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(Click for frequent words.) 75 downregulated 75 transiently transfected 74 transfected 74 constitutively active 74 CD#c 74 cells transfected 74 EGFP 73 mRNA expression 73 transfected cells 73 constitutively expressed 72 cytosolic 72 overexpressing 72 splenocytes 72 Rab5 72 CaM 72 HepG2 cells 72 1beta 72 ERalpha 72 1alpha 71 lysates 71 cytoplasmic domain 71 coexpression 71 supernatants 71 Rap1 71 VSV G 71 ChR2 71 hydrolase 71 beta actin 71 stably transfected 71 phosphorylates 71 ERK1 2 70 pDC 70 induced apoptosis 70 MDR1 70 Supplementary Fig 70 PC# cells 70 Kir#.# 70 catenin 70 induced phosphorylation 70 overexpressing cells 70 immunoreactive 70 PBMCs 70 constitutively 70 unmethylated 70 basolateral 70 deacetylation 70 hepatoma 70 mediated inhibition 70 HEK# cells 70 somatostatin 70 ERBB2 70 vascular endothelial cells 70 alpha subunit 70 TIMP 1 70 hydrolases 70 acyl CoA 70 transgenic mice expressing 69 plasmacytoid dendritic cells 69 P2X 69 astrocytic 69 stably expressing 69 monocyte chemotactic protein 69 MEFs 69 phosphatidylinositol 69 enterocytes 69 null mice 69 subcellular localization 69 regulated kinase 69 phosphoprotein 69 FasL 69 Overexpression 69 proximal tubule 69 induces apoptosis 69 p#Kip# 69 plasmacytoid 69 mitogen activated protein kinase 69 transferase 69 serine threonine kinase 69 erythrocytes 69 isomerase 69 immunostaining 69 transcriptional activation 69 diphosphate 69 CD# CD# 69 dimerization 69 constitutively activated 69 immunoreactivity 69 unmutated 69 homodimer 69 Upregulation 69 dimeric 69 mononuclear 68 carboxyl terminal 68 hematopoietic progenitors 68 isoenzyme 68 Extracellular 68 adenylate cyclase 68 promoter methylation 68 CD#b 68 aminopeptidase 68 Tie2 68 downregulates 68 ubiquitinated 68 Western blotting 68 potently inhibited 68 4E BP1 68 LNCaP cells 68 Kupffer cells 68 adipogenic 68 potently inhibits 68 Phosphorylation 68 peripheral blood mononuclear 68 upregulated 68 plasmid encoding 68 Oncogenic 68 upregulates 68 FGFR3 68 Cytotoxic T 68 IL #p# 68 LNCaP 68 annexin V 68 polyamine 68 monocytes macrophages 68 ErbB receptors 68 mitogenic 68 homodimers 68 ^ sup ^ 68 decarboxylase 68 tropomyosin 68 colon carcinoma 68 selectively binds 68 oxidase 68 transgene expression 68 DNMT1 68 tyrosine kinase receptor 68 dephosphorylation 68 lymphoid cells 68 transcriptional regulation 68 phosphorylate 68 TGF beta1 68 cell adhesion molecule 68 dependent protein kinase 68 GLUT4 68 isotypes 68 lyase 68 cytosol 68 effector memory 68 adrenoceptor 68 Activating mutations 67 antiproliferative activity 67 Tubulin 67 phospho 67 antiapoptotic 67 ERK pathway 67 alveolar epithelial cells 67 serine threonine 67 HIF 1alpha 67 β1 67 nucleolin 67 lysine residues 67 monocyte 67 IFN γ 67 proto oncogene 67 CagA 67 synthetase 67 mediated phosphorylation 67 syntaxin 67 Secretase 67 acyltransferase 67 selectively activates 67 neurofilament 67 glycosylated 67 Macrophage 67 cytokine receptor 67 cytochrome 67 caveolin 1 67 Supplemental Figure 67 p# MAPK 67 iNOS 67 hTERT 67 V#F mutation 67 syngeneic 67 ß catenin 67 TIMP 67 vimentin 67 lacZ 67 lysosomal 67 1α 67 TRPV4 67 mice lacking 67 cellular prion protein 67 dsRNA 67 Immunohistochemical analysis 67 secretory proteins 67 cyclin dependent kinase inhibitor 67 interleukin IL -# 67 p# mitogen activated 67 ATPase 67 binds selectively 67 deoxy 67 Peyer patches 67 ERK signaling 67 SIRT2 67 67 downregulation 67 mediated apoptosis 67 tyrosine phosphorylation 67 transferrin receptor 67 RRM1 67 EP4 67 phospholipase C 67 colocalization 67 Histone 67 androgen receptor AR 67 transmembrane protein 67 selectively inhibited 67 c Fos 67 P selectin 67 TNFalpha 67 glucose transporter 67 redox active 67 nucleolar 67 glutamyl 67 inhibitory effects 67 At#g# 67 vacuolar 67 tyrosine hydroxylase 67 SOCS3 67 kDa protein 67 thymocytes 67 phosphorylated 67 MMP2 67 Cathepsin B 67 VE cadherin 67 GHRH 67 GFP fusion 67 microsomal 67 BMAL1 67 heterodimers 67 upregulation 67 apical membrane 67 hippocampal neurons 67 Protein Kinase C 66 isoforms 66 proteolytic cleavage 66 TGF ß 66 thymidine kinase 66 covalently bound 66 protein tyrosine phosphatase 66 Fas ligand 66 murine 66 HER2 neu 66 peroxidase 66 transmembrane 66 virulence genes 66 cytidine 66 NOD SCID mice 66 Dysregulation 66 amino terminal 66 synthase 66 cathepsin B 66 CD# + [001] 66 CEACAM1 66 LPS induced 66 #ß 66 phospholipase 66 C#BL 6 mice 66 autophagic 66 tumorigenicity 66 activating mutation 66 Cytochrome 66 hematopoietic progenitor cells 66 E#F# 66 IFN g 66 lactate dehydrogenase 66 IL 1β 66 Chinese Hamster Ovary 66 Cre recombinase 66 umbilical vein 66 β catenin 66 hydroxylase 66 cytoplasmic 66 Cytoplasmic 66 cyclic AMP cAMP 66 c Src 66 matrix metalloproteinases 66 reductase 66 beta subunit 66 IgG1 66 ectopic expression 66 orthologs 66 nitric oxide synthase NOS 66 MDA MB 66 PTPN# 66 dipeptide 66 GFAP 66 PU.1 66 AhR 66 peptide receptor 66 cytochrome c oxidase 66 replicase 66 immunofluorescence microscopy 66 presynaptic 66 ribosomal protein 66 IGF1R 66 chemoattractant 66 differentially regulated 66 Corynebacterium 66 RANTES 66 cytokine secretion 66 extracellular domain 66 Catenin 66 oncoproteins 66 exocytosis 66 operon 66 receptor tyrosine kinase 66 wildtype 66 acinar 66 activating mutations 66 secretory 66 lysate 66 short hairpin RNAs 66 downregulate 66 regulated kinase ERK 66 transduce 66 protein secreted 66 pRb 66 miR #a [001] 66 motoneurons 66 thrombin receptor 66 mitotic progression 66 CD1d 66 ALDH 66 trophoblasts 66 homogenates 66 μ opioid receptor 66 potent inhibition 66 intestinal epithelial cells 66 HER2 HER2 66 TrkB 66 M1 muscarinic 66 dynactin 66 sphingomyelin 66 splice variants 66 protein tyrosine kinase 66 esterase 66 succinate dehydrogenase 66 Leydig cells 66 Foxp3 66 μM 65 ouabain 65 erythroid 65 apo AI 65 monocyte derived dendritic cells 65 tryptase 65 Pgp 65 LDL receptor 65 bronchial epithelial cells 65 IgG4 65 CCL# 65 STAT1 65 cyclic nucleotide 65 CD8 + 65 CD3 + 65 substrate specificity 65 MAP kinase 65 paxillin 65 phosphoinositide 65 telomerase reverse transcriptase 65 anaphase promoting complex 65 RhoA 65 Mice lacking 65 cyclase 65 receptor mediated endocytosis 65 Flt3 65 perivascular 65 ligand receptor 65 Transgenic Mice 65 immunodominant 65 overexpress 65 CD4 + CD# 65 RNA polymerases 65 γ 65 GAPDH 65 sequence homology 65 proteolysis 65 phosphorylase 65 HIF 1a 65 costimulatory molecules 65 cell lysates 65 c KIT 65 Dpp 65 Rac1 65 glyceraldehyde 3 65 COL#A# 65 NKG2D 65 Vps# 65 gastric carcinomas 65 SMN1 65 hepatic lipase 65 neurite outgrowth 65 oxidative phosphorylation 65 uPAR 65 methyltransferase 65 inducible nitric oxide synthase 65 expressing GFP 65 PKC isoforms 65 DNase 65 messenger ribonucleic acid 65 cotransporter 65 thioredoxin 65 isozymes 65 Jhdm2a 65 carcinoembryonic antigen 65 Monocytes 65 IFN gamma 65 transgenic mouse models 65 transactivation 65 cytokine signaling 65 kinase pathway 65 gene inactivation 65 IL 1ß 65 Superoxide 65 ribonuclease 65 functional polymorphism 65 histone H3 65 cystic fibrosis transmembrane conductance 65 PAM4 65 cathepsins 65 hypothalamic pituitary 65 mRNA transcripts 65 adenosine diphosphate ADP 65 proapoptotic 65 induce apoptosis 65 RQ PCR 65 triphosphate 65 acetyltransferase 65 β actin 65 receptor CD# 65 inhibitory activity 65 Mice deficient 65 bone marrow stromal cells 65 chemokine receptor 65 FGF signaling 65 FUS1 65 mutant p# 65 homozygotes 65 anterior pituitary 65 interferon γ 65 Sp1 65 muscarinic receptor 65 eNOS 65 transcriptional regulator 65 potent inducer 65 Hcrt 65 potently inhibit 65 isoleucine 65 endosomal 65 inducible 65 pyrophosphate 65 retinoic acid receptor 65 fig. S1 65 gene polymorphism 65 heterozygotes 65 aryl hydrocarbon receptor 65 CXCL# 65 tau phosphorylation 65 valine 65 neural stem 65 endocytic 65 missense mutation 65 Microtubule 65 fluorescently tagged 65 lipoxygenase 65 cytopathic 65 cisplatin resistant 65 PC3 cells 65 Intracellular 65 BRAF V#E 65 Epithelial 65 BCL2 65 acetyl CoA 65 selective agonist 65 radiolabeled 65 dinucleotide 65 haematopoietic 65 steroidogenesis 65 synthases 65 glomerular 65 immunostimulatory 65 serine protease 65 p# activation 65 adhesion molecule 65 ^ sup + 65 ^ sup #m 65 Notch1 65 Elevated serum 65 equimolar 65 coding genes 65 subcellular compartments 65 Dopaminergic 65 mononuclear cells 65 metalloproteinase 65 EphA2 65 basolateral membrane 65 ErbB4 65 p# deficient 65 aspartate 64 CYP# [002] 64 JAK STAT 64 FOXO3a 64 Tg mice 64 deficient mice 64 retroviral vector 64 erythrocyte 64 evolutionarily conserved 64 somatostatin receptor 64 D aspartate 64 MDCK cells 64 eIF4E 64 steroidogenic 64 FGFR4 64 cyclin E 64 radiosensitivity 64 inflammatory cytokine 64 Huntingtin 64 VEGFR1 64 JAK2 enzyme 64 TMPRSS2 ERG 64 PDGFR alpha 64 p# subunit 64 prostate epithelial cells 64 adipose cells 64 db db mice 64 Wnt1 64 ENaC 64 pyruvate kinase 64 Clusterin 64 mitogen activated protein kinases 64 monomeric 64 NF kappaB activation 64 genes encoding 64 heterochromatic 64 TXNIP 64 GSTP1 64 xenograft tumors 64 bile acid 64 proximal tubular 64 HER2 HER3 64 hypoxia inducible factor 64 tumor infiltrating lymphocytes 64 prolyl 64 VEGF receptor 64 pDCs 64 F actin 64 H#K#me# 64 5 hydroxytryptamine 64 mice overexpressing 64 immunoblotting 64 NFAT 64 carboxylase 64 allelic variants 64 transcriptional repressor 64 extracellular signal 64 cell adhesion molecules 64 tumor antigen 64 endosomes 64 neoplastic cells 64 hnRNP 64 outer membrane proteins 64 TRAIL induced apoptosis 64 HepG2 64 replicon 64 phosphatidylinositol 3 64 TGF alpha 64 PDGFR 64 morphogen 64 prostaglandin E2 PGE2 64 OCT4 64 coactivator 64 FLT3 64 heterodimer 64 EphB4 64 kD 64 PLA2 64 constitutive activation 64 Smad3 64 terminally differentiated 64 cell lysate 64 osteoblast 64 phorbol 64 T#M 64 c MET 64 acetylcholine receptor 64 SVZ 64 operons 64 PAX5 64 Hepatocytes 64 xenograft model 64 transduction 64 Interferon gamma 64 covalently linked 64 uracil 64 LRAT 64 PrP 64 myocyte enhancer factor 64 thyroid hormone receptor 64 protein kinase C 64 ubiquitination 64 Ki# 64 cytotoxicity assays 64 amine oxidase 64 mineralocorticoid 64 IL #R 64 proteinase 64 factor HGF 64 EF Tu 64 GPI anchored 64 ERK activation 64 basophils 64 HIF 1α 64 RAR beta 64 thymic 64 biotinylated 64 transmembrane receptor 64 mutant proteins 64 immunohistochemical analysis 64 Synuclein 64 mRNA encoding 64 striatal 64 cytokeratin 64 β galactosidase 64 Polymorphisms 64 HSP# 64 uM 64 nutlin 3a 64 activin 64 CTLs 64 hypermethylated 64 CCR9 64 hematoxylin eosin original 64 cholecystokinin CCK 64 nanomolar 64 MAPK 64 receptor gene 64 muscarinic 64 aberrantly activated 64 intracellular Ca 2 64 interleukin IL 64 thrombospondin 64 FABP 64 MAPK pathway 64 Fibroblast 64 C. albicans 64 melanoma antigens 64 chemokine receptors 64 Annexin V 64 Klf4 64 cytokines IL 64 microglial activation 64 SMAD4 64 guanosine 64 transmembrane domains 64 qRT PCR 64 enolase 64 polypeptides 64 hepatocellular carcinomas 64 potent inhibitors 64 Amino acid 64 μg ml 64 monophosphate 64 keratinocyte 64 MLH1 64 fig. S6 64 lung epithelial cells 64 E3 ligase 64 NADPH 64 Hypoxia Inducible Factor 64 #m Tc 64 AMPA receptor 64 mineralocorticoid receptor 64 IL 1beta 64 encodes protein 64 5alpha reductase 64 COOH terminal 64 JAK2 V#F 64 secretory pathway 64 BMP2 64 adenylyl cyclase 64 glycosyltransferase 64 hematopoietic cells 64 ,#,# [002] 64 Kv#.# 64 peroxisomal 64 aminobutyric acid 63 GTPase 63 Mutational 63 adenoviral 63 cells overexpressing 63 Fig. 1C 63 PI3K Akt 63 TUNEL 63 glutamatergic 63 epithelia 63 adenosine 5' triphosphate ATP 63 Mesenchymal 63 glutamic acid decarboxylase 63 erythropoiesis 63 kinase domain 63 intercellular adhesion molecule 63 DU# [002] 63 autocrine 63 clonogenic 63 FGFR1 63 induced cytotoxicity 63 CD# expression [001] 63 NKX#.# 63 EBNA1 63 ABCB1 63 intronic 63 interleukin IL -6 63 triacylglycerol 63 tumor lysate 63 Myeloid 63 intracellular signaling 63 ganglioside 63 PGC 1α 63 glucocorticoid receptor 63 oxidative metabolism 63 myeloid 63 luciferase reporter 63 CCR7 63 kinase gene 63 DRG neurons 63 matrix metalloproteinases MMPs 63 receptor subunit 63 Ca2 + 63 NMDAR 63 intratumoral injection 63 microglial 63 phagocytosis 63 gene encodes 63 glucokinase 63 neuronal differentiation 63 cultured neurons 63 HUVEC 63 #T# L1 63 immunofluorescence 63 Jurkat cells 63 selectively inhibits 63 Lymphocytes 63 lymphotoxin 63 potent stimulator 63 N acetyl 63 Inactivation 63 hENT1 63 costimulatory 63 binding affinities 63 podocytes 63 GRP# 63 embryonal carcinoma 63 5 HT4 receptor 63 DNA intercalator 63 acetylated 63 preferentially bind 63 N. benthamiana 63 cysteine protease 63 lysyl oxidase 63 Fig. 3B 63 isoenzymes 63 actin binding 63 ATP synthase 63 MyD# 63 Polymorphism 63 H#K# methylation 63 soluble receptor 63 metabolizing enzyme 63 ERa 63 tetramer 63 Aß 63 N cadherin 63 inhibitory effect 63 receptor mediated 63 lytic 63 synaptogenesis 63 #β estradiol 63 PDGF receptor 63 Htt 63 colorectal carcinoma 63 ATP hydrolysis 63 lymphoblasts 63 adrenergic receptor agonist 63 oncogenic transformation 63 SGLT 63 NS5B 63 mutated p# 63 GlcNAc 63 inverse agonist 63 monocytic 63 adrenal cortex 63 K + ATPase 63 granzyme B 63 plasma membrane 63 #HT#A 63 experimental autoimmune encephalomyelitis 63 mesangial 63 microsomes 63 ssDNA 63 lipopolysaccharide 63 pathophysiological effects 63 fluorescently labeled 63 tyrosine residues 63 vesicle fusion 63 STIM1 63 Transcriptional 63 transient transfection 63 cytokine receptors 63 malignant prostate 63 ERK1 63 channel ENaC 63 fig. S2 63 Adrenergic 63 N methyl 63 cells PBMC 63 immunotoxin 63 intraperitoneal injection 63 engrafted cells 63 Fig. 1D 63 PPARg 63 stimulated insulin secretion 63 proline 63 Kinesin 63 AT1R 63 adipocyte 63 midgut 63 N acetyltransferase 63 palytoxin 63 tissue transglutaminase 63 PTHrP 63 lysophosphatidic acid 63 lymphoid organs 63 proteolytic 63 thymidine 63 Androgen receptor 63 polycystin 63 Nedd4 63 selective inhibition 63 proinflammatory mediators 63 Apc 63 glycated 63 Notch receptor 63 protein encoded 63 Stat1 63 adducts 63 TOP2A 63 beta tubulin 63 apoE 63 C#Y 63 mRNA molecules 63 hexose 63 5' triphosphate 63 apolipoproteins 63 Polymerase 63 alkaline phosphatase 63 endocytosis 63 enkephalin 63 receptor subtypes 63 de novo synthesis 63 adenomatous polyposis coli 63 sphingolipid 63 colony stimulating factor 63 NR2B subunit 63 diffusible 63 Heterozygous 63 muscarinic receptors 63 HLA DR4 immune 63 BMP signaling 63 intracellularly 63 actinin 63 efferent 63 glioma cells 63 cystic fibrosis transmembrane 63 Tyrosine Kinase 63 oligomerization 63 fibroblast 63 ß1 63 methylenetetrahydrofolate reductase 63 deaminase 63 thyrotropin 63 intermediate filaments 63 Th1 63 mouse xenograft models 63 polypeptide 63 gamma H2AX 63 5 HT2A serotonin 63 effector function 63 JNK1 63 CXCR4 expression 63 degranulation 63 mitochondrial respiration 63 Gleevec resistant 63 Drp1 63 tumoral 63 Src kinase 63 myc 63 annexin 63 MEK1 63 IgG antibody 63 efflux 63 nitrotyrosine 63 Immunohistochemical staining 63 isoform 63 TNF α 63 phosphorothioate 63 nAChRs 63 ligand induced 63 ubiquitylation 63 nNOS 63 striatal dopamine 63 Foxp3 + 63 GABAergic 63 anti CD3 63 homologue 63 beta amyloid peptide 63 cardiac fibroblasts 62 secretase 62 multinucleated 62 glutamatergic neurons 62 Cytochrome P# 62 intracellular 62 preferentially binds 62 histidine 62 posttranslational modification 62 defensin 62 receptor CXCR4 62 HER2 receptor 62 neuronal signaling 62 pyrimidine 62 leptin receptor 62 c MYC 62 CD# expressing 62 homolog 62 transgenic rats 62 Histone H3 62 SH2 domain 62 hypothalamic 62 cyclooxygenase COX 62 paralogs 62 DLC1 62 NS3 62 Leydig cell 62 Î ² 62 CD# ligand 62 MT1 MMP 62 Fig. 1B 62 mitogen activated protein 62 prostaglandin E 62 postsynaptic 62 carboxylate 62 p# Shc 62 IGFBP 3 62 poly ADP ribose polymerase 62 TGFβ 62 PECAM 62 Fig. 3a 62 alpha2 62 protease activated 62 Aâ 62 myeloid cells 62 lactone 62 plastid 62 ribonucleoprotein 62 nAChR 62 PrPSc 62 glutathione S transferase 62 prostanoid 62 methyl D aspartate 62 aggrecan 62 rat hepatocytes 62 murine model 62 nitric oxide synthase 62 dorsal root ganglion 62 HEK# 62 methylated DNA 62 KLF4 62 osteoblastic 62 K#R [002] 62 mM NaCl 62 deletion mutant 62 PIP2 62 normoxic 62 receptor inhibitor 62 missense 62 thrombopoietin TPO natural 62 gastric mucosa 62 CHO cells 62 LRP6 62 CCL2 62 Kinase Inhibitor