Related by context. All words. (Click for frequent words.) 70 SIRT1 70 sirtuin 68 SIRT3 67 SIRT1 gene 66 tumor suppressor protein 64 Sirtuins 64 PPAR gamma 64 hedgehog pathway 63 Sirtuin 63 PPARγ 63 HDACs 63 hormone leptin 62 tyrosine kinases 62 Sir2 62 melanocortin receptors 62 Notch signaling 62 PTP1B 62 signaling molecule 62 micro RNAs 61 SH#B# 61 proteases 61 ubiquitin ligases 61 p#/CBP 61 cell signaling pathways 61 GPR# [002] 61 Hedgehog pathway 61 EGFR signaling 61 ADDLs 60 histone deacetylases 60 PPAR γ 60 Sirt3 60 NF kB 60 FoxO1 60 Skp2 60 Six3 60 Wnt#b 60 protein kinases 60 receptor protein 60 CaM kinase II 60 Cdc# 60 Wnt pathway 60 microRNAs 60 FOXO 60 Klotho 60 endocannabinoid system 60 FOXO3a 60 tumor suppressor gene 60 Keap1 60 signaling pathway 60 p# MAPK 60 Wnt signaling pathway 60 riboswitches 60 CIB1 60 endocannabinoids 60 COX enzymes 60 Nrf2 60 calcineurin 60 MAPK 59 tumor suppressor 59 UCP2 59 PPAR alpha 59 MMPs 59 tumor suppressor genes 59 histone deacetylase inhibitors 59 Sirt1 59 Akt1 59 ADAM# 59 progerin 59 inflammasome 59 molecular pathways 59 ubiquitylation 59 GSK3 59 SIR2 59 HDAC6 59 p# pathway 59 S#K# 59 Src 59 glutamate receptors 59 KLF# 59 PPAR delta 59 synapse formation 59 beta catenin 59 HDAC inhibitors 59 Hsp# [001] 59 epigenetic 58 COX2 58 JAK3 58 calpain 58 biochemical mechanisms 58 epigenetic regulation 58 nicotinic receptors 58 TMEM#B 58 Klotho gene 58 apoE 58 POMC neurons 58 glucocorticoid receptors 58 PI3K 58 evolutionarily conserved 58 cholesterol metabolism 58 mTOR 58 PKM2 58 AMPK 58 miRNAs 58 protein misfolding 58 Wnts 58 5 hydroxymethylcytosine 58 metabolic enzymes 58 casein kinase 58 arginase 58 hedgehog signaling 58 glucocorticoid receptor 58 NKT cells 58 NMDA receptors 58 MEF2 58 glycolipids 58 proteins 58 Smurf1 58 microRNA molecules 58 non coding RNAs 58 Wnt signaling 58 BACE1 58 SGK1 58 FGF# 58 p# gene 58 SH2 B 58 SCD1 58 noncoding RNAs 58 TGF beta 58 molecular pathway 58 demethylase 57 cathepsins 57 Smoothened 57 STAT3 57 cellular pathways 57 TAp# 57 NFkappaB 57 neurogenesis 57 chromatin remodeling 57 IGFBP2 57 epigenetic changes 57 dopamine receptor 57 acetylation 57 tumorigenesis 57 LDL receptor 57 Akt3 57 PRDM# 57 PI3K pathway 57 CXCR7 57 activate SIRT1 57 neurofibromin 57 podocytes 57 protein SIRT1 57 SIR2 gene 57 VIPR2 57 LRRK2 57 neurodegeneration 57 Notch pathway 57 gene transcription 57 TRIM# 57 ligases 57 HSF1 57 PI3 kinase 57 gene p# 57 micro RNA 57 TGF beta pathway 57 molecular mechanism 57 cell signaling pathway 57 FGFR1 57 kinases 57 ABCA1 57 resistin 57 insulin receptors 57 oncogenes 57 paxillin 57 signaling cascades 57 Pin1 57 CB2 receptor 57 Hh pathway 56 SIRT6 56 glutamate receptor 56 CXCL5 56 androgen receptors 56 synaptogenesis 56 microRNAs miRNAs 56 HDAC 56 myogenesis 56 signaling molecules 56 Mcl 1 56 CPT1c 56 Stat3 56 CB1 receptor 56 resveratrol 56 Notch receptor 56 KLF4 56 serotonin receptor 56 estrogen receptors 56 primary cilia 56 CTLA 4 56 oncogenic 56 PGC 1a 56 c Abl 56 HOTAIR 56 leptin 56 telomerase enzyme 56 carbohydrate metabolism 56 mutated protein 56 TRPV3 56 lipid synthesis 56 epigenetics 56 SREBP 56 NF κB 56 cellular metabolism 56 MAPK pathway 56 PGC 1alpha 56 cannabinoid receptors 56 nitric oxide synthase 56 kinase pathway 56 ENaC 56 histone modifications 56 Srs2 56 protein kinase C 56 calorie restriction 56 FMRP 56 microcephalin 56 androgen receptor 56 RUNX3 56 receptor molecule 56 p#INK#a 56 WWP2 56 signaling pathways 56 GCN2 56 neuromuscular junction 56 glucose homeostasis 56 galanin 56 NMDA receptor 56 TGF ß 56 biochemical pathway 56 transcription factors 56 genes 56 DARPP 56 neuropeptides 56 histone acetylation 56 NFκB 56 peroxisome proliferator activated 56 selective inhibition 56 PKMzeta 56 non coding RNA 56 enzyme telomerase 56 sortilin 56 regulating gene expression 56 FGFs 56 glucagon receptor 56 fatty acid synthase 56 S#A# [002] 56 CRTC3 56 dopamine receptors 56 cyclins 56 GRK2 56 TGF β 56 Aurora kinases 56 calmodulin 56 activin 56 APOBEC3G 56 VEGF receptor 56 XBP1 56 endogenous ligands 55 cyclic AMP 55 potent inhibitors 55 lincRNAs 55 phosphatases 55 transdifferentiation 55 mimetics 55 cyclophilin D 55 MAP kinases 55 Smad3 55 miR #a [002] 55 IL#R 55 major histocompatibility complex 55 p# protein 55 neurotransmitter glutamate 55 Notch1 55 mutant huntingtin 55 protein kinase 55 Tregs 55 HDAC2 55 apoE4 55 nNOS 55 TRAF6 55 TORC2 55 IKK2 55 PGE2 55 NF kappaB 55 SOD1 55 microglial cells 55 TrkB 55 astrocytes 55 lipid metabolism 55 AMPA receptors 55 vitamin D receptors 55 MAP kinase 55 leptin receptors 55 epigenetic mechanisms 55 cellular senescence 55 Hedgehog signaling 55 tumor suppressors 55 SIRT2 55 PKD1 55 ubiquitin 55 fatty acid metabolism 55 alpha synuclein 55 KIAA# 55 pRb 55 neuronal plasticity 55 incretin 55 Akt 55 TERT 55 insulin sensitizers 55 mTOR signaling 55 retinoic acid 55 CaMKII 55 laforin 55 sphingolipids 55 BCL6 55 adenosine A2A receptor 55 huntingtin protein 55 tyrosine kinase 55 AMPA receptor 55 lipid mediators 55 membrane protein 55 mitogen activated protein kinase 55 FANCD2 55 immunoregulatory 55 TLE3 55 JAK STAT 55 neuropeptide Y NPY 55 secreted protein 55 CHD5 55 ARF1 55 #beta HSD1 55 PIK3CA 55 myostatin 55 binding proteins 55 IRF5 55 CALHM1 55 serine protease 55 molecular mechanisms 55 IKKa 55 Stat5 55 cell motility 55 orexin 55 humanin 55 tau protein 55 neuroligins 55 protein 55 Wnt 55 NF kappaB pathway 55 innate immunity 55 MeCP2 55 ALDH2 55 DNA methyltransferases 55 LIS1 55 miR #b [002] 55 glucokinase 55 molecular chaperones 55 LKB1 55 PP2A 55 DGAT1 55 ghrelin 55 Th# cells 55 palladin 55 telomerase 55 PKC beta 55 enzyme AMPK 55 ATF2 55 EZH2 55 NK1R 55 Sirtris 55 γ secretase 55 synaptic plasticity 55 PPARg 55 epigenetic alterations 55 adult neurogenesis 54 TLR4 54 LRP6 54 small molecule inhibitors 54 actin cytoskeleton 54 regulates gene expression 54 Orexin 54 adipokine 54 Leptin 54 TrkA 54 alpha synuclein gene 54 RNA polymerase II 54 adenosine receptors 54 SOCS1 54 TNF receptors 54 anti inflammatory cytokine 54 neuronal degeneration 54 Cdk5 54 Wnt proteins 54 cadherin 54 mitochondrial function 54 peptides 54 MDM2 54 mTOR mammalian target 54 p# [001] 54 MEK ERK 54 Bcl xL 54 microRNA 54 pro angiogenic 54 systemic inflammation 54 Symadex 54 RANKL 54 transmembrane proteins 54 kinase enzymes 54 ACE2 54 protein tyrosine phosphatases 54 neurotransmitter receptor 54 tRNA synthetase 54 CCR3 54 clusterin 54 selective inhibitors 54 PHD2 54 signal transduction 54 MIF protein 54 hedgehog signaling pathway 54 tenascin C 54 miRNA genes 54 antimicrobial peptides 54 airway remodeling 54 OGG1 54 lipoprotein metabolism 54 inflammatory cytokines 54 mitochondrial proteins 54 glycogen synthase kinase 54 Runx2 54 RAR beta 54 TRP channels 54 PTPN# 54 nestin 54 pre mRNA splicing 54 TLR8 54 kinase 54 CaM kinase 54 PKC enzyme 54 stathmin 54 RGS2 54 JAZ proteins 54 amyloid deposits 54 TNFα 54 PKCi 54 tetherin 54 vimentin 54 PTP 1B 54 PI3K/AKT 54 E1A 54 underlying molecular mechanisms 54 Sox9 54 FOXP3 54 cellular signaling pathways 54 JAK2 54 CB1 receptors 54 C EBP alpha 54 MC4R 54 chitinase 54 causative genes 54 gene expression 54 MicroRNAs 54 genes encoding 54 antioxidant enzymes 54 TSLP 54 intracellular signaling 54 oncogenesis 54 EphB2 54 DLC1 54 small RNAs 54 LXRs 54 4E BP1 54 GSK 3ß 54 SIRT4 54 epigenetic silencing 54 noncoding RNA 54 brain derived neurotrophic 54 oxidative stress 54 endoplasmic reticulum stress 54 GATA3 54 eotaxin 54 oncomodulin 54 estrogen metabolism 54 LRRK2 gene 54 mitochondrial mutations 54 melatonin receptor 54 antioxidant compounds 54 Kinases 54 protein p# 54 naturally occurring molecule 54 kappa opioid receptor 54 CCR9 54 Bryostatin 54 LPA1 54 c Myc 54 hyperactivation 54 sulforaphane 54 Myc 54 metabolic pathways 54 histone modification 54 cyclin D1 54 lipin 54 HMG CoA reductase 54 tumor suppressor p# 54 inhibit enzymes 54 enzymes 54 C1q 54 NKX#.# 54 Htt 54 receptor gene 54 Myostatin 54 receptor tyrosine kinase 54 ZNF# 54 ERK1 2 54 uPAR 54 NF KappaB 54 telomere shortening 54 obestatin 54 tumor suppressive 54 autophagy 54 DLX5 54 TH# cells 54 FKBP# 54 podocyte 54 beta arrestin 54 morphogen 53 biochemical pathways 53 Lyn kinase 53 sGC 53 EGF receptor 53 SIK2 53 GPR# [001] 53 thrombospondin 53 PTEN gene 53 HSP# 53 protein CETP 53 Androgen receptor 53 CYP#E# 53 estrogen receptor alpha 53 lipoic acid 53 telomere maintenance 53 ubiquitin ligase 53 c MYC 53 caloric restriction 53 RGS# 53 IL6 53 neurofibrillary tangles 53 biologic pathways 53 TXNIP 53 receptors 53 triterpenoids 53 CXCL# 53 chaperone protein 53 cannabinoid receptor 53 Foxp3 53 tau proteins 53 telomere 53 PPARs 53 inosine 53 LPA1 receptor 53 microglial 53 DHFR 53 JAK2 enzyme 53 synaptic transmission 53 Apobec3 53 interleukins 53 chromatin structure 53 neuroinflammation 53 FGFR2 53 p# MAP kinase 53 pDCs 53 TG2 53 IGF1 53 PAK1 53 eNOS 53 breast cancer metastasis 53 ubiquitination 53 neurexin 53 nicotinic receptor 53 retinoids 53 costimulatory 53 neurotrophic factors 53 NF KB 53 cyclic AMP cAMP 53 USP# 53 sphingolipid 53 gut microbiota 53 P#X# 53 leptin receptor 53 Clusterin 53 tumor angiogenesis 53 protein synthesis 53 Pdx1 53 Dr. Karsenty 53 tyrosine phosphorylation 53 FGF2 53 tumor microenvironment 53 Sgk1 53 TRF1 53 ion channels 53 PHLPP 53 nAChR 53 PDGFR 53 p# activation 53 peptide hormone 53 HCV replication 53 thyroid hormone receptor 53 CD#L 53 abscisic acid 53 PIP2 53 NAD + 53 SORL1 53 senescent cells 53 oncoprotein 53 neurotrophic 53 PDE#A 53 tyrosine 53 histone 53 kisspeptin 53 HER3 53 cryopyrin 53 mitochondrial dysfunction 53 Kuro o 53 cyclooxygenase 53 gene 53 TGFβ 53 urocortin 53 copper zinc superoxide 53 plasminogen 53 mTOR pathway 53 IFRD1 53 S1P 53 ceramide 53 Hedgehog signaling pathway 53 piRNAs 53 miR 53 protein homeostasis 53 phosphorylation 53 β catenin 53 macrophage 53 GGTase 53 oxidized lipids 53 NR2B 53 GRP# 53 oxysterols 53 SWI SNF 53 chemokine 53 regulate gene expression 53 cryptochromes 53 Fc receptor 53 ERK pathway 53 galectin 3 53 NFkB 53 suppressor cells 53 cardiac hypertrophy 53 estrogen receptor 53 BMAL1 53 Ras pathway 53 EGFR pathway 53 prostaglandin synthesis 53 STIM1 53 hormone ghrelin 53 PARP inhibitors 53 protein interleukin 53 GLI1 53 clioquinol 53 effector functions 53 cAMP signaling 53 Yap1 53 Syk 53 epigenetic modification 53 TRIM5 53 epicatechin 53 transcriptional regulation 53 ion channel 53 imprinted genes 53 TRIM5a 53 intracellular pathways 53 PIP3 53 neuronal function 53 bacterial enzymes 53 metabolic processes 53 E#F# 53 A3 adenosine receptor 53 insulin sensitizing 53 RNA silencing 53 molecular underpinnings 53 heme oxygenase 1 53 virulence genes 53 Hfq 53 stem cell pluripotency 53 c myc 53 D2 receptor 53 hsp# 53 DISC1 53 angiogenesis 53 neurotransmission 53 GnIH 53 apoptotic pathway 53 rapamycin 53 COX 2 53 GPCRs 52 ErbB3 52 pathogenic mechanisms 52 myeloid cells 52 miRNA 52 upregulate 52 glycation 52 ncRNAs 52 inhibitory 52 enzyme 52 FOXO1 52 LRP1 52 Piomelli 52 RecA 52 antiapoptotic 52 catenin 52 adhesion molecule 52 ERK signaling 52 cyclin dependent kinases 52 EphA2 52 dopamine transporter 52 transcriptional regulators 52 CCR2 52 remyelination 52 RNAs 52 proteolysis 52 PAR1 52 IL #R 52 adaptive immunity 52 chemokine receptor 52 protein tyrosine kinase 52 genotoxic stress 52 histone methylation 52 membrane fusion 52 Sonic Hedgehog 52 GABA neurotransmitter 52 calcium homeostasis 52 neurite outgrowth 52 signaling cascade 52 melanopsin 52 bioactive compounds 52 neuronal differentiation 52 tumor suppressing 52 HGPS 52 H#K# [002] 52 Ets2 52 miR #a [001] 52 demethylation 52 neurotrophins 52 heparan sulfate 52 Oct4 52 monoamines 52 RNA molecule 52 Eg5 52 cryptochrome 52 Pterostilbene 52 telomerase activity 52 neurotrophic factor 52 RNA molecules 52 primary cilium 52 MicroRNA 52 hypoxia inducible factor 52 microRNA expression 52 EGFr 52 NADPH oxidase 52 Irs2 52 IKKß 52 Arp2 3 52 MyoD 52 GABA receptor 52 LRP5 52 proto oncogene 52 cytoprotective 52 CCL5 52 CD# ligand 52 genetic modifiers 52 NKG2D 52 vascular disrupting agents 52 mutant SOD1 52 cystic fibrosis transmembrane conductance 52 ApoE 52 selectively inhibit 52 neuroprotective 52 kinase inhibitors 52 cardiolipin 52 PML RARA 52 Kv#.# 52 TNFa 52 neuronal stem cells 52 neuropeptide 52 mitochondrial enzyme 52 selenoproteins 52 receptor 52 TCF#L# 52 beta amyloid plaques 52 signal transduction pathways 52 Cx# [001] 52 Alu elements 52 TGF b 52 cytochrome P# 52 Rad# 52 matrix metalloproteinase 52 MeCP2 protein 52 RNAi pathway 52 RNA splicing 52 Sox2 52 dynamin 52 molecule 52 INF2 52 pericytes 52 leptin hormone 52 biochemical processes 52 CatB 52 phosphorylate 52 immunomodulatory effects 52 MAP kinase pathway 52 STAT1 52 inhibit angiogenesis 52 histone code 52 dystroglycan 52 MUC1 52 cholinergic 52 beta adrenergic receptors 52 thymidylate synthase 52 serine proteases 52 carcinogenesis 52 synaptic function 52 Kinase 52 Prox1 52 Pin1 enzyme 52 MCPIP 52 nitric oxide NO 52 lymphocyte activation 52 uPA 52 homeobox gene 52 heterochromatin 52 progranulin protein 52 WT1 52 genetically altered mice 52 flavopiridol 52 ERa 52 SGLT2 52 transcriptional activation 52 NNRs 52 myocardin 52 furin 52 enzymatic activity 52 mRNA decay 52 NF kB pathway 52 phosphoinositide 3 52 EETs 52 spermidine 52 NF kappa B 52 Nedd4 52 interferon pathway 52 anti microbial peptides 52 glia 52 lipoprotein lipase 52 dendritic spine 52 matrix metalloproteinases 52 plexin D1 52 intracellular signaling pathways 52 IRAK1 52 Sassone Corsi 52 circadian clock genes 52 PKC alpha 52 transthyretin 52 leptin signaling 52 Rab# 52 osteocalcin 52 biogenesis 52 mammalian cells 52 Sulforaphane 52 transmembrane receptor 52 utrophin 52 p#NTR 52 iNOS 52 Cyclin E 52 PDGF receptor 52 ACAT2 52 factor BDNF 52 calmodulin kinase II 52 intracellular signal transduction 52 leukocyte recruitment 52 CPEB 52 bile acid metabolism 52 neuronal signaling 52 GPx 52 palmitoylation 52 cysteine 52 chromosomal instability 52 lectins 52 STAT4 52 molecularly targeted 52 MUC1 * 52 hypocretin 52 chemopreventive 52 adhesion molecules 52 serotonin transporter 52 gastrin 52 aromatase 52 bryostatin 52 Src kinase 52 phosphate S1P 52 p# tumor suppressor 52 estrogen receptor beta 52 mGluR4 52 quorum sensing 52 glucocorticoid receptor GR 52 adipokines 52 ryanodine receptor 52 potent anticancer 52 TGF Beta 52 unicellular organism 52 biosynthesis 52 Caloric restriction 52 p#Kip# 52 muscarinic 52 mGluR2 NAM 52 Math1 52 klotho 52 neuroprotection 52 MMP2 52 antisense RNA 52 dopamine D2 receptors 52 invadopodia 51 neuronal synapses 51 metabolic 51 superfamily 51 glial cell 51 Rev erb 51 gamma secretase 51 CDK inhibitors 51 SOD1 protein 51 adiponectin 51 Jagged1 51 MEF2D 51 IL 1β 51 GnT 4a 51 TLRs 51 biological pathways 51 transient receptor 51 polyamine 51 Ii protein 51 protein encoded 51 osteoclast 51 CXCR2 51 NS5A 51 RANK ligand 51 MEK inhibitors 51 nicotinamide 51 IDH1 51 glycosylation 51 molecule interleukin 51 RNase L 51 proapoptotic 51 hepatic stellate cells 51 phosphorylated 51 glycoproteins 51 Cdc7 51 enzymology 51 collagen VI 51 APOE4 51 dietary restriction 51 cholesterol absorption 51 intracellular proteins 51 cofilin 51 resolvins 51 druggable targets 51 physiological mechanisms 51 HIF 1alpha 51 transcription factor 51 epigenetic modifications 51 TSP1 51 innate immune system 51 PI3K signaling pathway 51 beta1 integrin 51 RNA binding 51 retinoblastoma protein 51 IKK beta 51 innate immune 51 Mdm2 51 dopaminergic 51 E3 ubiquitin ligase 51 lipoxygenase 51 MMP7 51 AMACR 51 sulphoraphane 51 bioactive lipids 51 IGF IR 51 heme oxygenase 51 GAB2