Related by context. All words. (Click for frequent words.) 78 unmeasured confounders 73 unmeasured confounding 72 unmeasured factors 68 methodologic 68 prostate carcinogenesis 68 Subgroup analyzes 68 confounding variables 68 conditional logistic regression 67 generalizability 67 ascertainment bias 67 Genetic predisposition 67 plasma lipid 66 orofacial clefts 66 Observational studies 66 impaired insulin secretion 66 covariate 66 confounder 66 perioperative morbidity 66 etiologic 66 antioxidant supplementation 66 autonomic dysfunction 66 multivariate adjustment 66 Shlipak 65 logistic regression model 65 MDRD 65 multivariate Cox 65 methodological weaknesses 65 CVD mortality 65 correlational 65 sociodemographic factors 64 causal pathway 64 neurodevelopmental outcome 64 confounders 64 multivariate logistic regression 64 fetal malformations 64 multiple logistic regression 64 nonfasting triglycerides 64 biologic plausibility 64 differential gene expression 64 APOE genotype 64 nongenetic 64 intact parathyroid hormone 64 arterial stiffening 64 methodological limitations 64 AST ALT 63 lowering homocysteine 63 logistic regression analyzes 63 carotid plaque 63 clinically insignificant 63 confounding factors 63 Multivariate analysis 63 nonpharmacologic 63 logistic regression models 63 RBP4 levels 63 generalisability 63 surrogate markers 63 colorectal adenoma 63 HER2 expression 63 meta regression 63 subgroup analyzes 63 elevated CRP 63 Calcium intake 63 glucose abnormalities 63 elevated homocysteine 63 underlying pathophysiology 63 homocysteine concentrations 63 selenium supplementation 63 carotid bruit 63 meta analytic 63 univariate 63 causal inferences 63 hematopoietic cancers 63 carotid atherosclerosis 63 thyrotropin 63 testosterone supplementation 63 probiotic supplementation 63 dietary acrylamide 63 SRBD 63 Multiple linear regression 63 potential confounders 62 serotonin deficiency 62 antenatal depression 62 multivariable analysis 62 beta carotene supplementation 62 prognostic indicators 62 covariates 62 Kaplan Meier curve 62 Multiple logistic regression 62 abnormal lipid levels 62 Multivariate analyzes 62 thyroid hormone levels 62 gastric cardia 62 methodological shortcomings 62 serum calcium 62 fructose intake 62 postoperative AF 62 developmental neurotoxicity 62 serum BDNF 62 adiponectin levels 62 serum biomarkers 62 QTc prolongation 62 CYP #A# 62 potentially modifiable 62 serum homocysteine 62 psychiatric comorbidity 62 carotid IMT 62 visceral adiposity 62 lipoprotein profiles 62 cardioembolic stroke 62 Cochrane reviewers 62 subclinical hypothyroidism 62 plasma homocysteine 62 multiple linear regression 62 urinary calcium 62 glycaemia 62 intima media thickness 62 dietary folate 62 Secondhand smoke exposure 62 metabolic syndrome MetS 62 aortic stiffness 62 vitamin D inadequacy 62 subclinical atherosclerosis 62 methodological flaws 62 lipoprotein levels 62 myocardial ischaemia 62 Descriptive statistics 62 polyp recurrence 62 renal toxicity 62 familial predisposition 62 Leitzmann 62 aminotransferase levels 62 lipoprotein cholesterol 62 Subgroup analysis 62 noncancer 61 H. pylori eradication 61 impair fertility 61 Logistic regression analysis 61 cystatin C 61 androgen suppression 61 alexithymia 61 coronary calcification 61 Eunyoung Cho 61 incidentalomas 61 bivariate analysis 61 amyloid cascade 61 Socioeconomic status 61 LV dysfunction 61 Poisson regression 61 familial aggregation 61 multivariate analyzes 61 Premature menopause 61 serum vitamin D 61 hyperhomocysteinemia 61 multivariable Cox 61 subclinical hyperthyroidism 61 metabolite concentrations 61 prognostic significance 61 epistasis 61 hypoglycemic episodes 61 periprocedural MI 61 logistic regression analysis 61 abnormal glucose tolerance 61 fetal chromosomal 61 sociodemographic characteristics 61 TCF#L# gene 61 genetic susceptibilities 61 polygenic 61 NP CRNs 61 gastric carcinoma 61 NIHSS score 61 tHcy 61 subclinical inflammation 61 glomerular filtration 61 clinico pathological 61 remnant lipoproteins 61 postmenopausal estrogen 61 predisposing factor 61 pharmacokinetic interactions 61 MDRD equation 61 malabsorptive 61 univariate analyzes 61 stepwise logistic regression 61 Cardiorespiratory fitness 61 CYP#D# gene 61 poststroke depression 61 macrovascular disease 61 LRP5 61 multifactorial 61 limiting generalizability 61 folate deficiency 61 dyssynchrony 61 phenotypic variation 61 serum uric acid 61 thyrotropin levels 61 Genetic variation 61 Genetic variants 61 TNF blocker therapy 61 β blockers 61 statins cholesterol lowering 61 interindividual variability 61 Atkins dieters cardiovascular 61 adrenal suppression 61 nonrandomized 61 liver metastasis 61 borderline statistical significance 61 hepatotoxicity 61 PM#.# exposure 61 phenotypic expression 60 generalisable 60 stone formers 60 follicular adenoma 60 untreated hypothyroidism 60 bile acid metabolism 60 estrogen metabolism 60 Multivariate logistic regression 60 coronary stenosis 60 metabolic dysfunction 60 chronicity 60 nonfatal MI 60 Elevated triglycerides 60 non pharmacological interventions 60 CHD mortality 60 genetic polymorphisms 60 familial AF 60 microvascular disease 60 HOMA IR 60 clinicopathological 60 morphometric vertebral fractures 60 biological plausibility 60 nodal metastases 60 advanced adenoma 60 colorectal neoplasia 60 abdominal adiposity 60 plasma lipoprotein 60 mammographic density 60 pleiotropic effects 60 magnesium intake 60 familial clustering 60 urinary oxalate 60 serum GGT 60 chromosomal rearrangement 60 dysglycemia 60 serum lipid 60 interobserver 60 Heritability 60 Cognitive impairment 60 thromboembolic 60 Telomere length 60 myocardial dysfunction 60 K ras mutations 60 stratifying patients 60 glycemia 60 somatoform disorders 60 MMSE score 60 lipid abnormalities 60 Bacterial vaginosis 60 immunohistochemical 60 Univariate analysis 60 interobserver reliability 60 dietary calcium intake 60 Pischon 60 serum urate levels 60 intraobserver 60 bivariate 60 gallstone disease 60 thromboembolic disease 60 hippocampal volume 60 dietary modification 60 neurocognitive impairment 60 Tollerud committee 60 silent myocardial ischemia 60 HIV tropism 60 confidence intervals CIs 60 ovarian hormones 60 c reactive protein 60 atherogenesis 60 body fatness 60 transient elastography 60 elevated IOP 60 atherosclerotic lesion 60 obstructive coronary artery 60 dietary sodium 60 Soy isoflavones 60 dietary interventions 60 endometrial hyperplasia 60 Logistic regression 60 inflammatory biomarkers 60 nonvertebral fracture 60 echocardiographic parameters 60 thiazide 60 noncardiac 60 phthalate exposure 60 cortisol secretion 60 folate intake 60 underdiagnosis 60 hormone receptor status 60 tamoxifen metabolism 60 CTEPH 60 fermentable carbohydrates 60 heritable variation 60 Heavy snorers 60 intensive statin therapy 60 dietary antioxidants 60 inferential statistics 60 Reynolds Risk Score 60 Sensitivity analyzes 60 serum IGF 60 mitochondrial toxicity 60 SNP rs# [002] 60 conventional angiography 60 albumin excretion 60 eNO 60 Vitamin D insufficiency 60 metabolic acidosis 60 comorbid disorders 60 IFRD1 60 postoperative morbidity 60 Suicidal ideation 60 artifactual 60 cardiac fibrosis 60 testicular dysgenesis syndrome 60 bronchopulmonary dysplasia 60 PSA kinetics 60 Winkelmayer 59 triglyceride concentrations 59 atherogenic dyslipidemia 59 cytologic 59 histopathological 59 pituitary hormone 59 androgen depletion 59 hepatotoxic 59 premorbid 59 plasma pharmacokinetics 59 atherogenic 59 glycosylated hemoglobin HbA1c 59 platelet activation 59 Bonferroni correction 59 plasminogen activators 59 corneal thickness 59 convergent validity 59 statin medications 59 intima media thickness IMT 59 supine hypertension 59 neurocognitive deficits 59 Fasting glucose 59 O PPDS 59 CYP#D# genotype 59 untreated OSA 59 CARDIA study 59 lipid lowering therapy 59 BLLs 59 teratogenic 59 transferrin saturation 59 cerebral infarction 59 dietary folate intake 59 symptomatic VTE 59 immunotoxicity 59 serum parathyroid hormone 59 IUGR 59 left ventricular diastolic 59 ventricular remodeling 59 hydrolyzed formula 59 cTnT levels 59 TMPRSS2 ERG fusion 59 mitochondrial metabolism 59 FGFR2 gene 59 elevated bilirubin 59 haemodynamic 59 noncardiovascular 59 pretest probability 59 venous thromboembolic disease 59 postmenopausal hormone 59 Dietary intake 59 Helicobacter infection 59 selenium intake 59 thiopurine 59 Insulin sensitivity 59 Proteinuria 59 pathophysiologic 59 hepatic toxicity 59 mtDNA mutations 59 Cotinine 59 Glomerular filtration rate 59 perioperative complications 59 Vitamin D supplementation 59 causal inference 59 IV bisphosphonates 59 prostate cancer CaP 59 endocannabinoid signaling 59 androgen ablation 59 null hypothesis 59 elevated triglycerides 59 NNT = 59 authors hypothesize 59 cardiac conduction 59 hyperbilirubinemia 59 thromboembolism 59 serum triglycerides 59 clinicopathological features 59 coagulopathy 59 Cockcroft Gault 59 postoperative mortality 59 nonselective NSAIDs 59 serum IgE 59 glomerular filtration rate 59 G6PD deficiency 59 spontaneous regression 59 cartilage degeneration 59 Endothelial dysfunction 59 acetabular dysplasia 59 Singh Manoux 59 neurodevelopmental outcomes 59 comorbidity 59 serum creatinine levels 59 hemodilution 59 aminotransferases 59 elevated ALT 59 hyperglycaemia 59 Lp PLA 2 59 Hb A1C 59 serum lipids 59 GSTM1 gene 59 physico chemical properties 59 prognostic variables 59 d dimer 59 nitrite nitrate 59 journal Pharmacotherapy 59 biologically plausible 59 primary aldosteronism 59 spirometric 59 lipoprotein Lp 59 extrapyramidal side 59 comorbid conditions 59 pharmacodynamic parameters 59 Chronic pancreatitis 59 Rigorous scientific 59 hypercoagulable 59 obesity insulin resistance 59 coronary revascularizations 59 NRF2 gene 59 cardiac biomarkers 59 pleiotropy 59 postoperative pulmonary 59 prolonged QT interval 59 hemorrhagic complications 59 dysrhythmias 59 STRIDE PD 59 CSF biomarkers 59 pathophysiological 59 cranial irradiation 59 diabetic kidney 59 transgene expression 59 cardiac dysfunction 59 periodontal infection 59 FeNO 59 Univariate 59 prolactin levels 59 carotid stenosis 59 LDL HDL 59 androgen deficiency 59 postoperative delirium 59 aortic regurgitation 59 beta carotene supplements 59 vCJD epidemic 59 HER2 positivity 59 valvulopathy 59 symptom exacerbation 59 sotalol 59 delayed gastric emptying 58 antiplatelet therapies 58 riociguat 58 KDOQI 58 MetS 58 PTEN protein 58 serum cortisol 58 subclinical cardiovascular disease 58 nonadherence 58 procalcitonin 58 cardiac troponin 58 Erythropoietic therapies may 58 attain statistical significance 58 cardioprotective effect 58 serum cotinine levels 58 chromium supplementation 58 serum folate concentrations 58 CaM kinase II 58 multivariable adjusted 58 cardiovascular disease hypertension 58 trans palmitoleate 58 QT interval prolongation 58 intracerebral haemorrhage 58 SOD2 58 adnexal mass 58 postoperative hemorrhage 58 carotid artery thickness 58 mechanistic explanation 58 gestational diabetes mellitus 58 plasma lipids 58 BYSTOLIC 58 alkalosis 58 inversely associated 58 Meta analyzes 58 triglyceride concentration 58 radiographic findings 58 contrast induced nephropathy 58 chromosomal instability 58 ICD therapy 58 spontaneous preterm delivery 58 thromboembolic complications 58 penetrance 58 thyroid stimulating hormone 58 circadian misalignment 58 breast endometrial 58 Chlamydia psittaci 58 bezafibrate 58 etiological 58 cerebral microbleeds 58 albumin excretion rate 58 arterial calcification 58 pure fructose 58 Cystatin C 58 El Sohemy 58 de novo mutations 58 Fibroblast growth 58 postmenopausal hormones 58 coinfection 58 KRAS mutation status 58 syndromal 58 systemic toxicity 58 nitrotyrosine 58 periodontal infections 58 sperm morphology 58 pulmonary dysfunction 58 pharmacologic intervention 58 metabolic disturbances 58 nucleotide substitutions 58 hydroxyvitamin D levels 58 Cardiopulmonary bypass 58 aminotransferase 58 hematologic parameters 58 tumor histology 58 elevated triglyceride levels 58 serum LDL cholesterol 58 pentoxifylline 58 recurrent UTI 58 nondiabetics 58 cardiometabolic syndrome 58 testicular tumors 58 utero exposure 58 generalized estimating 58 NNRTI resistance 58 bronchopulmonary dysplasia BPD 58 growth hormone secretion 58 multivariate regression 58 adrenal function 58 modifiable lifestyle 58 chromosomal mutations 58 postoperative atrial fibrillation 58 colorectal carcinogenesis 58 body habitus 58 Prehypertension 58 BEXXAR Therapeutic Regimen 58 serum estradiol 58 myocardial viability 58 chemoprevention trials 58 recurrent venous thromboembolism 58 CYP#C# genotype 58 aldosterone antagonist 58 plasma homocysteine levels 58 squamous cell lung cancer 58 empiric 58 Joshua Schier 58 DHEA supplementation 58 obstructive CAD 58 fasting glucose levels 58 prion infection 58 loop diuretics 58 Uncontrolled hypertension 58 evolvability 58 STEP BD 58 macrovascular complications 58 psychobiological 58 #q# deletion 58 flavonoid intake 58 noncardiovascular mortality 58 HER2 overexpression 58 CYP#C# [001] 58 Magnesium deficiency 58 #q# deletion syndrome 58 Heavy menstrual bleeding 58 NHANES III 58 BRCA carriers 58 genomewide 58 micronutrient intake 58 troponin T 58 Fatty liver 58 psychopathological symptoms 58 CP CPPS 58 Bibbins Domingo 58 inherited predisposition 58 pathophysiological mechanisms 58 CETP inhibition 58 cellularity 58 natriuretic peptides 58 kidney allograft 58 vitamin B# supplements 58 APOE e4 58 scintigraphic 58 prothrombotic 58 F FDG PET 58 Tasigna prolongs 58 neuropsychological deficits 58 thiazide diuretics 58 newer atypical antipsychotics 58 UVB exposure 58 moderately heritable 58 ketogenic diets 58 Previous observational studies 58 Dr Chavarro 58 metabolic parameters 58 EEG abnormalities 58 Therein lurks 58 locoregional recurrence 58 insulin resistance syndrome 58 ConclusionThis 58 angiographically 58 impaired cognition 58 genotypic resistance 58 histopathologic 58 MTHFD1L gene 58 predictive validity 58 AMOR IPAT 58 recurrent miscarriage 58 potential confounding variables 58 thrombogenic 58 histopathologic diagnosis 58 genetic polymorphism 58 Maternal obesity 58 hawthorn extract 58 cardiac troponin T 58 creatine supplementation 58 sonographic diagnosis 58 laterality 58 Neugut 58 esophageal squamous cell carcinoma 58 fasting triglycerides 58 transaminase elevations 58 Orthostatic hypotension 58 ICD implantation 58 myocardial ischemia 58 #F FDG PET 58 Endothelial function 58 electrophysiologic 58 endometrial carcinoma 58 postoperative complication 58 nonvaccine 58 monogenic 58 tertiles 58 histologic subtype 58 steroidogenic 58 CALHM1 57 vasogenic edema 57 prenatal exposures 57 Personality traits 57 airflow limitation 57 chi squared 57 perimenopausal women 57 mortality morbidity 57 genomic alterations 57 chromosomal aberrations 57 #,# DCB 57 RBP4 57 exploratory endpoints 57 elevated TSH 57 causative pathogens 57 airway responsiveness 57 FUS protein 57 aetiology 57 endometrial thickness 57 gestational diabetes mellitus GDM 57 prognostic indicator 57 neuropsychological impairment 57 LVNC 57 D dimer 57 HPA axis 57 abstinent alcoholics 57 myopathy rhabdomyolysis 57 ratio WHR 57 bivariate analyzes 57 Adjuvant chemotherapy 57 phylloquinone 57 metaanalysis 57 nephrolithiasis 57 adenoma recurrence 57 impaired glucose metabolism 57 BCL#A 57 preoperative diagnosis 57 serum leptin 57 hypoperfusion 57 airway hyperresponsiveness 57 MGUS 57 FDG PET imaging 57 calcium supplementation 57 poor metabolizers 57 endogenous hormones 57 apolipoprotein B 57 comorbidities 57 NATRECOR ® 57 QTc intervals 57 hepatic fibrosis 57 haematologic 57 psychiatric comorbidities 57 IGRAs 57 serum cholesterol 57 semiquantitative 57 postprandial insulin 57 DNA methylation patterns 57 somatic symptoms 57 choline intake 57 antiangiogenic therapy 57 neurodevelopmental impairment 57 aetiological 57 helical CT 57 Abdominal obesity 57 NSAID induced GI 57 CYP #D# 57 Avandia Actos 57 FGFs 57 Previous epidemiological studies 57 Dr. Chenchen Wang 57 Schaffir 57 serum glucose 57 somatostatin analogs 57 hypercalciuria 57 distal colon 57 chest radiographs 57 chlamydial infection 57 atherothrombotic 57 Hyperparathyroidism 57 hypovitaminosis D 57 explanatory variables 57 PITX2 methylation 57 eosinophil count 57 arterial thromboembolic events 57 nonfasting triglyceride levels 57 intermittent hypoxia 57 amyloid deposition 57 liver transplant recipients 57 oral hypoglycemic agents 57 chromosomal imbalance 57 Skin sterol 57 Chronic insomnia 57 EBV infection 57 elevated LDL cholesterol 57 arrhythmogenic 57 IPAH 57 ROC curves 57 pharmacologic treatments 57 anovulatory infertility 57 apneic episodes 57 tibolone 57 Echocardiographic 57 glycated hemoglobin levels 57 inducible ischemia 57 parameter estimation 57 etiological factors 57 serum PTH 57 cardiovascular morbidity 57 lymph node metastasis 57 diabetes dyslipidemia 57 Multivariable logistic regression 57 brassinosteroid 57 hamartomas 57 histopathologic examination 57 predisposing factors 57 afterload 57 periprocedural 57 cerebral ischemia 57 multivariate regression analysis 57 macrovascular 57 Calorie restriction 57 Familial hypercholesterolemia 57 aneuploidy 57 dose ionizing radiation 57 lymphocyte activation 57 overdiagnosis 57 nutrient supplementation 57 pulmonary arterial 57 fibrate drugs 57 microdeletion 57 metaplasia 57 KRAS mutation 57 prospective longitudinal 57 impaired endothelial 57 exhaled nitric oxide 57 tumorigenicity 57 vascular dysfunction 57 phytoestrogen intake 57 esophageal motility 57 pressure natriuresis 57 covariance 57 behavioral disinhibition 57 carotid plaques 57 aldosterone antagonist therapy 57 lipid levels 57 Symptom severity 57 psychosocial variables 57 pharmacological intervention 57 atypical antipsychotic medications 57 prognostically 57 antidiabetes drugs 57 Abdominal fat 57 beta1 integrin 57 CHD CVD 57 antiarrhythmic medications 57 ecotoxicological 57 diagnosing ADHD 57 histological subtype 57 RfD 57 sociodemographic variables 57 androgen deprivation 57 lactate dehydrogenase 57 KIF6 carriers 57 Acute pancreatitis 57 underlying molecular mechanisms 57 nephron 57 STAT3 signaling 57 proinflammatory cytokine 57 urine albumin 57 Proximate cause 57 Histologic 57 oseltamivir resistance 57 CYP#C# [002] 57 multi factorial disease 57 Bresalier 57 neurologic complications 57 Francesca Bravi 57 Randomized trials 57 dose proportionality 57 renoprotective 57 depressive symptomatology 57 plasma creatinine 57 atopic disease 57 glycated hemoglobin HbA1c 57 neurocognitive functioning 57 gastrointestinal absorption 57 vitamin D insufficiency 57 hsCRP levels 57 ultrasound elastography 57 antitumor effect 57 hyperparathyroidism 57 prognostic marker 57 contraindicate 57 HbF levels 57 nonhematologic adverse reactions 57 lowering triglyceride levels 57 endocrinologic 57 Hallux valgus 57 initiating antiretroviral therapy 57 baseline serum bilirubin 57 mTOR inhibition 57 bronchial responsiveness 57 cTnI 57 triacylglycerol concentrations 57 author Katherine Flegal 57 autoregulation 57 estimated GFR 57 Non inferiority 57 folic acid deficiency 57 CYP#C# gene 57 neurohormonal 57 protein excretion 57 Hypoglycaemia 57 CLA supplementation 57 macroalbuminuria 57 CHADS2 57 gastrointestinal GI bleeding 57 gut microbiota 57 variant angina 57 serum lipid levels 57 thrombotic events 57 mitochondrial mutations 57 lethal arrhythmias 57 elevated serum ALT 57 shorten telomeres 57 arteriography 57 nonmelanoma skin cancers 57 Thalomid ® 57 QT prolongation 57 pathologic fractures 57 cTnT 57 Wactawski Wende 57 PNH patients 57 EMPOWER TM 57 arterial thickening 57 p#INK#a 57 p# activation 57 PTPN# 57 BRCA mutation carriers 57 plasma selenium 57 nonsignificant 57 metabolic abnormalities 57 abnormal glucose metabolism 57 serum PSA 57 Homocysteine levels 57 neurocognitive function 57 anovulation 57 FASPS 57 TWYNSTA 57 nonischemic 56 COPD exacerbations 56 klotho 56 endothelial dysfunction 56 Rh incompatibility 56 Homocysteine 56 colorectal neoplasms 56 preterm neonates 56 absolute contraindication 56 Estrogen deficiency 56 fluoroquinolone resistance 56 posttreatment 56 extrapyramidal symptoms 56 Vauthey 56 electroencephalographic 56 HbA1C levels 56 TCF#L# 56 C. pneumoniae 56 uric acid kidney stones 56 #OHD 56 prospectively stratified 56 oxidized phospholipids 56 hematological parameters 56 FDG uptake 56 VADT 56 spiral computed tomography 56 overt hypothyroidism 56 logistic regression 56 acetabular fractures 56 lung epithelium 56 autoimmune reactions 56 FQPA 56 hypoxemia 56 pulmonary toxicity 56 HbA 1c 56 TOP2A gene 56 isoflavone supplements 56 vestibular dysfunction 56 chromium picolinate supplementation 56 chorioamnionitis 56 Dietary fat 56 maintaining cardiorespiratory fitness 56 recurrent VTE 56 cardio metabolic 56 comorbid depression 56 Djousse 56 asymptomatic bacteriuria 56 Leydig cell 56 Modifiable risk 56 prospectively defined 56 intracranial stenosis 56 hormone adiponectin 56 mammographic breast density 56 nephrotoxicity 56 adjuvant therapies 56 multivitamin supplementation 56 antihypertensive therapy 56 Angiotensin converting enzyme 56 Genetic variations 56 creatine kinase 56 gastric carcinogenesis 56 perinatal outcomes 56 serum urate 56 compulsive hoarding syndrome 56 hyperinsulinemia 56 RCTs 56 gallstone formation 56 intestinal biopsy 56 glucose homeostasis 56 GH deficiency 56 chromosome #p#.# 56 Akt activation 56 pleiotropic 56 socioeconomic deprivation 56 observational cohort 56 dietary carbohydrate 56 neuropsychiatric symptoms 56 genotypic 56 KRAS status 56 hyperalgesia 56 shorter telomere length 56 CD# expression [002] 56 teratogenicity 56 genetic locus 56 capillary permeability 56 Mendelian randomization 56 nonfasting 56 HbF 56 Chlamydia pneumoniae 56 Primary endpoints