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(Click for frequent words.) 74 striatal dopamine 73 microglial 72 mRNA expression 72 hippocampal 71 presynaptic 71 c Fos 70 caudate 70 D2 receptor 70 immunoreactivity 70 hypothalamic 70 ACh 70 ERK1 2 70 posterior cingulate 70 noradrenergic 69 nAChR 69 glutamatergic 69 TrkB 69 medial prefrontal 69 neuronal dysfunction 69 neuropeptide Y 69 anterior cingulate 69 BMP signaling 69 prefrontal cortical 69 GABAergic interneurons 69 autoregulation 69 Rab5 69 somatosensory cortex 69 amyloid β 68 nociceptive 68 hippocampal neurons 68 autophagic 68 IFN γ 68 TNFalpha 68 dopamine receptors 68 catecholamine 68 HepG2 cells 68 medial temporal 68 acetylcholine receptor 68 neurite outgrowth 68 hyperactivation 68 GLUT4 68 inhibitory 68 serotonergic 68 postsynaptic 67 rCBF 67 ERalpha 67 serotonin transporter 67 hypothalamic pituitary adrenal axis 67 dorsolateral 67 NMDAR 67 arcuate nucleus 67 cytoskeletal 67 D aspartate 67 receptor subtypes 67 synaptogenesis 67 parietal cortices 67 dopamine transporter 67 hypometabolism 67 locomotor activity 67 c Src 67 NAc 67 IL 1ß 67 ATPase 67 electroencephalographic 67 MAP kinase 67 microglial activation 67 nitrotyrosine 67 histone acetylation 67 monoamine 67 glutamate receptors 67 tyrosine hydroxylase 67 subcellular localization 67 dopamine signaling 67 HPA axis 67 fronto 67 S#A# [002] 67 overactivation 67 DNMT1 67 astrocytic 67 lateral hypothalamus 67 cortical 67 CEACAM1 66 synaptic transmission 66 inflammatory cytokine 66 transmembrane 66 midbrain 66 dopaminergic 66 GH secretion 66 potentiation 66 adrenoceptor 66 mitogenic 66 nAChRs 66 c fos 66 extracellular signal 66 pyramidal cells 66 P cadherin 66 alpha subunit 66 aggrecan 66 TGF β 66 FKBP# 66 basal ganglia 66 antiapoptotic 66 neurotransmitters serotonin 66 Macrophage 66 gyrus 66 cortical activation 66 adhesion molecule 66 mediated inhibition 66 superior temporal gyrus 66 Purkinje cell 66 carcinoembryonic antigen 66 dopamine D2 receptor 66 rostral 66 deacetylation 66 muscarinic receptors 66 dehydrogenase 66 cortical regions 66 F actin 66 myocyte 66 constitutively expressed 66 eNOS 66 inducible nitric oxide synthase 66 dorsolateral prefrontal 66 p#Kip# 66 uPAR 66 serotonin receptor 66 proteolysis 66 motoneurons 66 thalamic 66 ERK activation 66 MMP9 66 estrogen receptor alpha 66 mesolimbic 66 insular cortex 66 p#NTR 66 glomerular 66 mitochondrial respiration 66 neurofilament 65 acyl CoA 65 serotonin transporters 65 VE cadherin 65 subgenual cingulate 65 vimentin 65 Wnt signaling 65 Aâ 65 T2 weighted images 65 osteoblast 65 Prefrontal 65 Western blotting 65 monocyte 65 raphe 65 corticospinal 65 plasma leptin 65 medial frontal cortex 65 Rap1 65 GABAergic 65 cytosolic 65 #ß 65 baroreceptor 65 thyrotropin 65 mRNA encoding 65 AMPA receptor 65 TGF ß 65 P2X 65 constitutively active 65 PDGFR 65 5 HT1A 65 inferior frontal 65 mPFC 65 cingulate 65 ß catenin 65 neuronal 65 upregulates 65 synaptic 65 paraventricular nucleus 65 temporal cortex 65 Supplementary Fig 65 cytosol 65 intracellular signaling 65 dorsal horn 65 glial 65 p# activation 65 RhoA 65 serum cortisol 65 mitochondrial enzyme 65 splenocytes 65 Runx2 65 habenula 65 GSTP1 65 amino acid substitutions 65 downregulation 65 M1 muscarinic 65 Ca2 + 65 CA1 65 circadian clock genes 65 SOCS3 65 IL #p# 65 H#K#me# 65 beta adrenergic receptors 65 Kupffer cells 65 dopamine receptor 65 paxillin 65 electrophysiological 65 TIMP 65 Hcrt 65 immunoreactive 65 lactate dehydrogenase 65 regulated kinase ERK 65 hormone secretion 65 pDCs 65 HOTAIR 65 Dysregulation 65 myo inositol 65 vascular endothelial 65 vagal 65 beta1 integrin 65 GluR1 65 modulatory 65 IRE1 65 E3 ubiquitin ligase 65 microsomal 65 transcriptional regulation 65 IL 1beta 65 RRM1 65 cyclic AMP cAMP 65 endothelial nitric oxide synthase 65 nNOS 65 FGF2 65 receptor gamma 64 downregulate 64 histone modifications 64 mitogen activated protein kinase 64 metabolizing enzyme 64 PON1 64 TIMP 1 64 neuromuscular junction 64 PC# cells 64 adenosine diphosphate ADP 64 matrix metalloproteinases 64 hypothalamic pituitary 64 isoprostane 64 neuromelanin 64 beta endorphin 64 myocytes 64 IL 1β 64 RIP1 64 thioredoxin 64 Purkinje cells 64 polyamine 64 tyrosine phosphorylation 64 acetylcholine receptors 64 cortical neurons 64 nitric oxide synthase 64 PTPN# 64 dose dependently 64 cerebellar 64 endothelial activation 64 ERK signaling 64 cytochrome 64 Fig. 1A 64 cardiac myocytes 64 coexpression 64 beta subunit 64 N acetylaspartate 64 hypothalamus pituitary 64 cAMP signaling 64 ventromedial 64 transcriptional activation 64 serine protease 64 VEGF receptor 64 Clusterin 64 cytokine interleukin 64 nitric oxide synthase NOS 64 transcriptional activity 64 TGF ß1 64 proteoglycan 64 Upregulation 64 calpain 64 mu opioid 64 gyri 64 TGF beta1 64 neuronal plasticity 64 osteoblastic 64 cathepsin B 64 TRPV1 receptors 64 immunostaining 64 MT1 MMP 64 hypoperfusion 64 LPS induced 64 Sgk1 64 proinflammatory 64 interferon γ 64 triacylglycerol 64 μ opioid receptor 64 AT1R 64 cell adhesion molecule 64 p# MAPK 64 receptor subtype 64 chemoattractant 64 decarboxylase 64 striated muscle 64 steroidogenic 64 hippocampal formation 64 globus pallidus 64 MDR1 64 CaMKII 64 lysophosphatidic acid 64 CXCL# 64 kinase domain 64 dorsolateral prefrontal cortex 64 matrix metalloproteinase 64 anterior temporal 64 ectopic expression 64 Fig. 1C 64 lesional 64 fluorescently tagged 64 detrusor 64 neuritic 64 GAPDH 64 neurotransmitter receptors 64 proinflammatory mediators 64 transduced 64 microvessel density 64 Dopaminergic 64 medial temporal lobe MTL 64 excitatory 64 circadian genes 64 Inhibitory 64 caveolin 1 64 noradrenaline 64 β 64 opioid receptor 64 CD1d 64 granzyme B 64 corticotropin releasing factor 64 TGFβ 64 lipoprotein lipase 64 PER2 64 D2 receptors 64 proteolytic cleavage 64 pDC 64 potent inhibition 64 Aß 64 adenylate cyclase 64 interstitial fibrosis 64 pyramidal neurons 64 phosphorylated tau 64 ß amyloid 64 tumorigenicity 64 receptor gene 64 leukocyte infiltration 64 lymphangiogenesis 64 OGG1 64 CaM 64 putamen 64 neuropeptides 64 homodimers 64 MAPK pathway 64 β1 64 PGC 1α 64 NKT cell 64 ERK pathway 64 dorsomedial 64 granule cells 64 Smad3 63 neuroimaging studies 63 oligomerization 63 urothelial 63 fig. S1 63 vascular endothelial cells 63 perivascular 63 #HT#A 63 cell adhesion molecules 63 Rac1 63 UCP2 63 Hippocampal 63 substrate specificity 63 BMAL1 63 Cathepsin B 63 leptin deficient mice 63 anterior pituitary 63 HuR 63 catenin 63 agonist induced 63 colocalization 63 Fig. 3b 63 KLF4 63 elastase 63 creatine kinase 63 cholecystokinin CCK 63 miRNA expression 63 myometrium 63 urocortin 63 phosphoinositide 63 leukocyte counts 63 Amino acid 63 Hypothalamic 63 overactivity 63 gene polymorphisms 63 acyltransferase 63 mitochondrial biogenesis 63 GABAB receptors 63 subcellular 63 FUS1 63 c MYC 63 epididymal 63 dorsal root ganglia 63 db db mice 63 serotonergic neurons 63 NMDA receptors 63 glycosyltransferase 63 guanosine 63 neuronal nitric oxide synthase 63 VEGFR1 63 glutamatergic neurons 63 Ki# 63 synaptic plasticity 63 CD#b 63 Fig. 3B 63 GABAA receptors 63 basal forebrain 63 cytochrome c oxidase 63 neuronal signaling 63 bronchoalveolar lavage fluid 63 sensory neurons 63 myogenic 63 contractility 63 dentate gyrus 63 rs# [004] 63 capillary density 63 Androgen receptor 63 protein tyrosine kinase 63 N cadherin 63 Immunohistochemical analysis 63 Prolactin 63 ligand induced 63 glutamate receptor 63 pRb 63 TRPV1 63 inosine 63 cytochrome P 63 phosphorylates 63 immunoblotting 63 metalloproteinases 63 TGF β1 63 gliosis 63 syntaxin 63 phospholipase 63 Brodmann Area 63 VEGF expression 63 ventromedial prefrontal cortex 63 cholesterol efflux 63 heterodimers 63 parietal 63 leptin receptor 63 MAPK 63 downregulates 63 neuropeptide 63 homodimer 63 phagocyte 63 paracrine 63 PBMCs 63 6S RNA 63 RNA polymerases 63 MMP# 63 nigrostriatal 63 adrenocortical 63 nucleolar 63 neurosteroid 63 sensory gating 63 genes encoding 63 XBP1 63 ouabain 63 TOP2A gene 63 NFkappaB 63 phasic 63 Leydig cell 63 GABA receptor 63 5 hydroxytryptamine 63 GFAP 63 neuronal activity 63 inhibitory interneurons 63 premotor 63 immunofluorescence 63 1alpha 63 anterior cingulate gyrus 63 Figure 1C 63 HER2 expression 63 Fig. 1B 63 mononuclear 63 caveolae 63 ABCA1 63 cortico 63 CD#c 63 myocardial tissue 63 neuroanatomical 63 CD# expression [001] 63 MMP2 63 dysbindin 63 occipital cortex 63 NAcc 63 inhibitory effects 63 osteoclastic 63 lipid rafts 63 upregulation 63 pro angiogenic 63 tenascin C 63 cytoplasmic domain 63 reductase 63 mu opioid receptors 63 afferent 63 left ventricular diastolic 63 prefrontal brain 63 cerebral cortical 63 VMAT2 63 SVZ 62 Neurogenesis 62 ubiquitin ligase 62 Rb#/p# 62 IL6 62 Sirt1 62 frontal parietal 62 BMP4 62 FGFs 62 neuronal differentiation 62 uM 62 tryptase 62 anterior temporal lobe 62 protein kinase C 62 effector memory 62 somatostatin 62 kinase pathway 62 enkephalin 62 cells transfected 62 EGF receptors 62 subcortical 62 isoenzyme 62 NR2B subunit 62 p tau 62 plasma lipids 62 FDG uptake 62 catabolism 62 epithelia 62 immunofluorescence microscopy 62 cyclooxygenase 2 62 fig. S4 62 gamma aminobutyric acid GABA 62 receptor activation 62 proximal tubule 62 Fig. 1D 62 amygdala neurons 62 CYP#B# 62 receptor kinase 62 caveolin 62 serotonin neurons 62 EGFP 62 HT 1A 62 β2 62 Cdc# 62 histone H4 62 GLI1 62 axonal 62 IKKß 62 ventrolateral 62 N methyl 62 cingulate cortex 62 miR #a [002] 62 endocannabinoid 62 62 interleukin 1beta 62 monocyte chemotactic protein 62 transgene expression 62 Brain derived neurotrophic 62 induced apoptosis 62 eotaxin 62 STAT1 62 dorsal root ganglion 62 β catenin 62 nicotinic 62 lymph node metastasis 62 atherogenesis 62 entorhinal cortex 62 rostral anterior cingulate cortex 62 downregulated 62 cyclin E 62 hypocretin neurons 62 focal adhesions 62 protein tyrosine phosphatase 62 dysregulation 62 PDGFR alpha 62 TXNIP 62 NF kappaB activation 62 intracellular 62 umbilical vein 62 sensorimotor 62 TET2 62 calcium ion 62 depolarization 62 dimerization 62 palmitate 62 hyperintensity 62 ATP hydrolysis 62 dorsal anterior cingulate cortex 62 cadherin 62 activin 62 cardiac autonomic 62 thyroglobulin 62 amyloid deposition 62 CB1 receptors 62 urinary excretion 62 ceruloplasmin 62 Vps# 62 MEF2 62 phosphatidylinositol 62 Phosphorylation 62 HEK# cells 62 neurone 62 SLC#A# [002] 62 functional polymorphism 62 exocytosis 62 colorectal tumor 62 corticotropin 62 orbitofrontal cortex 62 lateral ventricle 62 vasodilatation 62 γ secretase 62 extracellular 62 adipokines 62 fusiform gyrus 62 parietal regions 62 HDAC2 62 proto oncogene 62 EphA2 62 hindbrain 62 prostaglandin E 62 baroreflex 62 adenosine receptors 62 platelet activation 62 morphogen 62 proinflammatory cytokines 62 excitatory neurotransmitter glutamate 62 temporoparietal 62 ß1 62 PEDF 62 denervation 62 transgenic mice expressing 62 inverse agonist 62 malonyl CoA 62 SIRT2 62 lactate dehydrogenase LDH 62 semaphorin 62 HIF 1a 62 hyperalgesia 62 mice lacking 62 4E BP1 62 primary somatosensory cortex 62 intracoronary 62 5 HT2A 62 metaplasia 62 P selectin 62 cotransporter 62 SUMOylation 62 gamma aminobutyric acid 62 constitutively 62 prostaglandin E2 62 gene encoding 62 pulmonary vascular 62 alveolar macrophages 62 receptor subunit 62 innervation 62 hepatic enzyme 62 immunohistochemical analysis 62 proapoptotic 62 Fig. 1E 62 synaptic vesicles 62 caspase activation 62 mesangial 62 IgG antibody 62 methyl D aspartate 62 inhibin B 62 junctional 62 NR2B 62 transcriptional repressor 62 dephosphorylation 62 miR #a [001] 62 inhibitory neurotransmitters 62 interconversion 62 renal fibrosis 62 corticospinal tract 62 adipogenic 62 telomeric 62 hepatic stellate cells 62 vesicle fusion 62 Fig. 2b 62 N acetyl 62 PPARg 62 inhibitory synapses 62 dendritic spines 62 medial frontal 62 Extracellular 62 heterodimer 62 CYP#A# [002] 62 adipocyte 62 isoform 62 FasL 62 homeostatic 62 proinflammatory cytokine 62 perirhinal cortex 62 nicotinic receptor 62 afferents 62 Pgp 62 middle temporal gyrus 62 FGFR4 62 Oncogenic 62 melatonin receptor 62 dopaminergic neurons 62 ipsilateral 62 isoenzymes 62 lymphoid cells 62 inhibitory receptor 61 cytochrome c 61 uracil 61 iNOS 61 anti apoptotic 61 isomerase 61 BDNF gene 61 Neuropeptide Y 61 plasminogen activator inhibitor 61 integrin expression 61 COL#A# 61 BMP receptor 61 alveolar epithelial cells 61 histone 61 c myc 61 macrophage infiltration 61 midgut 61 vasoactive 61 endogenous opioid 61 glucose transporter 61 cultured neurons 61 β amyloid 61 ^ sup #m 61 primary visual cortex 61 serum albumin 61 leukocyte 61 fig. S2 61 beta catenin 61 striatum 61 synaptic function 61 thyroid carcinoma 61 tropomyosin 61 autocrine 61 medial prefrontal cortex 61 GRP# 61 parahippocampal gyrus 61 Sonic Hedgehog 61 transmembrane protein 61 #β HSD1 61 orbital frontal cortex 61 adrenal cortex 61 neuropeptide Y NPY 61 netrin 1 61 efferent 61 secretory 61 P#X# receptors 61 ephrin 61 cortices 61 pulse amplitude 61 Monocyte 61 potentiated 61 polyglutamine 61 #β estradiol 61 lipopolysaccharide 61 beta amyloid peptide 61 bronchial epithelial cells 61 γ 61 DNA methylation patterns 61 LRP6 61 ALDH 61 ubiquitylation 61 Cx# [001] 61 glutamate transporters 61 rRNA 61 cingulate gyrus 61 hippocampal cells 61 receptor tyrosine kinase 61 prostaglandin E2 PGE2 61 transporter proteins 61 experimentally induced 61 cannabinoid receptors 61 PDZ domain 61 gamma H2AX 61 TSLP 61 ligand TRAIL 61 NQO1 61 basophils 61 hypothalamic pituitary adrenal HPA 61 PPARgamma 61 endothelium dependent 61 posterior parietal cortex 61 rat hippocampus 61 mitogen 61 ligand binding 61 endogenous cannabinoids 61 Tubulin 61 HDAC6 61 #p#.# [002] 61 cyclic adenosine monophosphate 61 mTOR signaling 61 serine threonine 61 lipoxygenase 61 radiosensitivity 61 phosphoprotein 61 glucocorticoid 61 circular dichroism 61 γδ T cells 61 ligand receptor 61 PIP2 61 cholinergic 61 remyelination 61 amygdalae 61 insulin signaling pathways 61 methylation patterns 61 Dpp 61 fractional anisotropy 61 mineralocorticoid 61 superior temporal sulcus 61 ErbB4 61 frontotemporal 61 epithelial cells lining 61 Hh 61 osteoclast 61 toxic beta amyloid 61 AMPA receptors 61 leptin concentrations 61 3'UTR 61 conduction velocity 61 cTnI 61 tyrosine residues 61 cyclin B1 61 vacuolar 61 calcium homeostasis 61 GABAergic neurons 61 dopamine reuptake 61 TMEM#B 61 CD# + [001] 61 hyperinsulinemia 61 insulin receptors 61 prefrontal 61 glucocorticoid receptor 61 methyltransferase 61 Skeletal muscle 61 NKG2D 61 1beta 61 metalloproteinase 61 Fig. 4a 61 synaptic proteins 61 oculomotor 61 muscarinic receptor 61 inferior parietal lobule 61 Tie2 61 Fig. 2C 61 bile acid 61 CagA 61 posttranslational modification 61 ESR1 61 intact parathyroid hormone 61 metabolizing enzymes 61 TNF α 61 alanine aminotransferase ALT 61 endocytic 61 transthyretin 61 intramolecular 61 parietal cortex 61 osteocalcin 61 factor BDNF 61 intestinal permeability 61 Histologic 61 p# alpha [001] 61 oligomer 61 retinol binding protein 61 cyclic nucleotide 61 isoforms 61 heme oxygenase 1 61 enkephalins 61 H2AX 61 posterior cingulate cortex 61 ribosomal protein 61 salivary cortisol 61 TRPV4 61 tracer uptake 61 cyclic adenosine monophosphate cAMP 61 protein conformation 61 nociceptors 61 neurohormonal 61 glucokinase 61 Leydig cells 61 neuroendocrine 61 cyclic AMP 61 E cadherin 61 beta amyloid peptides 61 aminobutyric acid 61 synthetase 61 TGFß 61 synapse formation 61 capillary endothelial cells 61 ventral striatum 61 HT 2A 61 endothelial cell 61 neuroD2 61 electrophysiological recordings 61 2A receptor 61 chromatin remodeling complex 61 NFκB 61 hydroxylase 61 PI3K Akt 61 AMACR 61 basolateral 61 trophoblast cells 61 chromatin remodeling 61 PARP1 61 TUNEL 61 Fc receptor 61 CYP#E# 61 transduction 61 TGF b 61 PTH secretion 61 transgenic mouse model 61 PKC inhibitors 61 ribosomal proteins 61 Kv#.# 61 ER alpha 61 monocytes macrophages 61 focal adhesion 61 cytochrome oxidase 61 CD# expression [002] 61 synovial tissue 61 spectrin 61 apoptotic 61 PIP3 61 TrkA 61 PLA2 61 purine 61 fibrogenesis 61 tubule 61 endonuclease 61 S nitrosylation 61 MLH1 61 Aβ 61 dopamine synthesis 61 nicotinic receptors 61 FGF# 61 vasodilation 61 catalase 61 PGE2 61 brain derived neurotrophic 61 somatosensory 61 PPAR γ 61 EGF receptor 61 steroidogenesis 61 Supplementary Table 61 airway hyperresponsiveness 61 ultrastructural 61 D aspartic acid 61 synaptic cleft 61 IFN gamma 61 Elevated serum 61 heterozygotes 61 RUNX3 61 p# mitogen activated 61 5 HT2C receptor 61 mdx mice 61 GRK2 61 Fig. 1a 61 Lp PLA 2 61 transmembrane receptor 61 oligomeric 61 oncogenic transformation 61 neurite 61 accumbens 61 GPIHBP1 61 nicotinic acetylcholine receptor 61 plasma membrane 61 explants 61 mice overexpressing 61 neuronal degeneration 61 Smoothened 61 metabolite concentrations 61 Hedgehog signaling 61 cytokeratin 61 intestinal epithelium 61 extracellular domain 61 WNK1 61 lysosomal 61 genotoxic stress 61 dopamine D2 61 Lyn kinase 61 NMDA receptor 61 hippocampus