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(Click for frequent words.) 75 polymorphisms 73 alleles 73 allele 70 rs# [003] 70 genotype 68 rs# [004] 68 rs# [002] 67 heterozygous 67 haplotype 67 MTHFR 66 homozygous 66 haplotypes 66 mutation 66 rs# [001] 66 DRD2 65 #q# [001] 65 genotypes 65 chromosome #q# [002] 65 phenotype 65 5 HTTLPR 64 homozygosity 64 phenotypes 64 heterozygotes 64 homozygotes 64 PTPN# 64 single nucleotide polymorphism 64 SNPs 64 APOE4 64 mutations 63 loci 63 genes encoding 63 intergenic 63 MTHFR gene 63 chromosome #q# [001] 63 APOE e4 63 functional polymorphism 63 allelic 63 gene variant 63 intron 63 gene polymorphisms 63 VNTR 62 germline mutations 62 ABCB1 62 linkage disequilibrium 62 SNP rs# [001] 62 APOC3 62 genetic polymorphism 62 susceptibility gene 62 CDKN2A 62 promoter polymorphism 62 CNVs 62 apolipoprotein E gene 61 gene polymorphism 61 mRNA expression 61 SLC#A# [002] 61 mutant allele 61 genetic variant 61 apolipoprotein E 61 FGFR2 61 subcellular localization 61 FMR1 gene 61 subtype 61 homozygote 61 TCF#L# 61 chromosome #q 61 #q# [002] 60 DRD2 gene 60 missense mutations 60 allele frequencies 60 G allele 60 #q#.# [001] 60 orthologs 60 methylenetetrahydrofolate reductase 60 IL#B 60 C#Y 60 susceptibility genes 60 heterozygosity 60 apoE4 60 heterozygote 60 KLF4 60 BDNF gene 60 PON1 60 homologs 60 DQB1 * 60 ALDH2 60 genetic polymorphisms 60 ESR1 60 dinucleotide 60 TT genotype 60 gene variants 60 chromosome #p# [001] 60 clusterin 60 microdeletions 60 apolipoprotein 59 constitutively active 59 #p# [003] 59 gene encoding 59 MLH1 59 segmental duplications 59 IGFBP 59 CagA 59 exon 59 dopamine receptor gene 59 CGG repeats 59 genotypic 59 EF Tu 59 COL#A# 59 caveolin 59 homology 59 gene locus 59 TCF#L# gene 59 isoform 59 CFH gene 59 allelic variants 59 inducible 59 Polymorphisms 59 HLA B 59 OPRM1 gene 59 penetrance 59 variant allele 59 #p#.# [001] 59 X chromosome 58 transmembrane protein 58 chromosomal rearrangement 58 SNP rs# [002] 58 ApoE gene 58 PALB2 58 intronic 58 tyrosine phosphorylation 58 MnSOD 58 mtDNA 58 VKORC1 58 ERBB2 58 alternatively spliced 58 karyotype 58 cyclin D1 58 receptor binding 58 ApoE 58 ribosomal protein 58 CHEK2 58 dopamine transporter gene 58 gene 58 #p# [001] 58 BARD1 58 At#g# 58 uPAR 58 dysbindin 58 TMEM#B 58 heritable 58 #q#.# [002] 58 cyclin E 58 chromosome #p#.# 58 paternally inherited 58 DRD4 58 HLA DRB1 * 58 sequence homology 58 promoter methylation 58 cadherin 58 APOE gene 58 MSH2 58 quantitative trait loci 58 GSTM1 58 serotonin transporter gene 58 eNOS 58 CNTNAP2 58 LIS1 58 CYP#D# 58 missense mutation 58 LPA gene 58 KIAA# 58 #S rRNA 58 CAG repeats 58 major histocompatibility complex 58 virulence genes 58 H#K#me# 58 APOE 58 serotonin transporter 58 KIF6 gene 58 WNK1 58 constitutively 58 GSTP1 58 #p#.# [002] 58 epistasis 58 nucleotide sequence 57 genetic variants 57 gene loci 57 paralogs 57 transgene expression 57 evolutionarily conserved 57 transactivation 57 MAOA 57 orthologous 57 amino terminal 57 indels 57 frameshift mutation 57 polygenic 57 somatic mutations 57 genes predisposing 57 gene APOE 57 proband 57 transcriptional repressor 57 gene expression profiles 57 c KIT 57 downregulated 57 overexpression 57 microcephalin 57 Apolipoprotein E 57 homodimers 57 Heterozygous 57 receptor gene 57 COMT gene 57 indel 57 null mice 57 gene amplification 57 GABRA2 57 chromosome #q#.# [001] 57 Polymorphism 57 HLA B# 57 ADRB2 57 Akt 57 COX2 57 mice lacking 57 microdeletion 57 protein tyrosine phosphatase 57 genotyped 57 methylation 57 mosaicism 57 CpG 57 CYP#D# gene 57 genetic variation 57 amino acid residues 57 autosomal 57 BRCA1 mutations 57 Supplementary Fig 57 vimentin 57 catechol O methyltransferase 57 human leukocyte antigen 57 mRNA transcripts 57 synuclein 57 C#BL/#J 57 GTPase 57 variant alleles 57 rRNA 57 HFE gene 56 Hh 56 UGT#B# 56 LRRK2 gene 56 S. cerevisiae 56 proto oncogene 56 chromosome 56 CHD7 56 GSTT1 56 MetS 56 hypermethylation 56 chromosomal regions 56 CDH1 56 susceptibility locus 56 haplogroups 56 epitope 56 TOP2A 56 PTEN mutations 56 RASSF1A 56 gene expression patterns 56 CYP# [002] 56 serine protease 56 glycoproteins 56 APOE ε4 56 MYH9 gene 56 esterase 56 serine 56 cystatin 56 serum concentrations 56 estrogen receptor 56 cytochrome 56 cyclin 56 LRP6 56 HMGA2 56 missense 56 amino acid substitutions 56 MEK1 56 mutant gene 56 UGT#A# * 56 noncoding 56 PCa 56 apoE 56 gene mutation 56 isoforms 56 microglial 56 protein encoded 56 isoenzyme 56 APOL1 56 apo AI 56 adenoma 56 autosomal recessive 56 Genetic variation 56 HLA DRB1 56 apolipoproteins 56 Clusterin 56 aneuploidy 56 tumor suppressor gene 56 inherited mutations 56 ApoE4 56 serine threonine kinase 56 BRCA1 56 homolog 56 transcription factor 56 valine 56 leptin receptor 56 CEACAM1 56 NF1 56 monozygotic twins 56 mutated gene 56 STAT4 56 miRNA expression 56 OPRM1 56 isoenzymes 56 receptor kinase 56 dopamine D4 receptor 56 pseudogenes 56 QTLs 56 E cadherin 56 genes 56 GlcNAc 56 proline rich 56 Cx# [001] 56 SORL1 56 Haplotype 55 IKZF1 55 IL#B gene 55 genes CYP#C# 55 microsatellite markers 55 ZNF# 55 microsatellite instability 55 MC1R gene 55 amino acid substitution 55 phosphorylated 55 mtDNA mutations 55 nucleolar 55 presenilin 55 Alu elements 55 aromatase 55 substrate specificity 55 HLA DRB1 SE 55 methylation patterns 55 protein kinase 55 MC1R 55 TOP2A gene 55 CYP#E# gene 55 haplogroup 55 CYP#A# [002] 55 5q 55 CYP#C# [002] 55 cell adhesion molecule 55 proteolytic cleavage 55 HLA DQ2 55 polymorphic 55 estrogen receptor alpha 55 mutant alleles 55 MAPK pathway 55 HOTAIR 55 karyotypes 55 homologue 55 autoantibody 55 AMACR 55 matrix metalloproteinase 55 A. thaliana 55 Fig. 1C 55 cis regulatory 55 Supplemental Figure 55 BRAF V#E 55 autoantibodies 55 IL#R 55 sporadic ALS 55 catenin 55 CYP#E# 55 COMT 55 prodynorphin 55 transferase 55 coexpression 55 IL6 55 introns 55 eIF4E 55 MHC molecules 55 globin genes 55 IGF2 55 Vps# 55 TGFß 55 miRNAs miR 55 TSC1 55 probands 55 telomeric 55 breast cancer genes BRCA1 55 FLT3 55 premutation 55 ataxin 55 methylated 55 SNCA 55 cytosolic 55 phenotypic variation 55 transcriptional regulation 55 gene mutations 55 STAT1 55 tocopherol 55 activin 55 CC genotype 55 NF1 gene 55 aggrecan 55 chromosomal 55 ncRNAs 55 MAOA gene 55 colocalization 55 mitochondrial 55 phospholipase 55 allele frequency 55 codon 55 N Myc 55 astrocytic 55 constitutively expressed 55 hyperinsulinemia 55 univariate 55 SLC#A# [001] 55 coding sequences 55 rs# rs# 55 alanine 55 eotaxin 55 p# MAPK 55 kDa protein 55 K#N 55 DNMT1 55 activating mutations 55 autism susceptibility genes 55 miRNA genes 55 TP# mutations 55 SE alleles 55 beta subunit 55 meiotic recombination 55 BRCA2 55 K ras mutations 55 Supplementary Table 55 PDGFR 55 subunit 55 TNF α 55 β 55 succinate dehydrogenase 55 mPGES 1 55 CXCL# 54 forkhead 54 hnRNP 54 MECP2 gene 54 differentially expressed genes 54 cysteine 54 estrogen receptor beta 54 autosomes 54 ErbB2 54 Rap1 54 hydroxylase 54 dopamine receptor 54 3'UTR 54 heterodimers 54 V#F mutation 54 NFAT 54 D. melanogaster 54 EGFR gene 54 chromosomal instability 54 glycosylation 54 centrosome 54 phosphatidylinositol 54 thymine 54 IL #R 54 genomewide 54 miR #a [001] 54 subtypes 54 NFkB 54 P cadherin 54 hepatic lipase 54 immunoreactivity 54 kinase domain 54 RRM1 54 genetic loci 54 DARPP 54 cytoplasmic tail 54 hereditary hemochromatosis 54 3' UTR 54 cytoplasmic 54 Th1 54 RUNX3 54 LDL receptor 54 CYP#C# * 54 chromosome #q#.# [002] 54 phosphorylation 54 ABCA1 54 #β HSD1 54 BRCA2 mutation 54 upregulated 54 ER alpha 54 metabolizing enzymes 54 Aß 54 H#K# [002] 54 perilipin 54 EphB4 54 prostate cancer CaP 54 MIF gene 54 PRNP 54 coding genes 54 scavenger receptor 54 APOE allele 54 DRB1 * 54 methyltransferase 54 autosomal dominant 54 receptor gamma 54 triacylglycerol 54 glucose transporter 54 fig. S1 54 δ 54 defensin 54 ERK1 2 54 RhoA 54 telomere length 54 hydroxylation 54 Aβ 54 CCR5 delta# 54 apoC III 54 PUFA intake 54 causal variants 54 micro RNA 54 G#S mutation 54 BMP2 54 inactivating mutations 54 miRNAs 54 hydrolase 54 splice variants 54 calcium homeostasis 54 cagA 54 independent prognostic marker 54 heterologous expression 54 polypeptide 54 multivariate analysis 54 R#W [002] 54 proteolysis 54 gene expression 54 occludin 54 homologues 54 synthases 54 PB1 F2 54 KRAS oncogene 54 tyrosine residues 54 melatonin receptor 54 interferon IFN 54 CNTNAP2 gene 54 fig. S4 54 cytosine 54 APOA5 54 multivariate analyzes 54 ribosomal proteins 54 ultraconserved elements 54 binding affinity 54 JAK2 mutation 54 eukaryotic 54 NNRTI resistance 54 Pgp 54 ß1 54 cytochrome b 54 dimers 54 encodes protein 54 alpha subunit 54 claudin 54 IgA deficiency 54 epithelia 54 transfected 54 HDL2 54 androgen receptor gene 54 cytokeratin 54 p# mutation 54 metabolizing enzyme 54 mitogen activated protein kinase 54 FXTAS 54 FMR1 54 SMAD4 54 thrombospondin 54 C#BL 6 54 decarboxylase 54 HepG2 cells 54 ADAM# 54 SOD2 54 germline 54 transcriptional activation 54 oxytocin receptor 54 ortholog 54 IL 1β 54 receptor subtypes 54 chromosomal translocations 54 HBx 54 nucleotide 54 β amyloid 54 Phylogenetic analysis 54 ADH1B * 53 deacetylation 53 allelic variation 53 PAX5 53 ligand receptor 53 GSTM1 gene 53 DISC1 53 operon 53 polyadenylation 53 KRAS mutations 53 upregulation 53 Wwox 53 acetylation 53 transgene 53 mRNAs 53 papillary RCC 53 downregulation 53 phenotypic 53 SHANK3 53 VHL gene 53 metalloprotease 53 PTEN gene 53 Brain derived neurotrophic 53 FGFR2 gene 53 #S rRNA genes 53 Jhdm2a 53 mitochondrial gene 53 HMGA2 gene 53 Fig. 1A 53 hypermethylated 53 bacterial genomes 53 polycystin 53 leucine zipper 53 prognostic factor 53 estrogen receptor ER 53 PTP1B 53 APOE genotype 53 breast carcinoma 53 receptor tyrosine kinase 53 chromatin structure 53 prognostic marker 53 serotonin receptor 53 NR2B 53 induced apoptosis 53 diploid 53 postsynaptic 53 alpha2 53 TCF4 53 untranslated regions 53 IFN gamma 53 HT 2A 53 NAT2 53 dopamine transporter 53 Gly 53 colorectal neoplasia 53 PIK3CA 53 cDNAs 53 centromeres 53 mu opioid receptor 53 p# activation 53 enzymatic activity 53 ENaC 53 tumor suppressor protein 53 ribosomal DNA 53 HNPCC 53 tRNA synthetase 53 C#T [002] 53 Nf1 53 hTERT 53 WT1 53 inhibin 53 nitrotyrosine 53 tropomyosin 53 Sp1 53 LNCaP cells 53 lipoprotein 53 SGK1 53 wildtype 53 GPR# [002] 53 proinflammatory cytokine 53 HLA DR 53 unmethylated 53 SH#B# 53 Overexpression 53 KLF# 53 homologous 53 p# mutations 53 CYP#C# gene 53 JNK1 53 oncogenic 53 aldehyde dehydrogenase 53 CCR7 53 dimeric 53 ERK2 53 pRb 53 alternative splicing 53 Upregulation 53 amino acid sequence 53 NPY gene 53 ploidy 53 chromosome #p# [002] 53 Genotypes 53 Fig. 1c 53 miRNA 53 rDNA 53 MLL2 53 PDE#A 53 Immunohistochemical analysis 53 Htt 53 myostatin gene 53 transcriptional regulator 53 SHBG 53 phenotypically 53 Fig. 3a 53 differential gene expression 53 underlying pathophysiology 53 β1 53 bacterial virulence 53 CDK4 53 MDR1 53 atypical hyperplasia 53 transmembrane 53 esophageal squamous cell carcinoma 53 Hashimoto thyroiditis 53 hypervariable 53 BRCA mutations 53 OCA2 53 cytoplasmic domain 53 hepatocyte 53 beta globin 53 adenylate cyclase 53 MC4R gene 53 monogenic 53 iNOS 53 autosomal recessive disease 53 drug metabolizing enzymes 53 CYP#B# 53 PDGFR alpha 53 DNA methylation 53 Cowden syndrome 53 alpha synuclein gene 53 condensin 53 platelet activation 53 BRCA1 gene 53 colorectal carcinoma 53 tyrosine kinases 53 comorbidity 53 TGFBR1 * 6A 53 neuroligins 53 CDK9 53 transmembrane receptor 53 histone modifications 53 DRD4 gene 53 MyoD 53 Foxp3 53 immunodominant 53 transgenic mice expressing 53 #S rRNA gene 53 MeCP2 gene 53 Skp2 53 PrP 53 Fig. 2C 53 heterogeneity 53 alpha1 53 VEGF receptor 53 chromosomal abnormalities 53 gastric carcinogenesis 53 Fig. 3b 53 regulator CFTR gene 53 MIF protein 53 amino acid valine 53 phosphorylate 53 demethylase 53 alexithymia 53 adipocyte 53 Leydig cell 53 TMPRSS2 ERG fusion 53 Fas ligand 53 GLUT1 53 GAPDH 53 TNFAIP3 53 SOX9 53 multigenic 53 inhibitory 53 transmembrane domain 53 exons 53 ankyrin repeat 53 K#R [002] 53 oligomerization 53 apolipoprotein E APOE 53 IFN alpha 53 EBNA1 53 protein phosphatase 53 deleterious mutations 53 LRRK2 mutation 52 MLL gene 52 Fig. 3B 52 germline mutation 52 transcription factors 52 transcriptome 52 LRP5 52 SCN5A 52 pulvinar 52 Dysregulation 52 tau gene 52 inducible nitric oxide synthase 52 transcriptional 52 apolipoprotein B 52 NFKBIA 52 cathepsin B 52 γ 52 EGFR mutations 52 epigenetic silencing 52 TIMP 1 52 Heterogeneity 52 telomere lengths 52 CYP#A# gene 52 mutational 52 lymphocyte 52 colorectal tumor 52 MDM2 52 CTCF 52 EGFP 52 AMPA receptor 52 ERK signaling 52 GH IGF 52 ß = 52 CYP#C# [001] 52 Fig. 1E 52 autoantigen 52 6S RNA 52 ERalpha 52 incomplete penetrance 52 chromosomal aberrations 52 cells transfected 52 Smad3 52 prognostic significance 52 proline 52 TNFalpha 52 Notch1 52 TP# gene 52 TIMP 52 immunoblotting 52 HER2 receptor 52 lupus anticoagulant 52 amino acid sequences 52 phospho 52 CCR3 52 amyloidogenic 52 PPARg 52 retinol binding protein 52 somatic mutation 52 X inactivation 52 IL# [001] 52 adenocarcinomas 52 estrogen metabolism 52 agonism 52 Sgk1 52 CCL#L# 52 herpesviruses 52 genetic variations 52 myo inositol 52 UTRs 52 chitinase 52 pathophysiological 52 monozygotic 52 de novo synthesis 52 glycosylated 52 HBsAg 52 mutant huntingtin protein 52 lysine residues 52 intergenic regions 52 transgenic mouse model 52 E selectin 52 metabolic syndrome 52 E3 ubiquitin ligase 52 BCL#A 52 NR#A# 52 mutated K ras 52 thymocyte 52 SCN1A 52 centromeric 52 logistic regression analysis 52 thyrotropin 52 μ opioid receptor 52 beta globin gene 52 ciliated 52 ERCC1 52 ALK gene 52 androgen receptor AR 52 telomerase reverse transcriptase 52 TP# mutation 52 ChIP seq 52 BRAF mutation 52 BRCA mutation 52 RNA sequences 52 Fig. 1B 52 heterochromatin 52 steroidogenic 52 overexpressing 52 amyloid peptide 52 transthyretin 52 gene MECP2 52 proapoptotic 52 interleukin IL 52 cytidine 52 SMN1 52 Cyclin E 52 coding exons 52 TRIM5 52 neutralizing antibody 52 chromosomal deletions 52 H#K# methylation 52 lipoxygenase 52 KCNQ1 52 c myc 52 haematopoietic 52 MSH6 52 miR #b [001] 52 plasminogen activator inhibitor 52 p# p# 52 T2DM 52 CYP #D# 52 urocortin 52 guanine nucleotide exchange 52 imprinted genes 52 ß catenin 52 Phenotypic 52 parkin gene 52 T#M 52 endonuclease 52 Prox1 52 SOCS3 52 plasma folate 52 clades 52 FGFR1 52 spontaneous mutations 52 variant rs# 52 superfamily 52 Genotype 52 ABCA1 gene 52 chromosomal alterations 52 estrone 52 codon usage 52 somatostatin 52 progerin 52 neuroendocrine 52 resistin 52 nondiabetic 52 leukemic cell 52 HbF 52 cysteines 52 OCT4 52 Saccharomyces cerevisiae 52 mitochondrial proteins 52 histone acetylation 52 BMAL1 52 C. pneumoniae 52 HTLV 52 MEF2A 52 protein isoforms 52 presynaptic 52 CXCR4 52 TYMS 52 CD1d 52 overexpressed 52 amplicons 52 subfamily 52 vacuolar 52 tetramers 52 colorectal adenoma 52 Li Fraumeni syndrome 52 tHcy 52 Bcl xL 52 melanocyte 52 BRCA2 mutation carriers 52 glycan 52 immunoreactive 52 phosphorylates 52 genetic mutation 52 mRNA 52 T2D 52 PON1 gene 52 phosphatases 52 CHD5 52 glucocorticoid 52 hepatoma 52 suppressor gene 52 Rab5 52 ubiquitinated 52 trimer 52 breast carcinomas 52 S#A# [002] 52 Abl 52 Haplogroup 52 noncoding RNAs 52 autophagic 52 KCNE2 52 murine 52 mammographic density 52 epigenetic modification 52 XLHED 52 TACI mutations 52 acetylcholine receptor