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(Click for frequent words.) 74 vitro ADME 73 predictive toxicology 73 metabonomics 71 kinase profiling 71 biomarker validation 71 HTRF 70 therapeutic monoclonal antibody 70 optical biosensors 69 metabolite profiling 69 genomic proteomic 69 microRNA profiling 69 Western Blotting 69 multiplex assay 69 SNP Genotyping 69 biomarker identification 68 rxRNA 68 multiplex assays 68 quantitative proteomics 68 biomarkers predictive 68 DMPK 68 Locked Nucleic Acid LNA 68 Peptidomics 68 eTag assays 67 biochemical profiling 67 metabolomic 67 novel peptide 67 throughput RNAi 67 protein biochip 67 human microdosing 67 KineMarker TM 67 protein biomarker discovery 67 vivo pharmacology 67 Genedata Screener ® 67 qNPA 67 diagnostic prognostic 67 novel peptides 66 biomarker discovery 66 BACcel 66 systemic RNAi 66 isoform selective 66 kinase assay 66 Activity Assay 66 Alfacell proprietary ribonuclease 66 peptide synthesis 66 multiplex immunoassay 66 quantitative PCR qPCR 66 Onconase 66 SELDI 66 toxicogenomic 66 LentiVector technology 66 liposomal delivery 66 biased ligand 66 Corus CAD 66 biomarker assays 66 delipidation 66 AAG geldanamycin analog 66 bioanalysis 66 molecular assays 66 Infinium assay 66 LC-MS/MS 66 multiplexed assays 66 VeraTag 66 anticoagulant reversing agent 66 SiMoA 66 immunoassay kits 66 bioprocesses 66 protein quantitation 66 tubulin inhibitor 66 ADME Tox 65 metabolomics driven 65 miRNA biomarkers 65 kinase assays 65 quantitative gene expression 65 Mass Spectrometry MS 65 GLP toxicology studies 65 NEUGENE R 65 Detect Ready MRSA 65 xCELLigence 65 RT qPCR 65 Genedata Expressionist 65 radiolabeling 65 protein biomarker 65 proprietary LNA 65 LC MALDI 65 comparative genomic hybridization 65 transfection reagents 65 mass spectrometric 65 biomolecular interactions 65 nucleic acid isolation 65 GLP toxicology 65 DNA methylation biomarkers 65 phenotyping 65 enzymatic reactions immunodiagnostics 65 immunotherapeutics 65 synthetic peptides 65 Anticalins R 65 OTCBB PWRM.OB 65 protein ligand interactions 65 Isis antisense 65 massively parallel sequencing 65 detection reagents 65 QPCR 64 EndoTAG TM 64 PK PD 64 molecular diagnostic assays 64 NADiA 64 Quantitation 64 accurate quantitation 64 MALDI-TOF/TOF 64 multiparametric 64 BioFocus DPI Galapagos 64 proprietary PEGylation 64 biophysical techniques 64 DiLA2 64 microdroplet based 64 pharmacophore 64 ArQule Kinase Inhibitor Platform 64 GelSite polymer 64 Protein Expression 64 therapeutic monoclonal antibodies 64 targeted radiotherapeutic 64 therapeutic peptide 64 toxicogenomics 64 CA9 SCAN 64 SinuNase ™ 64 gene expression assays 64 Luminex xMAP technology 64 BACcel ™ system 64 protein microarrays 64 biocatalytic 64 preclinical efficacy 64 quantitative PCR 64 Anticalin ® 64 GelSite R polymer 64 Enhanze Technology 64 RNA amplification 64 antibody reagents 64 p# inhibitor 64 GIPET 64 LTQ Orbitrap Velos 64 glycomics 64 SureSelect 64 SILAC 64 novel histone deacetylase 64 genotyping assays 64 biologic therapeutics 64 TOF TOF 64 recombinant antibodies 64 HTRF R 64 vitro assay 64 PET tracers 64 Adnectin 64 NeuroSTAT ® 64 amaZon 64 Micromet BiTE 64 HepDirect R 64 NEUGENE antisense 64 LabChip GX 64 surface plasmon resonance SPR 64 immunodiagnostic 64 molecular biomarkers 64 Quotient Bioresearch 64 Single Molecule Array SiMoA 63 adrenergic regulation 63 LCQ Fleet 63 Anavex #-# 63 N glycan 63 therapeutic radiopharmaceuticals 63 protein purification 63 xMAP technology 63 throughput mass spectrometry 63 small molecule PEGylation 63 cheminformatics 63 Epitome Biosystems 63 metabolomic profiling 63 comparative genomic 63 Rosetta Syllego 63 LC MS MS 63 Affymetrix GeneChip 63 HybSelect 63 A3 adenosine receptor 63 iTRAQ 63 Pichia pastoris 63 Cisbio 63 Kapa Biosystems 63 proteomics bioinformatics 63 APTIMA HPV 63 recombinant biopharmaceutical 63 CCR9 antagonist 63 nCounter 63 microbial genome sequencing 63 Affymetrix GeneChip ® 63 oligonucleotide ligation 63 genomic profiling 63 vitro toxicology 63 ESI TOF 63 CBLC# 63 Trofex 63 #T# L1 63 Theranostics 63 automated microscopy 63 nucleic acid purification 63 TaqMan assay 63 novel therapeutic antibodies 63 Rosetta Elucidator 63 liquid chromatography tandem 63 multiplex PCR 63 proteomics genomics 63 metabolomics 63 zinc finger nuclease 63 quantitation 63 nucleic acid extraction 63 Posiphen TM 63 proteomics metabolomics 63 mass spectrometry instrumentation 63 ultrasensitive detection 63 genotyping gene expression 63 EGFR HER 63 pharmaceutically relevant 63 transcriptomics proteomics 63 Anticalins ® 63 diagnostic assays 63 bisulfite sequencing 63 GeneICE 63 MassARRAY platform 63 Squalamine 63 PORxin TM 63 cytometry 63 humanized monoclonal antibodies 63 Applied Biosystems TaqMan 63 Alkaline Phosphatase 63 Proteomic 63 Abbott ARCHITECT 63 mda 7 63 MDRNA proprietary 63 Technology LVT 63 histone deacetylase HDAC 63 SELDI TOF MS 63 nucleic acid assays 63 Genedata Expressionist ® 63 Pertuzumab 63 TaqMan R 63 targeted resequencing 63 genetics genomics 63 Quantitative PCR 63 kidney urologic 63 ionization mass spectrometry 62 Vaxfectin TM 62 ClinProt 62 protein electrophoresis 62 G Protein Coupled 62 immunochemistry 62 Selexis 62 Spraytec 62 theranostic 62 peptidomimetic 62 HTS assay 62 proteomic analyzes 62 mass spectrometry MS 62 Orbitrap 62 trastuzumab DM1 T DM1 62 biomarker discovery validation 62 immune modulating 62 IMA# 62 Spiegelmer 62 experimentally validated 62 PSMA ADC 62 chemogenomics 62 DHPLC 62 Array CGH 62 Supernus Pharmaceuticals 62 MetaCore TM 62 SIX RO ROG 62 qualitative serum 62 HLA genotyping 62 Sequence Capture 62 SoftGenetics 62 RONDEL ™ 62 GAP #B# 62 Perflubutane Polymer Microspheres 62 lipidomics 62 thetreatment 62 immunodiagnostics 62 dotLab System 62 Enhanze 62 nCounter Analysis System 62 ZFN modified 62 BAL# [002] 62 LTQ Orbitrap 62 Aptamer 62 NTDDS 62 selective estrogen receptor modulator 62 OpenArray platform 62 Archexin 62 novel immunotherapeutic 62 Epigenomics proprietary 62 molecular imaging radiopharmaceuticals 62 oral prodrug 62 AFFITOME R 62 reagent kits 62 recombinant polyclonal antibodies 62 SGLT Inhibitors 62 AVEO integrates proprietary 62 HPAPIs 62 anionic backbone 62 Immunotherapeutic 62 flow cytometric 62 investigational therapies 62 Angiocept 62 novel orally bioavailable 62 COLD PCR 62 enzymes immunodiagnostics 62 ARCHITECT HIV 62 XOMA 3AB 62 genomics transcriptomics 62 Avantra 62 ADVIA Centaur XP 62 Mass spectrometry 62 transcriptomics 62 antibody arrays 62 ATL# [001] 62 FOLOTYN ® 62 genomic biomarkers 62 ENMD # 62 NADiA ProsVue 62 Cloretazine ® 62 delivery polymer matrix 62 nanomedicines 62 non nucleoside 62 BACcelr8r TM 62 miRview mets 62 Xanafide 62 HCV protease inhibitors 62 ImmuKnow TM 62 vivo potency 62 Genisphere 62 MelaFind R 62 preclinically 62 SmartChip System 62 Isolation Kit 62 epigenetic therapies 62 BRAF inhibitors 62 Panzem 62 multiplex immunoassays 62 HCV polymerase 62 NMR LipoProfile test 62 THR beta agonist 62 cell lysate 62 MALDI TOF mass spectrometry 62 HPV genotyping 62 platform HDL Mimetic 62 Gamunex C 62 TriGrid 62 Stapled Peptide 62 deCODE chemistry 62 ChIP chip 62 CRD5 62 small molecule agonists 62 Prodarsan R 62 molecular biomarker 62 ALTROPANE R 62 Aplidin 62 Cand5 62 triple quadrupole mass spectrometer 62 Illumina Solexa 62 oligonucleotide synthesis 62 Rosetta Genomics microRNA 62 taxane derivative 62 hyaluronidase enzyme 62 Novolimus 62 PCR reagents 62 NASDAQ CPHD 62 Erimos 62 small molecule modulators 62 depsipeptide 62 peptide conjugated 61 Curaxin 61 Watson LIMS 61 BioMAP 61 ADME 61 ATL/TV# 61 diagnostic biomarker 61 bioimaging 61 immunotherapeutic vaccine 61 BiTE 61 leachables 61 xCELLigence System 61 Genedata 61 throughput genomic 61 transcriptome sequencing 61 Nanobody ® 61 illumigene C. difficile 61 quantitative Nuclease Protection 61 bioinnovation 61 NuMimetic TM 61 ONCONASE R 61 Ice COLD PCR 61 anticancer therapeutics 61 biotransformation 61 vitro transcription 61 Syllego system 61 Genomatix 61 radiolabelled 61 indibulin 61 DepoVax TM 61 Elagolix 61 HE4 test 61 epigenetic profiling 61 Affibody 61 PROfusion 61 ospemifene 61 NADiA R 61 radiotracers 61 synthetic siRNA 61 Affymetrix microarray technology 61 liquid chromatography mass spectrometry 61 miRview TM mets 61 NYSE Amex PBTH 61 index assay IVDMIA 61 pharmacodynamic markers 61 Nasdaq CGEN 61 PHX# 61 enzymology 61 methylation markers 61 multiplex biomarker 61 antitumoral 61 MDx tests 61 NB S# strontium malonate 61 Warfarin Sensitivity Test 61 potently inhibit 61 Tr DNA 61 ProteinChip 61 small molecule activators 61 ZEVALIN ® 61 Liposomal 61 vivo preclinical 61 PhG alpha 1 61 Inc. Nasdaq SDIX 61 genomic biomarker 61 molecular profiling 61 preclinical pharmacology 61 PDE4 inhibitor 61 Monogram Trofile TM 61 anti amnesic 61 rheometer 61 NPC 1C 61 OTCBB PYTO 61 radiotherapeutic 61 tumor hypoxia 61 selective orally bioavailable 61 Akebia Therapeutics 61 CellPort Technologies 61 multi analyte 61 MEK inhibitors 61 ADME properties 61 Flow cytometry 61 Septin9 biomarker 61 HemoGenix 61 MetaBase TM represents 61 MKC# MKC# PP 61 biocatalyst 61 hot melt extrusion 61 investigational humanized monoclonal antibody 61 ESBA# 61 Genpathway 61 Bioral Amphotericin B. 61 ProNAi 61 pathophysiological effects 61 SNP genotyping 61 SynCon TM 61 dotLab 61 Co Receptor Tropism 61 P2V TM 61 AQUA ® 61 biomarker 61 nucleic acid detection 61 high throughput genotyping 61 HDL Mimetic Peptide 61 antimitotic 61 ELISA kit 61 RECOTHROM R 61 Aquinox 61 XmAb 61 siRNA conjugates 61 FT IR spectroscopy 61 AVI NEUGENE 61 BGC# 61 2D gel 61 TRV# [001] 61 IDI MRSA 61 MT#/MEDI-# 61 selective kinase inhibitors 61 synDNA TM 61 FlexmiR 61 inhibit metastasis 61 lipid nanoparticle 61 fusion enhancers 61 generation sequencing NGS 61 dasatinib Sprycel 61 InterfeRx TM 61 Kahalalide F 61 biomarker assay 61 DiLA 2 61 MALDI TOF TOF 61 radezolid 61 serum biomarkers 61 siRNA synthesis 61 BioScale 61 SpectraMax R 61 PathHunter 61 MaxCyte STX 61 TPI ASM8 61 PROSTASCINT R 61 multimodality imaging 61 siRNA therapeutic 61 TSQ Quantum 61 bioinformatic approaches 61 Bioanalysis 61 nitric oxide donating 61 clinically validated 61 chemoinformatics 61 LANCE Ultra 61 POTELLIGENT ® 61 biostatistical analysis 61 oral taxane 61 LentiVector 61 epothilone 61 superparamagnetic iron oxide nanoparticles 61 metaglidasen 61 Affibody ® molecules 61 DNA intercalator 61 NEUGENE 61 reagent kit 61 Spiegelmer ® 61 virus AAV 61 cobas 61 CINtec R 61 cMET 61 peptide therapeutics 61 PLAC test 61 silico modeling 61 synDNA 61 cellular immunotherapy 61 CyPath R 61 QTinno TM 61 combinatorial libraries 60 delta isoform 60 DNA Methylation 60 liposomal formulation 60 MALDI MS 60 SimCell 60 assay detects 60 preanalytical 60 AvalonRx R 60 PEGylated interferon 60 Accium 60 QTRAP 60 bioanalytical chemistry 60 vivo molecular imaging 60 proteomics 60 Onalta 60 xTAG RVP 60 targeting CD# 60 QuantiGene 60 pharmacogenetic testing 60 radiolabeled 60 NuroPro R 60 bioproduction 60 Vevo LAZR system 60 non nucleoside HCV 60 delafloxacin 60 HeliScope Sequencer 60 synthetic retinoid 60 chemometrics 60 PCR assay 60 Comparative Genomic Hybridization 60 Cisbio Bioassays 60 Rosetta Genomics Nasdaq ROSG 60 IMiDs ® 60 renin inhibitors 60 Qdot 60 genomic epigenomic 60 PCR Arrays 60 vivo imaging 60 highly selective inhibitor 60 DiLA2 delivery 60 dSLIM 60 XmAb ™ 60 PK PD modeling 60 vinca alkaloid 60 orally inhaled migraine 60 behavioral neurobiology 60 RapidChek SELECT 60 Deforolimus 60 acetylcholinesterase AChE 60 GMX# 60 selective kinase inhibitor 60 Epothilones 60 mutational analysis 60 Solulin 60 genomics proteomics 60 please visit www.metabolon.com 60 molecular diagnostic assay 60 protein crystallography 60 buccal delivery 60 Elan NanoCrystal 60 virosome 60 exon skipping 60 IVDMIA 60 translational genomics 60 Biomarker Discovery 60 ADVIA Centaur 60 Detect Ready 60 skeletal sarcomere activators 60 vivo fluorescence imaging 60 candidates Azedra TM 60 Transfluor 60 TAKSTA 60 BrachySil TM 60 predictive biomarker 60 blood serum biomarkers 60 sDNA 60 haplotyping 60 potent suppressor 60 TaqMan 60 ChIP seq 60 Omacetaxine 60 PhenoSense GT 60 generation URAT1 inhibitor 60 silico prediction 60 MetaDrug TM 60 nucleotide analog 60 proteomic 60 favorable pharmacokinetic profile 60 CRMD# 60 commercializing anti infective 60 Nasdaq IDRA today 60 Azedra 60 phosphatidylserine PS targeting 60 DPOLT 60 molecular chaperone amplification 60 ALK inhibitors 60 plasmid DNA vaccine 60 Time Resolved Fluorescence 60 ETD PTR 60 ALN TTR 60 Bioral 60 Transfection Reagent 60 HER1 60 vitro dissolution 60 CCX# 60 liquid chromatographic 60 GenWay 60 Annexin A5 60 HepDirect prodrug 60 triphendiol 60 AMPAKINE 60 pathogen detection 60 immatics 60 SCIB1 60 Taqman 60 xMAP Technology 60 Fleximer R 60 SERCA2a 60 ZFN technology 60 Epi proColon 60 HuMax TAC 60 ZFP technology 60 assay kits 60 novel immunotherapies 60 APTIMA 60 cellular bioenergetics 60 Exherin TM 60 Hedgehog inhibitor 60 YONDELIS R 60 Kosan dependence 60 Pepducin 60 ICH guidelines 60 VERSANT 60 hERG 60 Micromet proprietary BiTE 60 transcriptomic 60 genotyping assay 60 EGS# 60 patented Bioral 60 Dynabeads 60 Cerashield ™ 60 DOS# 60 menstrual stem cell 60 Cytometry 60 Guava EasyCyte 60 tiapamil 60 CytomX Therapeutics 60 enzyme immunoassay 60 shRNA libraries 60 Kinexus 60 pharmacogenetic 60 macromolecular structure 60 GVAX ® 60 predictive biomarkers 60 Metabolism Excretion 60 LEAPS TM 60 microRNA biomarkers 60 5 hmC 60 NP2 60 LNP formulations 60 Intravail ® 60 Varespladib 60 immunohistochemistry IHC 60 encapsulates siRNAs 60 DXL# 60 CompoZr 60 Applied Biosystems MDS SCIEX 60 anti infective treatments 60 Annexin V 60 lysate 60 proteomic biomarkers 60 dAbs 60 CCR1 60 affinity ligands 60 anti secretory 60 Nanobodies R 60 Pfenex Expression Technology 60 next generation URAT1 60 Progenta TM 60 chromatin immunoprecipitation ChIP 60 Chimigen 60 intranasal delivery 60 glyco 60 ZFN 60 Respiratory Viral Panel 60 optimal dosing regimens 60 HuCAL PLATINUM 60 Corixa Corporation 60 homology modeling 60 oncolytic virus therapies 60 cytotoxicity assays 60 Solazed TM 60 bioprocess engineering 60 vivo validation 60 vidofludimus 60 polyketides 60 mGluR2 NAM 60 Davanat 60 ADMET Predictor ™ 60 situ hybridisation 60 RNAi therapeutic targeting 60 near infrared spectroscopic 60 antibody MAb 60 ERYtech Pharma 60 Pharmacodynamic 60 monoclonal antibody mAb 60 recombinant PSMA vaccine 60 humanised antibody 60 protein biochips 60 PORxin TM platforms 60 patented Enhanced Photoemission 60 pharmacological chaperone 60 RIGScan 60 CINQUIL 60 Panzem NCD 60 attach auristatin 60 NanoCrystal technology 60 genetic biomarkers 60 ADMETRx 60 SynCon 60 physiologically relevant 60 AltheaDx 60 RNA interference RNAi therapeutics 60 VITROS R 60 aCGH 60 biophotonic 60 LAB CGRP 60 VivaGel ™ 60 ProMIS TM 60 patented NanoStat ™ 60 Cdc7 60 STEDESA 60 MediVas 60 Aganocide ® 60 microdosing 60 nasal decolonization 60 anti JCV antibody 60 KeyGene 60 Nautilus Biotech 60 multiphoton microscopy 60 CYT# potent vascular disrupting 60 Solorel TM 60 BioSilicon 60 Scil Proteins 60 CGH CNV 60 siRNA binds 60 combinatorial chemistry 60 staphylococcal vaccine 60 EGIR 60 RainStorm 60 Protagen 60 PAION AG ISIN 60 Puratein R 60 Anticalin R 60 Novosom 60 GFT# 60 oral picoplatin 60 engineered proteases 60 biochemical assays 60 neratinib 59 topoisomerase II inhibitor 59 Cervista HPV HR 59 Ceragenin ™ 59 RNA oligonucleotides 59 microarray gene expression 59 vascular disrupting agents 59 Phase 1a clinical 59 Addex Pharmaceuticals www.addexpharma.com discoverMunsif Khan spokesman 59 protein tyrosine phosphatase 1B 59 siRNA therapeutics 59 Fleximer 59 fast skeletal troponin 59 Nanobodies ® 59 validate biomarkers 59 ImmuKnow R 59 CEQ# 59 QIAsymphony RGQ 59 adrenal steroid hormones 59 bioactive compound 59 modified nucleoside 59 Kreatech 59 TEM STEM 59 proprietary polysaccharide 59 Receptors GPCRs 59 peptides proteins 59 Capsulution 59 viral tropism 59 Presents Preclinical 59 cyclophilin inhibitor 59 bioassays 59 eligen 59 Injectable Suspension 59 oligonucleotide microarrays 59 BACcelr8r 59 HuMax CD#b 59 trodusquemine 59 Arcelis ™ 59 Potelligent 59 galectin 59 SPL# Gel vaginal microbicide 59 Dataflow Manager 59 bioassay 59 transcriptome analysis 59 ddRNAi 59 gene expression profiling 59 SensoLyte ® 59 quantitative polymerase chain 59 VitiGam 59 include VALSTAR TM 59 afamelanotide 59 Next Generation Sequencing 59 HyACT 59 Vaxfectin 59 Therapeutic Competitors Companies 59 potent antiproliferative 59 microbial genomics 59 Soliris eculizumab 59 transcutaneous immunization TCI 59 antisense inhibitors 59 Phenyx 59 CellCiphr 59 HuCAL R 59 DiLA2 Platform 59 de novo sequencing 59 RNAi compounds 59 Alexza Staccato 59 Exosome 59 LTQ Velos 59 GlycosBio 59 OGAP R 59 DispersinB ® 59 Phase Ib II 59 Myeloperoxidase 59 ZFP Therapeutics 59 monoclonal antibody MAb 59 CRLX# 59 proprietary transdermal 59 ColoMarker 59 Vidofludimus 59 antagomirs 59 selective adenosine 59 immunotoxin 59 immunotherapeutic approaches 59 Spiegelmers 59 BioLeap 59 OMP #M# 59 osteopontin OPN 59 Guanilib 59 Next Generation Sequencing NGS 59 YONDELIS 59 NS#/#A protease 59 Agilent microarray 59 Monoclonal antibody 59 Senexis 59 TELINTRA R 59 neuronal nicotinic receptor NNR 59 humanized monoclonal 59 Elucidator system 59 neutrophil gelatinase associated lipocalin 59 photostability 59 renin inhibitor 59 Protein Kinase C 59 GAMMAGARD 59 splice variants 59 allosteric modulation 59 oral antiviral 59 OpenArray ® 59 Proxeon 59 CyPath ® 59 emulsion PCR 59 Azedra ™ 59 ChIP 59 proteomic profiling 59 MVA BN R 59 MedChem Studio 59 LNA TM 59 UsiRNAs 59 Homspera ® 59 histone acetyltransferase 59 Evotec OAI 59 stable nucleic acid 59 HER2 ErbB2 59 phage display technology 59 intranasal formulation 59 SensoLyte ™ 59 mRNA Seq 59 IMiDs R 59 ELISA assays 59 MassWorks 59 Bioo Scientific 59 DNA microarray 59 purinergic receptors P#X# 59 PCA3 gene 59 torezolid 59 CardioPET 59 Anidulafungin 59 Selective Electrochemical Tumor Ablation 59 Activotec 59 isatoribine 59 biocatalysis 59 sulfonylhydrazine class 59 commercial bioproduction 59 Geniom RT Analyzer 59 potency selectivity 59 Vitro Diagnostic IVD 59 DiscoveRx 59 mediated inhibition 59 Zemiva TM 59 fosbretabulin 59 MP4 molecule 59 butyrylcholinesterase 59 GLP compliant 59 PERCIVIA 59 LungExpress Dx TM 59 KinomeScan 59 protein kinase inhibitors 59 PCR Polymerase Chain Reaction 59 HCV NS3 protease 59 Breast Cancer Assay 59 EP #R 59 AFREZZA TM 59 orally inhaled 59 Cumulase 59 PET radiopharmaceuticals 59 Roche AmpliChip 59 clinically differentiated 59 qPCR 59 CyPath ® assay 59 biocatalytic processes 59 anti CD3 59 nanopharmaceutical 59 recombinant antibody 59 liposome formulation 59 diagnostic reagents 59 HDL Therapy 59 ImmunoCAP ® 59 pharmacodynamic parameters 59 metabolite profiles 59 custom peptide synthesis 59 Dyax phage display 59 recombinant albumin 59 picomolar 59 BACcel ™ 59 Prodarsan ® 59 eFlow R 59 transcriptome profiling 59 Thiovir 59 RECAF TM 59 Liquid Chromatography Mass Spectrometry 59 SNP arrays 59 affinity purification 59 Locked Nucleic Acid 59 oral ghrelin agonist