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(Click for frequent words.) 74 transduced 73 EGFP 72 mRNA expression 72 transfected cells 72 HepG2 cells 71 murine 71 cells transfected 70 constitutively active 70 dsRNA 70 supernatants 69 vimentin 69 constitutively 69 downregulated 69 transgene expression 69 overexpressing 69 phosphorylated 69 VSV G 69 MDCK cells 68 peripheral blood mononuclear 68 constitutively expressed 68 beta actin 68 colon carcinoma 68 virulence genes 68 HEK# cells 68 syngeneic 68 homodimers 68 wildtype 68 hTERT 68 db db mice 68 ERBB2 67 splenocytes 67 xenografts 67 μg ml 67 catenin 67 amino terminal 67 annexin V 67 cells overexpressing 67 MDA MB 67 upregulated 67 tumorigenicity 67 CD# CD# 67 induced apoptosis 67 overexpressed 67 PC3 cells 67 monocyte chemotactic protein 67 LNCaP cells 67 ^ sup #m 67 pDCs 66 ERK1 2 66 isogenic 66 inducible 66 plasmacytoid dendritic cells 66 GSTP1 66 cytokeratin 66 transiently transfected 66 stably transfected 66 pDC 66 carcinoembryonic antigen 66 NOD SCID mice 66 phospho 66 Rap1 66 induces apoptosis 66 lysates 66 constitutively activated 66 immunostaining 66 mRNA transcripts 66 MEFs 66 phosphorylate 66 survivin 66 WT1 66 hematopoietic progenitors 66 isoforms 66 overexpression 66 lacZ 66 μM 66 cytosolic 66 subcellular localization 66 xenograft tumors 66 Immunohistochemical analysis 66 genes encoding 66 hepatoma 66 methyltransferase 66 luciferase reporter 66 PC# cells 66 PBMCs 66 stably expressing 65 null mice 65 IFN gamma 65 K#R [002] 65 cytoplasmic 65 immunoreactivity 65 immunohistochemical staining 65 unmethylated 65 biotinylated 65 TIMP 65 Supplementary Fig 65 short hairpin RNAs 65 cyclin dependent kinase inhibitor 65 apical membrane 65 homozygotes 65 cytotoxicity 65 CagA 65 orthologs 65 alveolar epithelial cells 65 ectopic expression 65 valine 65 Th1 65 cathepsin B 65 C#BL 6 mice 65 fig. S1 65 iNOS 65 EpCAM 65 transgenic mice 65 dinucleotide 65 mice lacking 65 histone H3 65 miR #a [001] 65 bone marrow stromal cells 65 immunofluorescence staining 65 glycosylated 64 phosphorylates 64 promoter methylation 64 lymphoid cells 64 EGFRvIII 64 immunofluorescence 64 ChR2 64 cisplatin resistant 64 melanoma antigens 64 ErbB2 64 Overexpression 64 MDR1 64 receptor CD# 64 transgenic mice expressing 64 heterozygous 64 HER2/neu 64 qRT PCR 64 phosphatidylinositol 64 CXCR4 64 heterozygotes 64 luciferase 64 xenograft model 64 heterodimers 64 antiproliferative activity 64 HLA DR 64 overexpress 64 operon 64 TIMP 1 64 GHRH 64 transfection 64 1alpha 64 FLT3 64 kDa protein 64 monocyte 64 CD#c 64 coexpression 64 RANTES 64 FasL 64 RRM1 64 cDNA 64 carboxyl terminal 64 FGFR3 64 GPC3 64 cultured cells 64 lysine residues 64 erythrocytes 64 uPAR 64 cell adhesion molecule 64 cyclin E 64 neutralizing antibody 64 TNFa 64 EphB4 64 IGFBP 64 transmembrane protein 64 bronchial epithelial cells 64 nucleolin 64 Supplemental Figure 64 CD#b 64 androgen receptor AR 64 phosphatase 64 tumor antigen 64 P selectin 64 cytokines IL 64 hepatocellular carcinomas 64 Foxp3 64 cytokine secretion 64 IL 1beta 63 immunodeficient mice 63 cytochrome 63 IL #p# 63 PDGFR 63 lactate dehydrogenase 63 replicon 63 myeloma cells 63 antigen 63 caveolin 1 63 mononuclear cells 63 isoform 63 inhibitory activity 63 substrate specificity 63 TNF α 63 tumor specific antigen 63 VEGFR2 63 selectively binds 63 TNFalpha 63 pyruvate kinase 63 mRNA encoding 63 short hairpin RNA 63 somatostatin 63 regulated kinase 63 interleukin IL 63 potent inhibition 63 beta subunit 63 NS3 63 Western blotting 63 homodimer 63 immunodominant 63 transmembrane 63 μmol L 63 IL 1β 63 63 Tie2 63 unmutated 63 genotypes 63 Kupffer cells 63 overexpressing cells 63 ALDH 63 glutamyl 63 Jurkat cells 63 nanomolar 63 Flt3 63 extracellular domain 63 microsomal 63 adenoviral 63 colorectal carcinoma 63 orthotopic 63 CD3 + 63 TGF ß 63 potently inhibited 63 CXCL# 63 tyrosine kinase receptor 63 hepatocytes 63 phenotype 63 ERalpha 63 midgut 63 mutant p# 63 ^ Tc 63 CDK4 63 intercellular adhesion molecule 63 transactivation 63 lipoxygenase 63 intraperitoneal injection 63 Rab5 63 GFAP 63 Peyer patches 63 microRNA miR 63 peroxidase 63 aggrecan 63 outer membrane proteins 63 HIF 1alpha 63 triphosphate 63 heterologous 63 PTPN# 63 cytidine 63 TAp# 63 tyrosine hydroxylase 63 decarboxylase 63 differentially regulated 63 #F FDG 63 Annexin V 62 mediated inhibition 62 immunoblotting 62 lysosomal 62 H#K#me# 62 cDNAs 62 FGFR4 62 deacetylation 62 HER-2/neu 62 miRNA expression 62 lysate 62 plasmid encoding 62 shRNA 62 Immunohistochemical staining 62 gp# [002] 62 glycoprotein 62 nM 62 allelic variants 62 gene encoding 62 E. faecalis 62 quantitative RT PCR 62 radiolabeled 62 COL#A# 62 coding genes 62 CHO cells 62 Saccharomyces cerevisiae 62 CaM 62 alkaline phosphatase 62 transferase 62 thymocytes 62 OCT4 62 GlcNAc 62 IFN α 62 HER2 receptor 62 proto oncogene 62 DNMT1 62 lymph node metastasis 62 effector memory 62 IFN ß 62 Leydig cells 62 IFN g 62 isoenzyme 62 cytoplasmic domain 62 TGF beta1 62 ciliated 62 fusion protein 62 fig. S2 62 mRNA 62 bleomycin 62 selective agonist 62 STAT1 62 oncoproteins 62 embryonal carcinoma 62 MTHFR 62 microglial 62 c MET 62 immunized mice 62 immunoreactive 62 BALB c mice 62 LDLR 62 shRNAs 62 fluorescently tagged 62 tryptase 62 defensin 62 phosphoprotein 62 neuropilin 62 cysteine protease 62 ß catenin 62 amplicons 62 RhoA 62 lyase 62 FLT3 ITD 62 Cx# [001] 62 adenylate cyclase 62 1α 62 C#Y 62 intronic 62 p#Kip# 62 CTLs 62 neuroblastoma cells 62 lymphoid 62 AMACR 62 Fig. 1A 62 dimerization 62 secretory proteins 62 c MYC 62 Ki# 62 polypeptides 62 MnSOD 62 intestinal epithelial cells 62 splice variants 62 JAK2 V#F 62 CD# [002] 62 interleukin IL -# 62 hENT1 62 MUC1 62 glioma cells 62 Cre recombinase 62 vesicular stomatitis virus 62 HER2 neu 62 E#F# 62 CCL# 62 thymidine 62 CCR9 62 fibroblast cells 62 CD8 + 62 RASSF1A 62 cells PBMC 62 soluble receptor 62 glioblastoma cells 62 Tubulin 62 SOCS3 62 CCR7 62 annexin 62 keratinocyte 62 polycystin 62 HepG2 62 transcriptional regulator 62 neoplastic 62 protein secreted 62 monomeric 62 aminopeptidase 62 passaged 62 GRP# 62 xenograft 62 C. albicans 62 colocalization 62 deficient mice 62 transcriptional activation 62 KIT mutations 62 epithelial cells lining 62 NKG2D 62 epithelial tumors 62 c myc 62 Transgenic Mice 62 TGF ß1 62 hepatocyte 62 IFN alpha 62 stromal cells 62 IgG antibodies 62 ,#,# [002] 62 factor HGF 62 Fig. 2A 62 synthases 62 hydroxylase 62 proteinase 62 glucose transporter 62 immunohistochemical 62 vascular endothelial cells 62 isomerase 62 etoposide 61 IFN γ 61 gene amplification 61 thymic 61 receptor CXCR4 61 transduce 61 CD# + [001] 61 tetramer 61 inhibitory receptor 61 adduct 61 matrix metalloproteinases 61 HDACi 61 BMP signaling 61 specific CD8 + 61 MLH1 61 epithelial 61 Pgp 61 Fig. 1B 61 5alpha reductase 61 dimeric 61 XL# inhibits 61 CD# + [002] 61 activating mutation 61 Eg5 61 prostate carcinoma 61 activating mutations 61 synthase 61 myocyte enhancer factor 61 IgG1 61 selectively inhibited 61 peptide antigens 61 dephosphorylation 61 VEGF receptor 61 IGF1R 61 CLL cells 61 β 61 hypoxia inducible factor 61 CYP# [002] 61 retroviral vector 61 suppressor gene 61 enterocytes 61 hypermethylated 61 tropomyosin 61 uM 61 hnRNP 61 PTHrP 61 Corynebacterium 61 acyl CoA 61 heterozygote 61 tumor xenografts 61 IL 1ß 61 phospholipase 61 thioredoxin 61 transgene 61 Ab# 61 aberrantly activated 61 interferon γ 61 claudin 61 JAK2 61 beta galactosidase 61 downregulation 61 explants 61 cell lysates 61 syntaxin 61 differentially expressed 61 Fig. 2b 61 costimulatory molecules 61 ligand receptor 61 β1 61 PKM2 61 NY ESO 61 hypermethylation 61 N. benthamiana 61 Chinese hamster ovary 61 homozygous 61 immunostimulatory 61 astrocytic 61 ERK signaling 61 IgA antibodies 61 fluorescently labeled 61 receptor binding 61 CD1d 61 pyrimidine 61 Heterozygous 61 pRb 61 #S rRNA 61 ER alpha 61 TRAIL receptor 61 epithelial cell 61 thymidine kinase 61 membrane proximal 61 ribosomal protein 61 differentially expressed genes 61 adipogenic 61 gastric carcinomas 61 1beta 61 potently inhibits 61 cytotoxin 61 transcriptional regulation 61 apo AI 61 PDGF receptor 61 thyroid hormone receptor 61 microsomes 61 breast carcinomas 61 SIRT2 61 γ 61 triacylglycerol 61 V#F mutation 61 BrdU 61 glycosyltransferase 61 xenograft models 61 downregulate 61 anti CD3 61 coactivator 61 myocytes 61 Notch1 61 isoprostane 61 p#NTR 61 mononuclear 61 CXCR4 expression 61 vitro cytotoxicity 61 lung epithelial cells 61 GM CSF 61 S#A# [002] 61 ERCC1 61 rs# [001] 61 ssDNA 61 peptide 61 ribonuclease 61 serine threonine kinase 61 ubiquitinated 61 antisense inhibition 61 MyoD 61 μ opioid receptor 61 BoNT 61 #S rRNA gene 61 PGCs 61 mesenchymal cells 61 cell lysate 61 cytokine interleukin 61 transmembrane domains 61 mitogen activated protein kinase 61 LRP6 61 thymosin 61 homologue 61 PU.1 61 avidin 61 glyceraldehyde 3 61 chemokine receptor 61 polyamine 61 P. gingivalis 61 A. thaliana 61 FLT3 kinase 61 Vps# 61 Clusterin 61 N Myc 61 GAPDH 61 leukemic cell 61 receptor tyrosine kinase 61 transcriptional repressor 61 fibroblast 61 homozygote 61 isotypes 61 kD 61 inhibited tumor 60 LNCaP 60 At#g# 60 immunohistochemical analysis 60 immunotoxin 60 cultured neurons 60 Th2 60 ovalbumin 60 induce apoptosis 60 cytokine IL 60 macrophage colony stimulating 60 FUS1 60 draining lymph nodes 60 binding affinity 60 hydrolase 60 adenoviral vector 60 nutlin 3a 60 cyclin dependent kinase 60 telomerase reverse transcriptase 60 acetylated 60 GPNMB 60 situ hybridization 60 LPS induced 60 tyrosine phosphorylation 60 receptor gene 60 binds selectively 60 equimolar 60 P2X 60 thermosensitive 60 lytic 60 elastase 60 cystic fibrosis transmembrane conductance 60 CD8 T cells 60 IL# [001] 60 matrix metalloproteinase 60 protein encoded 60 GLI1 60 potent inhibitors 60 LRAT 60 paxillin 60 vitro experiments 60 Fig. 3b 60 NRTI resistance 60 angiopoietin 60 azacytidine 60 neurofilament 60 granulocytes 60 HSCs 60 CEACAM1 60 microdissected 60 PAK1 60 RNA transcripts 60 transgenic mouse model 60 activin 60 inhibitory effects 60 IGFBP 3 60 amino acid residues 60 TGF β 60 Supplementary Table 60 #S rDNA 60 receptor mediated endocytosis 60 β catenin 60 E selectin 60 trophoblast cells 60 serine protease 60 ganglioside 60 pro apoptotic 60 cysteines 60 Abl 60 α 60 effector function 60 homogenates 60 adenosine diphosphate ADP 60 COOH terminal 60 TGF β1 60 trophoblasts 60 transferrin receptor 60 anterior pituitary 60 IgG 60 MAP kinase 60 orthologous 60 sequence homology 60 VNTR 60 interferon IFN 60 mutant proteins 60 HER2 HER2 60 mimetic peptide 60 preferentially bind 60 caveolin 60 Fig. 1C 60 KLF4 60 TGF alpha 60 CYP#B# 60 alpha2 60 mutant allele 60 T#I [002] 60 steroidogenic 60 apolipoprotein B 60 transgenic rats 60 #ß 60 CpG 60 miR #b [001] 60 intermediate filaments 60 GLUT4 60 FDG uptake 60 c KIT 60 Klf4 60 inverse agonist 60 immunofluorescence microscopy 60 B7 H1 60 radiosensitivity 60 IL #R 60 Sprague Dawley rats 60 basolateral 60 thyroglobulin 60 BALB c 60 interleukin IL -6 60 motoneurons 60 CD4 + T lymphocytes 60 plasmid DNA 60 monocytic 60 p# mitogen activated 60 proline 60 Epithelial 60 bcl 2 60 ribosomal proteins 60 Chinese Hamster Ovary 60 haematopoietic 60 homologs 60 methylated DNA 60 IL#B 60 C#BL 6 60 mediated apoptosis 60 plasmacytoid 60 Fig. 2B 60 5' triphosphate 60 neutralizing antibody responses 60 Dpp 60 p# deficient 60 enzymatic activity 60 EBNA1 60 anaphase promoting complex 60 bone morphogenic protein 60 ablated 60 intracellular 60 monocyte chemoattractant protein 60 mammalian cells 60 proteolytic cleavage 60 CD# expression [002] 60 deoxy 60 BRAF V#E 60 chemotactic 60 immunoprecipitation 60 K ras mutations 60 assay detects 60 MT1 MMP 60 autoantibody 60 cholera toxin 60 eotaxin 60 neoplastic cells 60 EGF receptor 60 hepatocyte growth 60 exon 60 p# p# 60 PCa 60 ex vivo 60 cytopathic 60 heterochromatic 60 papillary RCC 60 murine model 60 Fas ligand 60 AAV2 60 serum concentrations 60 autophagic 60 mitogenic 60 SNP rs# [001] 60 SOD1 60 oncogenic transformation 60 HCV replicon 60 cysteine residues 60 ErbB4 60 normal karyotype 60 Cytotoxic T 60 lymphocytic 60 carboxylase 60 histone H4 60 poly ADP ribose polymerase 60 monocytes macrophages 60 IGF IR 60 proapoptotic 60 downregulates 60 gamma globin 60 potent inhibitor 60 epitope 60 fluorescence intensity 60 TRAIL R2 60 serine threonine 60 galactosidase 60 upregulation 60 TTR gene 60 ErbB1 60 cells PBMCs 60 SMase 60 monoclonal 60 adrenoceptor 60 serine 60 DNase 60 athymic mice 60 vivo 60 ^ sup + 60 PAX5 60 IgG4 60 P gp 60 kinase pathway 60 GSTT1 60 HCV protease 60 inducible nitric oxide synthase 60 cytotoxicity assays 60 4E BP1 60 induced phosphorylation 60 Hepatocytes 60 Fig. 1E 60 metalloproteinase 60 variant allele 60 MMP2 59 Fig. 1D 59 enolase 59 oxidase 59 apolipoproteins 59 Genotypes 59 umbilical vein 59 rat hepatocytes 59 polymorphisms 59 intratumoral injection 59 keratinocytes 59 cytochrome P 59 Enterococcus faecalis 59 glutamic acid decarboxylase 59 cytokine signaling 59 DRG neurons 59 Fig. 3a 59 mM 59 5 hydroxytryptamine 59 PCR assay 59 SCID mice 59 #β estradiol 59 p# MAPK 59 myoblasts 59 Caveolin 1 59 methylation patterns 59 perivascular 59 CC genotype 59 mol L 59 immunoglobulin G 59 quantitative PCR 59 prion proteins 59 Aβ 59 diphosphate 59 Pharmacokinetics PK 59 5HT 59 scFv 59 lentiviral vector 59 transfection efficiency 59 immunocytochemistry 59 polyclonal 59 bile acid 59 secretory 59 procaspase 3 59 1ß 59 Figure 2C 59 evolutionarily conserved 59 hippocampal neurons 59 SMN1 59 PCR amplified 59 antiapoptotic 59 rs# [004] 59 protein tyrosine phosphatase 59 acyltransferase 59 SDS PAGE 59 hematopoietic 59 expressing GFP 59 HIF 1a 59 Î ² 59 cyclic AMP cAMP 59 transgenic mouse models 59 acetyl CoA 59 osteoblast 59 laminin 59 cDNA libraries 59 microglial activation 59 mannose 59 variant alleles 59 ovarian carcinoma 59 tissue transglutaminase 59 replicase 59 lentiviral vectors 59 receptor antagonists 59 melanocyte 59 JAK STAT 59 BCL2 59 NSCLC tumors 59 kinase domain 59 regulated kinase ERK 59 receptor inhibitor 59 inhibitory effect 59 Leydig cell 59 cathepsins 59 tumorigenic 59 centromeric 59 Cytoplasmic 59 NFkB 59 antigens 59 MDM2 59 Histone 59 nanomolar range 59 nAChR 59 mutated KRAS 59 Macrophage 59 #m Tc 59 PDGF B 59 subcutaneously injected 59 LDL receptor 59 Hepatocyte 59 alleles 59 leukemic stem cells 59 homolog 59 deoxyglucose 59 CCL2 59 neurokinin 59 affinity purified 59 HOTAIR 59 alternatively spliced 59 adhesion molecule 59 epithelia 59 endothelial cell 59 proximal tubule 59 3' 59 Interferon gamma 59 synthetase 59 IgM 59 hematoxylin 59 suppressor cells 59 monolayers 59 CHO cell 59 eNOS 59 tumoral 59 diploid 59 BCR ABL 59 surface glycoprotein 59 BMP2 59 DU# [002] 59 ATPase 59 Fig. 2C 59 Monocytes 59 mouse embryonic fibroblasts 59 missense mutation 59 drug metabolizing enzymes 59 NS4A 59 NF kappaB activation 59 tumor antigens 59 mRNAs 59 Monocyte 59 alkaline phosphatase ALP 59 cDNA library 59 M1 muscarinic 59 hematopoietic cells 59 pancreatic adenocarcinoma 59 CD8 59 interleukin 1ß 59 malignant prostate 59 proteases 59 IKKß 59 PI3K inhibitor 59 Jhdm2a 59 pro angiogenic 59 leptin receptor 59 rRNA 59 cellular prion protein 59 TNFR1 59 RUNX3 59 S. enterica 59 Cytochrome 59 GFP fusion 59 bispecific 59 colony stimulating factor 59 GenBank accession 59 myc 59 dimers 59 Cry1Ac 59 Vpu 59 VEGFR1 59 hemagglutinin HA 59 genotyped 59 anti inflammatory cytokine 59 HSP# 59 FGFR1 59 L. pneumophila 59 CD# expressing 59 polypeptide 59 cytotoxic T lymphocyte 59 MSH2 59 conjugates 59 granulocyte 59 DR4 59 pertussis toxin 59 PKC delta 59 hMSCs 59 RNA polymerases 59 miR# 59 oligomerization 59 EGFR 59 muscarinic receptor 59 lymphoid organs 59 β2 59 PrP 59 enzyme cytochrome 59 prostate epithelial cells