Related by context. All words. (Click for frequent words.) 72 thrombolytic agents 72 thrombolytic agent 71 alteplase 71 antiplatelet drugs 70 GP IIb IIIa inhibitors 70 tissue plasminogen activator tPA 70 clot dissolving drug 70 fibrinolytic 69 fibrinolytics 69 streptokinase 69 clot busters 69 aspirin clopidogrel 68 rt PA 68 rFVIIa 68 β blockers 68 intra arterial 68 milrinone 68 antithrombotics 68 fibrinolytic therapy 68 tenecteplase 68 thrombolytic therapy 68 pamidronate 68 antiplatelet medication 68 recombinant tissue plasminogen 68 reteplase 67 nicardipine 67 antiarrhythmic drugs 67 plasminogen activators 67 antiplatelet agent 67 epoprostenol 67 calcineurin inhibitor 67 VAPRISOL 67 INTEGRILIN R 67 anticlotting drugs 67 antithrombotic 67 fondaparinux 67 systemic corticosteroids 67 ximelagatran 67 inotropes 67 oral anticoagulants 67 idraparinux 67 Losartan 67 thrombotic complications 67 DVT prophylaxis 67 opioid analgesia 67 TMP SMX 66 DAPT 66 aldosterone antagonists 66 hypotensive 66 xanthine oxidase inhibitor 66 oral anticoagulation 66 Tacrolimus 66 fibrinolysis 66 ß blockers 66 intracoronary 66 dobutamine 66 aldosterone antagonist 66 vasodilators 66 lipid lowering agents 66 calcineurin inhibitors 66 pharmacokinetic interactions 66 systemic hypotension 66 LMWH 66 IOP lowering 66 glycoprotein IIb IIIa inhibitors 66 salmeterol fluticasone 66 somatostatin analogues 66 preventing restenosis 66 LHRH agonists 66 perioperatively 66 Cleviprex TM clevidipine 66 Natalizumab 66 FIRMAGON 66 antiplatelet medications 66 thromboprophylaxis 66 CINTREDEKIN BESUDOTOX 66 thiazide diuretic 66 argatroban 66 Tranexamic acid 65 mycophenolate mofetil 65 Vaprisol 65 valdecoxib 65 reperfusion therapy 65 pantoprazole 65 cerebral vasospasm 65 FRAGMIN R 65 Gliadel Wafer 65 antiplatelet therapies 65 anticholinergic agents 65 oral anticoagulant therapy 65 irbesartan 65 direct thrombin inhibitors 65 antihypertensive agents 65 MYLOTARG 65 carvedilol 65 thienopyridines 65 bypass grafting 65 antithrombotic therapy 65 coronary intervention 65 levosimendan 65 ARIXTRA 65 cidofovir 65 surgical revascularization 65 elective PCI 65 dalteparin 65 intravenous cyclophosphamide 65 NMDA antagonist 65 ketorolac 65 arterial grafts 65 Carvedilol 65 FASLODEX 65 granisetron 65 levodopa carbidopa 65 thrombolysis 65 anti angiogenic agents 65 deferoxamine 64 pegfilgrastim 64 Starlix 64 GnRH agonists 64 intravenous diuretics 64 revascularisation 64 Ivabradine 64 Dabigatran 64 drug eluting stent implantation 64 immunosuppressive therapies 64 angina pectoris 64 paclitaxel eluting stents 64 BeneFIX 64 antiplatelet agents 64 nonischemic 64 periprocedural 64 antithrombotic agents 64 symptomatic intracranial 64 neointimal hyperplasia 64 lanreotide 64 lipid lowering therapies 64 LEUKINE 64 cangrelor 64 nimodipine 64 ReoPro 64 peripheral vasculature 64 fulvestrant 64 antiarrhythmic 64 clevidipine 64 factor Xa inhibitor 64 AV fistulas 64 immunomodulatory therapy 64 NATRECOR ® 64 INVEGA ® 64 clopidogrel Plavix 64 ALGRX 64 VTE prophylaxis 64 INTEGRILIN 64 heparins 64 COREG 64 lung resection 64 pimecrolimus 64 antiemetics 64 ciclosporin 64 Dacogen decitabine 64 Factor Xa inhibitors 64 tolvaptan 64 LOVENOX R 64 docetaxel Taxotere ® 64 thrombus aspiration 64 thalidomide Thalomid 64 Abbokinase 64 FXIII 64 KAPIDEX 64 Hypotension 64 interferon beta therapy 64 thrombocytopenic 64 conventional angiography 64 MULTAQ 64 cilostazol 64 glatiramer 64 inhaled iloprost 64 thrombotic events 64 verapamil 64 saphenous vein graft 64 embolisation 64 transdermal estrogen 64 Octreolin 64 arterial thrombosis 64 thienopyridine 64 clot busting therapy 64 invasive candidiasis 64 XIENCE V stent 64 platelet inhibitor 64 Neupogen ® 64 Pemetrexed 64 vasopressor 64 liposomal amphotericin B 63 anticoagulant warfarin 63 cediranib 63 eplerenone 63 interventional therapies 63 bivalirudin 63 immunosuppressive agents 63 captopril 63 angioplasty stenting 63 bezafibrate 63 coronary stenting 63 drug eluting coronary stents 63 antifibrinolytic 63 Plasmin 63 acute myocardial infarction AMI 63 thrombolytic 63 unfractionated heparin 63 intravenous thrombolysis 63 primidone 63 amphotericin B 63 Noxafil 63 revascularization procedures 63 topical formulations 63 colorectal liver metastases 63 renoprotective 63 mTOR inhibitors 63 transarterial 63 Procoralan 63 antiemetic 63 edifoligide 63 intravenous bisphosphonates 63 fluticasone salmeterol 63 angiotensin converting enzyme inhibitor 63 enalapril 63 antibiotic prophylaxis 63 indinavir 63 QVAR R 63 reinfarction 63 nephrotoxicity 63 latanoprost 63 HeartNet 63 inotropic agents 63 idarubicin 63 intravascular 63 Intra arterial 63 paricalcitol 63 IFN beta 63 PDE4 inhibitors 63 factor Xa 63 Elitek 63 skeletal muscle relaxant 63 cinacalcet 63 VIIBRYD 63 hepatorenal syndrome 63 cerebral ischemia 63 thromboembolic events 63 herpetic keratitis 63 tipranavir 63 ZYVOX 63 ropivacaine 63 coronary revascularization 63 liver resection 63 tirofiban 63 sufentanil 63 SCIg 63 IIIa inhibitor 63 amikacin 63 occlusive disease 63 anti androgen 63 postprocedure 63 NAVISTAR R 63 TNF alpha inhibitor 63 doxorubicin HCl 63 labetalol 63 VEGF inhibitors 63 Advagraf 63 fluvastatin 63 Angiox R 63 revascularization procedure 63 riociguat 63 KETEK 63 RhuDex ® 63 macrolide antibiotic 63 Cardene ® 63 efalizumab 63 ticlopidine 63 deferiprone 63 acute coronary syndromes ACS 63 radiotherapy RT 63 immunosuppressives 63 warfarin Coumadin 63 percutaneous intervention 63 STELARA ™ 63 APTIVUS r 63 Mestinon 63 topical retinoids 63 AGILECT R 63 antithrombotic agent 63 oxcarbazepine 63 G CSF 63 rHuEPO 63 Diovan HCT 63 therapeutic regimens 63 Cilostazol 63 Interferon alpha 63 Mitomycin C 63 potent CYP#A# inhibitors 63 Cyclosporine 63 nadolol 63 voriconazole 63 bisoprolol 63 dexmedetomidine 63 hyperalgesia 63 parathyroidectomy 62 prasugrel Effient 62 factor Xa inhibitors 62 eptifibatide 62 FRAGMIN 62 epoetin alfa 62 sevoflurane 62 CONTRAINDICATIONS 62 Kepivance 62 zoledronate 62 anticoagulated 62 reperfusion 62 NATRECOR R 62 rtPA 62 carotid artery stenting CAS 62 oral transmucosal 62 valve implantation 62 DMARDS 62 typical antipsychotics 62 intravesical 62 infusional 62 Angiox 62 Prilosec omeprazole 62 inotropic 62 immunosuppressive regimen 62 tolterodine 62 thromboembolic 62 tigecycline 62 trandolapril 62 Cremophor 62 aripiprazole Abilify 62 eculizumab therapy 62 QuadraSphere 62 inotropic therapy 62 hypervascular tumors 62 antiangiogenic drugs 62 dihydroergotamine 62 Neulasta ® 62 transplantation HCT 62 MIRAPEX 62 TREDAPTIVE 62 H2 antagonists 62 postoperative morbidity 62 bivalirudin alone 62 stent implantation 62 Arixtra 62 terlipressin 62 DOXIL 62 bovine thrombin 62 superficial femoral 62 anagrelide 62 prokinetic 62 intradermal injection 62 YONDELIS 62 pancrelipase 62 everolimus eluting stents 62 thromboembolism 62 vecuronium 62 anti emetic 62 cardiac repolarization 62 pyridostigmine 62 IV tPA 62 mitomycin C 62 Evicel 62 Filgrastim 62 macrolide antibiotics 62 Perforomist ™ Inhalation Solution 62 trimethoprim sulfamethoxazole 62 insulin detemir 62 REOPRO 62 capsule formulation 62 steroid dexamethasone 62 Teriparatide 62 palliation 62 transfemoral 62 GnRH agonist 62 refractory angina 62 Nifedipine 62 PRISTIQ 62 concurrent chemoradiation 62 sipuleucel T 62 thrombectomy 62 MYCAMINE 62 flecainide 62 immunosuppressant drug 62 dissolving blood clots 62 catheter occlusion 62 activator rt PA 62 STEMI patients 62 imipenem 62 antiplatelet therapy 62 terfenadine 62 pegylated interferon alfa 62 LATUDA 62 percutaneous interventions 62 clodronate 62 dabigatran etexilate 62 beta blocker atenolol 62 Nebulized 62 Aceon 62 peripheral vascular stent 62 alpha blocker 62 interferon alfa 2b 62 endotracheal intubation 62 GP IIb IIIa inhibitor 62 ischemic complications 62 parenteral nutrition 62 tamponade 62 ACE inhibitor ramipril 62 ranibizumab Lucentis 62 leukotriene receptor antagonist 62 bolus injection 62 BYSTOLIC 62 TORISEL 62 either acutely decompensated 62 systemic corticosteroid 62 left ventricular dysfunction 62 clot busting medication 62 Vidaza azacitidine 62 cardiopulmonary bypass CPB 62 TRILIPIX 62 candidemia 62 patients undergoing CABG 62 micafungin 62 vinorelbine 62 coxib 62 HIPEC 62 lactulose 62 antimuscarinic 62 octreotide 62 non valvular atrial 62 Atacand 62 vasospasm 62 Prostacyclin 62 remifentanil 62 antiepileptics 62 thrombogenic 62 atorvastatin #mg 62 COPD exacerbations 62 anticoagulant heparin 62 CIMZIA ™ 62 COREG CR 62 hepatic metastases 62 interferon ribavirin 62 upper gastrointestinal bleeding 62 saphenous vein grafts 62 mycophenolate 62 percutaneous vertebroplasty 62 candesartan cilexetil 62 divalproex sodium 62 Methylnaltrexone 62 Certolizumab pegol 62 MAGE A3 ASCI 62 fondaparinux sodium 62 MitraClip device 62 hypertonic saline 62 palliative radiotherapy 62 Taxol ® 62 ATACAND 62 ACZ# 62 patients undergoing percutaneous 62 angiotensin receptor blocker ARB 62 adjuvant therapies 61 zotarolimus 61 portal vein thrombosis 61 adult chronic ITP 61 Embosphere Microspheres 61 antiangiogenic therapy 61 visilizumab 61 Aprotinin 61 Olmesartan 61 TNF inhibitor 61 LNG IUS 61 pyrimethamine 61 distal anastomosis 61 CYP#A# inhibitors 61 pioglitazone Actos 61 AGGRASTAT R 61 Torisel 61 thoracoscopic lobectomy 61 parecoxib 61 radiochemotherapy 61 synthetic grafts 61 DU #b 61 treprostinil 61 resynchronization therapy 61 anticoagulant medications 61 percutaneous transluminal coronary angioplasty 61 perioperative mortality 61 antiplatelets 61 cerebrovascular events 61 anticoagulation therapy 61 inhibits platelet aggregation 61 intratumoral 61 Erlotinib 61 DepoDur TM 61 paracentesis 61 inhibit platelet function 61 sirolimus 61 anticoagulants 61 sotalol 61 infliximab Remicade 61 chemoembolization 61 external beam radiotherapy 61 gatifloxacin 61 palivizumab 61 anti thrombotic 61 carotid stents 61 postoperative atrial fibrillation 61 bolus dose 61 Fondaparinux 61 cintredekin besudotox 61 Desferal 61 eluting stent 61 intravenous IV infusion 61 mycophenolate mofetil MMF 61 Factor VIIa 61 cefazolin 61 unstable angina pectoris 61 primary percutaneous coronary 61 paliperidone 61 antimicrobial prophylaxis 61 abacavir lamivudine 61 recurrent GBM 61 metastatic neuroendocrine tumors 61 clot dissolving 61 glitazones 61 topical ophthalmic 61 systemic antifungal 61 nebulization 61 olmesartan 61 allogeneic HSCT 61 Thrombin 61 Dasatinib 61 lapatinib Tykerb 61 AMEVIVE 61 antimetabolite 61 TNF alpha antagonist 61 coagulation factors 61 cytoreductive surgery 61 busulfan 61 pravastatin Pravachol 61 mRCC 61 CYPHER R Sirolimus eluting 61 inhibitor RG# 61 desflurane 61 TNF blocker 61 thromboembolic disease 61 anticoagulant therapy 61 CKD ND 61 Vimpat R 61 Budesonide 61 flutamide 61 inhaled glucocorticoids 61 biliary stents 61 dacarbazine 61 antiepileptic 61 abacavir Ziagen 61 mechanically ventilated patients 61 bowel resection 61 sublingual tablets 61 Oral corticosteroids 61 decitabine 61 glycoprotein IIb IIIa 61 intravesical therapy 61 endovascular aneurysm repair 61 bronchodilators 61 trabeculectomy 61 Adjunctive 61 adrenal suppression 61 conventional DMARDs 61 lipid lowering therapy 61 lenalidomide dexamethasone 61 aspirin heparin 61 Onbrez Breezhaler 61 platelet activation 61 reperfusion injury 61 hyperprolactinemia 61 antiangiogenic agents 61 abciximab 61 oxybutynin 61 intravenous tissue plasminogen 61 pioglitazone HCl 61 cardiotoxic 61 omeprazole Prilosec 61 mycophenolic acid 61 curative therapy 61 #beta estradiol 61 basal insulins 61 nitrofurantoin 61 vinorelbine tartrate 61 pleurodesis 61 drug zotarolimus 61 prednisone prednisolone 61 oral corticosteroid 61 indomethacin 61 plasma kallikrein inhibitor 61 beta interferons 61 levalbuterol 61 pyrazinamide 61 electrical cardioversion 61 artery stenosis 61 azacitidine 61 rosuvastatin #mg 61 ancrod 61 thrombolytic drugs 61 graft patency 61 titrated glipizide 61 LHRH agonist 61 intraperitoneal chemotherapy 61 Tambocor 61 quinidine 61 Fluticasone 61 Tekamlo 61 IV Busulfex 61 interferon therapy 61 apomorphine 61 ADP receptor antagonist 61 prophylactic therapy 61 hypotension bradycardia 61 immunomodulation 61 renal dysfunction 61 endovascular interventions 61 symptomatic VTE 61 Pioglitazone 61 clomipramine 61 pulmonary artery banding 61 terbutaline 61 ganciclovir 61 LV dysfunction 61 GW# [003] 61 Anti Bacterial Envelope 61 raloxifene Evista 61 Voraxaze ™ 61 goserelin 61 DACH platinum 61 6R BH4 61 docetaxel Taxotere 61 sympathectomy 61 PSVT 61 metastatic malignant 61 etanercept Enbrel 61 acute ischemic stroke 61 oral antiplatelet 61 NIASPAN 61 oxaliplatin Eloxatin 61 r hGH 61 SANVAR 61 TELINTRA 61 Aviptadil 61 gefitinib Iressa 61 epidural analgesia 61 Zemplar 61 sorafenib Nexavar 61 AVELOX 61 Revascor TM 61 direct thrombin inhibitor 61 Spiriva ® 61 ischaemia 61 antiarrhythmic drug 61 Oxaliplatin 61 Mimpara 61 strong CYP#A# inducers 61 pharmacologic stress 61 imatinib Gleevec 61 somatostatin analogue 61 Abciximab 61 Captopril 61 long acting bronchodilator 61 ischemic cardiomyopathy 61 Mycophenolate Mofetil 61 carotid endarterectomy CEA 61 thrombi 61 acute coronary syndromes 61 desmopressin 61 vaso occlusive crisis 61 OZURDEX ® 61 octreotide LAR 61 dosage regimens 61 timolol 61 antihypertensive drugs 61 sitaxsentan 61 endocrine therapies 61 dihydrochloride 61 Metoprolol 61 activator tPA 61 thromboembolic complications 61 NUCYNTA R 61 dosing frequency 61 endothelin receptor antagonists 61 anti coagulants 61 tacrolimus ointment 61 TAXUS Stent 61 myopathy rhabdomyolysis 61 mecasermin 61 Navelbine ® 61 heparin induced thrombocytopenia 61 acetazolamide 60 reintervention 60 Moxifloxacin 60 ischemia reperfusion 60 sirolimus eluting stents 60 biologic DMARD 60 Rocuronium 60 menadione 60 azelastine 60 receiving prophylactic anticoagulation 60 nephrotoxic drugs 60 Retavase 60 epoetin alpha 60 hemorrhagic complications 60 carotid artery stenting 60 H2 receptor antagonists 60 vincristine 60 hepatic insufficiency 60 iodixanol 60 Ventavis ® 60 alpha interferons 60 administered systemically 60 TEMODAL 60 Thal Dex 60 Acute Myocardial Infarction AMI 60 erythropoietic 60 Candesartan 60 sodium stibogluconate 60 infarct size 60 peripheral arterial 60 Embolic Protection Device 60 corticosteroid dexamethasone 60 Velcade bortezomib 60 radioiodine therapy 60 clot dissolving drugs 60 corticosteroid therapy 60 bronchodilatory 60 methylnaltrexone 60 lansoprazole 60 Tredaptive 60 ranitidine Zantac 60 TPV r 60 coronary artery bypass grafts 60 hereditary deficiency 60 factor G CSF 60 intracranial hemorrhage ICH 60 oral anticoagulant 60 tumor lysis syndrome 60 tumor resection 60 acitretin 60 Src inhibitors 60 droperidol 60 Mycamine 60 severe renal impairment 60 oral antidiabetic drugs 60 Fibrin Pad 60 Vfend 60 romiplostim 60 saline placebo 60 potentially hepatotoxic 60 variceal hemorrhage 60 aprepitant 60 thromboses 60 fistula closure 60 immuno modulatory 60 DEFLUX 60 OMS# 60 Enbrel Humira 60 gastrointestinal toxicity 60 leflunomide 60 doxazosin 60 Bivalirudin 60 metastatic RCC 60 chemoradiation therapy 60 small molecule tyrosine 60 gastrointestinal perforation 60 oxymorphone ER 60 β blocker 60 neuroleptics 60 BrachySil TM 60 Zetia ezetimibe 60 transapical 60 chemotherapy induced neutropenia 60 otamixaban 60 ciprofloxacin hydrochloride 60 coronary interventions 60 ARB telmisartan 60 everolimus eluting stent 60 isoproterenol 60 recombinant interferon 60 graft occlusion 60 oral rivaroxaban 60 choroidal neovascularization 60 transarterial chemoembolization 60 relapsed MM 60 controlled analgesia PCA 60 Saizen R 60 Sanvar R 60 calcium antagonists 60 malignant ascites 60 angiotensin receptor blockers 60 stented 60 Telmisartan 60 oncologic outcomes 60 edoxaban 60 anticlotting 60 Keppra XR 60 thiazides 60 immunomodulatory 60 glatiramer acetate 60 overt nephropathy 60 Paliperidone 60 autologous bone marrow 60 basiliximab 60 NEUPOGEN 60 angiotensin converting enzyme inhibitors 60 Hydroxyurea 60 post thrombotic syndrome 60 SPRIX ® 60 cerebral perfusion 60 proton pump inhibitor PPI 60 CANCIDAS 60 directed thrombolysis 60 PlGF 60 biventricular pacing 60 cannulation 60 SilverHawk Plaque Excision System 60 proton pump inhibitors PPIs 60 trabectedin 60 biologic therapy 60 myocardial reperfusion 60 vertebral compression fractures 60 MMP inhibitors 60 antiinflammatory 60 dasatinib Sprycel 60 receptor tyrosine kinase inhibitor 60 Pegylated Liposomal Doxorubicin 60 meropenem 60 Thalomid ® 60 platelet inhibition 60 antidiabetic 60 TNF antagonist 60 polidocanol 60 antiresorptive 60 indapamide 60 postoperative mortality 60 somatostatin analog 60 hylan GF 60 Surgical resection 60 AstraZeneca Toprol XL 60 nebulized 60 sumatriptan 60 topical ocular 60 Actimmune ® 60 pulmonary artery catheterization 60 nucleoside analogs 60 Intravesical 60 Trastuzumab 60 corifollitropin alfa 60 haloperidol Haldol 60 simvastatin ezetimibe 60 Thrombolysis 60 oral antidiabetic medication 60 HYLENEX recombinant 60 PASI scores 60 stavudine d4T 60 dorzolamide 60 alpha interferon 60 buccal tablet 60 Lenalidomide 60 #mg doses [002] 60 pimozide 60 Resten NG 60 procedural sedation 60 unfractionated heparin UFH 60 Biolimus A9 60 hemorrhagic shock 60 acetonide FA 60 SIMCOR 60 transapical approach 60 concomitant medications 60 chemoradiotherapy 60 OPCAB 60 cerebral angiography 60 Traficet EN 60 monoamine oxidase inhibitors 60 PERLANE 60 ReFacto 60 subcutaneous immunoglobulin 60 Glypromate 60 Inhaled nitric oxide 60 ACE inhibitor lisinopril 60 selective modulator 60 hemostatic agents 60 Fludara 60 FOLFOX4 60 secondary hyperparathyroidism 60 Sinemet 60 cytotoxic chemotherapy 60 BENICAR HCT 60 renal denervation 60 induce orthostatic hypotension 60 intravenous tPA 60 invasive aspergillosis 60 CMV reactivation 60 loop diuretics 60 dipyridamole 60 orally inhaled 60 interferon beta 1b 60 Gleevec imatinib 60 NPH insulin 60 nesiritide 60 biologic DMARDs 60 alfuzosin 60 retransplantation 60 functional mitral regurgitation 60 Plavix clopidogrel 60 NSTE ACS 60 VIRAMUNE 60 diabetic gastroparesis 60 Femara letrozole 60 glycoprotein IIb IIIa inhibitor 60 rotigotine transdermal patch 60 paclitaxel eluting stent 60 SYN# 60 intermittent claudication 60 lumiracoxib 60 selegiline 60 phosphate binder 60 Peg IFN 60 hemodynamic instability 60 antidiabetic drugs 60 ARIMIDEX 60 Integrilin 60 ropinirole 60 potassium sparing diuretics 60 oxypurinol 60 hyperkalemia 60 Certican 60 postoperative pulmonary 60 Degarelix 60 IGIV 60 verteporfin 60 angiotensin receptor blockers ARBs 60 carbidopa levodopa 60 hypoperfusion 60 Brinavess 60 esomeprazole 60 levetiracetam Keppra 60 Cotavance 60 icatibant 60 insulin sensitizing 60 immunomodulatory agents 60 intravenously administered 60 Ticagrelor 60 lipid lowering drugs 60 liver metastasis 60 fibrin deposition 60 hyperacute 60 Intravenous immunoglobulin 60 Amicar 60 Zyprexa olanzapine 60 vidofludimus 60 acute decompensation 60 metoprolol succinate 60 CYP #A# 60 diclofenac Voltaren 60 thrombocytopenic patients 60 levodopa therapy 60 nonoperative treatment 60 propafenone 60 galiximab 60 oral antidiabetic 60 renal parenchyma 60 fibrin sealants 60 GSK# [001] 60 XOPENEX Inhalation Solution 60 tamoxifen Nolvadex ® 60 hepatotoxicity 60 ramipril Altace 60 ribavirin RBV 60 blood clot dissolving 60 neutropenic patients 60 Aldactone 60 Ecallantide 60 hypovolemic 60 rFSH 60 PRADAXA 60 prostate TURP 60 Exforge HCT 60 torsade de pointes 60 Mg Uk 60 aortic insufficiency 60 dissolve clots 60 angiographic outcomes 60 procainamide 60 ADAGIO study