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(Click for frequent words.) 79 Orphan Drug Designation 77 granted orphan 77 orphan designation 76 Orphan Drug designation 75 orphan medicinal product 74 Orphan Medicinal Product 74 Orphan Drug 72 Orphan Drug status 68 Orphan designation 68 Orphan Drug designations 66 Fast Track designation 66 granted Orphan Drug 66 FDA Orphan Drug 64 granted orphan medicinal 64 Orphan Designation 63 Priority Review 62 Orphan Status 61 Fast Track Designation 61 Granted Orphan Drug 61 Firazyr 61 Fast Track Status 60 Phenoptin 60 Evoltra ® 60 Medicinal Products EMEA 60 Orphan Drug Status 60 Icatibant 59 TEMODAL 59 OMP designation 59 Fast Track designations 58 Orphan Drugs 58 Orphan medicinal 58 clofarabine 58 Arcalyst 58 Lambert Eaton Myasthenic 58 Somatuline Depot 58 Advexin 58 ATryn ® 58 Amrubicin 58 Vandetanib 58 Preotact 58 Ceflatonin 58 Zalbin 58 Kuvan 57 satraplatin 57 Civacir 57 ATryn R 57 Torisel 57 Clolar 57 Application MAA 57 Increlex 57 amifampridine phosphate 57 investigational compound 57 Aryplase 57 Receives Fast Track 57 orphan medicinal 57 SJIA 57 BENLYSTA 57 severe gastroparesis 57 Noxafil 57 Elaprase 57 Cladribine Tablets 57 oncology indications 57 ELAPRASE 57 Kepivance 57 Evoltra TM 56 granted Fast Track 56 AA amyloidosis 56 Syndrome LEMS 56 Rapinyl 56 Mepact 56 Cladribine 56 investigational 56 targeted radiotherapeutic 56 tamibarotene 56 DPP4 inhibitor 56 relapsing forms 56 Dupuytren contracture 56 Junovan 56 Rituxan rituximab 56 XIAFLEX ™ 56 Pixantrone 56 Satraplatin 56 Cimzia 56 Marqibo 56 Bronchitol 56 Arzerra ofatumumab 56 Etanercept 56 Receives Orphan Drug 56 Esbriet 56 Accelerated Approval 56 JAK inhibitor 56 ELIQUIS 56 perifosine 56 Bayer Nexavar 56 Zenpep 56 Marketing Authorization Application 56 Increlex TM 56 Eprodisate KIACTA TM 56 proteasome inhibitor 56 Pirfenidone 56 rilonacept 55 Troxatyl 55 RANK Ligand inhibitor 55 histone deacetylase HDAC inhibitor 55 Orphan Drug Act 55 eprodisate Fibrillex TM 55 Maribavir 55 Actemra tocilizumab 55 investigational humanized monoclonal antibody 55 BEMA Fentanyl 55 Plenaxis R 55 Esbriet ® 55 Folotyn 55 Archexin 55 Fodosine 55 Jevtana 55 Uplyso 55 taliglucerase alfa 55 Onconase 55 Treanda 55 Fibrillex TM 55 Evoltra 55 ADVEXIN 55 Increlex R 55 Panzem R 55 Clofarabine 55 BENLYSTA ® 55 Peginterferon alfa 2b 55 Abstral 55 MEPACT 55 Tarceva TM 55 Cellegesic 55 oral cladribine 55 humanized monoclonal antibody 55 myelodysplastic syndromes 55 Revolade 55 Yondelis ® 55 HQK 55 Pfizer Sutent 55 Xyrem ® 55 maribavir 55 Raptiva R 55 Cethrin 55 SNT MC# 55 cladribine 55 Soliris TM eculizumab 55 EOquin 54 Grants Orphan Drug 54 Vidaza 54 Iluvien ® 54 Zelrix 54 eltrombopag 54 refractory APL 54 Zavesca 54 investigational therapies 54 SYCREST 54 alvimopan 54 SUTENT ® 54 Gencaro 54 Rhucin ® 54 Drug Eluting Stent System 54 post menopausal osteoporosis 54 Brilique 54 injectable formulation 54 Perifosine 54 Evoltra R 54 Receives Orphan Drug Designation 54 GTC recombinant human 54 TNF Tumor Necrosis Factor 54 MPS VI 54 heterozygous FH 54 ADVEXIN p# therapy 54 BAY #-# 54 Trobalt 54 Votrient 54 topical NSAID 54 carfilzomib 54 albinterferon alfa 2b 54 amrubicin 54 Positive Opinion 54 registrational 54 Ceplene 54 Rebif ® 54 TREANDA 54 Removab 54 Humira adalimumab 54 Liprotamase 54 Vpriv 54 XIAPEX ® 54 ankylosing spondylitis psoriatic arthritis 54 CryoSeal FS System 54 Receives Positive Opinion 54 pralatrexate 54 Junovan TM 54 Nexavar ® 54 Forsteo 54 Promacta 54 Alitretinoin 54 CHMP recommendation 54 OMAPRO ™ 54 BLA submission 54 Onco TCS 54 Behcet uveitis 54 Preotact R 54 tetrabenazine 54 Arranon 54 European Medicines Evaluation 54 Friedreich Ataxia FRDA 54 OHR/AVR# 54 Esbriet pirfenidone 54 novel oral anticoagulant 54 Nimotuzumab 54 forodesine hydrochloride 54 biologic therapy 54 Octreolin 54 Marketing Authorisation Application 54 Urocidin 54 orBec 54 Factor VIIa 54 Ilaris 54 Ceflatonin R 54 Aviptadil 54 Nebido 54 ambrisentan 54 RoActemra 54 Voraxaze 54 pirfenidone 54 MAGE A3 ASCI 54 FIRMAGON R 54 Pralatrexate 54 histamine dihydrochloride 54 Apricus Bio 54 Tetrabenazine 54 Nuedexta 53 Actemra 53 daclizumab 53 Febuxostat 53 small molecule Hedgehog 53 Sanvar R 53 Marketing Authorization 53 FRDA 53 Benlysta belimumab 53 Wyeth Torisel 53 PNP inhibitor 53 omacetaxine 53 ONSOLIS 53 methylnaltrexone bromide 53 Campath ® 53 Soliris eculizumab 53 thymalfasin 53 Mimpara 53 Traficet EN 53 HIV protease inhibitor 53 Santhera 53 Telavancin 53 Vidaza azacitidine 53 Romiplostim 53 orally administered 53 Clavis Pharma 53 Celgene Revlimid 53 Nexavar sorafenib 53 Antegren 53 FOLOTYN ® 53 Pegintron 53 GALNS 53 atacicept 53 Clolar ® 53 TELINTRA 53 investigational drug 53 reslizumab 53 ZEFTERA TM Zevtera TM 53 Alvesco R 53 relapsing multiple sclerosis 53 Abiraterone acetate 53 Bafetinib 53 pancreatic enzyme replacement 53 acetonide FA 53 Omapro 53 drug ISA# 53 Li Fraumeni Syndrome 53 Sebivo 53 ELND# 53 Replagal 53 Onalta 53 Naglazyme 53 Vilazodone 53 pseudobulbar affect PBA 53 Gamunex C 53 VEGF Trap 53 BYETTA ® 53 ixabepilone 53 PDE4 inhibitor 53 refractory chronic lymphocytic 53 Onsolis 53 refractory Hodgkin lymphoma 53 Albugon 53 Sutent sunitinib 53 cutaneous T 53 gastrointestinal stromal tumors 53 ankylosing spondylitis 53 hypereosinophilic syndrome 53 Saxagliptin 53 XGEVA 53 IAP inhibitor 53 Tostrex 53 Keppra ® levetiracetam 53 tiapamil 53 registrational studies 53 TORISEL TM 53 Ceflatonin ® 53 anticancer compound 53 Application BLA 53 Milnacipran 53 Pafuramidine 53 Teysuno 53 Zorbtive TM 53 NOXAFIL 53 hereditary angioedema 53 fidaxomicin 53 vemurafenib 53 phase IIb clinical 53 sorafenib tablets 53 nasal calcitonin product 53 HCV protease inhibitor 53 IMiDs 53 Virulizin 53 PREOS 53 Cimzia certolizumab pegol 53 sunitinib malate 53 REBETOL combination therapy 53 non alcoholic steatohepatitis 53 Fx #A 53 CNTO 53 P#X# antagonist 53 INC# 52 Nexavar tablets 52 Ambrisentan 52 class mGluR5 inhibitor 52 Zebinix R 52 anticancer agent 52 Orazol 52 azacitidine 52 Cinryze TM 52 ALN TTR 52 YONDELIS 52 orally administered inhibitor 52 MyVax R 52 apaziquone 52 rheumatoid arthritis psoriatic arthritis 52 Carfilzomib 52 Plicera 52 PDUFA date 52 Leukine 52 diabetic neuropathic pain 52 Gleevec imatinib mesylate 52 Sycrest 52 Zenvia ™ 52 Pradefovir 52 RAPAFLO 52 GlycoPEG GCSF 52 methylnaltrexone 52 Golimumab 52 Dacogen injection 52 tafamidis 52 davunetide 52 Pivotal Phase III 52 IRESSA 52 GTC recombinant form 52 Silodosin 52 Diamyd ® 52 Belimumab 52 romiplostim 52 Troxatyl TM 52 pancreatic insufficiency 52 LymphoStat B belimumab 52 Sylvie Gregoire President 52 Velcade bortezomib 52 Addrenex 52 Genasense ® 52 Herceptin trastuzumab 52 Hycamtin 52 Virulizin R 52 Tranzyme 52 HoFH 52 sNDA 52 HuMax CD4 52 equine osteoarthritis 52 systemic immunosuppressive drugs 52 investigational pharmacologically unique 52 TAXUS Element Stent System 52 Orathecin 52 Increlex ® 52 Glybera R 52 RELISTOR ® 52 Atrasentan 52 PGL# 52 molecular imaging radiopharmaceutical 52 Raptiva ® 52 Amigal 52 Horizant 52 forodesine 52 Modrenal R 52 Gattex 52 Tasigna nilotinib 52 palifermin 52 BLP# Liposome Vaccine 52 Orapred ODT 52 VPRIV 52 Opterone R 52 Dupuytren Contracture 52 FACTIVE R gemifloxacin 52 linaclotide 52 Intravenous CP 52 Clevudine 52 Marketing Authorisation 52 Centralized Procedure 52 IMGN# 52 Ixempra 52 Tibotec Therapeutics division 52 Nabi HB Intravenous 52 Cimzia ® certolizumab pegol 52 MAA submission 52 IL# PE#QQR 52 ZADAXIN ® 52 tivozanib 52 Advagraf 52 rolapitant 52 VIDAZA 52 Rapydan 52 OMAPRO 52 Combidex 52 Gleevec imatinib 52 severe hypercholesterolemia 52 Ustekinumab 52 peripheral neuropathic pain 52 Kuvan R 52 Panzem 52 Retacrit 52 Firdapse 52 Friedreich Ataxia 52 IMA# 52 Personalized Immunotherapy 52 Adenuric R 52 FIRAZYR 52 CEQ# 52 Pazopanib 52 chemotherapy induced neutropenia 52 PRTX 52 ALN PCS 52 Fresenius Biotech 52 mertansine 52 Biologics License Application BLA 52 Biologics License Application 52 autoimmune indications 52 actinic keratosis 52 UPLYSO 52 vandetanib 52 diarrhea predominant irritable 52 Bezielle 52 orBec R 52 Tramadol ER 52 Zavesca r 52 nephropathic cystinosis 52 INCB# [002] 52 recurrent refractory 52 Gleevec Glivec 52 Dynepo 52 Vertex telaprevir 52 cutaneous T cell 52 Supernus 52 liposomal formulation 52 GW# [003] 52 XIAPEX 52 terlipressin 52 pomalidomide 52 Ciclesonide 52 RNAi therapeutic targeting 52 Desmoteplase 52 Simulect 52 oral prodrug 52 ONCASPAR 52 GVAX cancer 52 Iluvien 52 ZACTIMA 52 Adcirca 52 Campath alemtuzumab 52 Tanespimycin 52 subcutaneously administered 52 ATG Fresenius S 52 cell lymphoma CTCL 52 post herpetic neuralgia PHN 52 Soliris 52 myelofibrosis 52 BENLYSTA TM 52 Allovectin 7 52 thalidomide Thalomid 52 Vectibix panitumumab 52 ocrelizumab 52 SEBIVO 52 Ganite R 52 highly selective adenosine 52 GI GVHD 52 sitaxsentan sodium 52 liver resection surgeries 52 #D#C# 52 Zerenex 52 pulmonary arterial hypertension PAH 52 StaphVAX 52 herpetic keratitis 52 mTOR inhibitor 52 Zingo TM 51 Riquent 51 Bayer Onyx 51 RSR# 51 Virulizin ® 51 postherpetic neuralgia 51 idursulfase 51 LUCASSIN 51 Australian Therapeutic Goods 51 MAXY G# 51 Mipomersen 51 Xanafide 51 advanced carcinoid 51 mild vasodilator 51 temsirolimus 51 ThermoDox ® 51 Lenalidomide 51 Plecanatide 51 CONBRIZA 51 Corlux 51 granted Orphan Designation 51 chronic idiopathic thrombocytopenic purpura 51 Zytiga 51 Sprycel 51 neovascular age 51 Relistor 51 dalbavancin 51 Cinryze ™ 51 Zarnestra 51 FTY# 51 obatoclax 51 RhuDex ® 51 tanespimycin 51 IMiD 51 markets HP Acthar 51 Actimmune ® 51 velaglucerase alfa 51 sapropterin dihydrochloride 51 TolerRx 51 Frova R 51 Teflaro 51 STELARA TM 51 Leukine ® 51 adalimumab Humira 51 6R BH4 51 DORIBAX 51 Somatuline R Autogel R 51 Argatroban 51 Annamycin 51 Angiox 51 RoACTEMRA 51 Rhucin 51 SUMAVEL DosePro 51 MAP# 51 rFVIIIFc 51 CCR5 antagonist 51 homozygous familial hypercholesterolemia 51 Cimzia TM 51 Everolimus 51 pediatric Crohn disease 51 UCB Cimzia 51 Ganite ® 51 acting muscarinic antagonist 51 acyclovir Lauriad R 51 ruxolitinib 51 Aclasta 51 APF# 51 HIV integrase inhibitor 51 Talabostat 51 Taliglucerase alfa 51 vascular disrupting agent 51 Subpart E 51 FDA Accepts 51 candidate Zenvia 51 Pegloticase 51 adult chronic ITP 51 ADP receptor antagonist 51 Camvia 51 DAVANAT ® 51 antisense drug 51 JAK2 inhibitor 51 oral ridaforolimus 51 Tasimelteon 51 Laquinimod 51 Allovectin 7 R 51 Exenatide LAR 51 Medidur 51 Zolinza 51 pregabalin Lyrica 51 TheraCIM 51 Allovectin 7 ® 51 Fabry Disease 51 eprodisate KIACTA TM 51 NEBIDO R 51 Vimovo 51 IgG1 monoclonal antibody 51 generation purine nucleoside 51 Loramyc 51 Vion Pharmaceuticals 51 indolent NHL 51 CDP# 51 biosimilar 51 hereditary angioedema HAE 51 Pathway Inhibitor 51 Alemtuzumab 51 severe malignant osteopetrosis 51 topically applied SEPA 51 AEG# 51 registrational trial 51 cinacalcet HCl 51 Xiaflex 51 PROMACTA 51 Proxinium TM 51 Morquio 51 receptor tyrosine kinase inhibitor 51 Triapine 51 torsemide ER 51 Yervoy 51 Prodarsan ® 51 pulmonary arterial hypertension 51 Idiopathic Pulmonary Fibrosis 51 Eligard R 51 pafuramidine 51 Xyotax 51 MORAb 51 subcutaneous formulation 51 ridaforolimus 51 oropharyngeal candidiasis 51 Sodium oxybate 51 TKM ApoB 51 Evicel 51 tocilizumab 51 TYZEKA 51 Peramivir 51 rheumatoid arthritis Crohn disease 51 biosimilar versions 51 Rhucin ® recombinant 51 Glybera 51 Receives Marketing Authorization 51 L BLP# 51 ACZ# 51 DR Cysteamine 51 Cimzia ® 51 successfully commercialize Iluvien 51 Oncophage 51 Emselex 51 visilizumab 51 relapsed leukemia 51 Joulferon 51 ANTEGREN 51 EGRIFTA TM 51 mTOR kinase 51 dirucotide MBP# 51 Rescula 51 biologic therapies 51 Vitrasert R 51 Rebif interferon beta 1a 51 Fibrillex 51 lintuzumab SGN 51 Meets Primary Endpoint 51 Mozobil 51 COLAZAL R 51 Aegerion 51 Rasagiline 51 postoperative ileus 51 Onrigin 51 EnzymeRx 51 Neurodex 51 Epratuzumab 51 ezogabine 51 Pfizer Lyrica 51 subsidiaries visit http:/www.apricusbio.com 51 Preos 51 PEG INTRON 51 formerly LymphoStat B 51 MTP inhibitor 51 R adalimumab 51 Orexo 51 Entocort 51 oral fludarabine 51 Cladribine tablets 51 virus HCV protease inhibitor 51 BiovaxID TM 51 PEGylated Fab fragment 51 Certican 51 Eliquis 51 relapsed multiple myeloma 51 dextromethorphan quinidine 51 use transdermal sumatriptan 51 ketolide antibiotic 51 Fortigel 51 Human Genetic Therapies 51 Arzerra 51 Oracea 51 Lodotra 51 topical anti infective 51 human antithrombin 51 INDs 51 Egrifta 51 neurogenic orthostatic hypotension 51 Luveniq 51 rNAPc2 51 markets Gelclair R 51 lorvotuzumab mertansine 51 Roche Actemra 51 SUTENT 51 Torisel temsirolimus 51 HDAC inhibitor 51 Mycograb 51 Firdapse TM amifampridine phosphate 51 AVASTIN 51 opioid induced constipation 51 tasocitinib 51 Anti TNF 51 long acting muscarinic 51 Reclast zoledronic acid 51 Filgrastim 51 gastrointestinal disorders characterized 51 Orphan Medicinal Products 51 volociximab 51 Solasia 51 ALKS 51 Hedgehog Pathway Inhibitor 51 CytoFab 51 HuMax EGFr 51 Zevtera 51 LUVENIQ 51 Rhucin R 51 buccal tablets 51 Aloxi R 51 hypoparathyroidism 51 DexaSite 51 idiopathic pulmonary fibrosis IPF 51 HP Acthar Gel repository 50 BiovaxID 50 Tezampanel 50 REMICADE infliximab 50 DAVANAT R 50 essential thrombocythemia ET 50 MEK inhibitor 50 targeted antifolate 50 Firdapse ™ amifampridine phosphate 50 Tofacitinib 50 opioid receptor antagonist 50 ZALBIN 50 PREOS R 50 Tyverb 50 Thrombin topical Recombinant 50 Dificid 50 Eltrombopag 50 IRX 2 50 vitreoretinal disorders 50 PROVENGE ® 50 Bendamustine 50 vinflunine 50 post operative ileus 50 investigational monoclonal antibody 50 Dapagliflozin 50 fostamatinib 50 hoFH 50 IBS C 50 recombinant thrombin 50 prokinetic agent 50 candidate epratuzumab 50 Eraxis 50 JAK1 50 Pruvel 50 filgrastim 50 Visudyne R 50 ASP# 50 Japanese Encephalitis Vaccine 50 TACI Ig 50 Dr. McHutchison 50 Oral BDP 50 alogliptin 50 DepoDur 50 TroVax ® 50 Ceplene TM 50 Ceplene R 50 chronic granulomatous disease 50 panitumumab Vectibix 50 Avastin bevacizumab 50 oral nucleoside analogue 50 ATPace TM 50 CIMZIA r 50 investigational antiplatelet agent 50 Cloretazine 50 Dacogen 50 Taxotere docetaxel 50 paliperidone palmitate 50 vilazodone 50 TORISEL 50 Familial Adenomatous Polyposis FAP 50 subependymal giant cell 50 Multiferon 50 crofelemer 50 Eribulin 50 R sorafenib tablets 50 Aurexis 50 fibromyalgia syndrome 50 MEK inhibitors 50 Ridaforolimus 50 Sumavel DosePro 50 Remicade infliximab 50 ustekinumab 50 HepaGam B 50 treat GI GVHD 50 Tocilizumab 50 Ostarine ™ 50 Halaven 50 OLEPTRO 50 IMiDs ® compound 50 BEMA TM Fentanyl 50 Aflibercept 50 Enzyme Replacement Therapy 50 Etravirine 50 OPAXIO 50 Istodax 50 ONTAK 50 Bonefos 50 opioid induced constipation OIC 50 ocular formulation 50 humanized anti 50 VISICOL R 50 Xgeva 50 etanercept Enbrel 50 Fludara ® 50 drug Mylotarg 50 Proquin XR 50 Oracea ® 50 DC Bead 50 DPX Survivac 50 Telzir 50 CINOD 50 Saphris 50 chronic ITP patients 50 Darunavir 50 Thalidomide Pharmion #mg 50 levocetirizine 50 mipomersen 50 Congenital Emphysema 50 supplemental Biologics License Application 50 ONGLYZA ™ 50 MGCD# [001] 50 Tyrima 50 ZOLINZA 50 NEUPREX R 50 tramiprosate 50 Arimoclomol 50 Nivestim 50 Insmed Incorporated NASDAQ INSM 50 dasatinib Sprycel ® 50 carcinoid syndrome 50 zanolimumab 50 albiglutide 50 erlotinib Tarceva ® 50 mifamurtide 50 Specifid 50 Azacitidine 50 Phase IIb clinical trials 50 RAPTIVA 50 Dyloject TM 50 Prestara 50 peripherally acting 50 talactoferrin 50 Vicinium TM 50 ACOMPLIA R 50 atypical antipsychotic medication 50 ORTHOVISC mini 50 Cx# [002] 50 Zybrestat 50 Gaucher disease 50 Xyfid TM 50 injectable enzyme 50 Kit CD# positive 50 MOVIPREP R 50 dirucotide 50 QRxPharma 50 Loramyc ® 50 REVLIMID lenalidomide 50 Sudhir Agrawal D.Phil 50 bazedoxifene 50 Oracea TM 50 systemic juvenile idiopathic 50 golimumab 50 Revlimid lenalidomide 50 Firazyr ® 50 peginesatide 50 aerosolized AAT 50 Sprycel dasatinib 50 torezolid phosphate 50 biogeneric 50 Insegia 50 GED aPC 50 EGFR targeting 50 Velcade 50 Cloretazine ® 50 pitavastatin 50 angiogenesis inhibitor 50 thetreatment 50 Gaucher Disease 50 TRISENOX 50 PrevOnco 50 Factor Xa inhibitor 50 DPP4 50 sodium glucose cotransporter 50 HepaSphere 50 prGCD 50 refractory acute promyelocytic 50 Daclizumab 50 briakinumab 50 Nexavar 50 delivers fluocinolone acetonide FA 50 IMiDs R 50 Neuromodulation System 50 Zirgan 50 Lipsovir 50 Cryopyrin Associated Periodic Syndromes 50 alefacept 50 inhaled antibiotic 50 mesylate tablets approved 50 autologous cellular immunotherapy 50 Abbott Humira 50 oral iron chelator 50 daptomycin 50 AP# [003] 50 AERIUS 50 Therapeutic Discovery Project 50 novel histone deacetylase 50 anticancer therapies 50 European Medicines Agency 50 novel synthetic PEGylated 50 lapatinib 50 ENZON 50 Phase III clinical 50 THALOMID 50 Yondelis 50 refractory CLL 50 Voreloxin 50 QVAR 50 Solzira TM 50 Degarelix 50 opioid induced bowel dysfunction 50 Investigational 50 Acetavance TM 50 Pyridorin 50 tramiprosate ALZHEMED TM 50 NOVARTIS 50 pain palliation 50 KIACTA ™ 50 mitogen activated ERK kinase 50 ceftobiprole 50 Roche PEGASYS R 50 paclitaxel Taxol ® 50 Azedra 50 octreotide implant 50 Phase 2b trial 50 photoprotective drug 50 seliciclib CYC# 50 Tygacil 50 ALVESCO R 50 voclosporin 50 myelodysplastic syndromes MDS 50 IPLEX 50 Synvisc One 50 omacetaxine mepesuccinate 50 oral antiviral 50 Preclinical studies suggest 50 5 lipoxygenase inhibitor 50 Cutaneous T 50 Neupro 50 relapsed refractory multiple myeloma 50 directed radiotherapeutic antibody 50 Movectro 50 Octreotide 50 Elagolix 50 milnacipran 50 ZENPEP 50 Initiates Phase III 50 PHX# 50 Tarceva erlotinib 50 Amigal TM 50 Development OOPD 50 paroxysmal nocturnal hemoglobinuria PNH 50 asenapine 50 REVLIMID 50 naproxen esomeprazole magnesium 50 AzaSite Plus 50 Initiate Clinical Trial