 60 perioperative complications 60 pathogenetic 60 overactivation 60 colonic polyps 60 overactivity 60 ectopic expression 60 asplenia 60 protein tau 60 chromosomal instability 60 extrapyramidal symptoms EPS 60 hyperactivation 60 neuronal degeneration 60 confounding variables 60 steatosis 60 Depressive symptoms 60 hypopneas 60 Radiographic findings 60 serum lipids 60 Mood disorders 60 delayed gastric emptying 60 serum calcium levels 60 hirsutism 60 Epidemiologic studies 60 SIADH 60 thyrotoxicosis 60 maturational 60 sonographic diagnosis 60 left ventricular dysfunction 60 apoE4 60 hypovitaminosis D 60 mitochondrial defects 60 neurofibrillary tangles 60 neurodevelopmental 60 serum albumin 60 breast endometrial 60 neurohormones 60 oxysterols 60 glial tumors 60 soluble CD# ligand 60 mitochondrial proteins 60 myoclonus 60 macroalbuminuria 60 #beta HSD1 60 penetrance 60 airway hyper responsiveness 60 familial adenomatous polyposis 60 plasma folate 60 adrenal suppression 60 cardioembolic stroke 60 GRK5 60 TMEM#B 60 dyslipidemia hypertension 60 LDL cholesterol concentrations 60 neuritic 60 Atypical antipsychotics 60 nonhereditary 60 cytopenias 60 elevated IOP 60 antiphospholipid antibodies 60 Iron deficiency anemia 60 comorbid anxiety 60 Dental caries 60 genetic polymorphism 60 cardiac insufficiency 60 GSTM1 60 Genetic variation 60 hyperexcitability 60 missense mutation 60 juvenile idiopathic arthritis JIA 60 Alpha synuclein 60 renal dysfunction 60 umol L 59 prolonged QT interval 59 Magnesium deficiency 59 baroreflex 59 heterotaxy 59 cardiac abnormalities 59 HMGA1 59 serum triglycerides 59 Abeta# 59 cerebrovascular diseases 59 airway constriction 59 etiological factors 59 T2D 59 pathophysiological processes 59 slow metabolizers 59 mGluR5 antagonist 59 liver scarring 59 gastrointestinal dysfunction 59 FMRP protein 59 hepatic lipase 59 MYCN amplification 59 neurotransmitter GABA 59 lymphocyte activation 59 atypical neuroleptics 59 galanin 59 Thiazolidinediones 59 MYH9 59 urolithiasis 59 hyperalgesia 59 neurosteroid 59 chromosomal alterations 59 CaM kinase II 59 amnestic MCI 59 arterial thickening 59 cholinergic tone 59 IL 1ß 59 IDDM 59 elevated serum creatinine 59 psychosocial functioning 59 autosomal dominant disorder 59 abnormal lipids 59 APOE ε4 59 Multivariate analyzes 59 magnesium intake 59 MECP2 gene 59 tyrosine phosphorylation 59 Secondhand smoke exposure 59 TGF beta signaling 59 prognostic markers 59 B7 H3 59 white matter hyperintensities 59 myeloproliferative neoplasms 59 thrombophilia 59 C. trachomatis 59 growth hormone secretion 59 genetic locus 59 Pulmonary hypertension 59 myocardial dysfunction 59 cognitively normal 59 elevated serum ALT 59 adipocyte 59 JAK2 enzyme 59 alcoholic fatty liver 59 inherited predisposition 59 amyloid β 59 telomere shortening 59 rhythm disturbances 59 arteriosclerotic 59 Non Alcoholic Fatty 59 TTR amyloidosis 59 apoC III 59 cerebellar 59 myocardial fibrosis 59 hyperkalemia 59 APOE gene 59 mitochondrial metabolism 59 affective psychoses 59 obese postmenopausal 59 inflammatory biomarkers 59 mitochondrial function 59 astrocytic 59 schizotypal traits 59 axonal damage 59 efferent 59 KIBRA 59 systolic dysfunction 59 UCP2 59 carotid plaque 59 myo inositol 59 testicular tumors 59 aortic atherosclerosis 59 IGFBP 59 #q#.# deletion syndrome 59 hypopituitarism 59 Calcium intake 59 Erythropoietic therapies may 59 cranial irradiation 59 G allele 59 hyperparathyroidism 59 coagulopathy 59 multi factorial disease 59 rs# [004] 59 endotoxemia 59 elevated uric acid 59 protein kinase C 59 degenerative neurological diseases 59 neuropsychological functioning 59 WNK1 59 leptin concentrations 59 PPARg 59 potent inhibitors 59 insulin sensitivity 59 astrocytomas 59 phenotype 59 hyperactivated 59 cortical excitability 59 cryptogenic 59 variant angina 59 adiponectin concentrations 59 neurological degeneration 59 fatty liver disease 59 Aortic stenosis 59 diabetic kidney 59 Bardet Biedl Syndrome 59 Elevated serum 59 Alzheimer Disease AD 59 kyphosis 59 osteomalacia 59 mal absorption 59 triacylglycerol concentrations 59 LV dysfunction 59 pituitary hormone 59 endometrial hyperplasia 59 Vascular dementia 59 allergic inflammation 59 lichen planus 59 folate intake 59 Flavanols 59 intestinal motility 59 dietary DHA 59 cardioprotective effects 59 receptor gamma 59 hyperprolactinemia 59 triglyceride levels 59 APOE genotype 59 Angiotensin II 59 Cyclin E 59 spermatogenesis 59 eNOS 59 Testosterone deficiency 59 genetic determinants 59 histone modifications 59 gastro oesophageal reflux 59 MAPK pathway 59 reproductive tract infections 59 hypometabolism 59 oxidized phospholipids 59 Wernicke encephalopathy 59 diabetic retinopathy DR 59 Fas ligand 59 Oxidative damage 59 induce orthostatic hypotension 59 heterozygous familial 59 podocytes 59 atherosclerotic lesions 59 SHBG levels 59 diastolic function 59 pathological hallmark 59 compensatory mechanisms 59 transaminase levels 59 recurrent miscarriage 59 atherosclerotic cardiovascular disease 59 atherosclerosis 59 neurocognitive function 59 lung fibrosis 59 underlying vasculopathy 59 mitochondrial toxicity 59 ApoE gene 59 hyperammonemia 59 lipid elevations 59 atrophic gastritis 59 nonfasting triglycerides 59 cardio metabolic 59 daytime drowsiness 59 non fasting triglycerides 59 neurological manifestations 59 neurofibrillary 59 serum vitamin D 59 hormones leptin 59 phenotypic variability 59 tau protein tangles 59 dietary carbohydrate 59 hemodilution 59 macrophage infiltration 59 epigenetic alterations 59 natriuretic peptides 59 neurodegeneration 59 undergoing radical prostatectomy 59 cellular prion protein 59 triiodothyronine 59 genetic syndromes 59 NAT2 59 chromosomal aberrations 59 psychosocial variables 59 catecholamine 59 apolipoprotein B 59 co morbidities 59 dopamine D2 receptors 59 SGPT 59 vascular reactivity 59 tryptase 59 Adiponectin 59 Skeletal muscle 59 cardio protective 59 microglial cells 59 thrombotic complications 59 cholestasis 59 leiomyomas 59 ventricular remodeling 59 PPARγ 59 muscarinic receptors 59 LQTS 59 SSc 59 maternally transmitted 59 subcortical 59 uric acid levels 59 myeloperoxidase 59 GABRA2 gene 59 aldosterone 59 metabolic disorders 59 malabsorption 59 gliosis 59 cAMP signaling 59 preserved ejection fraction 59 pathogenic mechanisms 59 apo B 59 mitochondrial enzyme 59 behavioral disturbances 59 anovulation 59 antenatal depression 59 serotonin transporters 59 lowers blood glucose 59 interindividual variability 59 clusterin 59 atherothrombotic disease 59 GABRA2 59 dopamine receptor gene 59 transfusion syndrome 59 serum markers 59 Telomere shortening 59 synaptogenesis 59 fatty acid metabolism 59 lipohypertrophy 59 Myocardial infarction 59 PM#.# exposure 59 urinary tract symptoms LUTS 59 comorbidities 59 PAOD 59 plasma triglycerides 59 insulin resistance precursor 59 susceptibility genes 59 arachidonic acid AA 59 susceptibility gene 59 congenital malformations 59 neuro degeneration 59 innervation 59 inactivating mutations 59 abstinent alcoholics 59 Prolactin 59 amyloid pathology 59 microalbuminuria 59 generalized seizures 59 intact parathyroid hormone 59 untreated sleep apnea 59 act synergistically 59 impaired endothelial 59 myelination 59 epigenetic mechanisms 59 thromboembolic complications 59 tHcy 58 tau pathology 58 Abdominal obesity 58 Chronic insomnia 58 Nonalcoholic Fatty Liver Disease 58 5 HT1A 58 TGF b 58 proinflammatory cytokine 58 Purkinje cells 58 hormonal disturbances 58 ventricular dilatation 58 CHD7 58 alpha synuclein gene 58 APOE allele 58 NKX2 58 gastric cardia 58 satiety hormones 58 Hyperthyroidism 58 glomerular 58 prolactin levels 58 hypercoagulable 58 lysosomal storage disease 58 brain atrophy 58 anticholinergic effects 58 metabolic alterations 58 p# mutation 58 gene rearrangements 58 primary ovarian insufficiency 58 nephron 58 aMCI precursor 58 vermis 58 obstructive coronary artery 58 Clusterin 58 activin 58 Eisenmenger syndrome 58 genetic susceptibility 58 glutamate receptors 58 nonischemic 58 Serum concentrations 58 dyslipidaemia 58 parasympathetic tone 58 progressive degeneration 58 distensibility 58 postprandial glycemia 58 glucose metabolism 58 esophageal squamous cell carcinoma 58 excitotoxic 58 LDL receptor 58 chromosome rearrangements 58 periodontal infections 58 mammary tumors 58 Diabetic neuropathy 58 placental function 58 progranulin mutations 58 physiologic parameters 58 unmeasured confounders 58 persistent pulmonary hypertension 58 proto oncogene 58 Subclinical 58 metabolizing enzyme 58 AT1R 58 habitual snoring 58 cognitive dysfunctions 58 endophenotypes 58 arrhythmogenic 58 hyperoxaluria 58 serum estradiol 58 goblet cells 58 ORMDL3 58 pharmacological approaches 58 TCF#L# 58 underactive thyroid gland 58 Obstructive sleep apnea 58 DQB1 * 58 neuronal plasticity 58 Torsades de Pointes 58 fibrotic disease 58 neuron degeneration 58 subfertility 58 fibrin deposition 58 p tau 58 transaminase elevations 58 pharmacologic treatments 58 modifiable lifestyle 58 pathophysiologic mechanisms 58 catabolism 58 nonobese 58 SCN5A 58 colorectal neoplasia 58 secondary hyperparathyroidism 58 nephrotoxicity 58 bone marrow suppression 58 autoinflammatory diseases 58 PLMs 58 tonic clonic seizures 58 alanine aminotransferase ALT 58 dopaminergic 58 glucocorticoid 58 congenital abnormalities 58 spinocerebellar ataxia 58 neurologic outcomes 58 anatomical abnormalities 58 nonalcoholic fatty liver 58 leptin deficient 58 bone resorption 58 myocardial ischemia 58 protein tyrosine phosphatase 58 differential gene expression 58 progranulin 58 amino acid metabolism 58 atopic disorders 58 chorioamnionitis 58 unhealthier lifestyles 58 plasma kallikrein