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(Click for frequent words.) 80 phenotypes 70 alleles 69 mRNA expression 69 homozygosity 69 genotypes 69 genotype 69 overexpression 69 phenotypic 69 heterozygous 68 gene expression 67 missense mutations 67 CD1d 67 isoform 67 polymorphisms 67 orthologs 66 heterozygotes 66 enzymatic activity 66 gene 66 phenotypically 66 mutations 66 mutation 66 allele 66 transgene expression 65 isoforms 65 substrate specificity 65 receptor gene 65 lymphoid cells 65 haplotype 65 methylation patterns 65 genes 65 proteolysis 65 autophagic 65 sporadic ALS 65 loci 65 polymorphism 65 miR #a [001] 65 EGFP 65 Foxp3 65 exon 65 intron 65 immunoreactivity 65 mice lacking 65 CEACAM1 64 gene expression patterns 64 airway hyperresponsiveness 64 PTPN# 64 miRNA expression 64 mammary epithelial cells 64 gene locus 64 glomerular 64 transcriptional repressor 64 germline mutations 64 neoplastic 64 murine 64 transgene 64 hippocampal neurons 64 DNA methylation patterns 64 morphological 64 neuroendocrine 64 tyrosine phosphorylation 64 Supplementary Fig 64 MECP2 gene 64 homozygous 64 A. thaliana 64 PTEN gene 64 mutant allele 64 Jhdm2a 64 MLH1 63 gene expression profiles 63 melanocyte 63 heterozygote 63 neuronal dysfunction 63 transcriptional activation 63 cyclin E 63 homologs 63 transcriptional regulation 63 constitutively 63 podocytes 63 PON1 63 constitutively expressed 63 constitutively active 63 deficient mice 63 morphologic 63 heterozygosity 63 microdeletion 63 histologically 63 KLF4 63 haplotypes 63 mosaicism 63 pDCs 63 beta globin 63 MT1 MMP 63 phenotypic variation 63 lymphoid 63 methylation 63 epithelial 63 chromosome #q# [002] 63 cardiac myocytes 63 transfected 63 S#A# [002] 63 microglial 63 activin 63 lymphocytic 63 beta globin gene 63 knockout mice 63 karyotypes 63 homolog 63 autosomal dominant 63 transmembrane protein 63 catenin 63 eNOS 63 radial glia 63 thymocytes 63 monocyte 63 Rap1 63 malignant transformation 63 tumorigenicity 63 genes encoding 63 HepG2 cells 62 vimentin 62 chromosomal regions 62 evolutionarily conserved 62 N Myc 62 ERK2 62 ectopic expression 62 quantitative trait loci 62 BMP signaling 62 mutant alleles 62 Htt 62 lysosomal 62 transactivation 62 renal fibrosis 62 MAPK pathway 62 homodimers 62 susceptibility genes 62 paralogs 62 transgenic mice 62 synaptogenesis 62 functional polymorphism 62 Fig. 1C 62 caveolin 62 gene encoding 62 neuronal 62 ERK1 2 62 de novo mutations 62 neural crest 62 homozygotes 62 apical 62 β 62 SLC#A# [002] 62 tumor suppressor gene 62 DNMT1 62 Th2 62 hypothalamic 62 lateral ventricle 62 epithelia 62 astrocytic 62 IFN gamma 62 cellular prion protein 62 LKB1 62 splenocytes 62 thymic 62 isoenzymes 62 histone modifications 62 beta1 integrin 62 PC# cells 62 LRAT 62 RhoA 62 miRNAs 62 C#BL 6 mice 62 allelic variants 62 gene polymorphism 62 chromosomal instability 62 IGF2 62 lymphocyte 62 Notch signaling 62 hepatocyte 62 transcriptional 62 phosphorylated 62 microsatellite instability 62 interneurons 62 heritable 62 ubiquitination 62 glycosylation 62 chromosomal rearrangement 62 HSF1 62 microglial activation 62 leptin receptor 62 transgenic mice expressing 61 MyoD 61 COL#A# 61 myocyte 61 Leydig cell 61 rs# [002] 61 pathologic 61 cytoplasmic 61 C#Y 61 pRb 61 hyperactivation 61 breast carcinoma 61 null mice 61 ERBB2 61 MSH2 61 subclinical 61 Th1 61 estrogen receptor alpha 61 deacetylation 61 BDNF gene 61 cytokine 61 haematopoietic 61 HMGA2 61 karyotype 61 autosomal 61 synthase 61 TGF ß 61 epigenetically 61 Wnt signaling 61 CHD7 61 Rab5 61 virulence genes 61 Aß 61 PrP 61 clonal expansion 61 transgenic mouse model 61 Prox1 61 gene polymorphisms 61 genetic polymorphism 61 epithelial cell 61 allelic 61 p# activation 61 CD8 + 61 microbiota 61 transcriptionally 61 mRNA 61 transduced 61 X inactivation 61 caveolin 1 61 testis 61 CXCL# 61 mRNAs 61 frameshift mutation 61 phosphorylation 61 suppressor gene 61 TGF β 61 fig. S1 61 ß1 61 CYP#B# 61 cerebellar 61 mesenchymal 61 wildtype 61 myocytes 61 mutant SOD1 61 CD#b 61 IL 1ß 61 cells transfected 61 epitope 61 inducible 61 β catenin 61 E cadherin 61 pathophysiological 61 histone H3 61 P cadherin 61 centromeres 61 metaplasia 61 apoE 61 estrogen receptor 61 syngeneic 61 genomic instability 61 proto oncogene 61 TGF b 61 missense mutation 61 lung fibroblasts 61 coexpression 61 S. cerevisiae 61 morphogen 61 rs# [003] 61 #p#.# [002] 61 motoneurons 61 mitochondrial 61 TIMP 60 Smad3 60 H#K# [002] 60 overexpressing 60 chromosome #q 60 epistasis 60 spermatogonia 60 DLC1 60 downregulated 60 neoplastic cells 60 circadian clock genes 60 clonally 60 autoantibody 60 iNOS 60 motor neuron degeneration 60 perivascular 60 Leydig cells 60 subcellular localization 60 chromosome #q#.# [001] 60 Id1 60 mitotic 60 mucinous 60 serotonin transporter 60 NF1 60 STAT1 60 XBP1 60 TNFalpha 60 striatal 60 MEFs 60 acinar 60 subtype 60 endothelial 60 neuroblasts 60 globin gene 60 LIS1 60 uPAR 60 mutant protein 60 microRNA expression 60 chaperone proteins 60 ciliated 60 GABAergic neurons 60 underlying pathophysiology 60 autosomal recessive 60 cadherin 60 microRNA miR 60 miR 60 ZNF# 60 E cadherin expression 60 homologue 60 intergenic 60 mutant huntingtin protein 60 downregulation 60 amino acid substitutions 60 caspase 60 intracellular signaling 60 striatal neurons 60 HPA axis 60 Hh 60 mutant proteins 60 alveolar epithelial cells 60 mutant mice 60 genetic loci 60 proteoglycan 60 postsynaptic 60 PECAM 1 60 WNK1 60 IL 1β 60 IGF1 60 histone 60 inhibitory receptor 60 proband 60 PrPSc 60 chromosome #q# [001] 60 monogenic 60 immunostaining 60 syntaxin 60 EBNA1 60 G allele 60 C1q 60 prognostic factor 60 Sgk1 60 FMR1 gene 60 breast epithelial cells 60 transcriptomes 60 DISC1 60 NKT cell 60 cAMP signaling 60 genetic variation 60 lymph node metastasis 60 prostate epithelial cells 60 Aβ 60 neuronal differentiation 60 myofibroblast 60 Dpp 60 β amyloid 60 IFN γ 60 recessive mutation 60 genes predisposing 60 TAp# 60 OPRM1 gene 60 TERT 60 LRP6 60 defensin 60 dopaminergic neuron 60 rs# [004] 60 gliosis 60 fibroblast cells 60 cellularity 60 homozygote 60 CCR7 60 ERK signaling 60 hypermethylation 60 amino acid sequence 60 molecular mechanisms underlying 60 DARPP 60 mutant p# 60 claudin 60 metabolic enzymes 60 thymocyte 60 PTEN mutations 60 prognostic significance 60 autosomal dominant disorder 60 penetrance 60 MMP# 60 globin genes 60 MDSCs 60 activating mutations 60 cytosolic 60 histopathological 60 thyroid carcinoma 60 Immunohistochemical analysis 60 p# [001] 60 genetic polymorphisms 59 α KG 59 p# Shc 59 CagA 59 gastric carcinomas 59 D. melanogaster 59 Genetic variation 59 ontogeny 59 centrosome 59 endogenous 59 major histocompatibility complex 59 MTHFR 59 androgen receptor AR 59 ABCB1 59 MnSOD 59 synthases 59 tropomyosin 59 epigenetic silencing 59 Clusterin 59 DNA methylation 59 glycoproteins 59 Notch1 59 SMN1 59 c Src 59 nNOS 59 cyclins 59 semaphorin 59 Mice deficient 59 secretory 59 mesenchymal cells 59 At#g# 59 gene variants 59 erythropoiesis 59 adipocyte 59 HLA DRB1 * 59 #q# [001] 59 mitochondrial dysfunction 59 erythrocytes 59 rRNA 59 PGCs 59 adult neurogenesis 59 autoregulation 59 NKT cells 59 signaling pathways 59 APOE4 59 E3 ligase 59 genetic variant 59 NADPH oxidase 59 NF κB activation 59 extramedullary 59 inhibitory 59 GLUT1 59 amino acid residues 59 trophoblast 59 monozygotic twins 59 H#K#me# 59 ß catenin 59 synuclein 59 chromosomal DNA 59 fibroblasts 59 serine 59 mtDNA mutations 59 PDGFR 59 malignant phenotype 59 chromosomal translocations 59 glucose homeostasis 59 genomewide 59 receptor 59 neural cells 59 fascin 59 promoter methylation 59 kinase domain 59 phosphatase 59 endoplasmic reticulum 59 fig. S4 59 p#NTR 59 serine threonine kinase 59 midgut 59 maternally inherited 59 neurones 59 breast carcinomas 59 lymphocyte activation 59 homology 59 TOP2A gene 59 dopaminergic neurons 59 rhodopsin 59 p# MAPK 59 steatohepatitis 59 metabolic abnormalities 59 TGF beta signaling 59 prognostic marker 59 glucose transporter 59 genotypic 59 effector functions 59 hTERT 59 inhibitory effects 59 FMR1 59 Smad4 59 Rac1 59 proteins 59 Pten 59 vasopressin receptor 59 hypogonadotropic hypogonadism 59 IKZF1 59 sexual dimorphism 59 imprinted genes 59 Fig. 3a 59 p# mutations 59 adiposity 59 orthologous 59 PTHrP 59 Cx# [001] 59 metaphase 59 eotaxin 59 upregulation 59 induced apoptosis 59 chronicity 59 C EBP alpha 59 Fc receptor 59 morphologically 59 allelic variation 59 ErbB2 59 ubiquitylation 59 leukemic stem cells 59 osteoblast 59 phenotypic expression 59 piRNAs 59 mutant gene 59 heritable traits 59 germinal center 59 CD#c 59 periventricular 59 chemokine receptor 59 myoblasts 59 hypothalamic pituitary 59 MHC molecules 59 genetic alteration 59 Mcl 1 59 Cdx2 59 E3 ubiquitin ligase 59 GSTM1 59 proapoptotic 59 C#BL/#J 59 VHL gene 59 colocalization 59 pathogenesis 59 miR# 59 QTLs 59 neural crest cells 59 tumor suppressor protein 59 intestinal microflora 59 podocyte 59 regulated kinase ERK 59 ERalpha 59 polyglutamine 59 upregulated 59 insulin resistance 59 H#K# methylation 59 FasL 59 Fig. 2C 59 occludin 59 syndromes 59 CD# expression [001] 59 LDL receptor 59 GSTP1 59 ribosomal protein 59 mammalian 59 FGFR2 59 transcriptome 59 laminin 59 centromere 59 rs# [001] 59 dimerization 59 germline 59 DRD2 59 chromatin structure 59 epigenetic mechanisms 59 histone modification 59 eusociality 59 spontaneous mutations 59 tumorigenesis 59 cell adhesion molecule 59 ubiquitin ligase 59 hamartomas 59 causative genes 59 ribosomal proteins 59 interferon γ 59 atherosclerotic lesions 59 paxillin 59 tumor antigen 59 #q#.# [002] 59 thrombospondin 59 H#K# [001] 59 differential gene expression 59 morphogenesis 59 BMP receptor 59 cardiomyocyte 59 N cadherin 58 sequence homology 58 chromosomal 58 neuromuscular junction 58 huntingtin protein 58 SNPs 58 morphology 58 F actin 58 cyclin 58 histone acetylation 58 mtDNA 58 myofibroblasts 58 cytoplasmic tail 58 ataxin 58 ortholog 58 intronic 58 acetylation 58 telomere length 58 beta catenin 58 unmethylated 58 cysteines 58 neuronal cell 58 mutated gene 58 DMT1 58 nitrotyrosine 58 cardiolipin 58 chromosome 58 Kupffer cells 58 JAK STAT signaling 58 transmembrane 58 insulin receptors 58 E#F# 58 IL#B 58 proximal tubule 58 zygotic 58 adipocytes 58 granulocyte 58 NF1 gene 58 adipogenic 58 FGFR1 58 receptor kinase 58 multigenic 58 primary visual cortex 58 Rab# 58 IGFBP 58 FGFR3 58 PAK1 58 allele frequencies 58 goblet cells 58 PIP2 58 Purkinje cells 58 phosphatases 58 chromosomal rearrangements 58 eukaryotic 58 LNCaP cells 58 cytochrome 58 histologic 58 3'UTR 58 p# mutation 58 hepatocytes 58 transcriptional regulator 58 myelination 58 SUMOylation 58 agonist induced 58 paternally inherited 58 oncogenic 58 ferritin 58 cytokeratin 58 cortical 58 glucose tolerance 58 signaling pathway 58 TOP2A 58 spermatogenesis 58 airway remodeling 58 mitochondrial enzyme 58 matrix metalloproteinase 58 recessive trait 58 dedifferentiation 58 SVZ 58 fibroblast 58 proteolytic cleavage 58 vivo 58 luminal 58 TGF beta1 58 Sonic hedgehog 58 estrogen receptor beta 58 Akt 58 transmembrane domains 58 cytoplasmic domain 58 chromosomal alterations 58 prion gene 58 glycoprotein 58 mitogen activated protein kinase 58 nucleoli 58 granule cells 58 RRM1 58 neoplasm 58 brain lesions 58 trophoblast cells 58 SOCS3 58 GRK2 58 glutamatergic 58 Overexpression 58 KRAS mutations 58 leukemic cells 58 phospho 58 oncoproteins 58 hypothalamic pituitary adrenal axis 58 mammary stem cells 58 TNFa 58 ADAM# 58 selfing 58 intestinal epithelium 58 dopamine transporter gene 58 pseudogenes 58 MAP kinase 58 glial 58 luminal cells 58 microsatellite markers 58 chromosomal deletions 58 GPR# [001] 58 axonal 58 myostatin gene 58 MEK1 58 Wnts 58 osteoclast 58 beta subunit 58 ultrastructural 58 hematopoietic cells 58 demyelination 58 E1A 58 tyrosine residues 58 nucleotide sequence 58 STAT4 58 secretory pathway 58 prion protein 58 hyperinsulinemia 58 presynaptic 58 gene rearrangements 58 sensory neurons 58 mitochondrial gene 58 SRY gene 58 CDH1 58 p#Kip# 58 transfected cells 58 Fas ligand 58 chromosomal aberrations 58 ERK activation 58 plastid 58 clusterin 58 GBM tumors 58 stromal cells 58 ESR1 58 Fig. 3B 58 Fig. 1D 58 SSc 58 STAT3 58 mPFC 58 UGT#B# 58 homeobox gene 58 supratentorial 58 immunohistochemical staining 58 APOE e4 58 neuroligins 58 Hsp# [001] 58 Th2 responses 58 Runx1 58 NKG2D 58 GSK 3ß 58 TLE3 58 PU.1 58 cofilin 58 mouse testes 58 mRNA transcripts 58 endothelial nitric oxide synthase 58 MMPs 58 autoantibodies 58 inhibition 58 linkage disequilibrium 58 dentate gyrus 58 neovascularization 58 SOD1 protein 58 telomeric 58 striatal dopamine 58 subtypes 58 Hcrt 58 trophoblasts 58 isotypes 58 neurite outgrowth 58 hyperplasia 58 neuropilin 58 dysregulation 58 Cre recombinase 58 HBx 58 FGF2 58 Rb#/p# 58 IgG4 58 condensin 58 histone H4 58 genetic alterations 58 Xenopus 58 ENaC 58 ouabain 58 skeletal muscle 58 protein kinase 58 homologues 58 chloroplast 58 palmitoylation 58 cell motility 58 ERCC1 58 #q#.# [001] 58 serum albumin 58 mesoderm 58 diploid 58 airway responsiveness 58 filaggrin 58 transcriptional repression 58 RASSF1A 58 microcephalin 58 coding sequences 58 immunocompetent 58 carcinoembryonic antigen 58 hypomethylation 58 immunological 58 CpG 58 HOTAIR 58 hnRNP 58 alpha synuclein gene 58 retinal neurons 58 aldehyde dehydrogenase 58 CHD5 58 Vps# 58 CFTR protein 58 KLF# 58 inhibin 58 mutational 58 mammary cells 58 single nucleotide polymorphism 58 epigenetic alterations 58 CFTR gene 58 Sox9 58 CNVs 58 synovial cells 58 Wwox 58 immunohistochemical 58 serotonin receptor 58 pseudogene 58 SIRT6 58 p#INK#a 58 EGFR expression 58 serum concentrations 58 nestin 58 circadian genes 58 RUNX3 58 MMP2 58 hyperplastic 58 MC1R gene 58 presenilin 58 cyclin D1 58 adhesion molecule 58 prognostic indicator 58 PTEN protein 58 β cell 58 sarcomatoid 58 ADPKD 58 reductase 58 miR #b [001] 58 tumoral 58 synaptic plasticity 58 Cdc# 58 cortices 58 WT1 58 PTP1B 58 tubule 57 olfactory sensory neurons 57 phylogenetically 57 cathepsin B 57 endothelial activation 57 genetic variants 57 #S rRNA 57 inbred strains 57 lymphangiogenesis 57 calpain 57 conformational 57 phospholipase 57 NFkB 57 ALDH 57 HIF 1alpha 57 efferent 57 prostate carcinoma 57 mutated protein 57 indel 57 meiotic 57 Wnt pathway 57 HLA molecules 57 ultrastructure 57 c myc 57 peripheral blood mononuclear 57 cerevisiae 57 scavenger receptor 57 KRAS gene 57 monomeric 57 osteocalcin 57 lacZ 57 V#F mutation 57 hippocampal function 57 protein tyrosine phosphatase 57 deleterious mutations 57 nucleotide 57 endophenotypes 57 glycosyltransferase 57 GABAergic interneurons 57 subfamily 57 Alu elements 57 Bcl xL 57 5 HT1A 57 dopamine signaling 57 arginase 57 skeletal muscle cells 57 dysregulated 57 focal adhesions 57 transcription factors 57 SLC#A# [001] 57 physiologic 57 APOL1 57 retroviral vector 57 receptor molecule 57 GlcNAc 57 rCBF 57 CTGF 57 protein kinase C 57 normal prion protein 57 molecular mechanism 57 GAPDH 57 incomplete penetrance 57 leucine zipper 57 overexpress 57 HSP# 57 synthetase 57 receptor signaling 57 paraneoplastic 57 chondrocyte 57 phosphatidylinositol 57 hepatoma 57 PAX5 57 SHANK3 57 osteochondroma 57 glutamate receptor 57 lung epithelium 57 μ opioid receptor 57 FGF# 57 clinicopathological 57 MMP9 57 genetic mutation 57 superoxide dismutase 57 perilipin 57 T#M 57 FOXO3a 57 K ras mutations 57 genotoxic stress 57 budding yeast 57 dopamine receptor 57 C. neoformans 57 MIF gene 57 Fig. 1B 57 HbF 57 myocardium 57 methylenetetrahydrofolate reductase 57 RIP1 57 Purkinje cell 57 inhibitory effect 57 cytoskeletal structure 57 colorectal carcinoma 57 amyloid deposition 57 melatonin receptor 57 overexpressing cells 57 gene mutations 57 actin cytoskeleton 57 prognostic factors 57 SNP rs# [002] 57 aneuploid 57 perirhinal cortex 57 proline rich 57 susceptibility gene 57 telomere lengths 57 kDa protein 57 alternatively spliced 57 Src 57 adiponectin 57 biochemically 57 FGF signaling